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  1. Article ; Online: Correction to: Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience.

    Rose, Tracy L / Weir, William H / Mayhew, Gregory M / Shibata, Yoichiro / Eulitt, Patrick / Uronis, Joshua M / Zhou, Mi / Nielsen, Matthew / Smith, Angela B / Woods, Michael / Hayward, Michele C / Salazar, Ashley H / Milowsky, Matthew I / Wobker, Sara E / McGinty, Katrina / Millburn, Michael V / Eisner, Joel R / Kim, William Y

    British journal of cancer

    2022  Volume 126, Issue 8, Page(s) 1237

    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-022-01781-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Fibroblast growth factor receptor 3 alterations and response to immune checkpoint inhibition in metastatic urothelial cancer: a real world experience.

    Rose, Tracy L / Weir, William H / Mayhew, Gregory M / Shibata, Yoichiro / Eulitt, Patrick / Uronis, Joshua M / Zhou, Mi / Nielsen, Matthew / Smith, Angela B / Woods, Michael / Hayward, Michele C / Salazar, Ashley H / Milowsky, Matthew I / Wobker, Sara E / McGinty, Katrina / Millburn, Michael V / Eisner, Joel R / Kim, William Y

    British journal of cancer

    2021  Volume 125, Issue 9, Page(s) 1251–1260

    Abstract: Background: FGFR3-altered urothelial cancer (UC) correlates with a non-T cell-inflamed phenotype and has therefore been postulated to be less responsive to immune checkpoint blockade (ICB). Preclinical work suggests FGFR3 signalling may suppress ... ...

    Abstract Background: FGFR3-altered urothelial cancer (UC) correlates with a non-T cell-inflamed phenotype and has therefore been postulated to be less responsive to immune checkpoint blockade (ICB). Preclinical work suggests FGFR3 signalling may suppress pathways such as interferon signalling that alter immune microenvironment composition. However, correlative studies examining clinical trials have been conflicting as to whether FGFR altered tumours have equivalent response and survival to ICB in patients with metastatic UC. These findings have yet to be validated in real world data, therefore we evaluated clinical outcomes of patients with FGFR3-altered metastatic UC treated with ICB and investigate the underlying immunogenomic mechanisms of response and resistance.
    Methods: 103 patients with metastatic UC treated with ICB at a single academic medical center from 2014 to 2018 were identified. Clinical annotation for demographics and cancer outcomes, as well as somatic DNA and RNA sequencing, were performed. Objective response rate to ICB, progression-free survival, and overall survival was compared between patients with FGFR3-alterations and those without. RNA expression, including molecular subtyping and T cell receptor clonality, was also compared between FGFR3-altered and non-altered patients.
    Results: Our findings from this dataset confirm that FGFR3-altered (n = 17) and wild type (n = 86) bladder cancers are equally responsive to ICB (12 vs 19%, p = 0.73). Moreover, we demonstrate that despite being less inflamed, FGFR3-altered tumours have equivalent T cell receptor (TCR) diversity and that the balance of a CD8 T cell gene expression signature to immune suppressive features is an important determinant of ICB response.
    Conclusions: Our work in a real world dataset validates prior observations from clinical trials but also extends this prior work to demonstrate that FGFR3-altered and wild type tumours have equivalent TCR diversity and that the balance of effector T cell to immune suppression signals are an important determinant of ICB response.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; CD8-Positive T-Lymphocytes/metabolism ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/genetics ; Carcinoma, Transitional Cell/immunology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immune Checkpoint Inhibitors/administration & dosage ; Immune Checkpoint Inhibitors/pharmacology ; Male ; Middle Aged ; Receptor, Fibroblast Growth Factor, Type 3/genetics ; Receptors, Antigen, T-Cell/metabolism ; Retrospective Studies ; Sequence Analysis, DNA ; Sequence Analysis, RNA ; Survival Analysis ; Treatment Outcome ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/immunology
    Chemical Substances Immune Checkpoint Inhibitors ; Receptors, Antigen, T-Cell ; FGFR3 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 3 (EC 2.7.10.1)
    Language English
    Publishing date 2021-07-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-021-01488-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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