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  1. Artikel: Epileptischer Anfall des Erwachsenen in der Notaufnahme

    Sauer, Raoul Benedikt / Minnerup, Jens / Möddel, Gabriel

    Notaufnahme up2date

    2024  Band 06, Heft 02, Seite(n) 141–156

    Schlagwörter Epilepsie ; Anfälle ; Neurologie ; EEG ; Stufentherapie
    Sprache Deutsch
    Erscheinungsdatum 2024-04-01
    Verlag Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ISSN 2628-7609 ; 2628-7595
    ISSN (online) 2628-7609
    ISSN 2628-7595
    DOI 10.1055/a-2051-9291
    Datenquelle Thieme Verlag

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  2. Artikel: EEG bei Bewusstseinsstörungen, Koma und Intensivpatienten

    Möddel, Gabriel

    Das Neurophysiologie-Labor

    2018  Band 40, Heft 1 Sonderh., Seite(n) 58

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 2006849-9
    ISSN 1439-4847
    Datenquelle Current Contents Medizin

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  3. Artikel ; Online: Severe disease exacerbation after mRNA COVID-19 vaccination unmasks suspected multiple sclerosis as neuromyelitis optica spectrum disorder: a case report.

    Lohmann, Lisa / Glaser, Felix / Möddel, Gabriel / Lünemann, Jan D / Wiendl, Heinz / Klotz, Luisa

    BMC neurology

    2022  Band 22, Heft 1, Seite(n) 185

    Abstract: Background: Since the beginning of the COVID-19 pandemic and development of new vaccines, the issue of post-vaccination exacerbation or manifestation of demyelinating central nervous system (CNS) disorders has gained increasing attention.: Case ... ...

    Abstract Background: Since the beginning of the COVID-19 pandemic and development of new vaccines, the issue of post-vaccination exacerbation or manifestation of demyelinating central nervous system (CNS) disorders has gained increasing attention.
    Case presentation: We present a case of a 68-year-old woman previously diagnosed with multiple sclerosis (MS) since the 1980s who suffered a rapidly progressive severe sensorimotor paraparesis with loss of bladder and bowel control due to an acute longitudinal extensive transverse myelitis (LETM) after immunization with the mRNA Pfizer-BioNTech COVID-19 vaccine. Detection of Aquaporin-4-antibodies (AQP4) in both serum and CSF led to diagnosis of AQP4-antibody positive neuromyelitis optica spectrum disorder (NMOSD). Treatment with intravenous corticosteroids and plasmapheresis led to a slight improvement of the patient's symptoms.
    Conclusions: Pathogenic mechanisms of post-vaccination occurrence of NMOSD are still unknown. However, cases like this should make aware of rare neurological disorders manifesting after vaccination and potentially contribute to improvement of management of vaccinating patients with inflammatory CNS disorders in the future. So far two cases of AQP4-antibody positive NMOSD have been reported in association with viral vector COVID-19 vaccines. To our knowledge, we report the first case of AQP4-antibody positive NMOSD after immunization with an mRNA COVID-19-vaccine.
    Mesh-Begriff(e) Aged ; Aquaporin 4/blood ; Aquaporin 4/cerebrospinal fluid ; Autoantibodies/blood ; Autoantibodies/cerebrospinal fluid ; BNT162 Vaccine/adverse effects ; BNT162 Vaccine/therapeutic use ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/therapeutic use ; Disease Progression ; Female ; Humans ; Multiple Sclerosis/blood ; Multiple Sclerosis/cerebrospinal fluid ; Multiple Sclerosis/complications ; Myelitis, Transverse/chemically induced ; Myelitis, Transverse/diagnosis ; Myelitis, Transverse/etiology ; Neuromyelitis Optica/blood ; Neuromyelitis Optica/cerebrospinal fluid ; Neuromyelitis Optica/diagnosis ; Neuromyelitis Optica/etiology ; Pandemics ; RNA, Messenger ; Vaccination/adverse effects
    Chemische Substanzen Aquaporin 4 ; Autoantibodies ; COVID-19 Vaccines ; RNA, Messenger ; BNT162 Vaccine (N38TVC63NU)
    Sprache Englisch
    Erscheinungsdatum 2022-05-18
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-022-02698-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Targeted and optimized multi-channel transcranial direct current stimulation for focal epilepsy: An N-of-1 trial.

