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  1. Artikel: Thinking outside the pyramidal cell: unexplored contributions of interneurons and neuropeptide Y to estrogen-induced synapse formation in the hippocampus.

    Nakamura, Nozomu H / Akama, Keith T / Yuen, Genevieve S / Mcewen, Bruce S

    Reviews in the neurosciences

    2007  Band 18, Heft 1, Seite(n) 1–13

    Abstract: Since the first finding that 17beta-estradiol (E) can regulate CA1 pyramidal cell synapse formation, subsequent studies have explored many potential E-dependent mechanisms occurring within CA1 pyramidal cells. Fewer studies have focused on E-dependent ... ...

    Abstract Since the first finding that 17beta-estradiol (E) can regulate CA1 pyramidal cell synapse formation, subsequent studies have explored many potential E-dependent mechanisms occurring within CA1 pyramidal cells. Fewer studies have focused on E-dependent processes outside of the pyramidal cell that may influence events activity of the pyramidal cells. This review considers hippocampal interneurons, which can potently regulate the excitability of simultaneously firing pyramidal cells. In particular, we discuss neuropeptide Y (NPY) expression by these interneurons because our published findings show that NPY expression is increased by E in a subset of interneurons which coincidentally exhibit E-regulated increase in GABA synthesis and are uniquely situated anatomically such that they may regulate synaptic activity. Here we review the role of different phenotypes of CA1 interneurons, and we propose a model in which E-stimulated NPY gene expression and the release of NPY by interneurons inhibits glutamate release presynaptically and alters glutamate-dependent synaptic events in the rat hippocampus during adulthood.
    Mesh-Begriff(e) Animals ; Estrogens/pharmacology ; Hippocampus/cytology ; Neurons/classification ; Neurons/metabolism ; Neurons/physiology ; Neuropeptide Y/metabolism ; Synapses/drug effects
    Chemische Substanzen Estrogens ; Neuropeptide Y
    Sprache Englisch
    Erscheinungsdatum 2007-03-27
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 639035-3
    ISSN 2191-0200 ; 0334-1763
    ISSN (online) 2191-0200
    ISSN 0334-1763
    DOI 10.1515/revneuro.2007.18.1.1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus.

    Kao, Hung-Teh / Li, Ping / Chao, Helen M / Janoschka, Stephen / Pham, Kara / Feng, Jian / Mcewen, Bruce S / Greengard, Paul / Pieribone, Vincent A / Porton, Barbara

    The Journal of comparative neurology

    2006  Band 507, Heft 6, Seite(n) 1860–1870

    Abstract: Synapsin III is a synaptic vesicle-associated protein that is expressed in cells of the subgranular layer of the hippocampal dentate gyrus, a brain region known to sustain substantial levels of neurogenesis into adulthood. Here we tested the hypothesis ... ...

    Abstract Synapsin III is a synaptic vesicle-associated protein that is expressed in cells of the subgranular layer of the hippocampal dentate gyrus, a brain region known to sustain substantial levels of neurogenesis into adulthood. Here we tested the hypothesis that synapsin III plays a role in adult neurogenesis with synapsin III knockout and wild-type mice. Immunocytochemistry of the adult hippocampal dentate gyrus revealed that synapsin III colocalizes with markers of neural progenitor cell development (nestin, PSA-NCAM, NeuN, and Tuj1) but did not colocalize with markers of mitosis (Ki67 and PCNA). Because neurogenesis consists of a number of stages, the proliferation, survival, and differentiation of neural progenitor cells were systematically quantitated in the hippocampal dentate gyrus of adult synapsin III knockout and wild-type mice. We found a 30% decrease in proliferation and a 55% increase in survival of neural progenitor cells in synapsin III knockout mice. We also observed a 6% increase in the number of neural progenitor cells that differentiated into neurons. No difference in the volume of the dentate gyrus was observed between synapsin III knockout and wild-type mice. Collectively, our results demonstrate a novel role for synapsin III in regulating the proliferation of neural progenitor cells in the adult hippocampal dentate gyrus. These findings suggest a distinct function for this synaptic vesicle protein, in addition to its role in neurotransmission.
    Mesh-Begriff(e) Age Factors ; Animals ; Biomarkers/metabolism ; Cell Differentiation/physiology ; Cell Proliferation ; Cell Survival/physiology ; DNA-Binding Proteins ; Dentate Gyrus/cytology ; Dentate Gyrus/metabolism ; Female ; Fluorescent Antibody Technique ; Intermediate Filament Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Growth Factors/genetics ; Nerve Tissue Proteins/metabolism ; Nestin ; Neural Cell Adhesion Molecule L1/metabolism ; Neuronal Plasticity/physiology ; Neurons/cytology ; Neurons/metabolism ; Nuclear Proteins/metabolism ; Sialic Acids/metabolism ; Stem Cells/cytology ; Stem Cells/metabolism ; Synapsins/genetics ; Time Factors ; Tubulin/metabolism
    Chemische Substanzen Biomarkers ; DNA-Binding Proteins ; Intermediate Filament Proteins ; Nerve Growth Factors ; Nerve Tissue Proteins ; Nes protein, mouse ; Nestin ; NeuN protein, mouse ; Neural Cell Adhesion Molecule L1 ; Nuclear Proteins ; Sialic Acids ; Synapsins ; Tubulin ; beta3 tubulin, mouse ; polysialyl neural cell adhesion molecule
    Sprache Englisch
    Erscheinungsdatum 2006-05-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.21643
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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