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  1. Article: Correlation between Neutrophil-to-Lymphocyte Ratio and Cerebral Edema in Children with Severe Diabetic Ketoacidosis.

    Scutca, Alexandra-Cristina / Nicoară, Delia-Maria / Mang, Niculina / Jugănaru, Iulius / Brad, Giorgiana-Flavia / Mărginean, Otilia

    Biomedicines

    2023  Volume 11, Issue 11

    Abstract: Diabetic ketoacidosis (DKA), a common onset modality of type 1 diabetes mellitus (T1DM), can lead, in rare instances, to the development of cerebral edema, which is the leading cause of mortality in T1DM. Aside from the identification of several ... ...

    Abstract Diabetic ketoacidosis (DKA), a common onset modality of type 1 diabetes mellitus (T1DM), can lead, in rare instances, to the development of cerebral edema, which is the leading cause of mortality in T1DM. Aside from the identification of several demographic and clinical risk factors for cerebral edema, attention has also been drawn to the possible link between systemic inflammation and neuroinflammation. This single-center retrospective study of 98 children with severe DKA aimed to investigate the possible relationship between neutrophil-to-lymphocyte ratio NLR) levels and the presence of cerebral edema. Patients were classified into three groups: alert (
    Language English
    Publishing date 2023-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11112976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Mathematik im Alltag

    Mang, Nathalie

    differenzierte Arbeitsblätter für den Mathematikunterricht ; 7./8. Klasse [Gymnasium]

    (Bergedorfer Unterrichtsideen ; Mathematik)

    2015  

    Author's details Nathalie Mang
    Series title Bergedorfer Unterrichtsideen
    Mathematik
    Keywords Mathematikunterricht
    Language German
    Size 98 S., Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Persen Verl., AAP Lehrerfachverl
    Publishing place Hamburg
    Document type Book
    ISBN 3403234541 ; 9783403234548
    Database Former special subject collection: coastal and deep sea fishing

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  3. Article ; Online: Assessing the Relationship between Systemic Immune-Inflammation Index and Metabolic Syndrome in Children with Obesity.

    Nicoară, Delia-Maria / Munteanu, Andrei-Ioan / Scutca, Alexandra-Cristina / Mang, Niculina / Juganaru, Iulius / Brad, Giorgiana-Flavia / Mărginean, Otilia

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Childhood obesity represents a worldwide concern as many countries have reported an increase in its incidence, with possible cardiovascular long-term implications. The mechanism that links cardiovascular disease to obesity is related to low-grade ... ...

    Abstract Childhood obesity represents a worldwide concern as many countries have reported an increase in its incidence, with possible cardiovascular long-term implications. The mechanism that links cardiovascular disease to obesity is related to low-grade inflammation. We designed this study to investigate the diagnostic utility of inflammatory indices (NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; SII, systemic immune-inflammation index; SIRI, systemic inflammation response index) in obese children with metabolic syndrome (MetS) and their relationship with cardiometabolic risk biomarkers, such as the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), triglyceride-to-high-density lipoprotein cholesterol (TG:HDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C). A total of 191 obese children from one large Romanian reference center was included in the study. Patients were classified in two groups according to the presence (MetS group) or absence (non-MetS group) of metabolic syndrome. According to our results, the SII index proved to have diagnostic value in distinguishing MetS patients among children with obesity (AUC = 0.843, a sensitivity of 0.83, and a specificity of 0.63). Furthermore, the SII was positively associated with cardiometabolic risk biomarkers (HOMA-IR,
    MeSH term(s) Humans ; Child ; Metabolic Syndrome/epidemiology ; Pediatric Obesity/complications ; Insulin Resistance/physiology ; Inflammation/complications ; Cholesterol ; Cardiovascular Diseases/etiology ; Triglycerides ; Cholesterol, HDL ; Biomarkers
    Chemical Substances Cholesterol (97C5T2UQ7J) ; Triglycerides ; Cholesterol, HDL ; Biomarkers
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Central precocious puberty in Prader-Willi syndrome: a narrative review.

    Nicoară, Delia-Maria / Scutca, Alexandra-Cristina / Mang, Niculina / Juganaru, Iulius / Munteanu, Andrei-Ioan / Vitan, Luiza / Mărginean, Otilia

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1150323

    Abstract: Prader-Willi syndrome (PWS, OMIM176270) is a rare genetic disorder with recognizable dysmorphic features and multisystemic consequences such as endocrine, neurocognitive and metabolic ones. Although most patients with Prader-Willi syndrome exhibit ... ...

