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  1. Artikel ; Online: The emotion paradox in the aging body and brain.

    Mather, Mara

    Annals of the New York Academy of Sciences

    2024  

    Abstract: With age, parasympathetic activity decreases, while sympathetic activity increases. Thus, the typical older adult has low heart rate variability (HRV) and high noradrenaline levels. Younger adults with this physiological profile tend to be unhappy and ... ...

    Abstract With age, parasympathetic activity decreases, while sympathetic activity increases. Thus, the typical older adult has low heart rate variability (HRV) and high noradrenaline levels. Younger adults with this physiological profile tend to be unhappy and stressed. Yet, with age, emotional experience tends to improve. Why does older adults' emotional well-being not suffer as their HRV decreases? To address this apparent paradox, I present the autonomic compensation model. In this model, failing organs, the initial phases of Alzheimer's pathology, and other age-related diseases trigger noradrenergic hyperactivity. To compensate, older brains increase autonomic regulatory activity in the pregenual prefrontal cortex (PFC). Age-related declines in nerve conduction reduce the ability of the pregenual PFC to reduce hyperactive noradrenergic activity and increase peripheral HRV. But these pregenual PFC autonomic compensation efforts have a significant impact in the brain, where they bias processing in favor of stimuli that tend to increase parasympathetic activity (e.g., stimuli that increase feelings of safety) and against stimuli that tend to increase sympathetic activity (e.g., threatening stimuli). In summary, the autonomic compensation model posits that age-related chronic sympathetic/noradrenergic hyperactivity stimulates regulatory attempts that have the side effect of enhancing emotional well-being.
    Sprache Englisch
    Erscheinungsdatum 2024-04-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.15138
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Applying human affectome framework to autonomic compensation model.

    Min, Jungwon / Mather, Mara

    Neuroscience and biobehavioral reviews

    2024  Band 159, Seite(n) 105611

    Mesh-Begriff(e) Humans ; Aging ; Emotions ; Autonomic Nervous System
    Sprache Englisch
    Erscheinungsdatum 2024-03-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2024.105611
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Is there a maximum desirable heart rate variability?

    Mather, Mara

    Neuroscience and biobehavioral reviews

    2021  Band 128, Seite(n) 87–89

    Mesh-Begriff(e) Anorexia Nervosa ; Body Mass Index ; Heart Rate ; Humans
    Sprache Englisch
    Erscheinungsdatum 2021-06-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2021.06.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Aging and the nervous system.

    Mather, Mara

    Seminars in cell & developmental biology

    2021  Band 116, Seite(n) 71

    Mesh-Begriff(e) Aging/physiology ; Humans ; Nervous System/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2021-05-14
    Erscheinungsland England
    Dokumenttyp Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2021.05.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Noradrenaline in the aging brain: Promoting cognitive reserve or accelerating Alzheimer's disease?

    Mather, Mara

    Seminars in cell & developmental biology

    2021  Band 116, Seite(n) 108–124

    Abstract: Many believe that engaging in novel and mentally challenging activities promotes brain health and prevents Alzheimer's disease in later life. However, mental stimulation may also have risks as well as benefits. As neurons release neurotransmitters, they ... ...

    Abstract Many believe that engaging in novel and mentally challenging activities promotes brain health and prevents Alzheimer's disease in later life. However, mental stimulation may also have risks as well as benefits. As neurons release neurotransmitters, they often also release amyloid peptides and tau proteins into the extracellular space. These by-products of neural activity can aggregate into the tau tangle and amyloid plaque signatures of Alzheimer's disease. Over time, more active brain regions accumulate more pathology. Thus, increasing brain activity can have a cost. But the neuromodulator noradrenaline, released during novel and mentally stimulating events, may have some protective effects-as well as some negative effects. Via its inhibitory and excitatory effects on neurons and microglia, noradrenaline sometimes prevents and sometimes accelerates the production and accumulation of amyloid-β and tau in various brain regions. Both α2A- and β-adrenergic receptors influence amyloid-β production and tau hyperphosphorylation. Adrenergic activity also influences clearance of amyloid-β and tau. Furthermore, some findings suggest that Alzheimer's disease increases noradrenergic activity, at least in its early phases. Because older brains clear the by-products of synaptic activity less effectively, increased synaptic activity in the older brain risks accelerating the accumulation of Alzheimer's pathology more than it does in the younger brain.
    Mesh-Begriff(e) Aging/genetics ; Alzheimer Disease/physiopathology ; Animals ; Brain/physiopathology ; Cognitive Reserve/physiology ; Disease Models, Animal ; Humans ; Mice ; Norepinephrine/adverse effects
    Chemische Substanzen Norepinephrine (X4W3ENH1CV)
    Sprache Englisch
    Erscheinungsdatum 2021-06-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2021.05.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch ; Online: Current Research and Emerging Directions in Emotion-Cognition Interactions

    Mather, Mara / Wang, Lihong / Dolcos, Florin

    2015  

    Abstract: Emotion can impact various aspects of our cognition and behavior, by enhancing or impairing them (e.g., enhanced attention to and memory for emotional events, or increased distraction produced by goal-irrelevant emotional information). On the other hand, ...

