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Artikel: Mechanical Properties of Lattice Structures with a Central Cube: Experiments and Simulations.

Guo, Shuai / Ma, Yuwei / Liu, Peng / Chen, Yang

2024 Band 17, Heft 6

Abstract: In this study, a new structure is proposed based on the body-centered cubic (BCC) lattice structure by adding a cubic truss in the center of the BCC structure and denoting it TLC (truss-lattice-cube). The different dimensions of the central cube can ... ...

Abstract	In this study, a new structure is proposed based on the body-centered cubic (BCC) lattice structure by adding a cubic truss in the center of the BCC structure and denoting it TLC (truss-lattice-cube). The different dimensions of the central cube can notably affect the mechanical properties of the lattice structure. With a fixed length (15 mm) of a unit cell, the optimal size for the central cube is determined to be 5 mm. Quasi-static compressive tests are performed on specimens made of polylactic acid (PLA) using additive manufacturing technology. The deformation characteristics of the new structure are analyzed in detail by experiments and numerical simulations. Compared to the BCC structure, the mechanical properties of the TLC structure were significantly improved. The initial flow stress of the TLC increased by 122% at a strain of 0.1; the specific strength enhanced by 293% at a strain of 0.5; and the specific energy absorption improved by 312% at a strain of 0.6. Printing defects in the lattice structure may remarkably damage its mechanical properties. In this work, incorporation of microcracks into the finite element model allows the simulation to capture the influence of printing defects and significantly improve the predictive accuracy of the simulation.
Sprache	Englisch
Erscheinungsdatum	2024-03-14
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17061329
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Numerical Investigation on Precipitation Hardening of Mg-Gd Alloys.

Ge, Yulong / Yang, Chunyan / Ma, Yuwei / Chen, Yang / Gupta, Manoj

Materials (Basel, Switzerland)

2024 Band 17, Heft 6

Abstract: The second-phase particles in magnesium alloys could affect the mechanical properties of the material significantly. In this work, 3D finite element models with explicit incorporation of second-phase particles are established. The simulations are ... ...

Abstract	The second-phase particles in magnesium alloys could affect the mechanical properties of the material significantly. In this work, 3D finite element models with explicit incorporation of second-phase particles are established. The simulations are calibrated with the experimental results of the Mg-1Gd alloy. The influences of factors, such as the particle distribution, size, and orientation of cylindrical particles, on precipitation hardening are investigated in detail. Three interface conditions between particles and the matrix-perfect bonding and high- and low-strength bonding-are studied at the same time. The interface conditions are shown to exert a stronger influence on precipitation hardening compared to the factors of particle distribution and size. In contrast, the influence of the orientation of cylindrical particles at grain boundaries outweighs the effect of interface property. When second-phase particles are relatively large and all located at grain boundaries, the hardening effect can be improved, and the magnesium alloy shows relatively high flow stress. However, the high hardening effect from the second-phase particles could result in high local stress concentration and possible early failure or low ductility of Mg alloys.
Sprache	Englisch
Erscheinungsdatum	2024-03-19
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17061393
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Silicon balance in the South China Sea

Ma, Yuwei / Zhang, Lanlan / Liu, Sumei / Zhu, Dongdong

Biogeochemistry. 2022 Feb., v. 157, no. 3

2022

Abstract: The South China Sea (SCS) is one of the largest marginal seas in the world, but the processes that control the silicon cycle are not well understood. Here, we analyse the factors that affect the distribution of biogenic silica (bSi) in SCS sediments and ... ...

