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  1. Artikel: Xenotransplantation and interspecies organogenesis: current status and issues.

    Kano, Mayuko / Mizutani, Eiji / Homma, Shota / Masaki, Hideki / Nakauchi, Hiromitsu

    Frontiers in endocrinology

    2022  Band 13, Seite(n) 963282

    Abstract: Pancreas (and islet) transplantation is the only curative treatment for type 1 diabetes patients whose β-cell functions have been abolished. However, the lack of donor organs has been the major hurdle to save a large number of patients. Therefore, ... ...

    Abstract Pancreas (and islet) transplantation is the only curative treatment for type 1 diabetes patients whose β-cell functions have been abolished. However, the lack of donor organs has been the major hurdle to save a large number of patients. Therefore, transplantation of animal organs is expected to be an alternative method to solve the serious shortage of donor organs. More recently, a method to generate organs from pluripotent stem cells inside the body of other species has been developed. This interspecies organ generation using blastocyst complementation (BC) is expected to be the next-generation regenerative medicine. Here, we describe the recent advances and future prospects for these two approaches.
    Mesh-Begriff(e) Animals ; Blastocyst ; Organogenesis/physiology ; Pluripotent Stem Cells ; Regenerative Medicine ; Transplantation, Heterologous
    Sprache Englisch
    Erscheinungsdatum 2022-08-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.963282
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Interspecies chimeras for human stem cell research.

    Masaki, Hideki / Nakauchi, Hiromitsu

    Development (Cambridge, England)

    2017  Band 144, Heft 14, Seite(n) 2544–2547

    Abstract: Interspecies chimeric assays are a valuable tool for investigating the potential of human stem and progenitor cells, as well as their differentiated progeny. This Spotlight article discusses the different factors that affect interspecies chimera ... ...

    Abstract Interspecies chimeric assays are a valuable tool for investigating the potential of human stem and progenitor cells, as well as their differentiated progeny. This Spotlight article discusses the different factors that affect interspecies chimera generation, such as evolutionary distance, developmental timing, and apoptosis of the transplanted cells, and suggests some possible strategies to address them. A refined approach to generating interspecies chimeras could contribute not only to a better understanding of cellular potential, but also to understanding the nature of xenogeneic barriers and mechanisms of heterochronicity, to modeling human development, and to the creation of human transplantable organs.
    Mesh-Begriff(e) Animals ; Apoptosis ; Embryonic Development ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/transplantation ; Humans ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/transplantation ; Species Specificity ; Stem Cell Research/ethics ; Transplantation Chimera
    Sprache Englisch
    Erscheinungsdatum 2017--15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.151183
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Skin graft with dermis and appendages generated in vivo by cell competition.

    Nagano, Hisato / Mizuno, Naoaki / Sato, Hideyuki / Mizutani, Eiji / Yanagida, Ayaka / Kano, Mayuko / Kasai, Mariko / Yamamoto, Hiromi / Watanabe, Motoo / Suchy, Fabian / Masaki, Hideki / Nakauchi, Hiromitsu

    Nature communications

    2024  Band 15, Heft 1, Seite(n) 3366

    Abstract: Autologous skin grafting is a standard treatment for skin defects such as burns. No artificial skin substitutes are functionally equivalent to autologous skin grafts. The cultured epidermis lacks the dermis and does not engraft deep wounds. Although ... ...

    Abstract Autologous skin grafting is a standard treatment for skin defects such as burns. No artificial skin substitutes are functionally equivalent to autologous skin grafts. The cultured epidermis lacks the dermis and does not engraft deep wounds. Although reconstituted skin, which consists of cultured epidermal cells on a synthetic dermal substitute, can engraft deep wounds, it requires the wound bed to be well-vascularized and lacks skin appendages. In this study, we successfully generate complete skin grafts with pluripotent stem cell-derived epidermis with appendages on p63 knockout embryos' dermis. Donor pluripotent stem cell-derived keratinocytes encroach the embryos' dermis by eliminating p63 knockout keratinocytes based on cell-extracellular matrix adhesion mediated cell competition. Although the chimeric skin contains allogenic dermis, it is engraftable as long as autologous grafts. Furthermore, we could generate semi-humanized skin segments by human keratinocytes injection into the amnionic cavity of p63 knockout mice embryos. Niche encroachment opens the possibility of human skin graft production in livestock animals.
    Mesh-Begriff(e) Animals ; Skin Transplantation/methods ; Keratinocytes/cytology ; Keratinocytes/transplantation ; Humans ; Dermis/cytology ; Dermis/transplantation ; Mice, Knockout ; Mice ; Epidermis/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/transplantation ; Skin, Artificial ; Epidermal Cells/transplantation ; Epidermal Cells/cytology ; Extracellular Matrix/metabolism ; Skin/cytology
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47527-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Publisher Correction: Hypoblast from human pluripotent stem cells regulates epiblast development.

