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  1. Artikel ; Online: A review on histotechnology practices in COVID-19 pathology investigations.

    Malloy, Seth / Wang, Yongfu

    Journal of histotechnology

    2020  Band 43, Heft 3, Seite(n) 153–158

    Abstract: COVID-19 disease in humans, caused by the novel SARS-CoV-2 virus, was first reported in the city of Wuhan, China in December 2019. This disease has quickly developed into a global pandemic, resulting in over 350,000 deaths worldwide and over 5 million ... ...

    Abstract COVID-19 disease in humans, caused by the novel SARS-CoV-2 virus, was first reported in the city of Wuhan, China in December 2019. This disease has quickly developed into a global pandemic, resulting in over 350,000 deaths worldwide and over 5 million confirmed infections in a matter of 6 months. Although the genome of this novel viral RNA was sequenced quickly and testing kits were manufactured to assist in combatting COVID-19, the diagnosis and treatment will remain relatively unsuccessful until the pathology of this disease is fully understood. Histotechnology plays an important role in understanding the pathology of many diseases, including COVID-19. The first postmortem biopsy of a COVID-19 patient was collected on 27 January 2020, and the pathology finding was published in mid-February 2020. Since then, more studies have been published in scientific literatures as the global outbreak continues. This mini-review summarizes the published articles in which histotechnology aspects were utilized with the intent to understand the pathology of COVID-19. In addition, it is anticipated there will be more molecular and immunohistochemical studies to further understand the mechanism of the disease in the near future.
    Mesh-Begriff(e) Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Disease Outbreaks/prevention & control ; Humans ; Immunohistochemistry/methods ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; RNA, Viral/genetics ; SARS-CoV-2
    Chemische Substanzen RNA, Viral
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604634-4
    ISSN 2046-0236 ; 0147-8885
    ISSN (online) 2046-0236
    ISSN 0147-8885
    DOI 10.1080/01478885.2020.1779484
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: A review on histotechnology practices in COVID-19 pathology investigations

    Malloy, Seth / Wang, Yongfu

    J Histotechnol

    Abstract: COVID-19 disease in humans, caused by the novel SARS-CoV-2 virus, was first reported in the city of Wuhan, China in December 2019. This disease has quickly developed into a global pandemic, resulting in over 350,000 deaths worldwide and over 5 million ... ...

    Abstract COVID-19 disease in humans, caused by the novel SARS-CoV-2 virus, was first reported in the city of Wuhan, China in December 2019. This disease has quickly developed into a global pandemic, resulting in over 350,000 deaths worldwide and over 5 million confirmed infections in a matter of 6 months. Although the genome of this novel viral RNA was sequenced quickly and testing kits were manufactured to assist in combatting COVID-19, the diagnosis and treatment will remain relatively unsuccessful until the pathology of this disease is fully understood. Histotechnology plays an important role in understanding the pathology of many diseases, including COVID-19. The first postmortem biopsy of a COVID-19 patient was collected on 27 January 2020, and the pathology finding was published in mid-February 2020. Since then, more studies have been published in scientific literatures as the global outbreak continues. This mini-review summarizes the published articles in which histotechnology aspects were utilized with the intent to understand the pathology of COVID-19. In addition, it is anticipated there will be more molecular and immunohistochemical studies to further understand the mechanism of the disease in the near future.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #640187
    Datenquelle COVID19

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  3. Artikel ; Online: A review on histotechnology practices in COVID-19 pathology investigations

    Malloy, Seth / Wang, Yongfu

    Journal of Histotechnology

    2020  Band 43, Heft 3, Seite(n) 153–158

    Schlagwörter Anatomy ; Medical Laboratory Technology ; Histology ; covid19
    Sprache Englisch
    Verlag Informa UK Limited
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    ZDB-ID 604634-4
    ISSN 2046-0236 ; 0147-8885
    ISSN (online) 2046-0236
    ISSN 0147-8885
    DOI 10.1080/01478885.2020.1779484
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: A freeze-substitution approach with solvent-based glyoxal fixative to prevent distortion of ocular structures.

    Pang, Ji / Zhao, Xia / Deng, Fengyan / Tsuchiya, Dai / Malloy, Seth / Parmely, Tari / Xie, Ting / Wang, Yongfu

    Journal of histotechnology

    2022  Band 45, Heft 4, Seite(n) 172–181

    Abstract: Investigating the function of delicate mammalian eyes often requires chemical fixation, histological sectioning, immunohistochemistry (IHC) ... ...