Abstract	The South China Sea (SCS) is one of the largest marginal seas in the world, but the processes that control the silicon cycle are not well understood. Here, we analyse the factors that affect the distribution of biogenic silica (bSi) in SCS sediments and discuss the silicon cycle based on a box model. Our results show that the bSi content (~ 1.2%) in the shelf-slope (< 2000 m) sediments is lower overall than that (~ 2%) in the basin (> 2000 m) sediments. The dilution by terrestrial input, degradation rate of biogenic materials and lateral transport by current patterns are the main factors influencing the bSi content in SCS sediments. The bSi burial flux in the shelf-slope region (161 ± 156 Gmol-Si yr⁻¹) is six times greater than that in the basin region (27 ± 18 Gmol-Si yr⁻¹) due to higher burial rates, larger sea area, and coarser sediments. The estimated bSi burial efficiency (ratio of the bSi burial rate divided by the sum of the benthic silicic acid (dSi) diffusion rate and the burial rate) in SCS sediments is 27%, comparable to those of other marginal seas. Therefore, at the sediment–water interface, 73% of Si is recycled back to the water column. From compiled datasets of water fluxes and dSi concentrations over the past decades, we calculate a total output silicon flux of dSi of 2259 ± 397 Gmol-Si yr⁻¹ for the SCS, which is not significantly different from the total input flux (2196 ± 458 Gmol-Si yr⁻¹), suggesting that the Si cycle of this marginal sea is in a steady state. Interestingly, the submarine groundwater discharge (SGD) flux (477 ± 140 Gmol-Si yr⁻¹) in the SCS is 2.5 times higher than the riverine dSi and dissolvable amorphous silica input (194 ± 40 Gmol-Si yr⁻¹).
Schlagwörter	basins ; biogeochemistry ; data collection ; groundwater ; models ; riparian areas ; sediment-water interface ; silica ; silicic acid ; silicon ; South China Sea
Sprache	Englisch
Erscheinungsverlauf	2022-02
Umfang	p. 327-353.
Erscheinungsort	Springer International Publishing
Dokumenttyp	Artikel
ZDB-ID	1478541-9
ISSN	1573-515X ; 0168-2563
ISSN (online)	1573-515X
ISSN	0168-2563
DOI	10.1007/s10533-021-00879-4
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Recent advances in primary cilia in bone metabolism.

Lian, Fenfen / Li, Hui / Ma, Yuwei / Zhou, Rui / Wu, Wei

Frontiers in endocrinology

2023 Band 14, Seite(n) 1259650

Abstract: Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways. The process of intraflagellar transport (IFT), which ... ...

Abstract	Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways. The process of intraflagellar transport (IFT), which is propelled by kinesin and dynein motors, plays a crucial role in the formation and functionality of cilia. Abnormalities in the cilia or ciliary transport system often cause a range of clinical conditions collectively known as ciliopathies, which include polydactyly, short ribs, scoliosis, thoracic stenosis and many abnormalities in the bones and cartilage. In this review, we summarize recent findings on the role of primary cilia and ciliary transport systems in bone development, we describe the role of cilia in bone formation, cartilage development and bone resorption, and we summarize advances in the study of primary cilia in fracture healing. In addition, the recent discovery of crosstalk between integrins and primary cilia provides new insights into how primary cilia affect bone.
Mesh-Begriff(e)	Cilia/metabolism ; Flagella/metabolism ; Biological Transport ; Kinesins/metabolism ; Dyneins
Chemische Substanzen	Kinesins (EC 3.6.4.4) ; Dyneins (EC 3.6.4.2)
Sprache	Englisch
Erscheinungsdatum	2023-10-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1259650
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The role of graphene/graphene oxide in cement hydration

Meng Shaoqiang / Ouyang Xiaowei / Fu Jiyang / Niu Yanfei / Ma Yuwei

Nanotechnology Reviews, Vol 10, Iss 1, Pp 768-

2021 Band 778

Abstract: 1) GO has a strong interaction with Ca2+. (2) G/GO accelerates C–S–H growth. (3) High mobility ions derived by G/GO facilitate hydration. ...

Abstract	(1) GO has a strong interaction with Ca2+. (2) G/GO accelerates C–S–H growth. (3) High mobility ions derived by G/GO facilitate hydration.
Schlagwörter	graphene ; graphene oxide ; cement paste ; hydration ; c–s–h ; calcium ion ; Technology ; T ; Chemical technology ; TP1-1185 ; Physical and theoretical chemistry ; QD450-801
Sprache	Englisch
Erscheinungsdatum	2021-08-01T00:00:00Z
Verlag	De Gruyter
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: The Application of 2d Mxene Nanosheet -Based Thermosensitive Gel Delivery System Loaded with Cisplatin and Imiquimod for Lung Cancer.

Ma, Yuwei / Jiang, Tao / Zhang, Rong / Liu, Fei / Song, Shilong / Zhang, Huijun / Huang, Jingwen / He, Zelai

International journal of nanomedicine

2024 Band 19, Seite(n) 4719–4733

Abstract: Introduction: Lung cancer's high incidence and dismal prognosis with traditional treatments like surgery and radiotherapy necessitate innovative approaches. Despite advancements in nanotherapy, the limitations of single-treatment modalities and ... ...

