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  1. Artikel ; Online: Courage, Cancer and COVID.

    Moore, Carol Kerrigan

    Delaware journal of public health

    2020  Band 6, Heft 2, Seite(n) 48–49

    Sprache Englisch
    Erscheinungsdatum 2020-07-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2639-6378
    ISSN (online) 2639-6378
    DOI 10.32481/djph.2020.07.014
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.

    Kalyani, Priyanka / Lippa, Sara M / Werner, J Kent / Amyot, Franck / Moore, Carol B / Kenney, Kimbra / Diaz-Arrastia, Ramon

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2023  Band 20, Heft 6, Seite(n) 1629–1640

    Abstract: Multiple phase III randomized controlled trials (RCTs) for pharmacologic interventions in traumatic brain injury (TBI) have failed despite promising results in experimental models. The heterogeneity of TBI, in terms of pathomechanisms and impacted brain ... ...

    Abstract Multiple phase III randomized controlled trials (RCTs) for pharmacologic interventions in traumatic brain injury (TBI) have failed despite promising results in experimental models. The heterogeneity of TBI, in terms of pathomechanisms and impacted brain structures, likely contributes to these failures. Biomarkers have been recommended to identify patients with relevant pathology (predictive biomarkers) and confirm target engagement and monitor therapy response (pharmacodynamic biomarkers). Our group focuses on traumatic cerebrovascular injury as an understudied endophenotype of TBI and is validating a predictive and pharmacodynamic imaging biomarker (cerebrovascular reactivity; CVR) in moderate-severe TBI. We aim to extend these studies to milder forms of TBI to determine the optimal dose of sildenafil for maximal improvement in CVR. We will conduct a phase II dose-finding study involving 160 chronic TBI patients (mostly mild) using three doses of sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor. The study measures baseline CVR and evaluates the effect of escalating sildenafil doses on CVR improvement. A 4-week trial of thrice daily sildenafil will assess safety, tolerability, and clinical efficacy. This dual-site 4-year study, funded by the Department of Defense and registered in ClinicalTrials.gov (NCT05782244), plans to launch in June 2023. Biomarker-informed RCTs are essential for developing effective TBI interventions, relying on an understanding of underlying pathomechanisms. Traumatic microvascular injury (TMVI) is an attractive mechanism which can be targeted by vaso-active drugs such as PDE-5 inhibitors. CVR is a potential predictive and pharmacodynamic biomarker for targeted interventions aimed at TMVI. (Trial registration: NCT05782244, ClinicalTrials.gov ).
    Mesh-Begriff(e) Humans ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Sildenafil Citrate/therapeutic use ; Cerebrovascular Circulation/physiology ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/drug therapy ; Brain Injuries, Traumatic/pathology ; Biomarkers
    Chemische Substanzen Phosphodiesterase 5 Inhibitors ; Cyclic Nucleotide Phosphodiesterases, Type 5 (EC 3.1.4.35) ; Sildenafil Citrate (BW9B0ZE037) ; Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2023-09-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-023-01430-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Regioselective degradation of [beta] 1,3 glucan by ferrous ion and hydrogen peroxide (Fenton oxidation)

    Ovalle, Rafael / Chen, Lijie / Soll, Clifford E / Moore, Carol Wood / Lipke, Peter N

    Carbohydrate research. 2020 Nov., v. 497

    2020  

    Abstract: Many species use Fe⁺² and H₂O₂ to oxidize a wide variety of compounds to simpler molecules. Both pathogen killing by leukocytes (neutrophils and lymphocytes) and degradation of cellulose by brown rot fungi rely on excretion of Fe⁺² ions and H₂O₂, the ... ...

