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  1. Article ; Online: Corrigendum to "Age-related bone loss and sarcopenia in men" [Maturitas 122 (2019) 51-56].

    Laurent, Michaël R / Dedeyne, Lenore / Dupont, Jolan / Mellaerts, Bea / Dejaeger, Marian / Gielen, Evelien

    Maturitas

    2021  Volume 156, Page(s) 67–68

    Language English
    Publishing date 2021-11-20
    Publishing country Ireland
    Document type Journal Article ; Published Erratum
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2021.11.010
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  2. Article ; Online: Age-related bone loss and sarcopenia in men.

    Laurent, Michaël R / Dedeyne, Lenore / Dupont, Jolan / Mellaerts, Bea / Dejaeger, Marian / Gielen, Evelien

    Maturitas

    2019  Volume 122, Page(s) 51–56

    Abstract: Bone and muscle are required for mobility but they also have endocrine and metabolic functions. In ageing as well as in many chronic diseases, bone loss and muscle atrophy occur simultaneously, leading to concomitant osteoporosis and sarcopenia. This ... ...

    Abstract Bone and muscle are required for mobility but they also have endocrine and metabolic functions. In ageing as well as in many chronic diseases, bone loss and muscle atrophy occur simultaneously, leading to concomitant osteoporosis and sarcopenia. This occurs in both genders but compared with postmenopausal women, men appear to be better protected against age-related bone and muscle decay. Sex steroids (both androgens like testosterone and oestrogens like estradiol) are mainly responsible for musculoskeletal sexual dimorphism. They stimulate peak bone and muscle mass accretion during puberty and midlife, and prevent subsequent loss in ageing men but not post-menopausal women. Still, recent studies have highlighted the importance of intrinsic ageing mechanisms such as cellular senescence and oxidative stress in both genders. Sarcopenia may predispose to dysmobility, frailty, falls and fractures, but whether so-called osteosarcopenia qualifies as a distinct entity remains debated. Although randomized clinical trials in male osteoporosis are smaller and therefore underpowered for some outcomes like hip fractures, the available evidence suggests that the clinical diagnostic and therapeutic approach to male osteoporosis is largely similar to that in postmenopausal women. There is a clear unmet medical need for effective and safe anabolic drugs to rebuild the ageing skeleton, muscle, and preferably both tissues simultaneously. The Wnt/sclerostin and myostatin/activin receptor signalling pathways appear particularly promising in this regard. In this narrative review, we aim to provide an overview of our current understanding of the pathophysiology and treatment of male osteoporosis and sarcopenia, and interactions between these two diseases.
    MeSH term(s) Animals ; Gonadal Steroid Hormones/blood ; Humans ; Male ; Osteoporosis/blood ; Osteoporosis/diagnosis ; Osteoporosis/epidemiology ; Sarcopenia/blood ; Sarcopenia/epidemiology
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2019-01-23
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2019.01.006
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  3. Article ; Online: Frailty and mortality in hospitalized older adults with COVID-19: retrospective observational study

    De Smet, R. / Mellaerts, B. / Vandewinckele, H. / Lybeert, P. / Frans, E. / Ombelet, S. / Lemahieu, W. / Symons, R. / Ho, E. / Frans, J. / Smismans, A. / Laurent, M. R.

    Abstract: Background: Older adults with coronavirus disease 2019 (COVID-19) face an increased risk of adverse health outcomes including mortality. Ethical guidelines consider allocation of limited resources based on likelihood of survival, frailty, co-morbidities ... ...

    Abstract Background: Older adults with coronavirus disease 2019 (COVID-19) face an increased risk of adverse health outcomes including mortality. Ethical guidelines consider allocation of limited resources based on likelihood of survival, frailty, co-morbidities and age. However, the association of frailty with clinical outcomes in older COVID-19 patients remains unclear. Objectives: To determine the association between frailty and short-term mortality in older adults hospitalized for COVID-19. Design: Retrospective single-center observational study. Setting and participants: N = 81 patients with COVID-19 confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR), at the Geriatrics department of Imelda general hospital, Belgium. Measurements: Frailty was graded according to the Rockwood Clinical Frailty Scale (CFS). Demographic, biochemical and radiological variables, co-morbidities, symptoms and treatment were extracted from electronic medical records. Results: Participants (N = 48 women, 59%) had a median age of 85 years (range 65 - 97 years), median CFS score of 7 (range 2 - 9), and 42 (52%) were long-term care residents. Within six weeks, eighteen patients died. Mortality was significantly but weakly associated with age (Spearman r = 0.241, P = 0.03) and CFS score (r = 0.282, P = 0.011), baseline lactate dehydrogenase (LDH) (r = 0.301, P = 0.009), lymphocyte count (r = -0.262, P = 0.02) and RT-PCR Ct value (r = -0.285, P = 0.015). Mortality was not associated with long-term care residence, dementia, delirium or polypharmacy. In multivariable logistic regression analyses, CFS, LDH and RT-PCR Ct values (but not age) remained independently associated with mortality. Both age and frailty had poor specificity to predict survival. A multivariable model combining age, CFS, LDH and viral load significantly predicted survival. Conclusions and implications: Although their prognosis is worse, even the oldest and most severely frail patients may benefit from hospitalization for COVID-19, if sufficient resources are available.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.05.26.20113480
    Database COVID19

