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  1. Article ; Online: Electrostimulable polymeric films with hyaluronic acid and lipid nanoparticles for simultaneous topical delivery of macromolecules and lipophilic drugs.

    Martin, Bianca Aparecida / Dalmolin, Luciana Facco / Lemos, Camila Nunes / de Menezes Vaidergorn, Miguel / da Silva Emery, Flavio / Vargas-Rechia, Carem Gledes / Ramos, Ana Paula / Lopez, Renata F V

    Drug delivery and translational research

    2024  

    Abstract: This study focused on developing electrically stimulable hyaluronic acid (HA) films incorporating lipid nanoparticles (NPs) designed for the topical administration of lipophilic drugs and macromolecules. Based on beeswax and medium-chain triglycerides, ... ...

    Abstract This study focused on developing electrically stimulable hyaluronic acid (HA) films incorporating lipid nanoparticles (NPs) designed for the topical administration of lipophilic drugs and macromolecules. Based on beeswax and medium-chain triglycerides, NPs were successfully integrated into silk fibroin/chitosan films containing HA (NP-HA films) at a density of approximately 10
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-024-01526-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A New Approach to Atopic Dermatitis Control with Low-Concentration Propolis-Loaded Cold Cream.

    Martin, Bianca Aparecida / Lemos, Camila Nunes / Dalmolin, Luciana Facco / Arruda, Caroline / Brait, Íris Sperchi Camilo / Cazarim, Maurílio de Souza / da Cruz-Cazarim, Estael Luzia Coelho / Bueno, Paula Carolina Pires / Júnior, Maurílio Polizello / Pereira, Leonardo Régis Leira / Cardili, Renata Nahas / Fonseca Vianna Lopez, Renata

    Pharmaceutics

    2021  Volume 13, Issue 9

    Abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease that is difficult to treat. Traditional cold cream, a water-in-oil emulsion made from beeswax, is used to alleviate AD symptoms in clinical practice, although its effectiveness has not been ... ...

    Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease that is difficult to treat. Traditional cold cream, a water-in-oil emulsion made from beeswax, is used to alleviate AD symptoms in clinical practice, although its effectiveness has not been scientifically proven. The addition of propolis has the potential to impart anti-inflammatory properties to cold cream. However, in high concentrations, propolis can trigger allergic reactions. Thus, the objective of this work was to develop a cold cream formulation based on purified beeswax containing the same amount of green propolis present in raw beeswax. The impact of adding this low propolis concentration to cold cream on AD control was evaluated in patients compared to cold cream without added propolis (CBlank). Raw beeswax was chemically characterized to define the propolis concentration added to the propolis-loaded cold cream (CPropolis). The creams were characterized as to their physicochemical, mechanical, and rheological characteristics. The effect of CPropolis and CBlank on the quality of life, disease severity, and skin hydration of patients with AD was evaluated in a triple-blind randomized preclinical study. Concentrations of 34 to 120 ng/mL of green propolis extract reduced TNF-α levels in LPS-stimulated macrophage culture. The addition of propolis to cold cream did not change the cream's rheological, mechanical, or bioadhesive properties. The preclinical study suggested that both creams improved the patient's quality of life. Furthermore, the use of CPropolis decreased the disease severity compared to CBlank.
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13091346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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