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  1. Artikel ; Online: Membrana de circulación extracorpórea en shock obstructivo secundario a enfermedad linfoproliferativa.

    Las Heras, Marcos J / Carboni Bisso, Indalecio / Fernández Ceballos, Ignacio / Montserrat Rivero, Ana / Dianti, José / San Román, Eduardo

    Medicina

    2019  Band 79, Heft 6, Seite(n) 506–508

    Abstract: The arteriovenous extracorporeal membrane is used in patients with hemodynamic and respiratory failure, unresponsive to conventional treatment. It provides transitory hemodynamic support, oxygenation and removal of CO2, allowing pulmonary rest. Moreover ... ...

    Titelübersetzung Oxygenation with extracorporeal membrane in obstructive shock secondary to lymphoproliferative disease.
    Abstract The arteriovenous extracorporeal membrane is used in patients with hemodynamic and respiratory failure, unresponsive to conventional treatment. It provides transitory hemodynamic support, oxygenation and removal of CO2, allowing pulmonary rest. Moreover it offers the possibility of ultraprotective ventilation and avoids generation of VILI (Ventilation-Induced Lung Injury). It is not frequently used in patients with hemodynamic failure secondary to obstructive shock due to mediastinal compromise. We present the case of a patient with obstructive shock, mediastinal mass of lymphoproliferative origin that was treated with extracorporeal arteriovenous circulation membrane.
    Mesh-Begriff(e) Adult ; Computed Tomography Angiography/methods ; Extracorporeal Membrane Oxygenation/methods ; Female ; Hemodynamics ; Humans ; Lymphoma, Large B-Cell, Diffuse/complications ; Lymphoma, Large B-Cell, Diffuse/diagnostic imaging ; Lymphoma, Large B-Cell, Diffuse/pathology ; Respiratory Insufficiency/therapy ; Shock, Cardiogenic/diagnostic imaging ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Tomography, X-Ray/methods ; Treatment Outcome
    Sprache Spanisch
    Erscheinungsdatum 2019-12-12
    Erscheinungsland Argentina
    Dokumenttyp Case Reports
    ZDB-ID 411586-7
    ISSN 1669-9106 ; 0025-7680 ; 0325-951X
    ISSN (online) 1669-9106
    ISSN 0025-7680 ; 0325-951X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Oxygenation with extracorporeal membrane in obstructive shock secondary to lymphoproliferative disease

    Marcos J. Las Heras / Indalecio Carboni Bisso / Ignacio Fernández Ceballos / Ana Montserrat Rivero / José Dianti / Eduardo San Román

    Medicina (Buenos Aires), Vol 79, Iss 6, Pp 506-

    2019  Band 508

    Abstract: The arteriovenous extracorporeal membrane is used in patients with hemodynamic and respiratory failure, unresponsive to conventional treatment. It provides transitory hemodynamic support, oxygenation and removal of CO2, allowing pulmonary rest. Moreover ... ...

    Abstract The arteriovenous extracorporeal membrane is used in patients with hemodynamic and respiratory failure, unresponsive to conventional treatment. It provides transitory hemodynamic support, oxygenation and removal of CO2, allowing pulmonary rest. Moreover it offers the possibility of ultraprotective ventilation and avoids generation of VILI (Ventilation-Induced Lung Injury). It is not frequently used in patients with hemodynamic failure secondary to obstructive shock due to mediastinal compromise. We present the case of a patient with obstructive shock, mediastinal mass of lymphoproliferative origin that was treated with extracorporeal arteriovenous circulation membrane.
    Schlagwörter lymphoma ; extracorporeal membrane oxygenation ; shock ; Medicine ; R ; Immunologic diseases. Allergy ; RC581-607 ; Infectious and parasitic diseases ; RC109-216
    Sprache Englisch
    Erscheinungsdatum 2019-12-01T00:00:00Z
    Verlag Fundación Revista Medicina
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: SEX-RELATED DIFFERENCES IN THE PHENOTYPE AND COURSE OF INFLAMMATORY BOWEL DISEASE: SEXEII STUDY OF ENEIDA.