    Antonakakis, Marios / Kaiser, Fabian / Rampp, Stefan / Kovac, Stjepana / Wiendl, Heinz / Stummer, Walter / Gross, Joachim / Kellinghaus, Christoph / Khaleghi-Ghadiri, Maryam / Möddel, Gabriel / Wolters, Carsten H

    Brain stimulation

    2024  Band 17, Heft 2, Seite(n) 221–223

    Mesh-Begriff(e) Humans ; Transcranial Direct Current Stimulation/methods ; Epilepsies, Partial/therapy ; Male ; Adult ; Female ; Middle Aged ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2024.02.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Two mutations in the nicotinic acetylcholine receptor subunit A4 (CHRNA4) in a family with autosomal dominant sleep-related hypermotor epilepsy.

    Langenbruch, Lisa / Biskup, Saskia / Young, Peter / Dräger, Bianca / Möddel, Gabriel

    Epileptic disorders : international epilepsy journal with videotape

    2020  Band 22, Heft 1, Seite(n) 116–119

    Abstract: Sleep-related hypermotor epilepsy, or nocturnal frontal lobe epilepsy, as it was formerly called, is a focal epilepsy with mostly sleep-related seizures of hypermotor, tonic or dystonic semiology. Sleep-related hypermotor epilepsy may be attributed to a ... ...

    Abstract Sleep-related hypermotor epilepsy, or nocturnal frontal lobe epilepsy, as it was formerly called, is a focal epilepsy with mostly sleep-related seizures of hypermotor, tonic or dystonic semiology. Sleep-related hypermotor epilepsy may be attributed to a monogenetic cause with autosomal dominant inheritance. Mutations are described in different genes, including the genes for three subunits of the nicotinic acetylcholine receptor. We present a family with members over four generations exhibiting sleep-related hypermotor epilepsy. Genetic testing was available for three members from three generations, and revealed two variants in the alpha-4 subunit of the nicotinic acetylcholine receptor (one of them being novel) which are likely to be disease-causing. As these mutations were identified in cis configuration (on the same allele), we do not know whether one of the variants alone or a combination of the two is responsible for the pathogenicity.
    Mesh-Begriff(e) Adult ; Aged ; Epilepsies, Partial/complications ; Epilepsies, Partial/genetics ; Epilepsies, Partial/physiopathology ; Female ; Humans ; Middle Aged ; Pedigree ; Receptors, Nicotinic/genetics ; Sleep Arousal Disorders/etiology ; Sleep Arousal Disorders/genetics ; Sleep Arousal Disorders/physiopathology ; Young Adult
    Chemische Substanzen Receptors, Nicotinic ; nicotinic acetylcholine receptor alpha4 subunit
    Sprache Englisch
    Erscheinungsdatum 2020-02-19
    Erscheinungsland France
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2086797-9
    ISSN 1950-6945 ; 1294-9361
    ISSN (online) 1950-6945
    ISSN 1294-9361
    DOI 10.1684/epd.2020.1140
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: „Anfälle“ im Schlaf – Was kann das sein?

    MÖDDEL, GABRIEL / YOUNG, PETER

    Schlaf

    2017  Band 06, Heft 04, Seite(n) 191–201

    Abstract: Bei über 4–5 % aller Erwachsenen kommt es immer wieder nachts im Schlaf zu Verhaltensauffälligkeiten, an die sich die Betroffenen selbst größtenteils nicht erinnern können. Die richtige diagnostische Einordnung solcher Attacken ist für die Beratung der ... ...

