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Artikel ; Online: Alterations of mRNAs and Non-coding RNAs Associated with Neuroinflammation in Alzheimer's Disease.

Hernández-Contreras, Karla Aketzalli / Martínez-Díaz, Jorge Antonio / Hernández-Aguilar, María Elena / Herrera-Covarrubias, Deissy / Rojas-Durán, Fausto / Chi-Castañeda, Lizbeth Donají / García-Hernández, Luis Isauro / Aranda-Abreu, Gonzalo Emiliano

Molecular neurobiology

2024  

Abstract: Alzheimer's disease is a neurodegenerative pathology whose pathognomonic hallmarks are increased generation of β-amyloid (Aβ) peptide, production of hyperphosphorylated (pTau), and neuroinflammation. The last is an alteration closely related to the ... ...

Abstract Alzheimer's disease is a neurodegenerative pathology whose pathognomonic hallmarks are increased generation of β-amyloid (Aβ) peptide, production of hyperphosphorylated (pTau), and neuroinflammation. The last is an alteration closely related to the progression of AD and although it is present in multiple neurodegenerative diseases, the pathophysiological events that characterize neuroinflammatory processes vary depending on the disease. In this article, we focus on mRNA and non-coding RNA alterations as part of the pathophysiological events characteristic of neuroinflammation in AD and the influence of these alterations on the course of the disease through interaction with multiple RNAs related to the generation of Aβ, pTau, and neuroinflammation itself.
Sprache Englisch
Erscheinungsdatum 2024-01-18
Erscheinungsland United States
Dokumenttyp Journal Article ; Review
ZDB-ID 645020-9
ISSN 1559-1182 ; 0893-7648
ISSN (online) 1559-1182
ISSN 0893-7648
DOI 10.1007/s12035-023-03908-5
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Zs.A 2411: Hefte anzeigen Standort:
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ab Jg. 2022: Lesesaal (EG)
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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