Artikel ; Online: Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog.
2022 Band 10, Heft 1
Abstract: Choroid plexus tumors are commonly described as intraventricular mass lesions and account for 7-10% of intracranial, primary tumors in dogs. A 3-year-old Shetland sheepdog was presented with a history of slowly progressive lethargy, vision impairment and ...
| Abstract | Choroid plexus tumors are commonly described as intraventricular mass lesions and account for 7-10% of intracranial, primary tumors in dogs. A 3-year-old Shetland sheepdog was presented with a history of slowly progressive lethargy, vision impairment and cognitive deficits. On magnetic resonance imaging, a subdural fluid accumulation (SFA) overlying and compressing the left parietotemporal lobe as well as multifocal changes consisting of cyst-like lesions, supposed intra-axial brain lesions and mild, multifocal meningeal thickening and generalized contrast enhancement were identified. Cerebrospinal fluid (CSF) analysis showed a mononuclear pleocytosis with negative results for infectious agents. The dog was treated with prednisolone followed by burr hole craniotomy with puncture of the SFA, which macroscopically appeared to be CSF-like fluid. After initial improvement, the dog deteriorated despite continuation of prednisolone and cytarabine therapy and was euthanized four weeks after surgery. Histopathology was consistent with a disseminated, neuroinvasive choroid plexus carcinoma (CPC) that involved the entire neuroaxis including the meninges of the brain and spinal cord. Immunohistochemical examination showed a strong Kir7.1 and a heterogenous cytokeratin-immunoreactivity in neoplastic cells. In conclusion, a CPC should be considered as a possible cause of a SFA even in the absence of an intraventricular mass lesion. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2022-12-30 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Case Reports |
| ZDB-ID | 2768971-2 |
| ISSN | 2306-7381 ; 2306-7381 |
| ISSN (online) | 2306-7381 |
| ISSN | 2306-7381 |
| DOI | 10.3390/vetsci10010024 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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