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  1. Artikel ; Online: Unraveling the role of the microbiome in chronic rhinosinusitis.

    Psaltis, Alkis J / Mackenzie, Brett Wagner / Cope, Emily K / Ramakrishnan, Vijay R

    The Journal of allergy and clinical immunology

    2022  Band 149, Heft 5, Seite(n) 1513–1521

    Abstract: Chronic rhinosinusitis (CRS) is a complex, heterogenous condition that is likely associated with infectious and inflammatory causative factors. Renewed interest in the role that microbes play in this condition has stemmed from advancements in microbe ... ...

    Abstract Chronic rhinosinusitis (CRS) is a complex, heterogenous condition that is likely associated with infectious and inflammatory causative factors. Renewed interest in the role that microbes play in this condition has stemmed from advancements in microbe identification and parallel research implicating the microbiome as having a role in other chronic inflammatory conditions. This clinical commentary provides a review of the current literature relevant to chronic rhinosinusitis. Particular focus is placed on factors specific to investigation of the sinonasal microbiome, evidence for the role of dysbiosis in the disease state, and influences that may affect the microbiome. Possible mechanisms of disease and therapeutic implications through microbial manipulation are also reviewed, as are deficiencies and limitations of the current body of research.
    Mesh-Begriff(e) Chronic Disease ; Dysbiosis ; Humans ; Microbiota ; Rhinitis/drug therapy ; Sinusitis/drug therapy
    Sprache Englisch
    Erscheinungsdatum 2022-03-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.02.022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: In vitro Nasodine Can be an Effective Antibiofilm Agent for Biofilms that May Cause CRS.

    Hale, Samuel J M / Lux, Christian A / Kim, Raymond / Biswas, Kristi / Tucker, Simon / Friedland, Peter / Mackenzie, Brett Wagner / Douglas, Richard G

    The Laryngoscope

    2023  Band 133, Heft 10, Seite(n) 2490–2495

    Abstract: Objectives: Bacterial biofilms on the sinonasal mucosa, especially biofilms of Staphylococcus aureus, are associated with greater severity and recalcitrance of chronic rhinosinusitis (CRS). There are few, if any, antibiofilm agents suitable for ... ...

    Abstract Objectives: Bacterial biofilms on the sinonasal mucosa, especially biofilms of Staphylococcus aureus, are associated with greater severity and recalcitrance of chronic rhinosinusitis (CRS). There are few, if any, antibiofilm agents suitable for sinonasal application available for the management of this problem. Nasodine® Nasal Spray (Nasodine) is a 0.5% povidone-iodine-based formulation that has been developed for sinonasal application. We investigated the antibiofilm efficacy of Nasodine to determine whether it may be a candidate for the treatment of biofilm-associated CRS.
    Methods: Biofilms of S. aureus ATCC 6538 were grown in vitro using the Centers for Disease Control biofilm reactor. Intact biofilms were treated by immersion in 0.9% saline (control), half concentration Nasodine, or full concentration Nasodine for between 5 min and 6 h. Further biofilm cells were dispersed into suspension then treated for between 30 s and 5 min. Surviving bacteria were then enumerated by culture and counting colonies, and the log
    Results: Nasodine demonstrated time and concentration-dependent bacterial killing against intact biofilm. Statistically significant reductions in viable bacteria from intact biofilms were seen with exposures as brief as 5 min. Nasodine consistently eradicated dispersed biofilm within 1 min.
    Conclusion: Nasodine is highly active against biofilms of S. aureus ATCC 6538 in vitro. Biofilm killing is impeded by the presence of the intact biofilm structure.
    Lay summary: In chronic rhinosinusitis (CRS), bacterial communities called biofilms are associated with more severe inflammation. An iodine-based nasal spray called Nasodine almost completely eradicates bacterial biofilms after 6 h of exposure. Nasodine may be useful for treating CRS. Laryngoscope, 133:2490-2495, 2023.
    Mesh-Begriff(e) Humans ; Staphylococcus aureus ; Nasal Sprays ; Sinusitis/complications ; Biofilms ; Povidone-Iodine/pharmacology ; Chronic Disease ; Rhinitis/complications
    Chemische Substanzen Nasal Sprays ; Povidone-Iodine (85H0HZU99M)
    Sprache Englisch
    Erscheinungsdatum 2023-01-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30558
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Improve Integration of In Vitro Biofilm Body of Knowledge to Support Clinical Breakthroughs in Surgical Site Infection.

