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  1. Artikel ; Online: Soluble FcγRIA expressed on monocytes (sCD64): A new serum biomarker of acute kidney injury in patients with suspected infection at emergency department admission.

    Mearelli, Filippo / Barbati, Giulia / Moras, Cristina / Ronco, Claudio / Biolo, Gianni

    Cytokine

    2021  Band 148, Seite(n) 155661

    Mesh-Begriff(e) Acute Kidney Injury/blood ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Emergency Service, Hospital ; Female ; Humans ; Infections/blood ; Male ; Monocytes/metabolism ; Patient Admission ; ROC Curve ; Receptors, IgG/blood ; Solubility
    Chemische Substanzen Biomarkers ; FCGR1A protein, human ; Receptors, IgG
    Sprache Englisch
    Erscheinungsdatum 2021-08-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2021.155661
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2840: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel ; Online: Intravenous immunoglobulin response in new-onset refractory status epilepticus (NORSE) COVID-19 adult patients.

    Manganotti, Paolo / Furlanis, Giovanni / Ajčević, Miloš / Moras, Cristina / Bonzi, Lucia / Pesavento, Valentina / Buoite Stella, Alex

    Journal of neurology

    2021  Band 268, Heft 10, Seite(n) 3569–3573

    Abstract: Neurological manifestations may be common in COVID-19 patients. They may include several syndromes, such as a suggested autoimmune abnormal response, which may result in encephalitis and new-onset refractory status epilepticus (NORSE). Quickly ... ...

    Abstract Neurological manifestations may be common in COVID-19 patients. They may include several syndromes, such as a suggested autoimmune abnormal response, which may result in encephalitis and new-onset refractory status epilepticus (NORSE). Quickly recognizing such cases and starting the most appropriate therapy is mandatory due to the related rapid worsening and bad outcomes. This case series describes two adult patients admitted to the university hospital and positive to novel coronavirus 2019 (SARS-CoV-2) infection who developed drug-resistant status epilepticus. Both patients underwent early electroencephalography (EEG) assessment, which showed a pathological EEG pattern characterized by general slowing, rhythmic activity and continuous epileptic paroxysmal activity. A suspected autoimmune etiology, potentially triggered by SARS-CoV-2 infection, encouraged a rapid work-up for a possible autoimmune encephalitis diagnosis. Therapeutic approach included the administration of 0.4 g/kg intravenous immunoglobulin, which resulted in a complete resolution of seizures after 5 and after 10 days, respectively, without adverse effects and followed by a normalization of the EEG patterns.
    Mesh-Begriff(e) Adult ; COVID-19 ; Electroencephalography ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; SARS-CoV-2 ; Seizures ; Status Epilepticus/drug therapy
    Chemische Substanzen Immunoglobulins, Intravenous
    Sprache Englisch
    Erscheinungsdatum 2021-03-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-021-10468-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Ui II Zs.40: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel ; Online: Lung ultrasound may support internal medicine physicians in predicting the diagnosis, bacterial etiology and favorable outcome of community-acquired pneumonia.

    Mearelli, Filippo / Casarsa, Chiara / Trapani, Alessandro / D'agaro, Pierlanfranco / Moras, Cristina / Spagnol, Francesca / Pellicori, Federica / Nunnari, Alessio / Massolin, Alice / Barbati, Giulia / Biolo, Gianni

    Scientific reports

    2021  Band 11, Heft 1, Seite(n) 17016

    Abstract: To assess the usefulness of lung ultrasound (LUS) for identifying community-acquired pneumonia (CAP) among adult patients with suspected lower respiratory tract infection (LRTI) and for discriminating between CAP with different cultural statuses, ... ...