    Abstract Emotion can impact various aspects of our cognition and behavior, by enhancing or impairing them (e.g., enhanced attention to and memory for emotional events, or increased distraction produced by goal-irrelevant emotional information). On the other hand, emotion processing is also susceptible to cognitive influences, typically exerted in the form of cognitive control of motion, or emotion regulation. Despite important recent progress in understanding emotion- cognition interactions, a number of aspects remain unclear. The present book comprises a collection of manuscripts discussing emerging evidence regarding the mechanisms underlying emotion- cognition interactions in healthy functioning and alterations associated with clinical conditions, in which such interactions are dysfunctional.-

    Initiated with a more restricted focus, targeting (1) identification and in depth analysis of the circumstances in which emotion enhances or impairs cognition and (2)identification of the role of individual differences in these effects, our book has emerged into a comprehensive collection of outstanding contributions investigating emotion-cognition interactions, based on approaches spanning from behavioral and lesion to pharmacological and brain imaging, and including empirical, theoretical, and review papers alike.Co-hosted by the Frontiers in Neuroscience - Integrative Neuroscience and Frontiers in Psychology - Emotion Science, the contributions comprising our book and the associated research topic are grouped around the following seven main themes, distributed across the two hosting journals: I. Emotion and Selectivity in Attention and Memory; II. The Impact of Emotional Distraction; Linking Enhancing and Impairing Effects of Emotion; III.-

    What Really is the Role of the Amygdala?; IV. Age Differences in Emotion Processing; The Role of Emotional Valence; V. Affective Face Processing, Social Cognition, and Personality Neuroscience; VI. Stress, Mood, Emotion, and the Prefrontal Cortex; The Role of Control in the Stress Response; VII. Emotion-Cognition Interactions in Clinical Conditions.As illustrated by the present collection of contributions, emotion-cognition interactions can be identified at different levels of processing, from perception and attention to long- term memory, decision making processes, and social cognition and behavior. Notably, these effects are subject to individual differences that may affect the way we perceive, experience, and remember emotional experiences, or cope with emotionally challenging situations.-
    Schlagwörter Neurosciences. Biological psychiatry. Neuropsychiatry ; Science (General) ; Psychology
    Umfang 1 electronic resource (740 p.)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT020090529
    ISBN 9782889194384 ; 2889194388
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  7. Artikel ; Online: How Do Cognitively Stimulating Activities Affect Cognition and the Brain Throughout Life?

    Mather, Mara

    Psychological science in the public interest : a journal of the American Psychological Society

    2020  Band 21, Heft 1, Seite(n) 1–5

    Mesh-Begriff(e) Aging ; Cognition ; Cognition Disorders/prevention & control ; Cognitive Reserve/physiology ; Early Intervention, Educational ; Educational Status ; Humans
    Sprache Englisch
    Erscheinungsdatum 2020-08-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 2160-0031
    ISSN (online) 2160-0031
    DOI 10.1177/1529100620941808
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Commentary on Aging and Positive Mood: Longitudinal Neurobiological and Cognitive Correlates.

    Mather, Mara

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2020  Band 28, Heft 9, Seite(n) 957–958

    Mesh-Begriff(e) Affect ; Aging ; Cognition ; Humans ; Neurobiology
    Sprache Englisch
    Erscheinungsdatum 2020-06-12
    Erscheinungsland England
    Dokumenttyp Editorial ; Comment
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2020.06.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Eye movements reveal age differences in how arousal modulates saliency priority but not attention processing speed.

    Kim, Andy Jeesu / Nguyen, Kristine / Mather, Mara

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The arousal-biased competition theory posits that inducing arousal increases attentional priority of salient stimuli while reducing priority of non-pertinent stimuli. However, unlike in young adults, older adults rarely exhibit shifts in priority under ... ...

    Abstract The arousal-biased competition theory posits that inducing arousal increases attentional priority of salient stimuli while reducing priority of non-pertinent stimuli. However, unlike in young adults, older adults rarely exhibit shifts in priority under increased arousal, and prior studies have proposed different neural mechanisms to explain how arousal differentially modulates selective attention in older adults. Therefore, we investigated how the threat of unpredictable shock differentially modulates attentional control mechanisms in young and older adults by observing eye movements. Participants completed two oculomotor search tasks in which the salient distractor was typically captured by attention (singleton search) or proactively suppressed (feature search). We found that arousal did not modulate attentional priority for any stimulus among older adults nor affect the speed of attention processing in either age group. Furthermore, we observed that arousal modulated pupil sizes and found a correlation between evoked pupil responses and oculomotor function. Our findings suggest age differences in how the locus coeruleus-noradrenaline system interacts with neural networks of attention and oculomotor function.
    Sprache Englisch
    Erscheinungsdatum 2024-05-08
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.05.06.592619
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Neuromodulatory systems in aging and disease.

    Dahl, Martin J / Werkle-Bergner, Markus / Mather, Mara

    Neuroscience and biobehavioral reviews

    2024  , Seite(n) 105647

    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland United States
    Dokumenttyp Editorial
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2024.105647
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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