    Irwin, Stuart / Mackenzie, Brett Wagner / Matthews, Brya G / Williams, Dustin L / Cornish, Jillian / Swift, Simon

    Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews

    2021  Band 5, Heft 11

    Abstract: Prosthetics increase the risk of deep surgical site infections in procedures intended to restore function. In orthopaedics, prosthetic joint infections can lead to repetitive surgeries, amputation, or worse. Biofilm formation both in vitro and in vivo ... ...

    Abstract Prosthetics increase the risk of deep surgical site infections in procedures intended to restore function. In orthopaedics, prosthetic joint infections can lead to repetitive surgeries, amputation, or worse. Biofilm formation both in vitro and in vivo involves stages of attachment, accumulation, and maturation. The level of maturation affects susceptibility to antibiotics, the immune system, and the success of surgical interventions. A review of the literature indicates that orthopedic publications are less likely to mention biofilm. We have reviewed animal models of infection to assess in vivo models of prosthetic infection. Although most prosthetic infections seem to originate from local skin microbiota, clinically representative biofilm inocula are unusual. Biofilm-related end points are more widely adopted, but studies rarely include both quantification of adherent microbial burden and imaging of the in vivo biofilm. Failure to differentiate between planktonic and biofilm infections can skew research away from needed chronic disease models. In this review, we address prosthetic joint infections as an important model for chronic biofilm infection research, identify critical requirements for in vivo models of chronic infection, and propose that resistance to the terminology of biofilm research exists within both research and regulation, which could limit progress toward important orthopaedic targets.
    Mesh-Begriff(e) Animals ; Anti-Bacterial Agents/therapeutic use ; Biofilms ; Prosthesis-Related Infections/drug therapy ; Surgical Wound Infection/therapy
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2021-11-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2898328-2
    ISSN 2474-7661 ; 1067-151X
    ISSN (online) 2474-7661
    ISSN 1067-151X
    DOI 10.5435/JAAOSGlobal-D-20-00217
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Oral microbial influences on oral mucositis during radiotherapy treatment of head and neck cancer.

    Vesty, Anna / Gear, Kim / Biswas, Kristi / Mackenzie, Brett Wagner / Taylor, Michael W / Douglas, Richard G

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2019  Band 28, Heft 6, Seite(n) 2683–2691

    Abstract: Purpose: Oral mucositis (OM) remains a significant complication developed by many patients undergoing radiotherapy (RT) to the head and neck region. Emerging data suggest oral microbes may contribute to the onset and severity of this acute side effect.!# ...