    Abstract Many species use Fe⁺² and H₂O₂ to oxidize a wide variety of compounds to simpler molecules. Both pathogen killing by leukocytes (neutrophils and lymphocytes) and degradation of cellulose by brown rot fungi rely on excretion of Fe⁺² ions and H₂O₂, the Fenton reagent. To elucidate the mechanism of Fenton oxidation of carbohydrates, β1,3 glucan (laminaran), a major fungal wall polysaccharide, was oxidized using a molar ratio of monomer/Fe⁺²/H₂O₂ of 10:1:1 (primarily). We labeled the reaction products and profiled them as fluorescent-labeled molecules in polyacrylamide gels and as hydrophobic-tagged molecules using reverse phase liquid chromatography/mass spectrometry (HPLC/MS).Sub-stoichiometric concentrations of Fe⁺² and H₂O₂ fragmented laminaran into smaller molecules containing carbonyl and carboxylic acid groups visible on fluorescent-labeled carbohydrate polyacrylamide gel electrophoresis. HPLC/MS analysis of glucan fragments showed masses consistent with six classes of molecules: aldoses, dialdoses, uronic acids, hexosuloses, aldonic acids, and hexulosonic acids.The results were consistent with published mechanisms where hydrogen radical (H•) abstraction from a C–H or O–H bond begins a cascade of reactions leading to 1) C–C bond cleavage to produce aldose/dialdose pairs; 2) oxo-group (O =) addition to produce uronic and aldonic acids; 3) hydroxyl group (HO-) addition to produce gluconolactone and hexosuloses; and 4) hexulosonic acids. Most products resulted from regioselective H• abstractions characteristic of oxidations by ferryl-oxo ion [(FeO)⁺²] or perferryl-oxo ion [(FeO)⁺³] in close contact with specific positions in the glycan. Therefore, oxidations initiated by regioselectively-bound Fe ions were the predominant initiators of polysaccharide degradations.
    Schlagwörter aldoses ; carboxylic acids ; cellulose ; cleavage (chemistry) ; excretion ; fluorescent labeling ; gluconolactone ; hydrogen ; hydrogen peroxide ; mass spectrometry ; neutrophils ; oxidation ; pathogens ; polyacrylamide ; polyacrylamide gel electrophoresis ; regioselectivity ; research ; reversed-phase liquid chromatography
    Sprache Englisch
    Erscheinungsverlauf 2020-11
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2020.108124
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Cerebrovascular Reactivity Measurement with Functional Near Infrared Spectroscopy.

    Amyot, Franck / Davis, Cora / Sangobowale, Mike / Moore, Carol / Silverman, Erika / Gandjbakhche, Amir / Diaz-Arrastia, Ramon / Kenney, Kimbra

    Journal of visualized experiments : JoVE

    2022  , Heft 184

    Abstract: Cerebrovascular reactivity (CVR) is the capacity of blood vessels in the brain to alter cerebral blood flow (either with dilation or constriction) in response to chemical or physical stimuli. The amount of reactivity in the cerebral microvasculature ... ...

    Abstract Cerebrovascular reactivity (CVR) is the capacity of blood vessels in the brain to alter cerebral blood flow (either with dilation or constriction) in response to chemical or physical stimuli. The amount of reactivity in the cerebral microvasculature depends on the integrity of the capacitance vasculature and is the primary function of endothelial cells. CVR is, therefore, an indicator of the microvasculature's physiology and overall health. Imaging methods that can measure CVR are available but can be costly, and require magnetic resonance imaging centers and technical expertise. In this study, we used fNIRS technology to monitor changes of oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) in the cerebral microvasculature to assess the CVR of 15 healthy controls (HC) in response to a vasoactive stimulus (inhaled 5% carbon dioxide or CO2). Our results suggest that this is a promising imaging technology that offers a non-invasive, accurate, portable, and cost-effective method of mapping cortical CVR and associated microvasculature function, resulting from a traumatic brain injury or other conditions associated with cerebral microvasculopathy.
    Mesh-Begriff(e) Brain/blood supply ; Brain/diagnostic imaging ; Carbon Dioxide ; Cerebrovascular Circulation/physiology ; Endothelial Cells ; Magnetic Resonance Imaging/methods ; Spectroscopy, Near-Infrared
    Chemische Substanzen Carbon Dioxide (142M471B3J)
    Sprache Englisch
    Erscheinungsdatum 2022-06-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Video-Audio Media ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/61284
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Regioselective degradation of [beta] 1,3 glucan by ferrous ion and hydrogen peroxide (Fenton oxidation).

