LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 686

Suchoptionen

  1. Artikel: The Exceedingly Rapid Development of an Intracranial Aneurysm.

    Massari, Francesco

    Cureus

    2022  Band 14, Heft 12, Seite(n) e32636

    Abstract: Despite significant diagnostic and technical progress in managing intracranial aneurysms, there are still open questions in understanding their pathophysiology: how fast can they form and grow? We had the chance to observe the "de novo" genesis and ... ...

    Abstract Despite significant diagnostic and technical progress in managing intracranial aneurysms, there are still open questions in understanding their pathophysiology: how fast can they form and grow? We had the chance to observe the "de novo" genesis and rupture of an aneurysm of a left MCA posterior trunk M3 branch within 14 days in one of our patients. We were in the position to compare an initially inconspicuous vessel, assessed during a diagnostic cerebral angiogram with 3D acquisitions, performed as an elective follow-up to monitor the decade stability of a transitional aneurysm in the same vascular territory, and the same vessel only two weeks after, harboring a new small ruptured aneurysm. Several studies along the intracranial aneurysms' pathophysiology have been reported but primarily oriented toward identifying uncommon conditions such as inherent defects in collagen synthesis, genetic or familial factors, or basic anatomic variations or abnormalities in the cerebral vasculature. Suppose this case report does not pretend to provide a clear answer to these questions. However, it is up to date, the shortest time (14 days) reported in the literature for a well-documented "de novo" genesis and rupture of an intracranial aneurysm "in vivo" in humans. The purpose of this case report is not only to underscore the unpredictability of this vascular disease but, even more, to support the idea that further investigation, with more modern methodologies, is of paramount importance in determining the etiopathogenesis and behavior of this stealthy disease.
    Sprache Englisch
    Erscheinungsdatum 2022-12-17
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.32636
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  2. Artikel ; Online: Adjuvant treatment in renal cell carcinoma: a never-ending story?

    Mollica, Veronica / Massari, Francesco

    Lancet (London, England)

    2023  Band 403, Heft 10425, Seite(n) 433–434

    Mesh-Begriff(e) Humans ; Carcinoma, Renal Cell/drug therapy ; Adjuvants, Immunologic ; Kidney Neoplasms/drug therapy
    Chemische Substanzen Adjuvants, Immunologic
    Sprache Englisch
    Erscheinungsdatum 2023-12-14
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)01672-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  3. Artikel ; Online: Belzutifan: enhancing the blockade of angiogenesis in renal cell carcinoma.

    Mollica, Veronica / Massari, Francesco

    The Lancet. Oncology

    2023  Band 24, Heft 5, Seite(n) 423–425

    Mesh-Begriff(e) Humans ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/pathology ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/pathology ; Cell Line, Tumor ; Morphogenesis ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology
    Chemische Substanzen belzutifan (7K28NB895L)
    Sprache Englisch
    Erscheinungsdatum 2023-03-31
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00123-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  4. Artikel ; Online: Overall survival with adjuvant pembrolizumab in renal cell carcinoma - the shock of the lightning.

    Massari, Francesco / Rosellini, Matteo / Mollica, Veronica

    Nature reviews. Urology

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-05-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-024-00896-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  5. Artikel: Supercritical-flow structures (backset-bedded sets and sediment waves) on high-gradient clinoform systems influenced by shallow-marine hydrodynamics

    Massari, F

    Sedimentary geology. 2017,

    2017  

    Abstract: Inferred supercritical structures and bedforms, including sediment waves and backset-bedded sets, are identified as components of coarse-grained siliciclastic and bioclastic, high-gradient clinoform wedges (Plio-Pleistocene of southern Italy) and canyon ... ...

