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  1. Artikel ; Online: Cognitive function in Mexican older adults 6-months after recovering from SARS-CoV-2 infection.

    Mimenza-Alvarado, Alberto Jose / Ambrosio-Palma, Abdias / Aguilar-Navarro, Sara Gloria

    Revista espanola de geriatria y gerontologia

    2024  Band 59, Heft 5, Seite(n) 101479

    Abstract: Background: SARS-CoV-2 infection has been associated with multiple short- and long-term complications including depression, and cognitive impairment (CI). However, older adults with CI after COVID-19 have not been fully documented.: Objective: To ... ...

    Abstract Background: SARS-CoV-2 infection has been associated with multiple short- and long-term complications including depression, and cognitive impairment (CI). However, older adults with CI after COVID-19 have not been fully documented.
    Objective: To evaluate cognitive function in Mexican adults post-recovery from SARS-CoV-2 infection.
    Methods: In this prospective observational cohort study, we assess cognitive function (CF) by the Montreal Cognitive Assessment (MOCA) test with a cut-off less than 26 points, and functional status via telemedicine. Eligible patients with a history of moderate-severe COVID-19 aged ≥60 years, cognitively healthy (evaluated by Everyday Cognition Scale) and required admission to an intensive care unit (ICU) were included. Patients with history of dementia, stroke, and delirium during the cognitive evaluation were excluded. The association between CI and COVID-19 was assessed with a Cox regression model.
    Results: From the 634 patients admitted to the ICU, 415 survived, afterward 308 were excluded and 107 were analyzed. Mean age was 70 years, 58% were female, and 53% had severe COVID. The mean MoCA score was 21±5 points, CI was present in 61 patients (57%). Infection severity (RR 1.87; 95% CI: 1.11-3.15, p<0.05), lower education (RR 0.92; 95% CI: 0.87-0.97, p<0.01), and activity daily living disability (RR 1.87; 95% CI: 1.07-3.26, p<0.05) were the main factors associated with CI (unadjusted model by age and sex). The delayed recall, orientation, and language (83.2, 77.6 and 72.9% respectively) domains were the most affected in patients with CI.
    Conclusions: Fifty-seven percent of patients analyzed developed CI six months post-ICU discharge due to SARS-CoV-2, and COVID severity was the main factor associated to its outcome.
    Sprache Englisch
    Erscheinungsdatum 2024-04-30
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ZDB-ID 605609-x
    ISSN 1578-1747 ; 0211-139X
    ISSN (online) 1578-1747
    ISSN 0211-139X
    DOI 10.1016/j.regg.2024.101479
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2677: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel ; Online: Brain health index as a predictor of possible vascular dementia in the Mexican health and aging study 2012-2015.

    Aguilar-Navarro, Sara G / Yeverino-Castro, Sara G / Mejía-Arango, Silvia / Moctezuma, Rogelio / Juárez-Cedillo, Teresa / Mimenza-Alvarado, Alberto José

    PloS one

    2024  Band 19, Heft 5, Seite(n) e0304234

    Abstract: To determine the burden of disease among subjects at risk of developing stroke or dementia, brain health indexes (BHI) tend to rely on anatomical features. Recent definitions emphasize the need of a broader perspective that encompasses cardiovascular ... ...