    Gargallo-Puyuelo, Carla J / Ricart, Elena / Iglesias, Eva / de Francisco, Ruth / Gisbert, Javier P / Taxonera, Carlos / Mañosa, Miriam / Peris, Mariam Aguas / Navarrete-Muñoz, Eva María / Sanahuja, Ana / Guardiola, Jordi / Mesonero, Francisco / Tirado, Montserrat Rivero / Barrio, Jesús / Mendoza, Isabel Vera / de Castro Parga, Luisa / García-Planella, Esther / Calvet, Xavier / Martín Arranz, María Dolores /
    García, Santiago / Sicilia, Beatriz / Carpio, Daniel / Domenech, Eugeni / Gomollón, Fernando

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2024  

    Abstract: Background and aims: The impact of patient sex on the presentation of inflammatory bowel disease (IBD) has been poorly evaluated. Our aims were to assess potential disparities in IBD phenotype and progression between sexes.: Methods: Observational ... ...

    Abstract Background and aims: The impact of patient sex on the presentation of inflammatory bowel disease (IBD) has been poorly evaluated. Our aims were to assess potential disparities in IBD phenotype and progression between sexes.
    Methods: Observational multicentre study that included patients with Crohn's disease (CD) or ulcerative colitis (UC) from the Spanish ENEIDA registry. Data extraction was conducted in July 2021.
    Results: 51,595 patients with IBD were included, 52% were males and 25,947 had CD. The median follow-up after diagnosis was 9 years in males and 10 in females. In CD, female sex was an independent risk factor for medium disease onset (17-40 years) (RRR 1.45, 95% CI 1.31-1.62), later disease onset (>40 years) (RRR 1.55, 95% CI: 1.38-1.73), exclusive colonic involvement (OR 1.24, 95%CI 1.14-1.34), inflammatory behaviour (OR 1.14, 95%CI 1.07-1.21) and extraintestinal manifestations (OR 1.48, 95%CI 1.38-1.59). However, female sex was a protective factor for upper gastrointestinal involvement (OR 0.84, 95%CI 0.79-0.90), penetrating behaviour (OR 0.76, 95%CI 0.70-0.82), perianal disease (OR 0.77, 95CI% 0.71-0.82) and complications (OR 0.73, 95%CI 0.66-0.80). In UC, female sex was an independent risk factor for extraintestinal manifestations (OR 1.48, 95%CI 1.26-1.61). However, female sex was an independent protective factor for disease onset from age 40 onward (RRR 0.76, IC 95%: 0.66-0.87), left sided colonic involvement (RRR 0.72, 95% CI 0.67-0.78), extensive colonic involvement (RRR 0.59, 95%CI 0.55-0.64) and abdominal surgery (OR 0.78, 95%CI 0.69-0.88).
    Conclusions: There is sexual dimorphism in IBD. The patient's sex should be taken into account in the clinical management of the disease.
    Sprache Englisch
    Erscheinungsdatum 2024-05-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2024.05.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Splenic rupture after colorectal cancer screening

    María José García-García / Ramón Castañera-González / Berta Martín-Rivas / Marcos Gómez-Ruiz / Montserrat Rivero-Tirado

    Revista Espanola de Enfermedades Digestivas, Vol 107, Iss 11, Pp 705-

    2015  Band 706

    Schlagwörter Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Erscheinungsdatum 2015-11-01T00:00:00Z
    Verlag The Spanish Society of Digestive Pathology
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Assessment of the intake of tryptophan-enriched cereals in the elderly and its influence on the sleep-wake circadian rhythm

    Rafael Bravo / Sergio Matito / Javier Cubero / Lourdes Franco / Cristina Sánchez / Ana B. Rodríguez / Montserrat Rivero / Carmen Barriga

    Antropologia Portuguesa, Iss

    2012  Band 29

    Abstract: Sleep-wake circadian rhythm disturbances are a common problem associated to aging. Although this problem can be caused by several factors, low levels of the indol melatonin are related with these alterations. Our aim was to evaluate if the consumption of ...