    Abstract Bei über 4–5 % aller Erwachsenen kommt es immer wieder nachts im Schlaf zu Verhaltensauffälligkeiten, an die sich die Betroffenen selbst größtenteils nicht erinnern können. Die richtige diagnostische Einordnung solcher Attacken ist für die Beratung der Betroffenen und für eine geeignete Therapie wichtig.:
    Sprache Deutsch
    Erscheinungsdatum 2017-01-01
    Verlag Schattauer GmbH
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ISSN 2568-0528 ; 2194-7880
    ISSN (online) 2568-0528
    ISSN 2194-7880
    DOI 10.1055/s-0038-1626182
    Datenquelle Thieme Verlag

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  7. Artikel ; Online: Clinically relevant interaction of rivaroxaban and valproic acid - A case report.

    Langenbruch, Lisa / Meuth, Sven G / Wiendl, Heinz / Mesters, Rolf / Möddel, Gabriel

    Seizure

    2020  Band 80, Seite(n) 46–47

    Mesh-Begriff(e) Administration, Oral ; Adult ; Anticoagulants/therapeutic use ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use ; Atrial Fibrillation ; Factor Xa Inhibitors/therapeutic use ; Humans ; Male ; Rivaroxaban/adverse effects ; Rivaroxaban/therapeutic use ; Stroke ; Treatment Outcome ; Valproic Acid/adverse effects ; Valproic Acid/therapeutic use ; Venous Thrombosis/chemically induced ; Venous Thrombosis/drug therapy
    Chemische Substanzen Anticoagulants ; Anticonvulsants ; Factor Xa Inhibitors ; Valproic Acid (614OI1Z5WI) ; Rivaroxaban (9NDF7JZ4M3)
    Sprache Englisch
    Erscheinungsdatum 2020-06-01
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1137610-7
    ISSN 1532-2688 ; 1059-1311
    ISSN (online) 1532-2688
    ISSN 1059-1311
    DOI 10.1016/j.seizure.2020.05.024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Occurrence of status epilepticus in persons with epilepsy is determined by sex, epilepsy classification, and etiology: a single center cohort study.

    Langenbruch, Lisa / Strippel, Christine / Görlich, Dennis / Elger, Christian E / Möddel, Gabriel / Meuth, Sven G / Kellinghaus, Christoph / Wiendl, Heinz / Kovac, Stjepana

    Journal of neurology

    2021  Band 268, Heft 12, Seite(n) 4816–4823

    Abstract: Background: Status epilepticus (SE) can occur in persons with or without epilepsy and is associated with high morbidity and mortality.: Methods: This survey aimed to record self-reported frequency of SE in persons with epilepsy, its association with ... ...

    Abstract Background: Status epilepticus (SE) can occur in persons with or without epilepsy and is associated with high morbidity and mortality.
    Methods: This survey aimed to record self-reported frequency of SE in persons with epilepsy, its association with clinical characteristics and patient level of information on SE and rescue medication. 251 persons with epilepsy at a tertiary epilepsy center were included in the study.
    Results: 87 (35%) had a history of SE defined as seizure duration of more than 5 min. These patients were less likely to be seizure-free, and had a higher number of present and past anti-seizure medication. Female sex, cognitive disability, younger age at epilepsy onset, defined epilepsy etiology, and focal epilepsy were associated with a history of SE. On Cox regression analysis, female sex, defined etiology and focal classification remained significant. 67% stated that they had information about prolonged seizures, and 75% knew about rescue medication. 85% found it desirable to receive information about SE at the time of initial diagnosis of epilepsy, but only 16% had been offered such information at the time.
    Conclusion: SE is frequent among persons with epilepsy and there remain unmet needs regarding patient education.
    Mesh-Begriff(e) Cohort Studies ; Epilepsy/complications ; Epilepsy/drug therapy ; Epilepsy/epidemiology ; Female ; Humans ; Seizures ; Status Epilepticus/complications ; Status Epilepticus/epidemiology ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2021-05-21
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-021-10600-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: The Effect of Head Model Simplification on Beamformer Source Localization.