    Abstract To determine the burden of disease among subjects at risk of developing stroke or dementia, brain health indexes (BHI) tend to rely on anatomical features. Recent definitions emphasize the need of a broader perspective that encompasses cardiovascular risk factors (CVRFS) and lifestyle components which can be considered partial contributors to optimal brain health. In this study, we aimed to establish the association and risk detected by a Brain Health Index and the risk of possible vascular dementia (PVD) using data from the Mexican Health and Aging Study (MHAS) 2012-2015. The MHAS is a longitudinal study of adults aged ≥ 50 years. We analyzed the data obtained between 2012 and 2015. CVRFS included in the index were diabetes mellitus, hypertension, myocardial infarction, depression, obesity, physical inactivity, and smoking history. A PVD diagnosis was established when scores in the Cross-Cultural Cognitive Examination were below reference norms and limitations in ≥1 instrumental activities of daily living and a history of stroke were present. A multinomial regression model was developed to determine the association between BHI scores and PVD. In 2015, 75 PVD cases were identified. Mean age was 67.1 ±13.2 years, 35.8% were female, and the mean educational level was 5.8 ±5.5 years. In cases with a higher score in the BHI, the model revealed a hazards ratio of 1.63 (95% CI: 1.63-1.64, p< 0.001) for PVD. In this longitudinal study, with the use of a feasible multifactorial BHI in the Mexican population, a greater score was associated with a 1.63-fold risk of developing PVD during the 3-year follow-up, while the risk for stroke was 1.75. This index could potentially be used to predict the risk of PVD in adults with modifiable CVRFS.
    Mesh-Begriff(e) Humans ; Female ; Male ; Mexico/epidemiology ; Aged ; Dementia, Vascular/epidemiology ; Middle Aged ; Longitudinal Studies ; Risk Factors ; Aging ; Brain/pathology ; Aged, 80 and over
    Sprache Englisch
    Erscheinungsdatum 2024-05-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0304234
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults.

    Aguilar-Navarro, Sara G / Gonzalez-Aparicio, Itzel I / Avila-Funes, José Alberto / Juárez-Cedillo, Teresa / Tusié-Luna, Teresa / Mimenza-Alvarado, Alberto Jose

    Brain sciences

    2021  Band 11, Heft 1

    Abstract: Mild cognitive impairment (MCI) (amnestic or non-amnestic) has different clinical and neuropsychological characteristics, and its evolution is heterogeneous. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, or dyslipidemia, and the ... ...

    Abstract Mild cognitive impairment (MCI) (amnestic or non-amnestic) has different clinical and neuropsychological characteristics, and its evolution is heterogeneous. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, or dyslipidemia, and the presence of the Apolipoprotein E ε4 (ApoE ε4) polymorphism have been associated with an increased risk of developing Alzheimer's disease (AD) and other dementias but the relationship is inconsistent worldwide. We aimed to establish the association between the ApoE ε4 carrier status and CVRF on MCI subtypes (amnestic and non-amnestic) in Mexican older adults. Cross-sectional study including 137 older adults (
    Sprache Englisch
    Erscheinungsdatum 2021-01-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci11010068
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Use of Fast Gamma Magnetic Stimulation Over the Left Prefrontal Dorsolateral Cortex for the Treatment of MCI and Mild Alzheimer's Disease: A Double-Blind, Randomized, Sham-Controlled, Pilot Study.

    Mimenza-Alvarado, Alberto José / Aguilar-Navarro, Sara Gloria / Martinez-Carrillo, Francisco M / Ríos-Ponce, Alma E / Villafuerte, Gabriel

    Frontiers in neurology

    2021  Band 12, Seite(n) 729872

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2021-09-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.729872
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: A task force for diagnosis and treatment of people with Alzheimer's disease in Latin America.

    Lopera, Francisco / Custodio, Nilton / Rico-Restrepo, Mariana / Allegri, Ricardo F / Barrientos, José Domingo / Garcia Batres, Estuardo / Calandri, Ismael L / Calero Moscoso, Cristian / Caramelli, Paulo / Duran Quiroz, Juan Carlos / Jansen, Angela Marie / Mimenza Alvarado, Alberto José / Nitrini, Ricardo / Parodi, Jose F / Ramos, Claudia / Slachevsky, Andrea / Brucki, Sonia María Dozzi

    Frontiers in neurology

    2023  Band 14, Seite(n) 1198869

    Abstract: Alzheimer's disease (AD) represents a substantial burden to patients, their caregivers, health systems, and society in Latin America and the Caribbean (LAC). This impact is exacerbated by limited access to diagnosis, specialized care, and therapies for ... ...

