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Artikel ; Online: Model-Based Antithymocyte Globulin in αβhaplo-Hematopoietic Stem Cell Transplantation Facilitates Engraftment, Expedites T Cell Recovery, and Mitigates the Risk of Acute Graft-versus-Host Disease.

Barbarito, Giulia / Hiroshima, Lyndsie / Oppizzi, Linda / Saini, Gopin / Kristovich, Karen / Klein, Orly / Hosszu, Kinga / Boehlke, Kylan / Gupta, Aditi / Mcavoy, Devin / Shyr, David / Boelens, Jaap Jan / Bertaina, Alice

Transplantation and cellular therapy

2024  

Abstract: In αβ T-cell/CD19 B-cell depleted hematopoietic stem cell transplantation (αβhaplo-HSCT) recipients, antithymocyte globulin (ATG; Thymoglobulin) is used for preventing graft rejection and graft-versus-host disease (GVHD). The optimal dosing remains to be ...

Abstract In αβ T-cell/CD19 B-cell depleted hematopoietic stem cell transplantation (αβhaplo-HSCT) recipients, antithymocyte globulin (ATG; Thymoglobulin) is used for preventing graft rejection and graft-versus-host disease (GVHD). The optimal dosing remains to be established, however. Here we present the first comparative analysis of 3 different ATG dosing strategies and their impact on immune reconstitution and GVHD. Our study aimed to evaluate the effects of 3 distinct dosing strategies of ATG on engraftment success, αβ
Sprache Englisch
Erscheinungsdatum 2024-05-18
Erscheinungsland United States
Dokumenttyp Journal Article
ZDB-ID 3062231-1
ISSN 2666-6367
ISSN (online) 2666-6367
DOI 10.1016/j.jtct.2024.05.015
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Zs.A 5082: Hefte anzeigen Standort:
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