    Ovalle, Rafael / Chen, Lijie / Soll, Clifford E / Moore, Carol Wood / Lipke, Peter N

    Carbohydrate research

    2020  Band 497, Seite(n) 108124

    Abstract: Many species use ... ...

    Abstract Many species use Fe
    Sprache Englisch
    Erscheinungsdatum 2020-08-28
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1435-7
    ISSN 1873-426X ; 0008-6215
    ISSN (online) 1873-426X
    ISSN 0008-6215
    DOI 10.1016/j.carres.2020.108124
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: As we age who will care for us?

    Moore, Carol

    The Kansas nurse

    2005  Band 80, Heft 7, Seite(n) 12–13

    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Frail Elderly ; Geriatric Nursing/manpower ; Geriatric Nursing/standards ; Geriatric Nursing/trends ; Geriatrics/manpower ; Geriatrics/standards ; Geriatrics/trends ; Health Services Needs and Demand/trends ; Humans ; Kansas ; Personnel Turnover ; Population Dynamics
    Sprache Englisch
    Erscheinungsdatum 2005-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 603710-0
    ISSN 0022-8710
    ISSN 0022-8710
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Activation of the Calcium Receptor by Calcimimetic Agents Is Preserved Despite Modest Attenuating Effects of Hyperphosphatemia.

    Goodman, William G / Ward, Donald T / Martin, Kevin J / Drayer, Debra / Moore, Carol / Xu, Jiahong / Lai, James / Chon, Yun / Nemeth, Edward F

    Journal of the American Society of Nephrology : JASN

    2021  Band 33, Heft 1, Seite(n) 201–212

    Abstract: Background: Phosphorus levels in the range seen clinically among patients undergoing dialysis have been reported to attenuate calcium receptor activation and modify parathyroid hormone (PTH) release from isolated parathyroid glands : Methods: To ... ...

    Abstract Background: Phosphorus levels in the range seen clinically among patients undergoing dialysis have been reported to attenuate calcium receptor activation and modify parathyroid hormone (PTH) release from isolated parathyroid glands
    Methods: To determine whether hyperphosphatemia diminishes the therapeutic response to calcimimetic agents, we used data from large clinical trials to analyze the effects of etelcalcetide and cinacalcet to lower plasma PTH levels in individuals on hemodialysis who had secondary hyperparathyroidism and varying degrees of hyperphosphatemia.
    Results: Plasma PTH levels declined progressively during 26 weeks of treatment with either etelcalcetide or cinacalcet without regard to the degree of hyperphosphatemia at baseline. However, with each calcimimetic agent, the decreases in PTH from baseline were less at each interval of follow-up during the trials among participants with serum phosphorus levels above one of three prespecified threshold values compared with those with serum phosphorus levels below these thresholds.
    Conclusions: These
    Mesh-Begriff(e) Aged ; Calcimimetic Agents/therapeutic use ; Cinacalcet/therapeutic use ; Female ; Humans ; Hyperparathyroidism, Secondary/blood ; Hyperparathyroidism, Secondary/complications ; Hyperparathyroidism, Secondary/drug therapy ; Hyperphosphatemia/blood ; Hyperphosphatemia/complications ; Male ; Middle Aged ; Parathyroid Hormone/blood ; Peptides/therapeutic use ; Phosphorus/blood ; Renal Dialysis ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy ; Retrospective Studies
    Chemische Substanzen Calcimimetic Agents ; Parathyroid Hormone ; Peptides ; Phosphorus (27YLU75U4W) ; etelcalcetide hydrochloride (72PT5993DU) ; Cinacalcet (UAZ6V7728S)
    Sprache Englisch
    Erscheinungsdatum 2021-11-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2021060825
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Bone-specific alkaline phosphatase and bone turnover in African American hemodialysis patients.

    Yessayan, Lenar / Moore, Carol / Lu, Mei / Yee, Jerry

    Hemodialysis international. International Symposium on Home Hemodialysis

    2016  Band 21, Heft 1, Seite(n) 90–96

    Abstract: Introduction: Noninvasive measures of bone activity include intact parathyroid hormone (iPTH) and bone-specific alkaline phosphatase (BSAP). Whether BSAP measurement alone or in combination with other biochemical data provides more reliable information ... ...

