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  1. Konferenzbeitrag: Females are poorly represented at the biannual meetings of the Society of British Neurological Surgeons

    Lawson Mclean, Aaron / Lawson Mclean, Anna

    2017  , Seite(n) Mi.24.03

    Veranstaltung/Kongress 68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS); Magdeburg; ; Society of British Neurological Surgeons; 2017
    Schlagwörter Medizin, Gesundheit
    Erscheinungsdatum 2017-06-09
    Verlag German Medical Science GMS Publishing House; Düsseldorf
    Dokumenttyp Konferenzbeitrag
    DOI 10.3205/17dgnc529
    Datenquelle German Medical Science

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  2. Artikel ; Online: Rodent models and imaging techniques to study liver regeneration.

    Wei, Weiwei / Dirsch, Olaf / Mclean, Anna Lawson / Zafarnia, Sara / Schwier, Michael / Dahmen, Uta

    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes

    2015  Band 54, Heft 3-4, Seite(n) 97–113

    Abstract: The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of ... ...

    Abstract The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of hepatotoxic chemicals or by surgical approach. The administration of hepatotoxic chemicals results in the death of liver cells and in subsequent hepatic regeneration and tissue repair. Surgery includes partial hepatectomy and portal vein occlusion or diversion: hepatectomy leads to compensatory regeneration of the remnant liver lobe, whereas portal vein occlusion leads to atrophy of the ipsilateral lobe and to compensatory regeneration of the contralateral lobe. Adaptation of modern radiological imaging technologies to the small size of rodents made the visualization of rodent intrahepatic vascular anatomy possible. Advanced knowledge of the detailed intrahepatic 3D anatomy enabled the establishment of refined surgical techniques. The same technology allows the visualization of hepatic vascular regeneration. The development of modern histological image analysis tools improved the quantitative assessment of hepatic regeneration. Novel image analysis tools enable us to quantify reliably and reproducibly the proliferative rate of hepatocytes using whole-slide scans, thus reducing the sampling error. In this review, the refined rodent models and the newly developed imaging technology to study liver regeneration are summarized. This summary helps to integrate the current knowledge of liver regeneration and promises an enormous increase in hepatological knowledge in the near future.
    Mesh-Begriff(e) Animals ; Chemical and Drug Induced Liver Injury ; Liver/anatomy & histology ; Liver/surgery ; Liver Regeneration ; Mice ; Models, Animal ; Rats
    Sprache Englisch
    Erscheinungsdatum 2015
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000368573
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

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  3. Artikel ; Online: Severe systemic lupus erythematosus induced by antiviral treatment for hepatitis C.

    Ho, Vincent / Mclean, Anna / Terry, Shaughan

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2008  Band 14, Heft 3, Seite(n) 166–168

    Abstract: We report the case of a 43-year-old man who developed systemic lupus erythematosus (SLE) after receiving pegylated alpha-interferon and ribavirin for chronic hepatitis C. He displayed 8 features of the American College of Rheumatology criteria for SLE: ... ...

    Abstract We report the case of a 43-year-old man who developed systemic lupus erythematosus (SLE) after receiving pegylated alpha-interferon and ribavirin for chronic hepatitis C. He displayed 8 features of the American College of Rheumatology criteria for SLE: glomerulonephritis, arthritis, serositis, a florid discoid rash, lymphopenia, oral ulcers, the development of high titers of antinuclear antibodies, and antidouble stranded DNA antibodies. Furthermore, his admission was complicated by the development of life threatening myopericarditis and vasculitis. This case is notable for the clinical severity and nature of multiorgan lupus involvement from hepatitis C antiviral therapy. Clinical signs of SLE have resolved and anti DS DNA has normalized.
    Mesh-Begriff(e) Adult ; Antibodies, Antinuclear/analysis ; Antiviral Agents/adverse effects ; Cyclophosphamide/therapeutic use ; Hepatitis C, Chronic/drug therapy ; Humans ; Interferon-alpha/adverse effects ; Lupus Erythematosus, Systemic/chemically induced ; Lupus Erythematosus, Systemic/drug therapy ; Male ; Polyethylene Glycols ; Recombinant Proteins
    Chemische Substanzen Antibodies, Antinuclear ; Antiviral Agents ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (30IQX730WE) ; interferon alfa-2b (43K1W2T1M6) ; Cyclophosphamide (8N3DW7272P) ; peginterferon alfa-2b (G8RGG88B68)
    Sprache Englisch
    Erscheinungsdatum 2008-06
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0b013e3181775e80
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4815: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Artikel ; Online: Rodent Models and Imaging Techniques to Study Liver Regeneration

    Wei, Weiwei / Dirsch, Olaf / Lawson Mclean, Anna / Zafarnia, Sara / Schwier, Michael / Dahmen, Uta

    European Surgical Research - Clinical and Experimental Surgery

    2015  Band 54, Heft 3-4, Seite(n) 113–197

    Abstract: The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of ... ...