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  4. Article ; Online: Frailty and Mortality in Hospitalized Older Adults With COVID-19: Retrospective Observational Study.

    De Smet, Robert / Mellaerts, Bea / Vandewinckele, Hannelore / Lybeert, Peter / Frans, Eric / Ombelet, Sara / Lemahieu, Wim / Symons, Rolf / Ho, Erwin / Frans, Johan / Smismans, Annick / Laurent, Michaël R

    Journal of the American Medical Directors Association

    2020  Volume 21, Issue 7, Page(s) 928–932.e1

    Abstract: Objectives: To determine the association between frailty and short-term mortality in older adults hospitalized for coronavirus disease 2019 (COVID-19).: Design: Retrospective single-center observational study.: Setting and participants: Eighty-one ...

    Abstract Objectives: To determine the association between frailty and short-term mortality in older adults hospitalized for coronavirus disease 2019 (COVID-19).
    Design: Retrospective single-center observational study.
    Setting and participants: Eighty-one patients with COVID-19 confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR), at the Geriatrics department of a general hospital in Belgium.
    Measurements: Frailty was graded according to the Rockwood Clinical Frailty Scale (CFS). Demographic, biochemical, and radiologic variables, comorbidities, symptoms, and treatment were extracted from electronic medical records.
    Results: Participants (N = 48 women, 59%) had a median age of 85 years (range 65-97 years) and a median CFS score of 7 (range 2-9); 42 (52%) were long-term care residents. Within 6 weeks, 18 patients died. Mortality was significantly but weakly associated with age (Spearman r = 0.241, P = .03) and CFS score (r = 0.282, P = .011), baseline lactate dehydrogenase (LDH; r = 0.301, P = .009), lymphocyte count (r = -0.262, P = .02), and RT-PCR cycle threshold (Ct, r = -0.285, P = .015). Mortality was not associated with long-term care residence, dementia, delirium, or polypharmacy. In multivariable logistic regression analyses, CFS, LDH, and RT-PCR Ct (but not age) remained independently associated with mortality. Both age and frailty had poor specificity to predict survival. A multivariable model combining age, CFS, LDH, and viral load significantly predicted survival.
    Conclusions and implications: Although their prognosis is worse, even the oldest and most severely frail patients may benefit from hospitalization for COVID-19, if sufficient resources are available.
    MeSH term(s) Aged ; Aged, 80 and over ; Belgium/epidemiology ; COVID-19 ; Cohort Studies ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Outbreaks/statistics & numerical data ; Female ; Frail Elderly ; Frailty/mortality ; Geriatric Assessment ; Hospital Mortality ; Hospitalization/statistics & numerical data ; Hospitals, General ; Humans ; Incidence ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Retrospective Studies
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2020.06.008
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  5. Article ; Online: New environmental reservoir of CPE in hospitals.

    Smismans, Annick / Ho, Erwin / Daniels, Davy / Ombelet, Sara / Mellaerts, Bea / Obbels, Dagmar / Valgaeren, Hanne / Goovaerts, Anja / Huybrechts, Eline / Montag, Ilke / Frans, Johan

    The Lancet. Infectious diseases

    2019  Volume 19, Issue 6, Page(s) 580–581

    MeSH term(s) Aged ; Aged, 80 and over ; Carbapenem-Resistant Enterobacteriaceae/isolation & purification ; Disease Reservoirs/microbiology ; Female ; Hospitals/statistics & numerical data ; Humans ; Infection Control/methods ; Male ; Toilet Facilities/statistics & numerical data ; United States
    Language English
    Publishing date 2019-05-20
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(19)30230-0
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  6. Article: Pulmonary nodule and aggressive tibialis posterior tenosynovitis in early rheumatoid arthritis.

    Joosen, H / Mellaerts, B / Dereymaeker, G / Westhovens, R

    Clinical rheumatology

    2000  Volume 19, Issue 5, Page(s) 392–395

    Abstract: We report the case of a 34-year-old man with a rheumatoid pulmonary nodule preceding the development of articular symptoms of rheumatoid arthritis. Pulmonary nodules are a well known feature of rheumatoid arthritis and are mostly seen in severe ... ...

