Artikel ; Online: Melanocytic matricoma with atypical features: A case of malignant melanocytic matricoma?
2022 Band 49, Heft 11, Seite(n) 1193–1197
Abstract: Melanocytic matricoma is a rarely reported, benign cutaneous adnexal neoplasm composed of epithelial cells exhibiting differentiation towards hair matrix as well as admixed, pigmented, dendritic melanocytes. The proposed malignant counterpart to ... ...
Abstract | Melanocytic matricoma is a rarely reported, benign cutaneous adnexal neoplasm composed of epithelial cells exhibiting differentiation towards hair matrix as well as admixed, pigmented, dendritic melanocytes. The proposed malignant counterpart to melanocytic matricoma, malignant melanocytic matricoma (MMM), is even more rare. Here we report a case of a melanocytic matricoma with atypical features in a 92-year-old female with a 1.2-cm pigmented nodule on the right nasal sidewall. Histopathology revealed a well-circumscribed dermal tumor composed of atypical matrical cells with scattered aggregates of anucleate keratinocytes (ghost cells), prominent intratumoral pigment, numerous mitotic figures (88 mitosis/10 high-power field [HPF]), and intermixed dendritic melanocytes. A literature review was performed for MMM to determine if the current case fit diagnostic criteria for this entity. Including the current case, 12 cases of MMM were identified and analyzed to investigate common clinical and histopathologic features. MMM commonly occurred on the head and neck (7/12 cases) of older individuals (median age of 80) with a slight male predominance (male-to-female ratio of 3:1) and on histopathology presented as a multinodular dermal tumor composed of mitotically active (average mitotic rate of >50 mitoses/10 HPF) pleomorphic epithelial cells with foci of ghost cells. Dendritic melanocytes were found throughout the tumor lobules in all cases. Given that only two of 12 cases have exhibited locally aggressive behavior, further study is warranted to determine the true malignant potential of MMM. |
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Mesh-Begriff(e) | Male ; Female ; Humans ; Aged, 80 and over ; Pilomatrixoma/pathology ; Hair Diseases/pathology ; Skin Neoplasms/pathology ; Neoplasms, Adnexal and Skin Appendage/pathology ; Melanocytes/pathology |
Sprache | Englisch |
Erscheinungsdatum | 2022-07-30 |
Erscheinungsland | England |
Dokumenttyp | Review ; Case Reports ; Journal Article |
ZDB-ID | 800103-0 |
ISSN | 1346-8138 ; 0385-2407 |
ISSN (online) | 1346-8138 |
ISSN | 0385-2407 |
DOI | 10.1111/1346-8138.16536 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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