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  1. Buch ; Dissertation / Habilitation: Retrospektive Analyse mikrobiologischer Befunde bei Patienten mit Peritonsillarabszess unter Berücksichtigung klinischer Aspekte

    Meyer, Maria Christine

    2022  

    Körperschaft Goethe-Universität Frankfurt am Main
    Verfasserangabe vorgelegt von Maria Christine Meyer
    Sprache Deutsch
    Umfang XI, 94 Seiten, Diagramme, 21 cm
    Erscheinungsort Frankfurt am Main
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2022
    Anmerkung Zusammenfassung auf Deutsch und Englisch
    HBZ-ID HT030011804
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2023 D 149 bestellbar zur Ausleihe Magazin

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  2. Buch ; Online ; Dissertation / Habilitation: Charakterisierung des Proteins Peter Pan in HeLa-Zellen

    Meyer, Maria Theresia [Verfasser]

    2021  

    Verfasserangabe Maria Theresia Meyer
    Schlagwörter Biowissenschaften, Biologie ; Life Science, Biology
    Thema/Rubrik (Code) sg570
    Sprache Deutsch
    Verlag Universität Ulm
    Erscheinungsort Ulm
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

    Volltext online

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  3. Artikel ; Online: Effects of the mineralocorticoid receptor antagonist eplerenone in experimental autoimmune encephalomyelitis.

    Alvarez Quintero, Guido S / Lima, Analia / Roig, Paulina / Meyer, Maria / de Kloet, E R / De Nicola, Alejandro F / Garay, Laura I

    The Journal of steroid biochemistry and molecular biology

    2024  Band 238, Seite(n) 106461

    Abstract: There is growing evidence indicating that mineralocorticoid receptor (MR) expression influences a wide variety of functions in metabolic and immune response. The present study explored if antagonism of the MR reduces neuroinflammation in the spinal cord ... ...

    Abstract There is growing evidence indicating that mineralocorticoid receptor (MR) expression influences a wide variety of functions in metabolic and immune response. The present study explored if antagonism of the MR reduces neuroinflammation in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE). Eplerenone (EPLE) (100 mg/kg dissolved in 30% 2-hydroxypropyl-β-cyclodextrin) was administered intraperitoneally (i.p.) daily from EAE induction (day 0) until sacrificed on day 17 post-induction. The MR blocker (a) significantly decreased the inflammatory parameters TLR4, MYD88, IL-1β, and iNOS mRNAs; (b) attenuated HMGB1, NLRP3, TGF-β mRNAs, microglia, and aquaporin4 immunoreaction without modifying GFAP. Serum IL-1β was also decreased in the EAE+EPLE group. Moreover, EPLE treatment prevented demyelination and improved clinical signs of EAE mice. Interestingly, MR was decreased and GR remained unchanged in EAE mice while EPLE treatment restored MR expression, suggesting that a dysbalanced MR/GR was associated with the development of neuroinflammation. Our results indicated that MR blockage with EPLE attenuated inflammation-related spinal cord pathology in the EAE mouse model of Multiple Sclerosis, supporting a novel therapeutic approach for immune-related diseases.
    Mesh-Begriff(e) Mice ; Animals ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Eplerenone/pharmacology ; Eplerenone/therapeutic use ; Mineralocorticoid Receptor Antagonists/pharmacology ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Neuroinflammatory Diseases ; Spinal Cord/pathology ; Mice, Inbred C57BL
    Chemische Substanzen Eplerenone (6995V82D0B) ; Mineralocorticoid Receptor Antagonists
    Sprache Englisch
    Erscheinungsdatum 2024-01-12
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2024.106461
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 708: Hefte anzeigen Standort:
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  4. Artikel ; Online: A deep learning model for brain segmentation across pediatric and adult populations.

    Simarro, Jaime / Meyer, Maria Ines / Van Eyndhoven, Simon / Phan, Thanh Vân / Billiet, Thibo / Sima, Diana M / Ortibus, Els

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 11735

    Abstract: Automated quantification of brain tissues on MR images has greatly contributed to the diagnosis and follow-up of neurological pathologies across various life stages. However, existing solutions are specifically designed for certain age ranges, limiting ... ...

