Artikel ; Online: Economic and outcomes consequences of TachoSil®: a systematic review.
Vascular health and risk management
2014 Band 10, Seite(n) 569–575
Abstract: Background: TachoSil(®) is a medicated sponge coated with human fibrinogen and human thrombin. It is indicated as a support treatment in adult surgery to improve hemostasis, promote tissue sealing, and support sutures when standard surgical techniques ... ...
| Abstract | Background: TachoSil(®) is a medicated sponge coated with human fibrinogen and human thrombin. It is indicated as a support treatment in adult surgery to improve hemostasis, promote tissue sealing, and support sutures when standard surgical techniques are insufficient. This review systematically analyses the international scientific literature relating to the use of TachoSil in hemostasis and as a surgical sealant, from the point of view of its economic impact. Methods: We carried out a systematic review of the PubMed literature up to November 2013. Based on the selection criteria, papers were grouped according to the following outcomes: reduction of time to hemostasis; decrease in length of hospital stay; and decrease in postoperative complications. Results: Twenty-four scientific papers were screened, 13 (54%) of which were randomized controlled trials and included a total of 2,116 patients, 1,055 of whom were treated with TachoSil. In the clinical studies carried out in patients undergoing hepatic, cardiac, or renal surgery, the time to hemostasis obtained with TachoSil was lower (1-4 minutes) than the time measured with other techniques and hemostatic drugs, with statistically significant differences. Moreover, in 13 of 15 studies, TachoSil showed a statistically significant reduction in postoperative complications in comparison with the standard surgical procedure. The range of the observed decrease in the length of hospital stay for TachoSil patients was 2.01-3.58 days versus standard techniques, with a statistically significant difference in favor of TachoSil in eight of 15 studies. Conclusion: This analysis shows that TachoSil has a role as a supportive treatment in surgery to improve hemostasis and promote tissue sealing when standard techniques are insufficient, with a consequent decrease in postoperative complications and hospital costs. |
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| Mesh-Begriff(e) | Blood Loss, Surgical/prevention & control ; Cost-Benefit Analysis ; Drug Combinations ; Drug Costs ; Fibrinogen/adverse effects ; Fibrinogen/economics ; Fibrinogen/therapeutic use ; Hemostatic Techniques/adverse effects ; Hemostatic Techniques/economics ; Hemostatics/economics ; Hemostatics/therapeutic use ; Hospital Costs ; Humans ; Length of Stay/economics ; Outcome and Process Assessment, Health Care/economics ; Postoperative Hemorrhage/economics ; Postoperative Hemorrhage/prevention & control ; Thrombin/adverse effects ; Thrombin/economics ; Thrombin/therapeutic use ; Time Factors ; Treatment Outcome | |||||
| Chemische Substanzen | Drug Combinations ; Hemostatics ; TachoSil ; Fibrinogen (9001-32-5) ; Thrombin (EC 3.4.21.5) | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2014-09-10 | |||||
| Erscheinungsland | New Zealand | |||||
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review | |||||
| ZDB-ID | 2186568-1 | |||||
| ISSN | 1178-2048 ; 1176-6344 | |||||
| ISSN (online) | 1178-2048 | |||||
| ISSN | 1176-6344 | |||||
| DOI | 10.2147/VHRM.S63199 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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