    Neugebauer, Frank / Möddel, Gabriel / Rampp, Stefan / Burger, Martin / Wolters, Carsten H

    Frontiers in neuroscience

    2017  Band 11, Seite(n) 625

    Abstract: Beamformers are a widely-used tool in brain analysis with magnetoencephalography (MEG) and electroencephalography (EEG). For the construction of the beamformer filters realistic head volume conductor modeling is necessary for accurately computing the EEG ...

    Abstract Beamformers are a widely-used tool in brain analysis with magnetoencephalography (MEG) and electroencephalography (EEG). For the construction of the beamformer filters realistic head volume conductor modeling is necessary for accurately computing the EEG and MEG leadfields, i.e., for solving the EEG and MEG forward problem. In this work, we investigate the influence of including realistic head tissue compartments into a finite element method (FEM) model on the beamformer's localization ability. Specifically, we investigate the effect of including cerebrospinal fluid, gray matter, and white matter distinction, as well as segmenting the skull bone into compacta and spongiosa, and modeling white matter anisotropy. We simulate an interictal epileptic measurement with white sensor noise. Beamformer filters are constructed with unit gain, unit array gain, and unit noise gain constraint. Beamformer source positions are determined by evaluating power and excess sample kurtosis (g
    Sprache Englisch
    Erscheinungsdatum 2017-11-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2017.00625
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Impaired processing of response conflicts in mesial temporal lobe epilepsy.

    Ramm, Markus / Möddel, Gabriel / Sundermann, Benedikt / Last, Annegret / Langenbruch, Lisa / Jungilligens, Johannes / Wellmer, Jörg / Young, Peter / Axmacher, Nikolai

    Journal of neuropsychology

    2019  Band 14, Heft 2, Seite(n) 283–300

    Abstract: Increasing evidence from neuroimaging studies points towards a hippocampal role in resolving approach-avoidance goal conflicts. Furthermore, previous neuroimaging findings suggest that the hippocampus (HC) contributes to successful conflict resolution as ...

    Abstract Increasing evidence from neuroimaging studies points towards a hippocampal role in resolving approach-avoidance goal conflicts. Furthermore, previous neuroimaging findings suggest that the hippocampus (HC) contributes to successful conflict resolution as it is measured, for example, in a Stroop paradigm. However, it is still an open question whether the hippocampus is indeed causally relevant for resolving cognitive conflicts. Here, we investigated whether conflict resolution performance is affected by hippocampal pathology. N = 30 patients with mesial temporal lobe epilepsy (MTLE), almost exclusively showing MRI signs of hippocampal sclerosis, and an equal number of age-matched healthy controls performed an auditory Stroop paradigm. Participants listened to the words 'high' and 'low', spoken in either a high or a low pitch. Subjects' response time and accuracy to the phonetic information in the presence of incongruent (conflict trials) or congruent (non-conflict trials) semantic information were assessed. In addition, patients' regional grey matter (GM) brain volumes were analysed. We observed an increased effect of conflict on accuracy in patients with MTLE compared to healthy controls. This effect was negatively correlated with right HC volume. The results suggest that the impairment in the resolution of a response conflict is related to hippocampal structural integrity and thus add further support to the notion that the HC is not only involved but even causally relevant for successful cognitive conflict processing.
    Mesh-Begriff(e) Adult ; Brain Mapping ; Case-Control Studies ; Electroencephalography ; Epilepsy, Temporal Lobe/physiopathology ; Female ; Hippocampus/physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Stroop Test ; Temporal Lobe/pathology
    Sprache Englisch
    Erscheinungsdatum 2019-06-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2380753-2
    ISSN 1748-6653 ; 1748-6645
    ISSN (online) 1748-6653
    ISSN 1748-6645
    DOI 10.1111/jnp.12186
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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