    Abstract Sleep-wake circadian rhythm disturbances are a common problem associated to aging. Although this problem can be caused by several factors, low levels of the indol melatonin are related with these alterations. Our aim was to evaluate if the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, can enhance sleep problems in elderly people. Participants (n=12; aged 55-67 yr) were selected from Elderly people University of The University of Extremadura. During all the assay participants wore a wrist actimeter and they filled every week an STAI anxiety test. Data were collected following this schedule: Control week: participants ingested a control cereal both at breakfast and dinner (22.5 mg tryptophan/ 30g product per dose); Treatment Week: volunteers consumed a tryptophan enriched cereal both at breakfast and dinner (60mg tryptophan/30g product per dose); Post-treatment week: participants ingested their habitual diet. We observed a decrease in sleep latency (p<0.01), wake bouts (p>0.05) and sleep fragmentation (p<0.001); on the other hand, an increase in actual sleep time (p<0.01), sleep efficiency (p<0.01) and immobile time (p<0.01) were detected. With respect to the anxiety test, there was an improvement in the state of anxiety. In conclusion, through a tryptophanenriched diet age related sleep problems can be improved.
    Schlagwörter Chrononutrition ; tryptophan ; sleep ; elderly ; Anthropology ; GN1-890 ; Ethnology. Social and cultural anthropology ; GN301-674
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2012-06-01T00:00:00Z
    Verlag Coimbra University Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Nationwide COVID-19-EII Study

    Yamile Zabana / Ignacio Marín-Jiménez / Iago Rodríguez-Lago / Isabel Vera / María Dolores Martín-Arranz / Iván Guerra / Javier P. Gisbert / Francisco Mesonero / Olga Benítez / Carlos Taxonera / Ángel Ponferrada-Díaz / Marta Piqueras / Alfredo J. Lucendo / Berta Caballol / Míriam Mañosa / Pilar Martínez-Montiel / Maia Bosca-Watts / Jordi Gordillo / Luis Bujanda /
    Noemí Manceñido / Teresa Martínez-Pérez / Alicia López / Cristina Rodríguez-Gutiérrez / Santiago García-López / Pablo Vega / Montserrat Rivero / Luigi Melcarne / Maria Calvo / Marisa Iborra / Manuel Barreiro de-Acosta / Beatriz Sicilia / Jesús Barrio / José Lázaro Pérez / David Busquets / Isabel Pérez-Martínez / Mercè Navarro-Llavat / Vicent Hernández / Federico Argüelles-Arias / Fernando Ramírez Esteso / Susana Meijide / Laura Ramos / Fernando Gomollón / Fernando Muñoz / Gerard Suris / Jone Ortiz de Zarate / José María Huguet / Jordina Llaó / Mariana Fe García-Sepulcre / Mónica Sierra / Miguel Durà

    Journal of Clinical Medicine, Vol 11, Iss 421, p

    Incidence, Environmental Risk Factors and Long-Term Follow-Up of Patients with Inflammatory Bowel Disease and COVID-19 of the ENEIDA Registry

    2022  Band 421

    Abstract: We aim to describe the incidence and source of contagion of COVID-19 in patients with IBD, as well as the risk factors for a severe course and long-term sequelae. This is a prospective observational study of IBD and COVID-19 included in the ENEIDA ... ...

    Abstract We aim to describe the incidence and source of contagion of COVID-19 in patients with IBD, as well as the risk factors for a severe course and long-term sequelae. This is a prospective observational study of IBD and COVID-19 included in the ENEIDA registry (53,682 from 73 centres) between March–July 2020 followed-up for 12 months. Results were compared with data of the general population (National Centre of Epidemiology and Catalonia). A total of 482 patients with COVID-19 were identified. Twenty-eight percent were infected in the work environment, and 48% were infected by intrafamilial transmission, despite having good adherence to lockdown. Thirty-five percent required hospitalization, 7.9% had severe COVID-19 and 3.7% died. Similar data were reported in the general population (hospitalisation 19.5%, ICU 2.1% and mortality 4.6%). Factors related to death and severe COVID-19 were being aged ≥ 60 years (OR 7.1, 95% CI: 1.8–27 and 4.5, 95% CI: 1.3–15.9), while having ≥2 comorbidities increased mortality (OR 3.9, 95% CI: 1.3–11.6). None of the drugs for IBD were related to severe COVID-19. Immunosuppression was definitively stopped in 1% of patients at 12 months. The prognosis of COVID-19 in IBD, even in immunosuppressed patients, is similar to that in the general population. Thus, there is no need for more strict protection measures in IBD.
    Schlagwörter COVID-19 ; SARS-CoV-2 ; inflammatory bowel disease ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