    Abstract Purpose: Oral mucositis (OM) remains a significant complication developed by many patients undergoing radiotherapy (RT) to the head and neck region. Emerging data suggest oral microbes may contribute to the onset and severity of this acute side effect.
    Methods: In this study, saliva and oral swabs from head and neck cancer patients undergoing RT were collected. We employed molecular microbiological techniques to study the bacterial communities present in saliva, and both the bacterial and fungal communities present on the buccal mucosa and lateral tongue. Changes in microbiota composition with increasing radiation dose and the presence of mucositis were examined.
    Results: The data suggest that the salivary microbiota remain stable during RT and are consistently dominated by Streptococcus, Prevotella, Fusobacterium and Granulicatella. Obligate and facultative anaerobic Gram-negative bacilli (GNB) Bacteroidales G2, Capnocytophaga, Eikenella, Mycoplasma and Sneathia, as well as anaerobic GNB in the periopathogenic genera Porphyromonas and Tannerella, were all positively correlated with ≥ grade 2 OM. Significant increases in the relative abundances of Bacteroidales G2, Fusobacterium and Sneathia were identified in buccal mucosa swabs at sites of ≥ grade 2 OM (p < 0.05). Furthermore, the abundance of several GNB (Fusobacterium, Haemophilus, Tannerella, Porphyromonas and Eikenella) on the buccal mucosa may influence patient susceptibility to developing OM. Candida was widely detected in buccal mucosa swabs, regardless of mucositis status.
    Conclusions: Our findings support previously hypothesized associations between oral health and the pathogenesis of OM, highlighting the importance of oral health interventions for head and neck cancer patients.
    Mesh-Begriff(e) Bacteria/classification ; Bacteria/isolation & purification ; Candida/isolation & purification ; Female ; Head and Neck Neoplasms/radiotherapy ; Humans ; Male ; Microbiota ; Middle Aged ; Mouth Mucosa/microbiology ; Oral Health ; Saliva/microbiology ; Stomatitis/etiology ; Stomatitis/microbiology ; Tongue/microbiology
    Sprache Englisch
    Erscheinungsdatum 2019-10-25
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-019-05084-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Sinonasal and gastrointestinal bacterial composition and abundance are stable after 1 week of once-daily oral antibiotic treatment for chronic rhinosinusitis.

    Siu, Joey / Mackenzie, Brett Wagner / Klingler, Lilian / Biswas, Kristi / Wang, Yi / Hung, Cheung-Tak / Jeong, Soo Hee / Barnett, Daniel / Tingle, Malcolm Drummond / Douglas, Richard George

    International forum of allergy & rhinology

    2021  Band 11, Heft 9, Seite(n) 1355–1366

    Abstract: Background: Despite the widespread prescription of antibiotics for the treatment of chronic rhinosinusitis (CRS), their efficacy remains uncertain. Limited penetration of systemic antibiotics into the sinonasal mucosa has been reported previously by ... ...

    Abstract Background: Despite the widespread prescription of antibiotics for the treatment of chronic rhinosinusitis (CRS), their efficacy remains uncertain. Limited penetration of systemic antibiotics into the sinonasal mucosa has been reported previously by this group. This study aimed to investigate the short-term effects of antibiotics on the sinus and gut microbiota as well as any relationships these had with drug distribution.
    Methods: Thirty subjects undergoing functional endoscopic sinus surgery for CRS were randomized to one of three groups: (1) doxycycline (100 mg daily for 7 days); (2) roxithromycin (300 mg daily for 7 days); and (3) control (no antibiotics given). Sinonasal and stool samples collected before and after treatment were analyzed using 16S ribosomal RNA (rRNA) gene-targeted amplicon sequencing and Droplet Digital polymerase chain reaction (PCR) for bacterial community composition and the quantification of bacterial DNA, respectively.
    Results: There were no significant major bacterial community shifts or changes to bacterial diversity and load following the treatment period in all patient groups. Non-significant trend reductions were observed in gut microbial diversity with antibiotics. For the roxithromycin group, sinonasal bacterial diversity was negatively correlated with serum drug levels and reduced overall compared to controls (p < 0.05). The relative abundance of Staphylococcus ASV129 in sinonasal samples reduced with increasing mucus doxycycline levels (p = 0.01).
    Conclusion: Antibiotic prescription for CRS should be further investigated because of preliminary evidence of poor sinonasal drug penetration, unproven efficacy, and the potential impact of dysbiosis in the sinuses and off-target sites. Further studies should consider distinguishing the presence of DNA from viable and nonviable bacteria.
    Mesh-Begriff(e) Anti-Bacterial Agents ; Chronic Disease ; Humans ; Microbiota ; RNA, Ribosomal, 16S/genetics ; Rhinitis/drug therapy ; Sinusitis/drug therapy
    Chemische Substanzen Anti-Bacterial Agents ; RNA, Ribosomal, 16S
    Sprache Englisch
    Erscheinungsdatum 2021-04-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.22799
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: A Description of the Skin Glands and Cloacal Morphology of the Plethodontid Salamander Karsenia koreana