    Abstract Prader-Willi syndrome (PWS, OMIM176270) is a rare genetic disorder with recognizable dysmorphic features and multisystemic consequences such as endocrine, neurocognitive and metabolic ones. Although most patients with Prader-Willi syndrome exhibit hypogonadotropic hypogonadism, there is variability regarding sexual maturation, with precocious puberty occurring in rare cases. Our aim is to elaborate a thorough review of Prader-Willi patients with central precocious puberty, in order to raise awareness of such cases and to enhance our knowledge regarding the diagnosis and prompt treatment of this particular PWS patients.
    MeSH term(s) Humans ; Prader-Willi Syndrome/complications ; Prader-Willi Syndrome/diagnosis ; Puberty, Precocious/diagnosis ; Puberty, Precocious/etiology ; Sexual Maturation ; Hypogonadism/complications ; Hypogonadism/diagnosis ; Knowledge
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1150323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Objective hand eczema severity assessment with automated lesion anatomical stratification.

    Amruthalingam, Ludovic / Mang, Nora / Gottfrois, Philippe / Gonzalez Jimenez, Alvaro / Maul, Julia-Tatjana / Kunz, Michael / Pouly, Marc / Navarini, Alexander A

    Experimental dermatology

    2023  Volume 32, Issue 4, Page(s) 521–528

    Abstract: Hand eczema (HE) is one of the most frequent dermatoses, known to be both relapsing and remitting. Regular and precise evaluation of the disease severity is key for treatment management. Current scoring systems such as the hand eczema severity index ( ... ...

    Abstract Hand eczema (HE) is one of the most frequent dermatoses, known to be both relapsing and remitting. Regular and precise evaluation of the disease severity is key for treatment management. Current scoring systems such as the hand eczema severity index (HECSI) suffer from intra- and inter-observer variance. We propose an automated system based on deep learning models (DLM) to quantify HE lesions' surface and determine their anatomical stratification. In this retrospective study, a team of 11 experienced dermatologists annotated eczema lesions in 312 HE pictures, and a medical student created anatomical maps of 215 hands pictures based on 37 anatomical subregions. Each data set was split into training and test pictures and used to train and evaluate two DLMs, one for anatomical mapping, the other for HE lesions segmentation. On the respective test sets, the anatomy DLM achieved average precision and sensitivity of 83% (95% confidence interval [CI] 80-85) and 85% (CI 82-88), while the HE DLM achieved precision and sensitivity of 75% (CI 64-82) and 69% (CI 55-81). The intraclass correlation of the predicted HE surface with dermatologists' estimated surface was 0.94 (CI 0.90-0.96). The proposed method automatically predicts the anatomical stratification of HE lesions' surface and can serve as support to evaluate hand eczema severity, improving reliability, precision and efficiency over manual assessment. Furthermore, the anatomical DLM is not limited to HE and can be applied to any other skin disease occurring on the hands such as lentigo or psoriasis.
    MeSH term(s) Humans ; Retrospective Studies ; Reproducibility of Results ; Severity of Illness Index ; Hand Dermatoses/diagnosis ; Eczema/pathology
    Language English
    Publishing date 2023-01-24
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14744
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3508: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Changes in the peripheral blood cell count in pediatric patients with Down syndrome.

    Mang, Niculina / Vizitiu, Anda C / Anghel, Andrei

    The Journal of international medical research

    2019  Volume 47, Issue 8, Page(s) 3757–3762

    MeSH term(s) Adolescent ; Blood Cell Count ; Case-Control Studies ; Child ; Child, Preschool ; Down Syndrome/blood ; Down Syndrome/pathology ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2019-05-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/0300060519850397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 925: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Factors Impacting the Reduction in Neophobia Prevalence in Phenylketonuria Patients.

    Bugi, Meda-Ada / Jugănaru, Iulius / Isac, Raluca / Simina, Iulia-Elena / Munteanu, Andrei-Ioan / Mang, Niculina / Brad, Georgiana-Flavia / Nicoară, Delia-Maria / Cîrnatu, Daniela / Mărginean, Otilia

    Nutrients

    2024  Volume 16, Issue 6

    Abstract: Food neophobia (FN), the fear of sampling new foods, can have a significant impact on children's eating habits. Children with phenylketonuria (PKU), a hereditary condition that inhibits the body's capacity to metabolize phenylalanine, should take this ... ...

    Abstract Food neophobia (FN), the fear of sampling new foods, can have a significant impact on children's eating habits. Children with phenylketonuria (PKU), a hereditary condition that inhibits the body's capacity to metabolize phenylalanine, should take this attitude with caution. Patients with PKU must follow a rigorous phenylalanine (Phe)-restricted diet to avoid brain malfunction that can include intellectual disability, seizures, and behavioral difficulties. The novelty of our work stems from the fact that we explored the origins of this incorrect intake pattern, which exacerbates PKU patients' already fragile health. We conducted a cross-sectional study on 34 previously diagnosed phenylketonuria patients and a control group ranging in age from 7 months to 40 years, with a sex ratio of M/F 2:1. The Food Neophobia Scale (FNS) was used to determine neophobia. We used JASP (version 0.18.1) statistical analysis to examine the relationship between neophobia and PKU condition, age and nutritional status at the time of study, diet compliance, parental educational level, period from birth to PKU diagnosis, and environmental (rural/urban) provenience of PKU patients. According to the data, 61.76% of patients with PKU were neophobic, as were 70.57% of the control group. Food neophobia was associated with PKU patients' present age, the period from birth to PKU diagnosis, and parental educational level.
    MeSH term(s) Child ; Humans ; Cross-Sectional Studies ; Prevalence ; Phenylketonurias ; Feeding Behavior ; Phenylalanine
    Chemical Substances Phenylalanine (47E5O17Y3R)
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16060768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Outpatient Parenteral Antimicrobial Therapy in a Safety Net Hospital: Opportunities for Improvement.