    Ana Gutiérrez / Pedro Zapater / Elena Ricart / María González-Vivó / Jordi Gordillo / David Olivares / Isabel Vera / Míriam Mañosa / Javier P. Gisbert / Mariam Aguas / Eugenia Sánchez-Rodríguez / Maia Bosca-Watts / Viviana Laredo / Blau Camps / Ignacio Marín-Jiménez / Yamile Zabana / María Dolores Martín-Arranz / Roser Muñoz / Mercè Navarro /
    Eva Sierra / Lucía Madero / Milagros Vela / José Lázaro Pérez-Calle / Empar Sainz / Xavier Calvet / Lara Arias / Victor Morales / Fernando Bermejo / Luis Fernández-Salazar / Manuel Van Domselaar / Luisa De Castro / Cristina Rodríguez / Carmen Muñoz-Villafranca / Rufo Lorente / Montserrat Rivero / Eva Iglesias

    Frontiers in Medicine, Vol

    2022  Band 9

    Abstract: BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain.MethodsProspective, observational, ... ...

    Abstract BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain.MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients.ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses.ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.
    Schlagwörter immigrant ; phenotype ; biologics ; inflammatory bowel disease ; Crohn's disease ; ulcerative colitis ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Performance of Screening Strategies for Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease

    Sabino Riestra / Carlos Taxonera / Yamile Zabana / Daniel Carpio / María Chaparro / Jesús Barrio / Montserrat Rivero / Antonio López-Sanroman / María Esteve / Ruth de Francisco / Guillermo Bastida / Santiago García-López / Miriam Mañosa / María Dolores Martin-Arranz / José Lázaro Pérez-Calle / Jordi Guardiola / Fernando Muñoz / Laura Arranz / José Luis Cabriada /
    Mariana Fe García-Sepulcre / Mercè Navarro / Miguel Ángel Montoro-Huguet / Elena Ricart / Fernando Bermejo / Xavier Calvet / Marta Piqueras / Esther Garcia-Planella / Lucía Márquez / Miguel Mínguez / Manuel Van Domselar / Luis Bujanda / Xavier Aldeguer / Beatriz Sicilia / Eva Iglesias / Guillermo Alcaín / Isabel Pérez-Martínez / Valeria Rolle / Andrés Castaño-García / Javier P. Gisbert / Eugeni Domènech / on behalf of the ENEIDA registry from GETECCU

    Journal of Clinical Medicine, Vol 11, Iss 13, p

    Results from the ENEIDA Registry of GETECCU

    2022  Band 3915

    Abstract: 1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study ... ...

    Abstract (1) Aims: Patients receiving antitumor necrosis factor (anti-TNF) therapy are at risk of developing tuberculosis (TB), usually due to the reactivation of a latent TB infection (LTBI). LTBI screening and treatment decreases the risk of TB. This study evaluated the diagnostic performance of different LTBI screening strategies in patients with inflammatory bowel disease (IBD). (2) Methods: Patients in the Spanish ENEIDA registry with IBD screened for LTBI between January 2003 and January 2018 were included. The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-ץ-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. (3) Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18–20%) had LTBI. Immunomodulator (IMM) treatment at screening decreased the probability of detecting LTBI (20% vs. 17%, p = 0.001). Regarding screening strategies, LTBI was more frequently diagnosed by dual screening than by a single screening strategy (IGRA, OR 0.60; 95% CI 0.50–0.73, p < 0.001; TST, OR 0.76; 95% CI 0.66–0.88, p < 0.001). Two-step TST increased the diagnostic yield of a single TST by 24%. More cases of LTBI were diagnosed by early screening than by routine screening before starting anti-TNF agents (21% [95% CI 20–22%] vs. 14% [95% CI 13–16%], p < 0.001). The highest diagnostic performance for LTBI (29%) was obtained by combining early and TST/IGRA dual screening strategies in patients without IMM. (4): Conclusions: Both early screening and TST/IGRA dual screening strategies significantly increased diagnostic performance for LTBI in patients with IBD, with optimal performance achieved when they are used together in the absence of IMM.
    Schlagwörter inflammatory bowel disease ; latent tuberculosis infection ; tuberculin skin test ; interferon gamma release assays ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Frequency, predictors, and consequences of maintenance infliximab therapy intensification in ulcerative colitis

    Luis Fernández-Salazar / Jesús Barrio / Fernando Muñoz / Concepción Muñoz / Ramón Pajares / Montserrat Rivero / Vanesa Prieto / Jesús Legido / Abdel Bouhmidi / Maite Herranz / Guillermo González-Redondo / Nereida Fernández / Fernando Santos / Ramón Sánchez-Ocaña / Diana Joao

    Revista Espanola de Enfermedades Digestivas, Vol 107, Iss 9, Pp 527-

    2015  Band 533

    Abstract: Introduction: Infliximab (IFX) therapy intensification in ulcerative colitis (UC) is more common than established in pivotal studies. Objectives: To establish the frequency and form of intensification for UC in clinical practice, as well as predictors, ... ...