    Abstract Alzheimer's disease (AD) represents a substantial burden to patients, their caregivers, health systems, and society in Latin America and the Caribbean (LAC). This impact is exacerbated by limited access to diagnosis, specialized care, and therapies for AD within and among nations. The region has varied geographic, ethnic, cultural, and economic conditions, which create unique challenges to AD diagnosis and management. To address these issues, the Americas Health Foundation convened a panel of eight neurologists, geriatricians, and psychiatrists from Argentina, Brazil, Colombia, Ecuador, Guatemala, Mexico, and Peru who are experts in AD for a three-day virtual meeting to discuss best practices for AD diagnosis and treatment in LAC and create a manuscript offering recommendations to address identified barriers. In LAC, several barriers hamper diagnosing and treating people with dementia. These barriers include access to healthcare, fragmented healthcare systems, limited research funding, unstandardized diagnosis and treatment, genetic heterogeneity, and varying social determinants of health. Additional training for physicians and other healthcare workers at the primary care level, region-specific or adequately adapted cognitive tests, increased public healthcare insurance coverage of testing and treatment, and dedicated search strategies to detect populations with gene variants associated with AD are among the recommendations to improve the landscape of AD.
    Sprache Englisch
    Erscheinungsdatum 2023-07-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1198869
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Frailty and Vascular Cognitive Impairment: Mechanisms Behind the Link.

    Aguilar-Navarro, Sara Gloria / Mimenza-Alvarado, Alberto José / Anaya-Escamilla, Antonio / Gutiérrez-Robledo, Luis Miguel

    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

    2016  Band 68, Heft 1, Seite(n) 25–32

    Abstract: The relationship between frailty and cognitive impairment has been recognized for decades, but it was not until a few years ago that the interest in this relationship increased and is now being understood. Epidemiological evidence suggests that physical ... ...

    Abstract The relationship between frailty and cognitive impairment has been recognized for decades, but it was not until a few years ago that the interest in this relationship increased and is now being understood. Epidemiological evidence suggests that physical frailty may be linked to cognitive impairment since both conditions share pathophysiological mechanisms at the cellular and systemic levels. Aging itself promotes multiple vascular changes, making the brain susceptible to cognitive decline through mechanisms such as thinning of blood vessels, increased collagen accumulation, rupture of the blood-brain barrier, inflammation, and oxidative damage. The prevalence of frailty and cognitive decline increases as individuals become older, and cognitive impairment attributable to cerebrovascular disease has become a major public health problem since vascular dementia is now the second most common subtype of dementia. However, full understanding of the mechanisms underlying the relationship between frailty and vascular cognitive impairment remains fragmented. This review examines the link between frailty and vascular cognitive decline and also explores the role of vascular changes in the genesis of both conditions.
    Mesh-Begriff(e) Aged ; Aging/physiology ; Brain/physiopathology ; Cognition Disorders/epidemiology ; Cognition Disorders/physiopathology ; Dementia/epidemiology ; Dementia/physiopathology ; Frail Elderly/psychology ; Humans ; Inflammation/epidemiology ; Inflammation/pathology ; Oxidative Stress/physiology ; Prevalence
    Sprache Englisch
    Erscheinungsdatum 2016-01
    Erscheinungsland Mexico
    Dokumenttyp Journal Article ; Review
    ZDB-ID 138348-6
    ISSN 0034-8376
    ISSN 0034-8376
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 288: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Artikel: Cerebral Vascular Reactivity in Frail Older Adults with Vascular Cognitive Impairment.

    Aguilar-Navarro, Sara G / Mimenza-Alvarado, Alberto José / Corona-Sevilla, Isaac / Jiménez-Castillo, Gilberto A / Juárez-Cedillo, Teresa / Ávila-Funes, José Alberto / Román, Gustavo C

    Brain sciences

    2019  Band 9, Heft 9

    Abstract: ... ...

    Abstract Background
    Sprache Englisch
    Erscheinungsdatum 2019-08-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci9090214
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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