    Abstract We report the case of a 34-year-old man with a rheumatoid pulmonary nodule preceding the development of articular symptoms of rheumatoid arthritis. Pulmonary nodules are a well known feature of rheumatoid arthritis and are mostly seen in severe established rheumatoid factor-positive cases. To differentiate between benign and malign pulmonary nodules we discuss the use of positron emission tomography (PET). Despite intensive therapy with steroids and methotrexate in our patient, within months he developed a severe tibialis posterior tendinitis, with partial rupture and evolution to a planovalgus deformity requiring surgery. Both these symptoms are rare but demonstrate the need for close follow-up in early rheumatoid arthritis.
    MeSH term(s) Adult ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnosis ; Biopsy, Needle ; Diagnosis, Differential ; Diagnostic Errors ; Humans ; Male ; Severity of Illness Index ; Solitary Pulmonary Nodule/diagnosis ; Solitary Pulmonary Nodule/etiology ; Synovial Membrane/pathology ; Tendons/pathology ; Tenosynovitis/diagnosis ; Tenosynovitis/etiology ; Tibia ; Tomography, Emission-Computed ; Tomography, X-Ray Computed
    Language English
    Publishing date 2000
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 604755-5
    ISSN 0770-3198
    ISSN 0770-3198
    DOI 10.1007/s100670070035
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  7. Article ; Online: Frailty and mortality in hospitalized older adults with COVID-19: retrospective observational study

    De Smet, Robert / Mellaerts, Bea / Vandewinckele, Hannelore / Lybeert, Peter / Frans, Eric / Ombelet, Sara / Lemahieu, Wim / Symons, Rolf / Ho, Erwin / Frans, Johan / Smismans, Annick / Laurent, Michael R

    medRxiv

    Abstract: Background: Older adults with coronavirus disease 2019 (COVID−19) face an increased risk of adverse health outcomes including mortality. Ethical guidelines consider allocation of limited resources based on likelihood of survival, frailty, co−morbidities ... ...

    Abstract Background: Older adults with coronavirus disease 2019 (COVID−19) face an increased risk of adverse health outcomes including mortality. Ethical guidelines consider allocation of limited resources based on likelihood of survival, frailty, co−morbidities and age. However, the association of frailty with clinical outcomes in older COVID−19 patients remains unclear. Objectives: To determine the association between frailty and short-term mortality in older adults hospitalized for COVID−19. Design: Retrospective single-center observational study. Setting and participants: N = 81 patients with COVID−19 confirmed by reverse-transcriptase polymerase chain reaction (RT−PCR), at the Geriatrics department of Imelda general hospital, Belgium. Measurements: Frailty was graded according to the Rockwood Clinical Frailty Scale (CFS). Demographic, biochemical and radiological variables, co−morbidities, symptoms and treatment were extracted from electronic medical records. Results: Participants (N = 48 women, 59%) had a median age of 85 years (range 65 − 97 years), median CFS score of 7 (range 2 − 9), and 42 (52%) were long−term care residents. Within six weeks, eighteen patients died. Mortality was significantly but weakly associated with age (Spearman r = 0.241, P = 0.03) and CFS score (r = 0.282, P = 0.011), baseline lactate dehydrogenase (LDH) (r = 0.301, P = 0.009), lymphocyte count (r = −0.262, P = 0.02) and RT-PCR Ct value (r = −0.285, P = 0.015). Mortality was not associated with long-term care residence, dementia, delirium or polypharmacy. In multivariable logistic regression analyses, CFS, LDH and RT-PCR Ct values (but not age) remained independently associated with mortality. Both age and frailty had poor specificity to predict survival. A multivariable model combining age, CFS, LDH and viral load significantly predicted survival. Conclusions and implications: Although their prognosis is worse, even the oldest and most severely frail patients may benefit from hospitalization for COVID−19, if sufficient resources are available.
    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.05.26.20113480
    Database COVID19

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  8. Article ; Online: Frailty and Mortality in Hospitalized Older Adults With COVID-19

    De Smet, Robert / Mellaerts, Bea / Vandewinckele, Hannelore / Lybeert, Peter / Frans, Eric / Ombelet, Sara / Lemahieu, Wim / Symons, Rolf / Ho, Erwin / Frans, Johan / Smismans, Annick / Laurent, Michaël R.

    Journal of the American Medical Directors Association

    Retrospective Observational Study

    2020  Volume 21, Issue 7, Page(s) 928–932.e1

    Keywords General Nursing ; Health Policy ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2020.06.008
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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