    Okubo, Takumi / Rivron, Nicolas / Kabata, Mio / Masaki, Hideki / Kishimoto, Keiko / Semi, Katsunori / Nakajima-Koyama, May / Kunitomi, Haruko / Kaswandy, Belinda / Sato, Hideyuki / Nakauchi, Hiromitsu / Woltjen, Knut / Saitou, Mitinori / Sasaki, Erika / Yamamoto, Takuya / Takashima, Yasuhiro

    Nature

    2024  Band 626, Heft 8001, Seite(n) E21

    Sprache Englisch
    Erscheinungsdatum 2024-02-10
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07166-w
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  5. Artikel ; Online: Functional calcium-responsive parathyroid glands generated using single-step blastocyst complementation.

    Kano, Mayuko / Mizuno, Naoaki / Sato, Hideyuki / Kimura, Takaharu / Hirochika, Rei / Iwasaki, Yasumasa / Inoshita, Naoko / Nagano, Hisato / Kasai, Mariko / Yamamoto, Hiromi / Yamaguchi, Tomoyuki / Suga, Hidetaka / Masaki, Hideki / Mizutani, Eiji / Nakauchi, Hiromitsu

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Band 120, Heft 28, Seite(n) e2216564120

    Abstract: Patients with permanent hypoparathyroidism require lifelong replacement therapy to avoid life-threatening complications, The benefits of conventional treatment are limited, however. Transplanting a functional parathyroid gland (PTG) would yield better ... ...

    Abstract Patients with permanent hypoparathyroidism require lifelong replacement therapy to avoid life-threatening complications, The benefits of conventional treatment are limited, however. Transplanting a functional parathyroid gland (PTG) would yield better results. Parathyroid gland cells generated from pluripotent stem cells in vitro to date cannot mimic the physiological responses to extracellular calcium that are essential for calcium homeostasis. We thus hypothesized that blastocyst complementation (BC) could be a better strategy for generating functional PTG cells and compensating loss of parathyroid function. We here describe generation of fully functional PTGs from mouse embryonic stem cells (mESCs) with single-step BC. Using CRISPR-Cas9 knockout of
    Mesh-Begriff(e) Humans ; Animals ; Mice ; Rats ; Parathyroid Glands ; Calcium ; Hypoparathyroidism/genetics ; Hypoparathyroidism/therapy ; Calcium, Dietary ; Blastocyst
    Chemische Substanzen Calcium (SY7Q814VUP) ; Calcium, Dietary
    Sprache Englisch
    Erscheinungsdatum 2023-06-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2216564120
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: [New approved markers of bone turnover for osteoporosis in Japan].

    Miki, Takami / Masaki, Hideki

    Clinical calcium

    2012  Band 22, Heft 6, Seite(n) 877–883

    Abstract: Various markers of bone turnover are already under clinical use in Japan, and mostly for clinical investigation in some countries. Standard values including ranges and variations are summarized in the previous edition of the guideline. The information of ...

    Abstract Various markers of bone turnover are already under clinical use in Japan, and mostly for clinical investigation in some countries. Standard values including ranges and variations are summarized in the previous edition of the guideline. The information of additional new markers adapted by government is summarized including clinical features in the new edition 2012. Among the new markers, the methods for measurement for TRACP-5b and ucOC are developed in Japan. As P1NP and TRACP-5b levels are not affected by meals, biological variations are smaller compared with other markers. ucOC is unique because it is to evaluate vitamin K insufficiency for bone. New bone markers adapted in the Japanese guideline 2012 will facilitate clinicians to utilize of metabolic markers of bone for osteoporosis treatment.
    Mesh-Begriff(e) Acid Phosphatase/blood ; Biomarkers/blood ; Bone and Bones/metabolism ; Humans ; Isoenzymes/blood ; Japan ; Osteocalcin/blood ; Osteoporosis/blood ; Osteoporosis/diagnosis ; Practice Guidelines as Topic ; Tartrate-Resistant Acid Phosphatase
    Chemische Substanzen Biomarkers ; Isoenzymes ; Osteocalcin (104982-03-8) ; ACP5 protein, human (EC 3.1.3.2) ; Acid Phosphatase (EC 3.1.3.2) ; Tartrate-Resistant Acid Phosphatase (EC 3.1.3.2)
    Sprache Japanisch
    Erscheinungsdatum 2012-06
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1206877883
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Hypoblast from human pluripotent stem cells regulates epiblast development.