    Sever, David M / Mackenzie Brett Wagner / Pinsoneault Adrienne D / Siegel Dustin S / Staub Nancy L

    Copeia. 2016 Dec., v. 104, no. 4

    2016  

    Abstract: The skin glands and cloacal morphology of the Korean crevice salamander, Karsenia koreana, were similar to those of other plethodontids. The skin contained mucous, granular, and modified granular glands in varying frequencies and sizes. Males had ... ...

    Abstract The skin glands and cloacal morphology of the Korean crevice salamander, Karsenia koreana, were similar to those of other plethodontids. The skin contained mucous, granular, and modified granular glands in varying frequencies and sizes. Males had sexually dimorphic glands in the skin of the chin (mental glands) and the dorsal tail base (caudal courtship glands). On the ventral surface of the tail base, modified granular glands were sexually dimorphic in size, with male glands larger than those in females. The cloacal glands in males, as in other plethodontids, consisted of four eosinophilic gland clusters (dorsal pelvic glands, lateral pelvic glands, caudal pelvic glands, and vent glands) and three basophilic glands (anterior ventral glands, posterior ventral glands, and Kingsbury's glands). In females, the only cloacal gland was the spermatheca, which, as in other plethodontids, was a compound tubulo-alveolar gland in the roof of the cloaca.
    Schlagwörter cloaca ; courtship ; females ; Karsenia ; males ; salamanders and newts ; sexual dimorphism ; skin glands ; spermatheca ; tail
    Sprache Englisch
    Erscheinungsverlauf 2016-12
    Umfang p. 816-823.
    Erscheinungsort The American Society of Ichthyologists and Herpetologists
    Dokumenttyp Artikel
    ZDB-ID 2198974-6
    ISSN 0045-8511
    ISSN 0045-8511
    DOI 10.1643%2FCG-16-468
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Bacteria are important dimethylsulfoniopropionate producers in coastal sediments.

    Williams, Beth T / Cowles, Kasha / Bermejo Martínez, Ana / Curson, Andrew R J / Zheng, Yanfen / Liu, Jingli / Newton-Payne, Simone / Hind, Andrew J / Li, Chun-Yang / Rivera, Peter Paolo L / Carrión, Ornella / Liu, Ji / Spurgin, Lewis G / Brearley, Charles A / Mackenzie, Brett Wagner / Pinchbeck, Benjamin J / Peng, Ming / Pratscher, Jennifer / Zhang, Xiao-Hua /
    Zhang, Yu-Zhong / Murrell, J Colin / Todd, Jonathan D

    Nature microbiology

    2019  Band 4, Heft 11, Seite(n) 1815–1825

    Abstract: Dimethylsulfoniopropionate (DMSP) and its catabolite dimethyl sulfide (DMS) are key marine ... ...

    Abstract Dimethylsulfoniopropionate (DMSP) and its catabolite dimethyl sulfide (DMS) are key marine nutrients
    Mesh-Begriff(e) Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacteria/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; Gene Regulatory Networks ; Geologic Sediments/microbiology ; Methionine/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Phylogeny ; Seawater/microbiology ; Sequence Analysis, RNA ; Sulfonium Compounds/metabolism
    Chemische Substanzen Bacterial Proteins ; Sulfonium Compounds ; Methionine (AE28F7PNPL) ; dimethylpropiothetin (C884XA7QGG) ; Methyltransferases (EC 2.1.1.-)
    Sprache Englisch
    Erscheinungsdatum 2019-08-19
    Erscheinungsland England
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-019-0527-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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