    Abstract Introduction: Infliximab (IFX) therapy intensification in ulcerative colitis (UC) is more common than established in pivotal studies. Objectives: To establish the frequency and form of intensification for UC in clinical practice, as well as predictors, and to compare outcomes between intensified and non-intensified treatment. Methods: A retrospective study of 10 hospitals and 144 patients with response to infliximab (IFX) induction. Predictive variables for intensification were analyzed using a Cox regression analysis. Outcome, loss of response to IFX, and colectomy were compared between intensified and non-intensified therapy. Results: Follow-up time from induction to data collection: 38 months [interquartile range (IQR), 20-62]. Time on IFX therapy: 24 months (IQR, 10-44). In all, 37% of patients required intensification. Interval was shortened for 36 patients, dose was increased for 7, and 10 subjects received both. Concurrent thiopurine immunosuppressants (IMM) and IFX initiation was an independent predictor of intensification [Hazard ratio, 0.034; p, 0.006; CI, 0.003-0.371]. In patients on intensified therapy IFX discontinuation for loss of response (30.4% vs. 10.2%; p, 0.002), steroid reintroduction (35% vs. 18%; p, 0.018), and colectomy (22% vs. 6.4%; p, 0.011) were more common. Of patients on intensification, 17% returned to receiving 5 mg/kg every 8 weeks. Conclusions: Intensification is common and occasionally reversible. IMM initiation at the time of induction with IFX predicts non-intensification. Intensification, while effective, is associated with poorer outcome.
    Schlagwörter Intensificación ; Optimización ; antiTNF ; Infliximab ; Colitis ulcerosa ; Medicine ; R ; Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Thema/Rubrik (Code) 610
    Erscheinungsdatum 2015-09-01T00:00:00Z
    Verlag The Spanish Society of Digestive Pathology
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease

    María José García / Montserrat Rivero / José Miranda-Bautista / Iria Bastón-Rey / Francisco Mesonero / Eduardo Leo-Carnerero / Diego Casas-Deza / Carmen Cagigas Fernández / Albert Martin-Cardona / Ismael El Hajra / Nerea Hernández-Aretxabaleta / Isabel Pérez-Martínez / Esteban Fuentes-Valenzuela / Nuria Jiménez / Cristina Rubín de Célix / Ana Gutiérrez / Cristina Suárez Ferrer / José María Huguet / Agnes Fernández-Clotet /
    María González-Vivó / Blanca Del Val / Jesús Castro-Poceiro / Luigi Melcarne / Carmen Dueñas / Marta Izquierdo / David Monfort / Abdel Bouhmidi / Patricia Ramírez De la Piscina / Eva Romero / Gema Molina / Jaime Zorrilla / Cristina Calvino-Suárez / Eugenia Sánchez / Andrea Nuñez / Olivia Sierra / Beatriz Castro / Yamile Zabana / Irene González-Partida / Saioa De la Maza / Andrés Castaño / Rodrigo Nájera-Muñoz / Luis Sánchez-Guillén / Micaela Riat Castro / José Luis Rueda / José Manuel Benítez / Pedro Delgado-Guillena / Carlos Tardillo / Elena Peña / Santiago Frago-Larramona / María Carmen Rodríguez-Grau

    Journal of Clinical Medicine, Vol 10, Iss 4402, p

    A Multicentre Study of Geteccu

    2021  Band 4402

    Abstract: Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of ... ...

    Abstract Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered “exposed”. The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2–2.0), urgent surgery (OR: 1.6; 95% CI: 1.2–2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1–1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3–2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97–1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03–2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections.
    Schlagwörter inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; anti-TNF ; ustekinumab ; vedolizumab ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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