    Abstract To assess the usefulness of lung ultrasound (LUS) for identifying community-acquired pneumonia (CAP) among adult patients with suspected lower respiratory tract infection (LRTI) and for discriminating between CAP with different cultural statuses, etiologies, and outcomes. LUS was performed at internal medicine ward admission. The performance of chest X-ray (CXR) and LUS in diagnosing CAP in 410 patients with suspected LRTI was determined. All possible positive results for pneumonia on LUS were condensed into pattern 1 (consolidation + / - alveolar-interstitial syndrome) and pattern 2 (alveolar-interstitial syndrome). The performance of LUS in predicting culture-positive status, bacterial etiology, and adverse outcomes of CAP was assessed in 315 patients. The area under the receiver operating characteristic curve for diagnosing CAP by LUS was significantly higher than for diagnosis CAP by CXR (0.93 and 0.71, respectively; p < 0.001). Pattern 1 predicted CAP with bacterial and mixed bacterial and viral etiologies with positive predictive values of 99% (95% CI, 94-100%) and 97% (95% CI, 81-99%), respectively. Pattern 2 ruled out mortality with a negative predictive value of 95% (95% CI, 86-98%), respectively. In this study, LUS was useful in predicting a diagnosis of CAP, the bacterial etiology of CAP, and favorable outcome in patients with CAP.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/diagnostic imaging ; Community-Acquired Infections/microbiology ; Female ; Humans ; Internal Medicine ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Physicians ; Pneumonia/diagnosis ; Pneumonia/diagnostic imaging ; Pneumonia/microbiology ; Treatment Outcome ; Ultrasonography ; X-Rays
    Sprache Englisch
    Erscheinungsdatum 2021-08-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-96380-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: The Integration of qSOFA with Clinical Variables and Serum Biomarkers Improves the Prognostic Value of qSOFA Alone in Patients with Suspected or Confirmed Sepsis at ED Admission.

    Mearelli, Filippo / Barbati, Giulia / Casarsa, Chiara / Giansante, Carlo / Breglia, Andrea / Spica, Andrea / Moras, Cristina / Olivieri, Gaia / Occhipinti, Alessandro Agostino / De Nardo, Margherita / Spagnol, Francesca / Fiotti, Nicola / Di Girolamo, Filippo Giorgio / Ruscio, Maurizio / Castello, Luigi Mario / Colonetti, Efrem / Marino, Rossella / Ronco, Claudio / Zanetti, Michela /
    Lupia, Enrico / Muiesan, Maria Lorenza / Di Somma, Salvatore / Avanzi, Gian Carlo / Biolo, Gianni

    Journal of clinical medicine

    2020  Band 9, Heft 4

    Abstract: Background: The prognostic value of quick sepsis-related organ failure assessment (qSOFA) outside intensive care units has been criticized. Therefore, we aimed to improve its ability in predicting 30-day all-cause mortality, and in ruling out the cases ... ...

    Abstract Background: The prognostic value of quick sepsis-related organ failure assessment (qSOFA) outside intensive care units has been criticized. Therefore, we aimed to improve its ability in predicting 30-day all-cause mortality, and in ruling out the cases at high risk of death among patients with suspected or confirmed sepsis at emergency department (ED) admission.
    Methods: This study is a secondary analysis of a prospective multicenter study. We built three predictive models combining qSOFA with the clinical variables and serum biomarkers that resulted in an independent association with 30-day mortality, in both 848 undifferentiated patients (Group 1) and in 545 patients definitively diagnosed with sepsis (Group 2). The models reaching the highest negative predictive value (NPV) with the minimum expenditure of biomarkers in Group 1 and in Group 2 were validated in two cohorts of patients initially held out due to missing data.
    Results: In terms of the area under the receiver-operating characteristic curve, all six models significantly exceeded qSOFA in predicting prognosis. An "extended" qSOFA (eqSOFA1) in Group 1 and an eqSOFA2 integrated with C-reactive protein and mid-regional proadrenomedullin (eqSOFA2+CRP+MR-proADM) in Group 2 reached the best NPV (0.94 and 0.93, respectively) and ease of use. eqSOFA1 and eqSOFA2+CRP+MR-proADM performed equally well in both the inception and validation cohorts.
    Conclusions: We have derived and validated two prognostic models that outweigh qSOFA in predicting mortality and in identifying the low risk of death among patients with suspected or confirmed sepsis at ED admission.
    Sprache Englisch
    Erscheinungsdatum 2020-04-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9041205
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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