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  1. Artikel: A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks

    Suchacki, Karla J / Alcaide-Corral, Carlos J / Nimale, Samah / Macaskill, Mark G / Stimson, Roland H / Farquharson, Colin / Freeman, Tom C / Tavares, Adriana A S

    Frontiers in medicine

    2021  Band 8, Seite(n) 740615

    Abstract: Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic interactions at a systems level remains rudimentary. ...

    Abstract Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic interactions at a systems level remains rudimentary.
    Sprache Englisch
    Erscheinungsdatum 2021-09-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.740615
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Microcalcification and Thoracic Aortopathy: A Window Into Disease Severity.

    Fletcher, Alexander J / Nash, Jennifer / Syed, Maaz B J / Macaskill, Mark G / Tavares, Adriana A S / Walker, Niki / Salcudean, Hannah / Leipsic, Jonathon A / Lim, Kelvin H H / Madine, Jillian / Wallace, William / Field, Mark / Newby, David E / Bouchareb, Rihab / Seidman, Michael A / Akhtar, Riaz / Sellers, Stephanie L

    Arteriosclerosis, thrombosis, and vascular biology

    2022  Band 42, Heft 8, Seite(n) 1048–1059

    Abstract: Background: Patients with thoracic aortopathy are at increased risk of catastrophic aortic dissection, carrying with it substantial mortality and morbidity. Although granular medial calcinosis (medial microcalcification) has been associated with ... ...

    Abstract Background: Patients with thoracic aortopathy are at increased risk of catastrophic aortic dissection, carrying with it substantial mortality and morbidity. Although granular medial calcinosis (medial microcalcification) has been associated with thoracic aortopathy, its relationship to disease severity has yet to be established.
    Methods: One hundred one thoracic aortic specimens were collected from 57 patients with thoracic aortopathy and 18 control subjects. Standardized histopathologic scores, immunohistochemistry, and nanoindentation (tissue elastic modulus) were compared with the extent of microcalcification on von Kossa histology and 18F-sodium fluoride autoradiography.
    Results: Microcalcification content was higher in thoracic aortopathy samples with mild (n=28; 6.17 [2.71-10.39];
    Conclusions: Medial microcalcification is a marker of aortopathy, although progression to severe aortopathy is associated with loss of both elastin fibers and microcalcification.
    Mesh-Begriff(e) Aorta ; Calcinosis/diagnostic imaging ; Elastin ; Humans ; Severity of Illness Index ; Sodium Fluoride
    Chemische Substanzen Sodium Fluoride (8ZYQ1474W7) ; Elastin (9007-58-3)
    Sprache Englisch
    Erscheinungsdatum 2022-06-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.122.317111
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: 18

    Syed, Maaz B J / Fletcher, Alexander J / Debono, Samuel / Forsythe, Rachel O / Williams, Michelle C / Dweck, Marc R / Shah, Anoop S V / Macaskill, Mark G / Tavares, Adriana / Denvir, Martin A / Lim, Kelvin / Wallace, William A / Kaczynski, Jakub / Clark, Tim / Sellers, Stephanie L / Masson, Neil / Falah, Orwa / Chalmers, Roderick T A / Tambyraja, Andrew L /
    van Beek, Edwin J R / Newby, David E

    JACC. Cardiovascular imaging

    2022  Band 15, Heft 7, Seite(n) 1291–1304

    Abstract: Background: Acute aortic syndrome is associated with aortic medial degeneration. : Objectives: In a proof-of-concept study, this investigation aimed to establish whether : Methods: Patients with aortic dissection or intramural hematomas and ... ...

    Abstract Background: Acute aortic syndrome is associated with aortic medial degeneration.
    Objectives: In a proof-of-concept study, this investigation aimed to establish whether
    Methods: Patients with aortic dissection or intramural hematomas and control subjects underwent
    Results: Aortic
    Conclusions: In patients with acute aortic syndrome,
    Mesh-Begriff(e) Aorta/diagnostic imaging ; Calcinosis ; Coronary Artery Disease ; Fluorine Radioisotopes ; Humans ; Plaque, Atherosclerotic ; Positron Emission Tomography Computed Tomography/methods ; Positron-Emission Tomography ; Predictive Value of Tests ; Radiopharmaceuticals ; Risk Factors ; Sodium Fluoride ; Tomography, X-Ray Computed
    Chemische Substanzen Fluorine Radioisotopes ; Radiopharmaceuticals ; Sodium Fluoride (8ZYQ1474W7)
    Sprache Englisch
    Erscheinungsdatum 2022-03-16
    Erscheinungsland United States
    Dokumenttyp Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2022.01.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Non-invasive in vivo imaging of acute thrombosis: development of a novel factor XIIIa radiotracer.

    Andrews, Jack P M / Portal, Christophe / Walton, Tashfeen / Macaskill, Mark G / Hadoke, Patrick W F / Alcaide Corral, Carlos / Lucatelli, Christophe / Wilson, Simon / Wilson, Ian / MacNaught, Gillian / Dweck, Marc R / Newby, David E / Tavares, Adriana A S

    European heart journal. Cardiovascular Imaging

    2019  Band 21, Heft 6, Seite(n) 673–682

    Abstract: Aims: Cardiovascular thrombosis is responsible a quarter of deaths annually worldwide. Current imaging methods for cardiovascular thrombosis focus on anatomical identification of thrombus but cannot determine thrombus age or activity. Molecular imaging ... ...

    Abstract Aims: Cardiovascular thrombosis is responsible a quarter of deaths annually worldwide. Current imaging methods for cardiovascular thrombosis focus on anatomical identification of thrombus but cannot determine thrombus age or activity. Molecular imaging techniques hold promise for identification and quantification of thrombosis in vivo. Our objective was to assess a novel optical and positron-emitting probe targeting Factor XIIIa (ENC2015) as biomarker of active thrombus formation.
    Methods and results: Optical and positron-emitting ENC2015 probes were assessed ex vivo using blood drawn from human volunteers and passed through perfusion chambers containing denuded porcine aorta as a model of arterial injury. Specificity of ENC2015 was established with co-infusion of a factor XIIIa inhibitor. In vivo18F-ENC2015 biodistribution, kinetics, radiometabolism, and thrombus binding were characterized in rats. Both Cy5 and fluorine-18 labelled ENC2015 rapidly and specifically bound to thrombi. Thrombus uptake was inhibited by a factor XIIIa inhibitor. 18F-ENC2015 remained unmetabolized over 8 h when incubated in ex vivo human blood. In vivo, 42% of parent radiotracer remained in blood 60 min post-administration. Biodistribution studies demonstrated rapid clearance from tissues with elimination via the urinary system. In vivo,18F-ENC2015 uptake was markedly increased in the thrombosed carotid artery compared to the contralateral patent artery (mean standard uptake value ratio of 2.40 vs. 0.74, P < 0.0001).
    Conclusion: ENC2015 rapidly and selectively binds to acute thrombus in both an ex vivo human translational model and an in vivo rodent model of arterial thrombosis. This probe holds promise for the non-invasive identification of thrombus formation in cardiovascular disease.
    Mesh-Begriff(e) Animals ; Factor XIIIa ; Fibrin/metabolism ; Molecular Imaging ; Rats ; Swine ; Thrombosis/diagnostic imaging ; Tissue Distribution
    Chemische Substanzen Fibrin (9001-31-4) ; Factor XIIIa (EC 2.3.2.13)
    Sprache Englisch
    Erscheinungsdatum 2019-07-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jez207
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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