    Abstract The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of hepatotoxic chemicals or by surgical approach. The administration of hepatotoxic chemicals results in the death of liver cells and in subsequent hepatic regeneration and tissue repair. Surgery includes partial hepatectomy and portal vein occlusion or diversion: hepatectomy leads to compensatory regeneration of the remnant liver lobe, whereas portal vein occlusion leads to atrophy of the ipsilateral lobe and to compensatory regeneration of the contralateral lobe. Adaptation of modern radiological imaging technologies to the small size of rodents made the visualization of rodent intrahepatic vascular anatomy possible. Advanced knowledge of the detailed intrahepatic 3D anatomy enabled the establishment of refined surgical techniques. The same technology allows the visualization of hepatic vascular regeneration. The development of modern histological image analysis tools improved the quantitative assessment of hepatic regeneration. Novel image analysis tools enable us to quantify reliably and reproducibly the proliferative rate of hepatocytes using whole-slide scans, thus reducing the sampling error. In this review, the refined rodent models and the newly developed imaging technology to study liver regeneration are summarized. This summary helps to integrate the current knowledge of liver regeneration and promises an enormous increase in hepatological knowledge in the near future.© 2014 S. Karger AG, Basel
    Schlagwörter Liver regeneration ; Surgical model ; Toxic model ; Imaging techniques
    Sprache Englisch
    Verlag S. Karger AG
    Erscheinungsort Basel
    Erscheinungsland Switzerland
    Dokumenttyp Artikel ; Online
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000368573
    Datenquelle Karger Verlag

    Volltext online

    Zusatzmaterialien

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 745: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel: Rodent Models and Imaging Techniques to Study Liver Regeneration

    Wei, Weiwei / Dirsch, Olaf / Lawson Mclean, Anna / Zafarnia, Sara / Schwier, Michael / Dahmen, Uta

    European Surgical Research

    2014  Band 54, Heft 3-4, Seite(n) 97–113

    Abstract: The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of ... ...

    Körperschaft Department of General, Visceral and Vascular Surgery, and Institute of Pathology, Jena University Hospital, and Faculty of Medicine, Friedrich Schiller University, Jena Department of Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, and Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany
    Abstract The liver has the unique capability of regeneration from various injuries. Different animal models and in vitro methods are used for studying the processes and mechanisms of liver regeneration. Animal models were established either by administration of hepatotoxic chemicals or by surgical approach. The administration of hepatotoxic chemicals results in the death of liver cells and in subsequent hepatic regeneration and tissue repair. Surgery includes partial hepatectomy and portal vein occlusion or diversion: hepatectomy leads to compensatory regeneration of the remnant liver lobe, whereas portal vein occlusion leads to atrophy of the ipsilateral lobe and to compensatory regeneration of the contralateral lobe. Adaptation of modern radiological imaging technologies to the small size of rodents made the visualization of rodent intrahepatic vascular anatomy possible. Advanced knowledge of the detailed intrahepatic 3D anatomy enabled the establishment of refined surgical techniques. The same technology allows the visualization of hepatic vascular regeneration. The development of modern histological image analysis tools improved the quantitative assessment of hepatic regeneration. Novel image analysis tools enable us to quantify reliably and reproducibly the proliferative rate of hepatocytes using whole-slide scans, thus reducing the sampling error. In this review, the refined rodent models and the newly developed imaging technology to study liver regeneration are summarized. This summary helps to integrate the current knowledge of liver regeneration and promises an enormous increase in hepatological knowledge in the near future. © 2014 S. Karger AG, Basel
    Schlagwörter Liver regeneration ; Surgical model ; Toxic model ; Imaging techniques
    Sprache Englisch
    Erscheinungsdatum 2014-11-12
    Verlag S. Karger AG
    Erscheinungsort Basel, Switzerland
    Dokumenttyp Artikel
    Anmerkung Invited Review
    ZDB-ID 205700-1
    ISSN 1421-9921 ; 0014-312X
    ISSN (online) 1421-9921
    ISSN 0014-312X
    DOI 10.1159/000368573
    Datenquelle Karger Verlag

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 745: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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