Abstract	Introduction: Lung cancer's high incidence and dismal prognosis with traditional treatments like surgery and radiotherapy necessitate innovative approaches. Despite advancements in nanotherapy, the limitations of single-treatment modalities and significant side effects persist. To tackle lung cancer effectively, we devised a temperature-sensitive hydrogel-based local injection system with near-infrared triggered drug release. Utilizing 2D MXene nanosheets as carriers loaded with R837 and cisplatin (DDP), encapsulated within a temperature-sensitive hydrogel-forming PEG-MXene@DDP@R837@SHDS (MDR@SHDS), we administered in situ injections of MDR@SHDS into tumor tissues combined with photothermal therapy (PTT). The immune adjuvant R837 enhances dendritic cell (DC) maturation and tumor cell phagocytosis, while PTT induces tumor cell apoptosis and necrosis by converting light energy into heat energy. Methods: Material characterization employed transmission electron microscopy, X-ray photoelectron spectroscopy, phase transition temperature, and near-infrared thermography. In vitro experiments assessed Lewis cell proliferation and apoptosis using CCK-8, Edu, and TUNEL assays. In vivo experiments on C57 mouse Lewis transplant tumors evaluated the photothermal effect via near-infrared thermography and assessed DC maturation and CD4+/CD8+ T cell ratios using flow cytometry. The in vivo anti-tumor efficacy of MDR@SHDS was confirmed by tumor growth curve recording and HE and TUNEL staining of tumor sections. Results: The hydrogel exhibited excellent temperature sensitivity, controlled release properties, and high biocompatibility. In vitro experiments revealed that MDR@SHDS combined with PTT had a greater inhibitory effect on tumor cell proliferation compared to MDR@SHD alone. Combining local immunotherapy, chemotherapy, and PTT yielded superior anti-tumor effects than individual treatments. Conclusion: MDR@SHDS, with its simplicity, biocompatibility, and enhanced anti-tumor effects in combination with PTT, presents a promising therapeutic approach for lung cancer treatment, offering potential clinical utility.
Mesh-Begriff(e)	Animals ; Cisplatin/pharmacology ; Cisplatin/chemistry ; Cisplatin/administration & dosage ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Mice ; Imiquimod/chemistry ; Imiquimod/administration & dosage ; Imiquimod/pharmacology ; Mice, Inbred C57BL ; Hydrogels/chemistry ; Apoptosis/drug effects ; Nanostructures/chemistry ; Photothermal Therapy/methods ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/administration & dosage ; Cell Line, Tumor ; Drug Delivery Systems/methods ; Humans ; Temperature ; Dendritic Cells/drug effects ; Drug Carriers/chemistry ; Carcinoma, Lewis Lung/drug therapy ; Carcinoma, Lewis Lung/pathology
Chemische Substanzen	Cisplatin (Q20Q21Q62J) ; Imiquimod (P1QW714R7M) ; Hydrogels ; Antineoplastic Agents ; Drug Carriers
Sprache	Englisch
Erscheinungsdatum	2024-05-25
Erscheinungsland	New Zealand
Dokumenttyp	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S449541
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells.

Cao, Hong / Zhou, Xuchang / Xu, Bowen / Hu, Han / Guo, Jianming / Ma, Yuwei / Wang, Miao / Li, Nan / Jun, Zou

Journal of Zhejiang University. Science. B

2024 Band 25, Heft 3, Seite(n) 212–232

Abstract: The endoplasmic reticulum is a key site for protein production and quality control. More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum. However, during protein folding, ... ...

Titelübersetzung	哺乳动物细胞蛋白质折叠和内质网相关降解的研究进展.
Abstract	The endoplasmic reticulum is a key site for protein production and quality control. More than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic reticulum. However, during protein folding, unfolded and/or misfolded proteins are prone to occur, which may lead to endoplasmic reticulum stress. Organisms can monitor the quality of the proteins produced by endoplasmic reticulum quality control (ERQC) and endoplasmic reticulum-associated degradation (ERAD), which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded proteins. The underlying mechanisms of protein folding and ERAD in mammals have not yet been fully explored. Therefore, this paper reviews the process and function of protein folding and ERAD in mammalian cells, in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.
Mesh-Begriff(e)	Animals ; Endoplasmic Reticulum-Associated Degradation ; Protein Folding ; Proteins ; Endoplasmic Reticulum Stress ; Mammals/metabolism
Chemische Substanzen	Proteins
Sprache	Chinesisch
Erscheinungsdatum	2024-03-07
Erscheinungsland	China
Dokumenttyp	Review ; Journal Article
ZDB-ID	2247290-3
ISSN	1862-1783 ; 1673-1581
ISSN (online)	1862-1783
ISSN	1673-1581
DOI	10.1631/jzus.B2300403
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: DUSP4 enhances therapeutic sensitivity in HER2-positive breast cancer by inhibiting the G6PD pathway and ROS metabolism by interacting with ALDOB.

