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  1. Artikel ; Online: The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus.

    Mason, William J / Vasilopoulou, Elisavet

    International journal of molecular sciences

    2023  Band 24, Heft 9

    Abstract: Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease ... ...

    Abstract Diseases affecting the glomerulus, the filtration unit of the kidney, are a major cause of chronic kidney disease. Glomerular disease is characterised by injury of glomerular cells and is often accompanied by an inflammatory response that drives disease progression. New strategies are needed to slow the progression to end-stage kidney disease, which requires dialysis or transplantation. Thymosin β4 (Tβ4), an endogenous peptide that sequesters G-actin, has shown potent anti-inflammatory function in experimental models of heart, kidney, liver, lung, and eye injury. In this review, we discuss the role of endogenous and exogenous Tβ4 in glomerular disease progression and the current understanding of the underlying mechanisms.
    Mesh-Begriff(e) Humans ; Disease Progression ; Kidney Glomerulus ; Renal Dialysis ; Renal Insufficiency, Chronic ; Thymosin
    Chemische Substanzen Thymosin (61512-21-8) ; thymosin beta(4) (549LM7U24W) ; TMSB4X protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-04-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24097684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice.

    Mason, William J / Jafree, Daniyal J / Pomeranz, Gideon / Kolatsi-Joannou, Maria / Rottner, Antje K / Pacheco, Sabrina / Moulding, Dale A / Wolf, Anja / Kupatt, Christian / Peppiatt-Wildman, Claire / Papakrivopoulou, Eugenia / Riley, Paul R / Long, David A / Vasilopoulou, Elisavet

    Scientific reports

    2022  Band 12, Heft 1, Seite(n) 12172

    Abstract: Plasma ultrafiltration in the kidney occurs across glomerular capillaries, which are surrounded by epithelial cells called podocytes. Podocytes have a unique shape maintained by a complex cytoskeleton, which becomes disrupted in glomerular disease ... ...

    Abstract Plasma ultrafiltration in the kidney occurs across glomerular capillaries, which are surrounded by epithelial cells called podocytes. Podocytes have a unique shape maintained by a complex cytoskeleton, which becomes disrupted in glomerular disease resulting in defective filtration and albuminuria. Lack of endogenous thymosin β4 (TB4), an actin sequestering peptide, exacerbates glomerular injury and disrupts the organisation of the podocyte actin cytoskeleton, however, the potential of exogenous TB4 therapy to improve podocyte injury is unknown. Here, we have used Adriamycin (ADR), a toxin which injures podocytes and damages the glomerular filtration barrier leading to albuminuria in mice. Through interrogating single-cell RNA-sequencing data of isolated glomeruli we demonstrate that ADR injury results in reduced levels of podocyte TB4. Administration of an adeno-associated viral vector encoding TB4 increased the circulating level of TB4 and prevented ADR-induced podocyte loss and albuminuria. ADR injury was associated with disorganisation of the podocyte actin cytoskeleton in vitro, which was ameliorated by treatment with exogenous TB4. Collectively, we propose that systemic gene therapy with TB4 prevents podocyte injury and maintains glomerular filtration via protection of the podocyte cytoskeleton thus presenting a novel treatment strategy for glomerular disease.
    Mesh-Begriff(e) Albuminuria ; Animals ; Cells, Cultured ; Doxorubicin ; Genetic Therapy ; Kidney Diseases ; Kidney Glomerulus ; Mice ; Podocytes ; Thymosin
    Chemische Substanzen thymosin beta(4) (549LM7U24W) ; Thymosin (61512-21-8) ; Doxorubicin (80168379AG)
    Sprache Englisch
    Erscheinungsdatum 2022-07-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-16287-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Images in clinical medicine. Crystalluria from acyclovir use.