    Okubo, Takumi / Rivron, Nicolas / Kabata, Mio / Masaki, Hideki / Kishimoto, Keiko / Semi, Katsunori / Nakajima-Koyama, May / Kunitomi, Haruko / Kaswandy, Belinda / Sato, Hideyuki / Nakauchi, Hiromitsu / Woltjen, Knut / Saitou, Mitinori / Sasaki, Erika / Yamamoto, Takuya / Takashima, Yasuhiro

    Nature

    2023  Band 626, Heft 7998, Seite(n) 357–366

    Abstract: Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human ... ...

    Abstract Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human embryos
    Mesh-Begriff(e) Humans ; Cell Differentiation ; Embryo Implantation ; Embryo, Mammalian/cytology ; Embryo, Mammalian/embryology ; Embryo, Mammalian/metabolism ; Embryonic Development/genetics ; Embryonic Development/physiology ; Germ Layers/cytology ; Germ Layers/embryology ; Germ Layers/metabolism ; Pluripotent Stem Cells/cytology ; Interleukin-6/metabolism ; Gastrula/cytology ; Gastrula/embryology ; Amnion/cytology ; Amnion/embryology ; Amnion/metabolism ; Ectoderm/cytology ; Ectoderm/embryology ; Ectoderm/metabolism ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Otx Transcription Factors/genetics ; Otx Transcription Factors/metabolism
    Chemische Substanzen Interleukin-6 ; DKK1 protein, human ; OTX2 protein, human ; IL6 protein, human ; Intercellular Signaling Peptides and Proteins ; Otx Transcription Factors
    Sprache Englisch
    Erscheinungsdatum 2023-12-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06871-2
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  8. Artikel: [Bone and calcium metabolism in elderly women].

    Masaki, Hideki / Miki, Takami

    Clinical calcium

    2011  Band 21, Heft 9, Seite(n) 1361–1367

    Abstract: Bone mass of elderly women reduces after menopause, but the rate of reduction differ individually especially in the elderly, because bone metabolism of the elderly is influenced by many factors such as hormones, fractures, drugs, ability of exercise and/ ... ...

    Abstract Bone mass of elderly women reduces after menopause, but the rate of reduction differ individually especially in the elderly, because bone metabolism of the elderly is influenced by many factors such as hormones, fractures, drugs, ability of exercise and/or nutritional level. Therefore, it is quite difficult to determine the normal ranges of the metabolism. As a whole, aging accelerates bone turnover slowly with wide range of individual variation. Subnormal renal function may effect on the excretion or metabolism of bone markers, such as osteocalcin. Urinary markers such as NTX corrected by urinary creatinine may be higher than the real level, because of low creatinine production in the elderly. These factors may influence on the elevated bone metabolism resulting in the discrepancy with morphometric evaluation.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Aging/genetics ; Aging/metabolism ; Biomarkers ; Bone and Bones/metabolism ; Calcium/metabolism ; Collagen Type I/urine ; Creatinine/urine ; Estrogens/metabolism ; Estrogens/physiology ; Female ; Glucuronidase/genetics ; Humans ; Kidney/metabolism ; Osteocalcin/metabolism ; Peptides/urine ; Polymorphism, Genetic ; Vitamin K Deficiency
    Chemische Substanzen Biomarkers ; Collagen Type I ; Estrogens ; Peptides ; collagen type I trimeric cross-linked peptide ; Osteocalcin (104982-03-8) ; Creatinine (AYI8EX34EU) ; Glucuronidase (EC 3.2.1.31) ; klotho protein (EC 3.2.1.31) ; Calcium (SY7Q814VUP)
    Sprache Japanisch
    Erscheinungsdatum 2011-09
    Erscheinungsland Japan
    Dokumenttyp English Abstract ; Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa110913611367
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Bazedoxifene improves renal function and increases renal phosphate excretion in patients with postmenopausal osteoporosis.

    Masaki, Hideki / Imanishi, Yasuo / Naka, Hiroshi / Nagata, Yuki / Kurajoh, Masafumi / Mori, Katsuhito / Emoto, Masanori / Miki, Takami / Inaba, Masaaki

    Journal of bone and mineral metabolism

    2020  Band 38, Heft 3, Seite(n) 405–411

    Abstract: Introduction: Because aging is a predictor of renal insufficiency in the general population, renal function is a concern in postmenopausal patients undergoing treatment for osteoporosis. Although high serum phosphate concentration is a predictor of ... ...