    Abstract Inferred supercritical structures and bedforms, including sediment waves and backset-bedded sets, are identified as components of coarse-grained siliciclastic and bioclastic, high-gradient clinoform wedges (Plio-Pleistocene of southern Italy) and canyon head infills (Tortonian of Venetian pre-Alps), showing evidence of having been built out in a setting influenced by shallow-marine hydrodynamics. The facies identified are dominated by a range of traction carpets, formed after segregation of coarser particles in the lower part of bipartite density underflows. The generation of backset-bedded sets is thought to imply scouring due to impact of a submerged hydraulic jump on the bed, and upstream migration of the jump, concomitant with the deposition of backset beds on the stoss side of the developing bedform. Submerged hydraulic jumps apparently formed spontaneously and in any position on the foreset and toeset, without requiring any precursor bed defect. The mostly solitary, non-cyclical character of the bedforms prevents their attribution to cyclic steps. The sets of backset beds are locally underlain by chaotic infills of deep, steep-sided scours attributed to vigorous erosion at the hydraulic jump, accompanied by instantaneous loss in transport capacity which results in rapid plugging of the scour (hydraulic jump facies of Postma et al., 2014). Gravel waves have a distinct internal stratigraphy, and their length to amplitude ratios show lower mean values and higher variability when compared to sediment waves consisting of sand. The presence of supercritical bedforms on steep foreset slopes of the studied clinoform systems, even in proximity to the topset-foreset rollover, is believed to reflect high inefficiency of mud-poor and short run-out bipartite underflows episodically transporting relatively small volumes of coarse-grained sediment. This may also account for common solitary, non-cyclical bedforms. It is proposed that during intense oceanographic events, such as coastal storms, seaward sediment entrainment, assisted by gravity, was very effective on the gently sloping subaqueous topset, and that, beyond the topset-foreset rollover, the flows evolved to high-concentration turbidity underflows with supercritical Froude numbers. The flows are inferred to have been sustained, probably lasting for the duration of the meteorological events, and to have commonly been unsteady in discharge, fluctuating in concentration and size of transported sediments, and subject to peaks in velocity. The characteristics of the structures are regarded as typical of the systems fed by oceanographic processes, and may fall into the class of coarse-grained “small sediment waves with mixed relief” of Symons et al. (2016), formed from a combination of erosion and deposition, and by the action of stratified flows depositing from denser basal layers, and typically restricted to small-scale shallow-marine slope systems.
    Schlagwörter canyons ; diarrhea ; gravel ; gravity ; hydrodynamics ; sand ; storms ; stratigraphy ; turbidity ; Italy
    Sprache Englisch
    Umfang p. .
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 216739-6
    ISSN 0037-0738
    ISSN 0037-0738
    DOI 10.1016/j.sedgeo.2017.09.003
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

  6. Artikel ; Online: Personalizing immunotherapy for renal cell carcinoma: how far have we come?

    Massari, Francesco / Mollica, Veronica

    Expert opinion on biological therapy

    2022  Band 22, Heft 10, Seite(n) 1221–1225

    Mesh-Begriff(e) Humans ; Carcinoma, Renal Cell/therapy ; Kidney Neoplasms/therapy ; Immunotherapy ; B7-H1 Antigen
    Chemische Substanzen B7-H1 Antigen
    Sprache Englisch
    Erscheinungsdatum 2022-09-09
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2022.2122809
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  7. Artikel ; Online: The role of bioelectrical phase angle in patients with heart failure.

    Scicchitano, Pietro / Massari, Francesco

    Reviews in endocrine & metabolic disorders

    2022  Band 24, Heft 3, Seite(n) 465–477

    Abstract: The most challenging feature of heart failure (HF) still remains the evaluation of congestion. Residual congestion at discharge and the difficulties in perfectly dosing therapies in order to balance the hydration status of the patient are the most ... ...

