Artikel ; Online: The Potential of miR-21 in Stem Cell Differentiation and its Application in Tissue Engineering and Regenerative Medicine.
2023 Band 19, Heft 5, Seite(n) 1232–1251
Abstract: MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These molecules can regulate various biological processes, including stem cell differentiation and self-renewal. One of ...
Abstract | MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These molecules can regulate various biological processes, including stem cell differentiation and self-renewal. One of the first known miRNAs in mammals is miR-21. Cancer-related studies have shown that this miRNA has proto-oncogene activity and is elevated in cancers. However, it is confirmed that miR-21 inhibits stem cell pluripotency and self-renewal and induces differentiation by targeting various genes. Regenerative medicine is a field of medical science that tries to regenerate and repair damaged tissues. Various studies have shown that miR-21 plays an essential role in regenerative medicine by affecting stem cell proliferation and differentiation. In this review, we will discuss the function of miR-21 in regenerative medicine of the liver, nerve, spinal cord, wound, bone, and dental tissues. In addition, the function of natural compounds and lncRNAs will be analyzed as potential regulators of miR-21 expression in regenerative medicine. |
|||||
---|---|---|---|---|---|---|
Mesh-Begriff(e) | Animals ; Tissue Engineering ; Regenerative Medicine ; RNA, Long Noncoding ; Cell Differentiation/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mammals/metabolism | |||||
Chemische Substanzen | RNA, Long Noncoding ; MicroRNAs | |||||
Sprache | Englisch | |||||
Erscheinungsdatum | 2023-03-11 | |||||
Erscheinungsland | United States | |||||
Dokumenttyp | Journal Article ; Review ; Research Support, Non-U.S. Gov't | |||||
ZDB-ID | 2495577-2 | |||||
ISSN | 2629-3277 ; 1558-6804 ; 1550-8943 | |||||
ISSN (online) | 2629-3277 ; 1558-6804 | |||||
ISSN | 1550-8943 | |||||
DOI | 10.1007/s12015-023-10510-8 | |||||
Signatur |
|
|||||
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 6198: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.