    Abstract Automated quantification of brain tissues on MR images has greatly contributed to the diagnosis and follow-up of neurological pathologies across various life stages. However, existing solutions are specifically designed for certain age ranges, limiting their applicability in monitoring brain development from infancy to late adulthood. This retrospective study aims to develop and validate a brain segmentation model across pediatric and adult populations. First, we trained a deep learning model to segment tissues and brain structures using T1-weighted MR images from 390 patients (age range: 2-81 years) across four different datasets. Subsequently, the model was validated on a cohort of 280 patients from six distinct test datasets (age range: 4-90 years). In the initial experiment, the proposed deep learning-based pipeline, icobrain-dl, demonstrated segmentation accuracy comparable to both pediatric and adult-specific models across diverse age groups. Subsequently, we evaluated intra- and inter-scanner variability in measurements of various tissues and structures in both pediatric and adult populations computed by icobrain-dl. Results demonstrated significantly higher reproducibility compared to similar brain quantification tools, including childmetrix, FastSurfer, and the medical device icobrain v5.9 (p-value< 0.01). Finally, we explored the potential clinical applications of icobrain-dl measurements in diagnosing pediatric patients with Cerebral Visual Impairment and adult patients with Alzheimer's Disease.
    Mesh-Begriff(e) Humans ; Deep Learning ; Adult ; Brain/diagnostic imaging ; Aged ; Child ; Adolescent ; Child, Preschool ; Aged, 80 and over ; Middle Aged ; Young Adult ; Female ; Male ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Image Processing, Computer-Assisted/methods ; Reproducibility of Results
    Sprache Englisch
    Erscheinungsdatum 2024-05-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-61798-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Buch ; Dissertation / Habilitation: Langzeitverlaufsbeobachtung von Patienten mit Erregungsbildungsstörungen des Herzens

    Meyer, Brigitte

    1999  

    Verfasserangabe vorgelegt von Brigitte Meyer
    Sprache Deutsch
    Umfang 56 S., graph. Darst., 21 cm
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Lübeck, Med. Univ., Diss., 1999
    HBZ-ID HT013059181
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2001 D 1545 bestellbar zur Ausleihe Magazin

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  6. Buch ; Dissertation / Habilitation: Therapeutisches Vorgehen bei Salmonellen-Enteritiden Erwachsener

    Meyer, Maria

    1980  

    Verfasserangabe vorlegt von Maria Meyer
    Umfang 54 S. : graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Frankfurt (Main), Univ., Diss., 1980
    HBZ-ID HT000272396
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    80 D 2384 bestellbar zur Ausleihe Magazin

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  7. Artikel ; Online: Validating the use of lyophilized natural organic matter as background material in GAC rapid small-scale column tests.

    Abulikemu, Gulizhaer / Speth, Thomas F / Vogt, Jeffrey A / Meyer, Maria / Hong, Ying / Pressman, Jonathan G

    Journal of water process engineering

    2022  Band 47

    Abstract: Utilities often test the effectiveness of different granular activated carbons (GACs) to determine which is most advantageous for their system. For surface water systems, in particular, the seasonal and annual variability of natural organic matter (NOM) ... ...

    Abstract Utilities often test the effectiveness of different granular activated carbons (GACs) to determine which is most advantageous for their system. For surface water systems, in particular, the seasonal and annual variability of natural organic matter (NOM) in the source water makes it difficult to benchmark the effectiveness of GACs over multiple contract periods. This study produced stable, lyophilized NOM from the filtered water (FW), i.e., the influent to GAC contactors, which was then reconstituted (Recon) and tested against the FW itself in parallel rapid small-scale column tests (RSSCTs). The results demonstrated nearly identical NOM breakthrough profiles. RSSCTs conducted with both FW and Recon were shown to simulate the full-scale contactor performance well, while similar RSSCTs with regenerated GAC yielded a slightly earlier breakthrough, possibly due to the changes in GAC characteristics during regeneration and grinding. RSSCTs evaluating the removal of microcystin-LR (MC-LR) in the presence of background NOM contained in FW and Recon showed slightly different results, possibly due to the difference in chloride concentrations of these two waters. This work validates that reconstituted lyophilized NOM can be used as a source water surrogate for GAC evaluations when the constituent of interest is NOM, and potentially for other constituents depending upon the influence of additional inorganic constituents that were not evaluated as part of this study.
    Sprache Englisch
    Erscheinungsdatum 2022-06-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 2214-7144
    ISSN (online) 2214-7144
    DOI 10.1016/j.jwpe.2022.102773
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Early Signs of Neuroinflammation in the Postnatal Wobbler Mouse Model of Amyotrophic Lateral Sclerosis.

    Meyer, Maria / Lima, Analia / Deniselle, Maria Claudia Gonzalez / De Nicola, Alejandro F

    Cellular and molecular neurobiology

    2022  Band 43, Heft 5, Seite(n) 2149–2163

    Abstract: The Wobbler mouse is an accepted model of sporadic amyotrophic lateral sclerosis. The spinal cord of clinically symptomatic animals (3-5 months old) shows vacuolar motoneuron degeneration, inflammation, and gliosis accompanied by motor impairment. ... ...

