Artikel: Programmed Cell Death Not as Sledgehammer but as Chisel: Apoptosis in Normal and Abnormal Craniofacial Patterning and Development.
Frontiers in cell and developmental biology
2021 Band 9, Seite(n) 717404
Abstract: Coordination of craniofacial development involves an complex, intricate, genetically controlled and tightly regulated spatiotemporal series of reciprocal inductive and responsive interactions among the embryonic cephalic epithelia (both endodermal and ... ...
| Abstract | Coordination of craniofacial development involves an complex, intricate, genetically controlled and tightly regulated spatiotemporal series of reciprocal inductive and responsive interactions among the embryonic cephalic epithelia (both endodermal and ectodermal) and the cephalic mesenchyme - particularly the cranial neural crest (CNC). The coordinated regulation of these interactions is critical both ontogenetically and evolutionarily, and the clinical importance and mechanistic sensitivity to perturbation of this developmental system is reflected by the fact that one-third of all human congenital malformations affect the head and face. Here, we focus on one element of this elaborate process, apoptotic cell death, and its role in normal and abnormal craniofacial development. We highlight four themes in the temporospatial elaboration of craniofacial apoptosis during development, namely its occurrence at (1) positions of epithelial-epithelial apposition, (2) within intra-epithelial morphogenesis, (3) during epithelial compartmentalization, and (4) with CNC metameric organization. Using the genetic perturbation of |
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| Sprache | Englisch |
| Erscheinungsdatum | 2021-10-08 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article ; Review |
| ZDB-ID | 2737824-X |
| ISSN | 2296-634X |
| ISSN | 2296-634X |
| DOI | 10.3389/fcell.2021.717404 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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