    Mason, William J / Nickols, Hilary H

    The New England journal of medicine

    2008  Band 358, Heft 13, Seite(n) e14

    Mesh-Begriff(e) Acyclovir/adverse effects ; Acyclovir/urine ; Antiviral Agents/adverse effects ; Antiviral Agents/urine ; Crystallization ; Dementia/etiology ; HIV Infections/complications ; Humans ; Male ; Middle Aged
    Chemische Substanzen Antiviral Agents ; Acyclovir (X4HES1O11F)
    Sprache Englisch
    Erscheinungsdatum 2008-03-27
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm066726
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Clinical problem-solving. Avoiding a rash diagnosis.

    Reznicek, Julie E / Mason, William J / Kaul, Daniel R / Saint, Sanjay / Bloch, Karen C

    The New England journal of medicine

    2011  Band 364, Heft 5, Seite(n) 466–471

    Mesh-Begriff(e) Aged ; Antibodies, Bacterial/blood ; Confusion/etiology ; Diagnosis, Differential ; Exanthema/etiology ; Humans ; Immunoglobulin G/blood ; Lethargy/etiology ; Male ; Meningoencephalitis/microbiology ; Rickettsia rickettsii/immunology ; Rocky Mountain Spotted Fever/complications ; Rocky Mountain Spotted Fever/diagnosis
    Chemische Substanzen Antibodies, Bacterial ; Immunoglobulin G
    Sprache Englisch
    Erscheinungsdatum 2011-02-03
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcps0906691
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia.

    Torres, Victor J / Attia, Ahmed S / Mason, William J / Hood, M Indriati / Corbin, Brian D / Beasley, Federico C / Anderson, Kelsi L / Stauff, Devin L / McDonald, W Hayes / Zimmerman, Lisa J / Friedman, David B / Heinrichs, David E / Dunman, Paul M / Skaar, Eric P

    Infection and immunity

    2010  Band 78, Heft 4, Seite(n) 1618–1628

    Abstract: The tremendous success of Staphylococcus aureus as a pathogen is due to the controlled expression of a diverse array of virulence factors. The effects of host environments on the expression of virulence factors and the mechanisms by which S. aureus ... ...

    Abstract The tremendous success of Staphylococcus aureus as a pathogen is due to the controlled expression of a diverse array of virulence factors. The effects of host environments on the expression of virulence factors and the mechanisms by which S. aureus adapts to colonize distinct host tissues are largely unknown. Vertebrates have evolved to sequester nutrient iron from invading bacteria, and iron availability is a signal that alerts pathogenic microorganisms when they enter the hostile host environment. Consistent with this, we report here that S. aureus senses alterations in the iron status via the ferric uptake regulator (Fur) and alters the abundance of a large number of virulence factors. These Fur-mediated changes protect S. aureus against killing by neutrophils, and Fur is required for full staphylococcal virulence in a murine model of infection. A potential mechanistic explanation for the impact of Fur on virulence is provided by the observation that Fur coordinates the reciprocal expression of cytolysins and a subset of immunomodulatory proteins. More specifically, S. aureus lacking fur exhibits decreased expression of immunomodulatory proteins and increased expression of cytolysins. These findings reveal that Fur is involved in initiating a regulatory program that organizes the expression of virulence factors during the pathogenesis of S. aureus pneumonia.
    Mesh-Begriff(e) Animals ; Bacterial Proteins/biosynthesis ; Bacterial Proteins/genetics ; Bacterial Proteins/physiology ; Chromatography, Liquid ; Disease Models, Animal ; Electrophoresis, Gel, Two-Dimensional ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Bacterial ; Gene Knockout Techniques ; Mass Spectrometry ; Mice ; Mice, Inbred C57BL ; Pneumonia, Staphylococcal/microbiology ; Proteome/analysis ; Repressor Proteins/genetics ; Repressor Proteins/physiology ; Staphylococcus aureus/pathogenicity ; Staphylococcus aureus/physiology ; Virulence Factors/biosynthesis
    Chemische Substanzen Bacterial Proteins ; Proteome ; Repressor Proteins ; Virulence Factors ; ferric uptake regulating proteins, bacterial
    Sprache Englisch
    Erscheinungsdatum 2010-01-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.01423-09
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 684: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Artikel: Staphylococcus aureus Fur Regulates the Expression of Virulence Factors That Contribute to the Pathogenesis of Pneumonia

