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  1. Artikel: Topical proactive therapy in dermatology. A scoping review.

    Makowska, Karolina / Nowaczyk, Joanna / Samochocki, Zbigniew / Blicharz, Leszek / Rudnicka, Lidia

    Postepy dermatologii i alergologii

    2023  Band 40, Heft 4, Seite(n) 510–517

    Abstract: The term 'proactive therapy' refers to a long-term management of clinically intact skin in previously disease-affected areas. This method was initially implemented in atopic dermatitis to maintain the remission and decrease the risk of exacerbations. ... ...

    Abstract The term 'proactive therapy' refers to a long-term management of clinically intact skin in previously disease-affected areas. This method was initially implemented in atopic dermatitis to maintain the remission and decrease the risk of exacerbations. Proactive therapy aims to limit the need for reactive treatment and improve the patients' quality of life. A proactive approach is likely to be adopted for other relapsing and inflammatory skin conditions in the future. This scoping review aims to identify dermatological conditions to be treated with the proactive approach, evaluate the available evidence for its efficacy and safety, as well as highlight the research gaps.
    Sprache Englisch
    Erscheinungsdatum 2023-09-01
    Erscheinungsland Poland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2596142-1
    ISSN 1642-395X
    ISSN 1642-395X
    DOI 10.5114/ada.2023.129454
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Insights into Modern Therapeutic Approaches in Pediatric Acute Leukemias.

    Panuciak, Kinga / Margas, Mikołaj / Makowska, Karolina / Lejman, Monika

    Cells

    2022  Band 11, Heft 1

    Abstract: Pediatric cancers predominantly constitute lymphomas and leukemias. Recently, our knowledge and awareness about genetic diversities, and their consequences in these diseases, have greatly expanded. Modern solutions are focused on mobilizing and impacting ...

    Abstract Pediatric cancers predominantly constitute lymphomas and leukemias. Recently, our knowledge and awareness about genetic diversities, and their consequences in these diseases, have greatly expanded. Modern solutions are focused on mobilizing and impacting a patient's immune system. Strategies to stimulate the immune system, to prime an antitumor response, are of intense interest. Amid those types of therapies are chimeric antigen receptor T (CAR-T) cells, bispecific antibodies, and antibody-drug conjugates (ADC), which have already been approved in the treatment of acute lymphoblastic leukemia (ALL)/acute myeloid leukemia (AML). In addition, immune checkpoint inhibitors (ICIs), the pattern recognition receptors (PRRs), i.e., NOD-like receptors (NLRs), Toll-like receptors (TLRs), and several kinds of therapy antibodies are well on their way to showing significant benefits for patients with these diseases. This review summarizes the current knowledge of modern methods used in selected pediatric malignancies and presents therapies that may hold promise for the future.
    Mesh-Begriff(e) Antibodies, Bispecific/pharmacology ; Antibodies, Bispecific/therapeutic use ; Child ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy/methods ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy
    Chemische Substanzen Antibodies, Bispecific ; Immune Checkpoint Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-01-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11010139
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Cyclosporine With and Without Systemic Corticosteroids in Treatment of Alopecia Areata: A Systematic Review.

    Nowaczyk, Joanna / Makowska, Karolina / Rakowska, Adriana / Sikora, Mariusz / Rudnicka, Lidia

    Dermatology and therapy

    2020  Band 10, Heft 3, Seite(n) 387–399

    Abstract: Introduction: Cyclosporine is commonly used in treatment for alopecia areata. It can be administered as a monotherapy or in combination with systemic corticosteroids, with various outcomes.: Methods: Efficacy of cyclosporine with and without systemic ...

    Abstract Introduction: Cyclosporine is commonly used in treatment for alopecia areata. It can be administered as a monotherapy or in combination with systemic corticosteroids, with various outcomes.
    Methods: Efficacy of cyclosporine with and without systemic corticosteroids for alopecia areata was evaluated by a systematic review. Cochrane, EBSCOhost, Pubmed, Scopus and Web of Science databases were searched. Only studies published before January 2020 were included.
    Results: A total of 2104 studies were initially examined, of which 14 were eligible for the systematic review. Among 340 reported cases, 213 had focal, multifocal or ophiasis form of alopecia areata, 60 were diagnosed with alopecia totalis and 67 with alopecia universalis. The mean response rate in the whole group of patients at the end of treatment was 65.00% (221/340; range 25-100%). Hair regrowth rate was higher in the group with cases of alopecia areata limited to scalp (124/165; mean 75.15%; range 40-100%) than in the cases with alopecia totalis (30/46; mean 65.22%; range 25-100%) or alopecia universalis (24/52; mean 46.15%; range 25-100%). The combined therapy with systemic corticosteroids was superior to the monotherapy (152/219; mean 69.41%; 0-80% vs. 69/121; mean 57.02%; range 6.67-100%) and had a lower recurrence rate (39/108; mean 36.11% vs. 34/46; mean 73.91%, respectively). The combined treatment with methylprednisolone was significantly more effective when compared to the cyclosporine monotherapy (124/183; mean 67.76%; range 0-80% vs. 69/121; mean 57.02%; range 6.67-100%). The mean time of treatment was 6.75 months (range 2-36).
    Limitations: Limitations of our study were the retrospective character of included studies, differences in doses of prescribed drugs, and duration of the treatment and follow-up times.
    Conclusion: Cyclosporine in combination with oral systemic corticosteroids is more effective than in monotherapy for severe alopecia areata.
    Sprache Englisch
    Erscheinungsdatum 2020-04-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2680284-3
    ISSN 2190-9172 ; 2193-8210
    ISSN (online) 2190-9172
    ISSN 2193-8210
    DOI 10.1007/s13555-020-00370-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The concept of estimation of elevator shaft control measurement results in the local 3D coordinate system