    Abstract Introduction: Noninvasive measures of bone activity include intact parathyroid hormone (iPTH) and bone-specific alkaline phosphatase (BSAP). Whether BSAP measurement alone or in combination with other biochemical data provides more reliable information about bone turnover than iPTH alone in African Americans on hemodialysis is unknown.
    Methods: This cross-sectional study aimed to determine the optimal predictor and cutoff points for BSAP, iPTH, calcium and phosphorus in classifying bone biopsy findings. Forty-three African American hemodialysis patients were available for analysis. Biochemical data on the day of biopsy across a spectrum of qualitative histologic bone features were compared. Classification and regression tree analysis was used to determine both the optimal predictor and cutoff points for BSAP, iPTH, calcium and phosphorus in identifying bone turnover status.
    Findings: Seven subjects had adynamic disease, 31 had mild/moderate hyperparathyroid bone features, and five had severe hyperparathyroid bone disease. BSAP was the optimal predictor of bone biopsy with a cutoff point of 22 ng/mL. Calcium and phosphorus had no predictive value. At BSAP ≤ 22 ng/mL, subjects had either adynamic bone disease or mild/moderate hyperparathyroid bone disease but iPTH was not useful in further classifying biopsy findings. When BSAP was >22 ng/mL, subjects had either mild/moderate or severe hyperparathyroid bone disease, and iPTH was useful in further classifying biopsy findings. With BSAP > 22 ng/mL and iPTH < 726 pg/mL, all subjects had mild/moderate bone turnover features.
    Discussion: Compared to iPTH, BSAP was shown to be the optimal predictor of biopsy findings with an optimal cutoff at 22 ng/mL.
    Mesh-Begriff(e) Adult ; African Americans ; Alkaline Phosphatase/metabolism ; Bone Remodeling/physiology ; Chronic Kidney Disease-Mineral and Bone Disorder ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Renal Dialysis/methods
    Chemische Substanzen Alkaline Phosphatase (EC 3.1.3.1)
    Sprache Englisch
    Erscheinungsdatum 2016-06-27
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 2192458-2
    ISSN 1542-4758 ; 1492-7535
    ISSN (online) 1542-4758
    ISSN 1492-7535
    DOI 10.1111/hdi.12454
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Buch: Technische und pflegerische Massnahmen in der Roentgendiagnostik

    Torres, Lillian S. / MOORE, CAROL M.

    e. Anleitung fuer roentgentechn. Assistenten

    1982  

    Titelvarianten BASIC MEDICAL TECHNIQUES AND PATIENT CARE FOR RADIOLOGIC TECHNOLOGISTS <DT.>
    Verfasserangabe LILLIAN S. TORRES ; CAROL MORRILL MOORE. DT. UEBERS. VON H. BRABAND
    Schlagwörter TECHNOLOGY, RADIOLOGIC
    Umfang VI, 106 S. : ILL., GRAPH. DARST.
    Verlag Thieme
    Erscheinungsort STUTTGART ; NEW YORK
    Dokumenttyp Buch
    Anmerkung EST: BASIC MEDICAL TECHNIQUES AND PATIENT CARE FOR RADIOLOGIC TECHNOLOGISTS <DT.>. - MIT 138 ABB., 13 TAB
    HBZ-ID HT002567149
    ISBN 3-13-615801-6 ; 978-3-13-615801-2
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  10. Buch: The harmonic structure of movement, music, and dance according to Rudolf Laban

    Moore, Carol-Lynne

    an examination of his unpublished writings and drawings

    2009  

    Verfasserangabe Carol-Lynne Moore
    Umfang 329 Seiten: Illustrationen
    Verlag Mellen; Lewiston, NY [u.a.]
    Dokumenttyp Buch
    HBZ-ID HT016063522
    ISBN 978-0-7734-4777-6 ; 0-7734-4777-6
    Datenquelle Zentralbibliothek der Sportwissenschaften der Deutschen Sporthochschule Köln

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