    Torres, Victor J / Attia, Ahmed S / Mason, William J / Hood, M. Indriati / Corbin, Brian D / Beasley, Federico C / Anderson, Kelsi L / Stauff, Devin L / McDonald, W. Hayes / Zimmerman, Lisa J / Friedman, David B / Heinrichs, David E / Dunman, Paul M / Skaar, Eric P

    Infection and immunity. 2010 Apr., v. 78, no. 4

    2010  

    Abstract: The tremendous success of Staphylococcus aureus as a pathogen is due to the controlled expression of a diverse array of virulence factors. The effects of host environments on the expression of virulence factors and the mechanisms by which S. aureus ... ...

    Abstract The tremendous success of Staphylococcus aureus as a pathogen is due to the controlled expression of a diverse array of virulence factors. The effects of host environments on the expression of virulence factors and the mechanisms by which S. aureus adapts to colonize distinct host tissues are largely unknown. Vertebrates have evolved to sequester nutrient iron from invading bacteria, and iron availability is a signal that alerts pathogenic microorganisms when they enter the hostile host environment. Consistent with this, we report here that S. aureus senses alterations in the iron status via the ferric uptake regulator (Fur) and alters the abundance of a large number of virulence factors. These Fur-mediated changes protect S. aureus against killing by neutrophils, and Fur is required for full staphylococcal virulence in a murine model of infection. A potential mechanistic explanation for the impact of Fur on virulence is provided by the observation that Fur coordinates the reciprocal expression of cytolysins and a subset of immunomodulatory proteins. More specifically, S. aureus lacking fur exhibits decreased expression of immunomodulatory proteins and increased expression of cytolysins. These findings reveal that Fur is involved in initiating a regulatory program that organizes the expression of virulence factors during the pathogenesis of S. aureus pneumonia.
    Schlagwörter Staphylococcus aureus ; animal models ; bacteria ; fur ; iron ; neutrophils ; pathogenesis ; pathogens ; pneumonia ; proteins ; vertebrates ; virulence
    Sprache Englisch
    Umfang p. 1618-1628.
    Erscheinungsort American Society for Microbiology
    Dokumenttyp Artikel
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 684: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Buch: Consumer plans to buy or sell housing in San Francisco

    Cave, Roy C / Mason, William J

    survey of November-December 1966

    (Consumer Research Institute, San Francisco State College, CPS Series ; 6 ; Consumer Research Institute, San Francisco State College, CRI Publication ; 8)

    1967  

    Verfasserangabe Roy C. Cave; William J. Mason
    Serientitel Consumer Research Institute, San Francisco State College, CPS Series ; 6
    Consumer Research Institute, San Francisco State College, CRI Publication ; 8
    Schlagwörter Wohnungsmarkt ; Grundbesitzwechsel ; Vereinigte Staaten ; San Francisco
    Umfang 25 S
    Erscheinungsort San Francisco/Calif
    Dokumenttyp Buch
    Datenquelle ECONomics Information System

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  8. Buch: San Francisco consumer buying plans and economic expectations

    Cave, Roy C / Mason, William J

    survey of August, 1965

    (CPS Series ; 3 ; Consumer Research Institute, San Francisco State College, CRI Publication ; 6)

    1965  

    Verfasserangabe Roy C. Cave; William J. Mason
    Serientitel CPS Series ; 3
    Consumer Research Institute, San Francisco State College, CRI Publication ; 6
    Schlagwörter Marktforschung ; Marktpsychologie ; Verbrauch ; Vereinigte Staaten ; San Francisco
    Umfang I, 108 S
    Erscheinungsort San Francisco/Calif
    Dokumenttyp Buch
    Datenquelle ECONomics Information System

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