    Filipiak-Kowszyk Daria / Gierski Waldemar / Kaminski Waldemar / Makowska Karolina

    E3S Web of Conferences, Vol 26, p

    2018  Band 00006

    Abstract: Geodetic control measurements play an important part because they provide information about the current state of repair of the construction, which has a direct impact on the safety assessment of its exploitation. Authors in this paper have focused on ... ...

    Abstract Geodetic control measurements play an important part because they provide information about the current state of repair of the construction, which has a direct impact on the safety assessment of its exploitation. Authors in this paper have focused on control measurements of the elevator shaft. The article discusses the problem of determining the deviation of elevator shaft walls from the vertical plane in the local 3D coordinate system. It presents a concept of estimation of measurements results base on the parametric method with conditions on parameters. The simulated measurement results were used to verify the concept presented in the paper.
    Schlagwörter Environmental sciences ; GE1-350
    Sprache Englisch
    Erscheinungsdatum 2018-01-01T00:00:00Z
    Verlag EDP Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: The Role of the Cutaneous Mycobiome in Atopic Dermatitis.

    Szczepańska, Milena / Blicharz, Leszek / Nowaczyk, Joanna / Makowska, Karolina / Goldust, Mohamad / Waśkiel-Burnat, Anna / Czuwara, Joanna / Samochocki, Zbigniew / Rudnicka, Lidia

    Journal of fungi (Basel, Switzerland)

    2022  Band 8, Heft 11

    Abstract: Atopic dermatitis is a chronic inflammatory skin disorder characterized by eczematous lesions, itch, and a significant deterioration in the quality of life. Recently, microbiome dysbiosis has been implicated in the pathogenesis of atopic dermatitis. ... ...

    Abstract Atopic dermatitis is a chronic inflammatory skin disorder characterized by eczematous lesions, itch, and a significant deterioration in the quality of life. Recently, microbiome dysbiosis has been implicated in the pathogenesis of atopic dermatitis. Changes in the fungal microbiome (also termed mycobiome) appear to be an important factor influencing the clinical picture of this entity. This review summarizes the available insights into the role of the cutaneous mycobiome in atopic dermatitis and the new research possibilities in this field. The prevalence and characteristics of key fungal species, the most important pathogenesis pathways, as well as classic and emerging therapies of fungal dysbiosis and infections complicating atopic dermatitis, are presented.
    Sprache Englisch
    Erscheinungsdatum 2022-10-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8111153
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Looking for novel, brain-derived, peripheral biomarkers of neurological disorders.

    Chmielewska, Natalia / Szyndler, Janusz / Makowska, Karolina / Wojtyna, Dawid / Maciejak, Piotr / Płaźnik, Adam

    Neurologia i neurochirurgia polska

    2018  Band 52, Heft 3, Seite(n) 318–325

    Abstract: The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, ... ...

    Abstract The role of blood brain barrier (BBB) is to preserve a precisely regulated environment for proper neuronal signaling. In many of the central nervous system (CNS) pathologies, the function of BBB is altered. Thus, there is a necessity to evaluate a fast, noninvasive and reliable method for monitoring of BBB condition. It seems that revealing the peripheral diagnostic biomarker whose release pattern (concentration, dynamics) will be correlated with clinical symptoms of neurological disorders offers significant hope. It could help with faster diagnosis and efficient treatment monitoring. In this review we summarize the recent data concerning exploration of potential new serum biomarkers appearing in the peripheral circulation following BBB disintegration, with an emphasis on epilepsy, traumatic brain injury (TBI) and stroke. We consider the application of well-known proteins (S100β and GFAP) as serum indicators in the light of recently obtained results. Furthermore, the utility of molecules like MMP-9, UCHL-1, neurofilaments, BDNF, and miRNA, which are newly recognized as a potential serum biomarkers, will also be discussed.
    Mesh-Begriff(e) Biomarkers ; Blood-Brain Barrier ; Humans ; Nervous System Diseases
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2018-02-13
    Erscheinungsland Poland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 415519-1
    ISSN 1897-4260 ; 0028-3843
    ISSN (online) 1897-4260
    ISSN 0028-3843
    DOI 10.1016/j.pjnns.2018.02.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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