    Abstract The Wobbler mouse is an accepted model of sporadic amyotrophic lateral sclerosis. The spinal cord of clinically symptomatic animals (3-5 months old) shows vacuolar motoneuron degeneration, inflammation, and gliosis accompanied by motor impairment. However, data are not conclusive concerning pathological changes appearing early after birth. To answer this question, we used postnatal day (PND) 6 genotyped Wobbler pups to determine abnormalities of glia and neurons at this early age period in the spinal cord. We found astrogliosis, microgliosis with morphophenotypic changes pointing to active ameboid microglia, enhanced expression of the proinflammatory markers TLR4, NFkB, TNF, and inducible nitric oxide synthase. The astrocytic enzyme glutamine synthase and the glutamate-aspartate transporter GLAST were also reduced in PND 6 Wobbler pups, suggesting excitotoxicity due to impaired glutamate homeostasis. At the neuronal level, PND 6 Wobblers showed swollen soma, increased choline acetyltransferase immunofluorescence staining, and low expression of the neuronal nuclear antigen NeuN. However, vacuolated motoneurons, a typical signature of older clinically symptomatic Wobbler mice, were absent in the spinal cord of PND 6 Wobblers. The results suggest predominance of neuroinflammation and abnormalities of microglia and astrocytes at this early period of Wobbler life, accompanied by some neuronal changes. Data support the non-cell autonomous hypothesis of the Wobbler disorder, and bring useful information with regard to intervening molecular inflammatory mechanisms at the beginning stage of human motoneuron degenerative diseases.
    Mesh-Begriff(e) Humans ; Animals ; Mice ; Infant ; Amyotrophic Lateral Sclerosis ; Neuroinflammatory Diseases ; Motor Neurons ; Inflammation ; Neuroglia ; Disease Models, Animal ; Gliosis ; Spinal Cord ; Mice, Neurologic Mutants
    Sprache Englisch
    Erscheinungsdatum 2022-10-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 283404-2
    ISSN 1573-6830 ; 0272-4340
    ISSN (online) 1573-6830
    ISSN 0272-4340
    DOI 10.1007/s10571-022-01294-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1727: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Artikel ; Online: Testosterone Reduces Myelin Abnormalities in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis.

    Esperante, Ivan J / Meyer, Maria / Banzan, Carolina / Kruse, Maria Sol / Lima, Analia / Roig, Paulina / Guennoun, Rachida / Schumacher, Michael / De Nicola, Alejandro F / Gonzalez Deniselle, Maria Claudia

    Biomolecules

    2024  Band 14, Heft 4

    Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron degenerative disease that is associated with demyelination. ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron degenerative disease that is associated with demyelination. The
    Mesh-Begriff(e) Animals ; Mice ; Myelin Sheath/metabolism ; Myelin Sheath/drug effects ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Male ; Disease Models, Animal ; Testosterone/pharmacology ; Spinal Cord/metabolism ; Spinal Cord/drug effects ; Spinal Cord/pathology ; Excitatory Amino Acid Transporter 2/metabolism ; Excitatory Amino Acid Transporter 2/genetics ; Microglia/drug effects ; Microglia/metabolism ; Microglia/pathology
    Chemische Substanzen Testosterone (3XMK78S47O) ; Excitatory Amino Acid Transporter 2
    Sprache Englisch
    Erscheinungsdatum 2024-04-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040428
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Awareness of alcohol as a risk factor for cancer: A population-based cross-sectional study among 3000 Danish men and women.

    Thomsen, Karen Linding / Christensen, Anne Sofie Plum / Meyer, Maria Kristine Hagelskær

    Preventive medicine reports

    2020  Band 19, Seite(n) 101156

    Abstract: Alcohol increases the risk of several cancer types. However, awareness of the link between alcohol and cancer is estimated to be low in Denmark. The objective of this study was to examine awareness of alcohol as a risk factor for cancer in the Danish ... ...

    Abstract Alcohol increases the risk of several cancer types. However, awareness of the link between alcohol and cancer is estimated to be low in Denmark. The objective of this study was to examine awareness of alcohol as a risk factor for cancer in the Danish population. 3000 Danish men and women aged 18-74 years, who are nationally representative participated in a cross-sectional study. Open and closed-ended questions were used to assess unprompted and prompted cancer awareness in relation to the respondents' demographic profile, alcohol consumption and use of tobacco. Unprompted, 22.2% of respondents were aware of the link between alcohol and cancer, whereas prompted 44.8% were aware of this. When prompted about specific cancer types, 39.5% were aware of the fact that alcohol increases the risk of liver cancer and only 9.6% were aware of the link between alcohol and breast cancer. Being aware of the link between alcohol and cancer was associated with being female, having a higher level of education, living in the Capital Region of Denmark, as well as being a non-smoker. There were no statistical significant associations between awareness of alcohol as a risk factor for cancer and the respondents' age, marital status and alcohol consumption. Conclusively, the study confirms a rather low public awareness of the link between alcohol and cancer in the Danish population, especially regarding certain cancer types such as breast cancer. There is a continued need to inform the public about the relationship between alcohol and cancer.
    Sprache Englisch
    Erscheinungsdatum 2020-07-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2020.101156
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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