    Abstract The most challenging feature of heart failure (HF) still remains the evaluation of congestion. Residual congestion at discharge and the difficulties in perfectly dosing therapies in order to balance the hydration status of the patient are the most worrisome issues when dealing with HF.The use of bioimpedance vector analysis (BIVA) might promote a different approach in the general management of patients with HF. BIVA is a reliable, fast, bedside tool able to assess the congestion status. It proved to be helpful to physicians for diagnosing congestive status, managing therapies, and providing prognostic information in the setting of HF.Bioelectrical Phase Angle (PhA) - as derived from equations related to the parameters of BIVA - recently surged as a possible biomarker for patients with HF. Studies provided data about the application of PhA in the clinical management and in the overall risk stratification of HF patients.Basically, the use of PhA might be considered as a holistic evaluation of patients with HF which includes the need for a multiparametric approach able to effectively depict the clinical status of patients. There is no definite biomarker able to comprehensively describe and identify all the features of HF patient, but scores based on molecules/techniques able to explore the different pathogenetic mechanisms of HF are desirable.The aim of this review was to provide a comprehensive evaluation of literature related to PhA role in HF and the impact of this biomarker on clinical management and risk stratification of HF patients.
    Mesh-Begriff(e) Humans ; Heart Failure/diagnosis ; Prognosis ; Biomarkers
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2022-10-25
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2185718-0
    ISSN 1573-2606 ; 1389-9155
    ISSN (online) 1573-2606
    ISSN 1389-9155
    DOI 10.1007/s11154-022-09757-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  8. Artikel ; Online: What is the risk of hepatotoxicity induced by immune-checkpoint inhibitors and how can we avoid it?

    Tassinari, Elisa / Rosellini, Matteo / Marchetti, Andrea / Mollica, Veronica / Massari, Francesco

    Expert opinion on drug metabolism & toxicology

    2024  Band 20, Heft 1-2, Seite(n) 5–8

    Mesh-Begriff(e) Humans ; Immune Checkpoint Inhibitors ; Drug-Related Side Effects and Adverse Reactions ; Antineoplastic Agents, Immunological ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/prevention & control ; Immunotherapy ; Neoplasms/drug therapy
    Chemische Substanzen Immune Checkpoint Inhibitors ; Antineoplastic Agents, Immunological
    Sprache Englisch
    Erscheinungsdatum 2024-02-05
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2024.2314059
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  9. Artikel ; Online: Relatlimab and nivolumab in untreated advanced melanoma: insight into RELATIVITY.

    Raschi, Emanuel / Comito, Francesca / Massari, Francesco / Gelsomino, Francesco

    Immunotherapy

    2023  Band 15, Heft 2, Seite(n) 85–91

    Abstract: With the recent regulatory approvals, the relatlimab-nivolumab combination brings new expectations and opens avenues toward effective immunotherapy combination in advanced melanoma. This work provides a critical insight into the recent phase II-III ... ...

    Abstract With the recent regulatory approvals, the relatlimab-nivolumab combination brings new expectations and opens avenues toward effective immunotherapy combination in advanced melanoma. This work provides a critical insight into the recent phase II-III RELATIVITY-047 trial (NCT03470922), including a comparison with the CheckMate 067 trial on the current standard ipilimumab-nivolumab combination, with a focus on immune-related adverse events. Some imbalances of rare toxicities were noted, deserving careful monitoring and assessment in the upcoming real-world use. The promising efficacy data, although still early, should be carefully balanced against these toxicities, thus making pharmacovigilance and global patient-level data sharing crucial to identify the target population, promote safer prescribing and eventually clarify its place in therapy.
    Mesh-Begriff(e) Humans ; Nivolumab/adverse effects ; Ipilimumab/adverse effects ; Melanoma/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemische Substanzen Nivolumab (31YO63LBSN) ; relatlimab ; Ipilimumab ; Antibodies, Monoclonal, Humanized
    Sprache Englisch
    Erscheinungsdatum 2023-01-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2022-0172
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

  10. Artikel ; Online: The future of immunotherapy in advanced renal cell carcinoma: beyond PD-1/PD-L1 inhibitors.

    Nuvola, Giacomo / Mollica, Veronica / Massari, Francesco / Suárez, Cristina

    Immunotherapy

    2023  Band 15, Heft 17, Seite(n) 1429–1433

    Mesh-Begriff(e) Humans ; Carcinoma, Renal Cell/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Programmed Cell Death 1 Receptor/therapeutic use ; Immunotherapy ; CTLA-4 Antigen ; Kidney Neoplasms/drug therapy ; B7-H1 Antigen
    Chemische Substanzen Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor ; CTLA-4 Antigen ; B7-H1 Antigen
    Sprache Englisch
    Erscheinungsdatum 2023-09-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2023-0218
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

Zum Seitenanfang