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  1. Artikel ; Online: An Alternative Approach for Treating a Type Ia Endoleak after Conventional EVAR Using the Nellix Endovascular Aneurysm Sealing.

    Martinelli, Ombretta / Fresilli, Mauro / Irace, Luigi / Venosi, Salvatore / Jabbour, Jihad / Picone, Veronica / Maruca, Debora / Di Girolamo, Alessia / Gossetti, Bruno

    Annals of vascular surgery

    2018  Band 49, Seite(n) 316.e5–316.e10

    Abstract: Background: To report the use of a Nellix endovascular aneurysm sealing (EVAS) device, to successfully treat a type Ia endoleak (EL) after an endovascular aortic repair (EVAR).: Case report: A 70-year-old man was diagnosed with a 90-mm aortic ... ...

    Abstract Background: To report the use of a Nellix endovascular aneurysm sealing (EVAS) device, to successfully treat a type Ia endoleak (EL) after an endovascular aortic repair (EVAR).
    Case report: A 70-year-old man was diagnosed with a 90-mm aortic aneurysm, suspicious for being inflammatory. It was initially treated successfully, with a Medtronic Endurant (Medtronic, Minneapolis, MN, USA). Five years after the index endovascular repair, an asymptomatic type Ia EL was detected on duplex ultrasound and computed tomographic angiogram. Other endovascular solutions in the form of proximal cuff, chimney was considered difficult to execute due to challenges in planning, manipulation, and renal cannulation caused by the short proximal sealing zone above the existing stent graft and the constraints of the previous endograft. Thus, a relining of the previous endoprothesis was performed using the Nellix system (Endologix, Inc., Irvine, CA, USA). One-year follow-up imaging demonstrated successful resolution of the EL and persistent sealing of the Nellix device.
    Conclusions: Nellix EVAS system can be an alternative and safe option for relining a stent graft with a type Ia EL. Nellix platform can be added to the clinician's armamentarium for treating type Ia EL after conventional EVAR of infrarenal abdominal aortic aneurysm (AAA).
    Mesh-Begriff(e) Aged ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/surgery ; Aortography/methods ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/instrumentation ; Computed Tomography Angiography ; Endoleak/diagnostic imaging ; Endoleak/etiology ; Endoleak/surgery ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Humans ; Male ; Prosthesis Design ; Stents ; Treatment Outcome ; Ultrasonography, Doppler, Duplex
    Sprache Englisch
    Erscheinungsdatum 2018-03-01
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2017.12.020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy.

    Venosi, Salvatore / Ceccarelli, Giancarlo / de Angelis, Massimiliano / Laghi, Luca / Bianchi, Laura / Martinelli, Ombretta / Maruca, Debora / Cavallari, Eugenio Nelson / Toscanella, Fabrizia / Vassalini, Paolo / Trinchieri, Vito / Oliva, Alessandra / d'Ettorre, Gabriella

    Journal of translational medicine

    2019  Band 17, Heft 1, Seite(n) 364

    Abstract: Background: A wide debate is ongoing regarding the role of cutaneous dysbiosis in the pathogenesis and evolution of difficult-to-treat chronic wounds. Nowadays, probiotic treatment considered as an useful tool to counteract dysbiosis but the evidence in ...

    Abstract Background: A wide debate is ongoing regarding the role of cutaneous dysbiosis in the pathogenesis and evolution of difficult-to-treat chronic wounds. Nowadays, probiotic treatment considered as an useful tool to counteract dysbiosis but the evidence in regard to their therapeutic use in the setting of difficult-to-treat cutaneous ulcers is still poor.
    Aim: CLINICAL REPORT: An 83-year-old woman suffering a critical limb ischemia and an infected difficult-to-treat ulcerated cutaneous lesion of the right leg, was complementary treated with local application of a mixture of probiotic bacteria.
    Methods: Microbiological and metabolomic analysis were conducted on wound swabs obtained before and after bacteriotherapy.
    Results: During the treatment course, a progressive healing of the lesion was observed with microbiological resolution of the polymicrobial infection of the wound. Metabolomic analysis showed a significant difference in the local concentration of propionate, 2-hydroxyisovalerate, 2-oxoisocaproate, 2,3-butanediol, putrescine, thymine, and trimethylamine before and after bacteriotherapy.
    Conclusion: The microbiological and metabolomic results seem to confirm the usefulness of complementary probiotic treatment in difficult-to-treat infected wounds. Further investigations are needed to confirm these preliminary findings.
    Mesh-Begriff(e) Administration, Topical ; Aged, 80 and over ; Chronic Disease ; Female ; Humans ; Ischemia/microbiology ; Ischemia/pathology ; Ischemia/therapy ; Leg ; Metabolome ; Probiotics/administration & dosage ; Probiotics/therapeutic use ; Skin/metabolism ; Skin/microbiology ; Skin/pathology ; Skin Ulcer/microbiology ; Skin Ulcer/pathology ; Skin Ulcer/therapy ; Translational Medical Research ; Wound Healing/physiology ; Wound Infection/microbiology ; Wound Infection/pathology ; Wound Infection/therapy
    Sprache Englisch
    Erscheinungsdatum 2019-11-09
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1479-5876
    ISSN (online) 1479-5876
    DOI 10.1186/s12967-019-2111-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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