Wang, Xuliren / Chi, Weiru / Ma, Yuwei / Zhang, Qi / Xue, Jingyan / Shao, Zhi-Ming / Xiu, Bingqiu / Wu, Jiong / Chi, Yayun

Translational oncology

2024 Band 46, Seite(n) 102016

Abstract: Background: Breast cancer (BC) poses a global threat, with HER2-positive BC being a particularly hazardous subtype. Despite the promise shown by neoadjuvant therapy (NAT) in improving prognosis, resistance in HER2-positive BC persists despite emerging ... ...

Abstract	Background: Breast cancer (BC) poses a global threat, with HER2-positive BC being a particularly hazardous subtype. Despite the promise shown by neoadjuvant therapy (NAT) in improving prognosis, resistance in HER2-positive BC persists despite emerging targeted therapies. The objective of this study is to identify markers that promote therapeutic sensitivity and unravel the underlying mechanisms. Methods: We conducted an analysis of 86 HER2-positive BC biopsy samples pre-NAT using RNA-seq. Validation was carried out using TCGA, Kaplan‒Meier Plotter, and Oncomine databases. Phenotype verification utilized IC Results: Our findings reveal that DUSP4 enhances therapeutic efficacy in HER2-positive BC by inhibiting the ROS pathway. Elevated DUSP4 levels correlate with increased sensitivity to HER2-targeted therapies and improved clinical outcomes. DUSP4 independently predicts disease-free survival (DFS) and overall survival (OS) in HER2-positive BC. Moreover, DUSP4 hinders G6PD activity via ALDOB dephosphorylation, with a noteworthy association with heightened ROS levels. Conclusions: In summary, our study unveils a metabolic reprogramming paradigm in BC, highlighting DUSP4's role in enhancing therapeutic sensitivity in HER2-positive BC cells. DUSP4 interacts with ALDOB, inhibiting G6PD activity and the ROS pathway, establishing it as an independent prognostic predictor for HER2-positive BC patients.
Sprache	Englisch
Erscheinungsdatum	2024-06-05
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2443840-6
ISSN	1936-5233
ISSN	1936-5233
DOI	10.1016/j.tranon.2024.102016
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Author Correction: Study on the preparation and mechanical properties of purple ceramics.

Wang, Lihe / Wang, Yonghui / Wang, Qingchun / Ma, Yuwei / Ruan, Fei / Zhang, Yonghe / Lv, Haodong / Jing, Qiang / Bao, Jinxiao

Scientific reports

2023 Band 13, Heft 1, Seite(n) 12196

Sprache	Englisch
Erscheinungsdatum	2023-07-27
Erscheinungsland	England
Dokumenttyp	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-38494-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Study on the preparation and mechanical properties of purple ceramics.

Wang, Lihe / Wang, Yonghui / Wang, Qingchun / Ma, Yuwei / Ruan, Fei / Zhang, Yonghe / Lv, Haodong / Jing, Qiang / Bao, Jinxiao

Scientific reports

2023 Band 13, Heft 1, Seite(n) 8755

Abstract: This paper aims at preparing a smart wearable purple ceramic that meet the color requirements of purple smart wear in the market after using zirconate neodymium as a chromogenic agent. However, the mechanical performance of zirconate neodymium purple ... ...

Abstract	This paper aims at preparing a smart wearable purple ceramic that meet the color requirements of purple smart wear in the market after using zirconate neodymium as a chromogenic agent. However, the mechanical performance of zirconate neodymium purple ceramic is not satisfactory, especially it has an extremely low fracture toughness. To solve this, a 3 mol% yttria-stabilized zirconia (3YSZ) is added to zirconate neodymium in the preparation of multiphase ceramics to improve its mechanical properties. In this experiment, a series of ceramic samples with addition of increasing amount of 3YSZ 0, 20, 40, 50, 60, 70 and 80% were prepared in the 1400-1500 °C sintering temperature range. It was found that at the same temperature, the mechanical properties of the ceramic samples gradually improved with the increase in the 3YSZ content. Moreover, with the same content, the mechanical properties of the ceramic samples gradually improved with the decrease in temperature. The results show that when 3YSZ has a mass fraction of 80% and is sintered at 1400 °C, the fracture toughness of the prepared ceramic samples reaches 8.15 MPa‧m
Sprache	Englisch
Erscheinungsdatum	2023-05-30
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-35957-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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