    Abstract Investigating the function of delicate mammalian eyes often requires chemical fixation, histological sectioning, immunohistochemistry (IHC) and
    Mesh-Begriff(e) Animals ; Mice ; Fixatives/pharmacology ; Glyoxal/pharmacology ; Solvents ; Paraffin ; In Situ Hybridization ; Mammals
    Chemische Substanzen Fixatives ; Glyoxal (50NP6JJ975) ; Solvents ; Paraffin (8002-74-2)
    Sprache Englisch
    Erscheinungsdatum 2022-09-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604634-4
    ISSN 2046-0236 ; 0147-8885
    ISSN (online) 2046-0236
    ISSN 0147-8885
    DOI 10.1080/01478885.2022.2111744
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Correction to: Identification and Localization of Cell Types in the Mouse Olfactory Bulb Using Slide-SeqV2.

    Fang, Ai / Petentler, Kaitlyn / Price, Andrew / Malloy, Seth / Peterson, Michael / Maddera, Lucinda / Russell, Jonathon / Treese, McKenzie / Li, Hua / Wang, Yongfu / McKinney, Sean / Perera, Anoja / Yu, C Ron

    Methods in molecular biology (Clifton, N.J.)

    2023  Band 2710, Seite(n) C1

    Sprache Englisch
    Erscheinungsdatum 2023-10-11
    Erscheinungsland United States
    Dokumenttyp Published Erratum
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3425-7_17
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Identification and Localization of Cell Types in the Mouse Olfactory Bulb Using Slide-SeqV2.

    Fang, Ai / Petentler, Kaitlyn / Price, Andrew / Malloy, Seth / Peterson, Michael / Maddera, Lucinda / Russell, Jonathon / Treese, McKenzie / Li, Hua / Wang, Yongfu / McKinney, Sean / Perera, Anoja / Yu, C Ron

    Methods in molecular biology (Clifton, N.J.)

    2023  Band 2710, Seite(n) 171–183

    Abstract: Spatial transcriptomics maps RNA molecules to the location in a tissue where they are expressed. Here we document the use of Slide-SeqV2 to visualize gene expression in the mouse olfactory bulb (OB). This approach relies on spatially identified beads to ... ...

    Abstract Spatial transcriptomics maps RNA molecules to the location in a tissue where they are expressed. Here we document the use of Slide-SeqV2 to visualize gene expression in the mouse olfactory bulb (OB). This approach relies on spatially identified beads to locate and quantify individual transcripts. The expression profiles associated with the beads are used to identify and localize individual cell types in an unbiased manner. We demonstrate the various cell types and subtypes with distinct spatial locations in the olfactory bulb that are identified using Slide-SeqV2.
    Mesh-Begriff(e) Animals ; Mice ; Olfactory Bulb ; Gene Expression Profiling
    Sprache Englisch
    Erscheinungsdatum 2023-09-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3425-7_13
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Compartmentalized ocular lymphatic system mediates eye-brain immunity.

    Yin, Xiangyun / Zhang, Sophia / Lee, Ju Hyun / Dong, Huiping / Mourgkos, George / Terwilliger, Gordon / Kraus, Aurora / Geraldo, Luiz Henrique / Poulet, Mathilde / Fischer, Suzanne / Zhou, Ting / Mohammed, Farrah Shalima / Zhou, Jiangbing / Wang, Yongfu / Malloy, Seth / Rohner, Nicolas / Sharma, Lokesh / Salinas, Irene / Eichmann, Anne /
    Thomas, Jean-Leon / Saltzman, W Mark / Huttner, Anita / Zeiss, Caroline / Ring, Aaron / Iwasaki, Akiko / Song, Eric

    Nature

    2024  Band 628, Heft 8006, Seite(n) 204–211

    Abstract: The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the ... ...

    Abstract The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected in the eye, particularly in the retina
    Mesh-Begriff(e) Animals ; Female ; Humans ; Male ; Mice ; Rabbits ; Bacteria/immunology ; Brain/anatomy & histology ; Brain/immunology ; Dependovirus/immunology ; Eye/anatomy & histology ; Eye/immunology ; Glioblastoma/immunology ; Herpesvirus 2, Human/immunology ; Intravitreal Injections ; Lymphatic System/anatomy & histology ; Lymphatic System/immunology ; Lymphatic Vessels/anatomy & histology ; Lymphatic Vessels/immunology ; Macaca mulatta ; Meninges/immunology ; Optic Nerve/immunology ; Swine ; Zebrafish ; Vascular Endothelial Growth Factor C/immunology ; Vascular Endothelial Growth Factor C/metabolism ; Vascular Endothelial Growth Factor C/pharmacology
    Chemische Substanzen Vascular Endothelial Growth Factor C
    Sprache Englisch
    Erscheinungsdatum 2024-02-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07130-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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