Article ; Online: Brain-Derived Neurotrophic Factor, Nociception, and Pain.
2024 Volume 14, Issue 5
Abstract: This article examines the involvement of the brain-derived neurotrophic factor (BDNF) in the control of nociception and pain. BDNF, a neurotrophin known for its essential role in neuronal survival and plasticity, has garnered significant attention for ... ...
Abstract | This article examines the involvement of the brain-derived neurotrophic factor (BDNF) in the control of nociception and pain. BDNF, a neurotrophin known for its essential role in neuronal survival and plasticity, has garnered significant attention for its potential implications as a modulator of synaptic transmission. This comprehensive review aims to provide insights into the multifaceted interactions between BDNF and pain pathways, encompassing both physiological and pathological pain conditions. I delve into the molecular mechanisms underlying BDNF's involvement in pain processing and discuss potential therapeutic applications of BDNF and its mimetics in managing pain. Furthermore, I highlight recent advancements and challenges in translating BDNF-related research into clinical practice. |
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MeSH term(s) | Brain-Derived Neurotrophic Factor/metabolism ; Humans ; Nociception ; Pain/metabolism ; Pain/drug therapy ; Animals ; Neuronal Plasticity |
Chemical Substances | Brain-Derived Neurotrophic Factor ; BDNF protein, human (7171WSG8A2) |
Language | English |
Publishing date | 2024-04-30 |
Publishing country | Switzerland |
Document type | Journal Article ; Review |
ZDB-ID | 2701262-1 |
ISSN | 2218-273X ; 2218-273X |
ISSN (online) | 2218-273X |
ISSN | 2218-273X |
DOI | 10.3390/biom14050539 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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