    Abstract Introduction: Because aging is a predictor of renal insufficiency in the general population, renal function is a concern in postmenopausal patients undergoing treatment for osteoporosis. Although high serum phosphate concentration is a predictor of renal insufficiency, the effect of selective estrogen receptor modulator (SERM) on renal function and phosphate homeostasis remains to be established.
    Materials and methods: We administered 20 mg/day bazedoxifene to 48 postmenopausal osteoporotic women who had been taking alfacalcidol for ≥ 6 months, and assessed lumbar spine bone mineral density (LS-BMD), renal function (by calculating estimated glomerular filtration rate using serum cystatin-C levels [eGFRcys] [range 38.0-98.2 mL/min/1.73 m
    Results: LS-BMD was significantly higher 6 months after the initiation of bazedoxifene administration. eGFRcys had increased by 3 months after initiation and was stable until 12 months. Serum phosphate gradually decreased after initiation, reaching statistical significance at 6 months. The changes in serum phosphate were also significant when the maximum tubular reabsorption rate of phosphate was normalized to glomerular filtration rate (TmP/GFR), indicating that bazedoxifene treatment reduces serum phosphate by increasing the urinary excretion of phosphate. The change in eGFRcys after the initiation of bazedoxifene was significantly negatively correlated with the change in serum phosphate, suggesting that a reduction in serum phosphate improves renal function.
    Conclusion: Bazedoxifene improves renal function, possibly by increasing renal phosphate excretion, in postmenopausal osteoporotic women without severe renal insufficiency.
    Mesh-Begriff(e) Aged ; Bone Density/drug effects ; Female ; Fibroblast Growth Factors/blood ; Glomerular Filtration Rate/drug effects ; Homeostasis ; Humans ; Indoles/pharmacology ; Indoles/therapeutic use ; Kidney/drug effects ; Kidney/physiopathology ; Linear Models ; Osteoporosis, Postmenopausal/blood ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/physiopathology ; Osteoporosis, Postmenopausal/urine ; Parathyroid Hormone/blood ; Phosphates/blood ; Phosphates/urine
    Chemische Substanzen Indoles ; Parathyroid Hormone ; Phosphates ; Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE) ; bazedoxifene (Q16TT9C5BK)
    Sprache Englisch
    Erscheinungsdatum 2020-01-02
    Erscheinungsland Japan
    Dokumenttyp Clinical Trial ; Journal Article
    ZDB-ID 1295123-7
    ISSN 1435-5604 ; 0914-8779
    ISSN (online) 1435-5604
    ISSN 0914-8779
    DOI 10.1007/s00774-019-01073-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: [New development in bisphosphonate treatment. Bisphosphonates and gastrointestinal adverse effects].

    Miki, Takami / Masaki, Hideki

    Clinical calcium

    2009  Band 19, Heft 1, Seite(n) 91–97

    Abstract: Endoscopic examination suggested gastric mucosal damage by NSAID is more serious than that of bisphosphonates. In addition, the incidence of GI-adverse effects (AEs) is reported to be insignificant, if the incidence is adjusted by history of peptic ulcer, ...

    Abstract Endoscopic examination suggested gastric mucosal damage by NSAID is more serious than that of bisphosphonates. In addition, the incidence of GI-adverse effects (AEs) is reported to be insignificant, if the incidence is adjusted by history of peptic ulcer, drugs for comorbidity, sex, age and/or ways of evaluation of the AEs. The anxiety for taking medication under empty stomach may contribute to the increase of GI-AEs. Some consideration must be taken for patients with past history of peptic ulcer, and/or drug user such as NSAIDs.
    Mesh-Begriff(e) Animals ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Bone Density Conservation Agents/administration & dosage ; Bone Density Conservation Agents/adverse effects ; Dinoprostone/metabolism ; Diphosphonates/administration & dosage ; Diphosphonates/adverse effects ; Female ; Fibroblast Growth Factors/metabolism ; Gastrointestinal Diseases/chemically induced ; Gastrointestinal Diseases/pathology ; Humans ; Male ; Vascular Endothelial Growth Factor A/metabolism
    Chemische Substanzen Anti-Inflammatory Agents, Non-Steroidal ; Bone Density Conservation Agents ; Diphosphonates ; Vascular Endothelial Growth Factor A ; Fibroblast Growth Factors (62031-54-3) ; Dinoprostone (K7Q1JQR04M)
    Sprache Japanisch
    Erscheinungsdatum 2009-01
    Erscheinungsland Japan
    Dokumenttyp English Abstract ; Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa09019197
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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