Artikel ; Online: Comparative study of in vitro activity of tedizolid and linezolid against Mycobacterium avium complex.
Journal of global antimicrobial resistance
2022 Band 30, Seite(n) 395–398
Abstract: Objectives: The aim of this study is to compare the in vitro activity and minimal inhibitory concentration (MIC) distributions of tedizolid and linezolid against Mycobacterium avium complex (MAC) strains using a reference broth microdilution assay and a ...
| Abstract | Objectives: The aim of this study is to compare the in vitro activity and minimal inhibitory concentration (MIC) distributions of tedizolid and linezolid against Mycobacterium avium complex (MAC) strains using a reference broth microdilution assay and a macrodilution assay with the Bactec-MGIT-960. Methods: A total of 37 clinical isolates of MAC were included in the study. Reference broth microdilution was performed according to CLSI guidelines in a range of concentrations from 64 to 0.064 mg/L. Macrodilution was performed with the Bactec-MGIT-960 system. The cut-off points defined by CLSI for linezolid (resistant: > 16 mg/L, intermediate: 16 mg/L, susceptible: <16 mg/L) were used to define clinical categories of this drug. Essential agreement for both linezolid and tedizolid and categorical agreement for linezolid were defined following FDA criteria. Results: The MIC Conclusions: Tedizolid showed higher in vitro activity than linezolid against the tested MAC isolates. Macrodilution using the BD Bactec-MGIT-960 system is a practical approach to determine the susceptibility of MAC strains to tedizolid. |
|---|---|
| Mesh-Begriff(e) | Anti-Bacterial Agents/pharmacology ; Humans ; Linezolid/pharmacology ; Mycobacterium avium Complex ; Mycobacterium avium-intracellulare Infection ; Organophosphates/pharmacology ; Oxazoles/pharmacology ; Oxazolidinones ; Tetrazoles |
| Chemische Substanzen | Anti-Bacterial Agents ; Organophosphates ; Oxazoles ; Oxazolidinones ; Tetrazoles ; tedizolid (97HLQ82NGL) ; Linezolid (ISQ9I6J12J) |
| Sprache | Englisch |
| Erscheinungsdatum | 2022-07-18 |
| Erscheinungsland | Netherlands |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2710046-7 |
| ISSN | 2213-7173 ; 2213-7173 |
| ISSN (online) | 2213-7173 |
| ISSN | 2213-7173 |
| DOI | 10.1016/j.jgar.2022.07.012 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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