    Bouzigard, Rory / Arnold, Mark / Msibi, Sithembiso S / Player, Jacob K / Mang, Norman / Hall, Brenton / Su, Joseph / Lane, Michael A / Perl, Trish M / Castellino, Laila M

    Open forum infectious diseases

    2024  Volume 11, Issue 5, Page(s) ofae190

    Abstract: Background: Outpatient parenteral antimicrobial therapy (OPAT) is a safe and cost-effective transitional care approach administered via different delivery models. No standards exist for appropriate OPAT program staffing. We examined outcomes of patients ...

    Abstract Background: Outpatient parenteral antimicrobial therapy (OPAT) is a safe and cost-effective transitional care approach administered via different delivery models. No standards exist for appropriate OPAT program staffing. We examined outcomes of patients receiving OPAT via different care models to identify strategies to improve safety while reducing health care overuse.
    Methods: Retrospective demographic, clinical, and outcome data of patients discharged with OPAT were reviewed in 2 periods (April-June 2021 and January-March 2022; ie, when staffing changed) and stratified by care model: self-administered OPAT, health care OPAT, and skilled nursing facility OPAT.
    Results: Of 342 patients, 186 (54%) received OPAT in 2021 and 156 (46%) in 2022. Hospital length of stay rose from 12.4 days to 14.3 in 2022. In a Cox proportional hazards regression model, visits to the emergency department (ED) within 30 days of OPAT initiation (hazard ratio, 1.76; 95% CI, 1.13-2.73;
    Conclusions: In a well-established OPAT program, greater health care utilization-length of stay, ED visits, and readmissions-were seen during periods of higher staff turnover and attrition. Rather than blunt metrics such as ED visits and readmissions, which are influenced by multiple factors besides OPAT, our findings suggest the need to develop OPAT-specific outcome measures as a quality assessment tool and to establish optimal OPAT program staffing ratios.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Mathematik im Alltag

    Mang, Nathalie

    differenzierte Arbeitsblätter für den Mathematikunterricht ; 5./6. Klasse ; [Gymnasium]

    (Bergedorfer Unterrichtsideen)

    2012  

    Author's details Nathalie Mang
    Series title Bergedorfer Unterrichtsideen
    Keywords Mathematikunterricht ; Unterstufe
    Language German
    Size 85 S., Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Persen
    Publishing place Buxtehude
    Document type Book
    ISBN 3403232239 ; 9783403232230
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article: Implementation of IV Push Antibiotics for Outpatients During a National Fluid Shortage Following Hurricane Maria.

    Yagnik, Kruti J / Brown, L Steven / Saad, Hala A / Alvarez, Kristin / Mang, Norman / Bird, Cylaina E / Cerise, Fred / Bhavan, Kavita P

    Open forum infectious diseases

    2022  Volume 9, Issue 5, Page(s) ofac117

    Abstract: Background: Prior to the introduction of intravenous (IV) drip infusion, most IV drugs were delivered in a syringe bolus push. However, intravenous drip infusions subsequently became the standard of care. Puerto Rico is the largest supplier of IV fluid ... ...

    Abstract Background: Prior to the introduction of intravenous (IV) drip infusion, most IV drugs were delivered in a syringe bolus push. However, intravenous drip infusions subsequently became the standard of care. Puerto Rico is the largest supplier of IV fluid bags and in the aftermath of Hurricane Maria, there was a nationwide fluid bag shortage. This shortage required stewardship measures to maintain the operation of the self-administered outpatient parenteral antimicrobial therapy (OPAT) program at Parkland Health.
    Methods: Parkland pharmacists evaluated all self-administered antimicrobials for viability of administration as an IV syringe bolus push (IVP) instead of an IV-drip infusion. Medications deemed appropriate were transitioned to IVP. The hospital EMR was used to identify patients discharged to the OPAT clinic using all methods of parenteral drug delivery. Data was collected for patient demographics, patient satisfaction, and clinical outcomes. Finally cost of care was calculated for IVP and IV drip administration.
    Results: One-hundred and thirteen self-administered IVP and 102 self-administered IV drip treatment courses were identified during the study period. Individuals using IVP had a statistically significant decrease in hospital length of stay. Patient satisfaction was greater with IVP and IVP saved 504 liters of normal saline resulting in a savings of $43,652 over 6 months. The 30-day readmission rate and mortality were similar.
    Conclusion: The abrupt IV fluid shortage following a natural disaster led to implementation of a high value care model that improved efficiency, reduced costs, and did not affect safety or efficacy.
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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