Artikel ; Online: Exceptional response to the ALK and ROS1 inhibitor lorlatinib and subsequent mechanism of resistance in relapsed
Cold Spring Harbor molecular case studies
2021 Band 7, Heft 4
Abstract: Treatment of high-risk neuroblastoma typically incorporates multiagent chemotherapy, surgery, radiation therapy, autologous stem cell transplantation, immunotherapy, and differentiation therapy. The discovery of activating mutations in ALK receptor ... ...
Abstract | Treatment of high-risk neuroblastoma typically incorporates multiagent chemotherapy, surgery, radiation therapy, autologous stem cell transplantation, immunotherapy, and differentiation therapy. The discovery of activating mutations in ALK receptor tyrosine kinase ( |
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Mesh-Begriff(e) | Aminopyridines/therapeutic use ; Anaplastic Lymphoma Kinase/antagonists & inhibitors ; Antineoplastic Agents/therapeutic use ; Child, Preschool ; DNA Mutational Analysis ; Drug Resistance, Neoplasm/genetics ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Lactams/therapeutic use ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Protein Kinase Inhibitors/therapeutic use ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Proto-Oncogene Proteins/antagonists & inhibitors ; Pyrazoles/therapeutic use ; Recurrence |
Chemische Substanzen | Aminopyridines ; Antineoplastic Agents ; Lactams ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins ; Pyrazoles ; ALK protein, human (EC 2.7.10.1) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; ROS1 protein, human (EC 2.7.10.1) ; lorlatinib (OSP71S83EU) |
Sprache | Englisch |
Erscheinungsdatum | 2021-08-02 |
Erscheinungsland | United States |
Dokumenttyp | Case Reports ; Journal Article |
ZDB-ID | 2835759-0 |
ISSN | 2373-2873 ; 2373-2873 |
ISSN (online) | 2373-2873 |
ISSN | 2373-2873 |
DOI | 10.1101/mcs.a006064 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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