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  1. Artikel ; Online: Introduction of New Dengue Virus Lineages of Multiple Serotypes after COVID-19 Pandemic, Nicaragua, 2022.

    Cerpas, Cristhiam / Vásquez, Gerald / Moreira, Hanny / Juarez, Jose G / Coloma, Josefina / Harris, Eva / Bennett, Shannon N / Balmaseda, Ángel

    Emerging infectious diseases

    2024  Band 30, Heft 6, Seite(n) 1203–1213

    Abstract: Major dengue epidemics throughout Nicaragua's history have been dominated by 1 of 4 dengue virus serotypes (DENV-1-4). To examine serotypes during the dengue epidemic in Nicaragua in 2022, we performed real-time genomic surveillance in-country and ... ...

    Abstract Major dengue epidemics throughout Nicaragua's history have been dominated by 1 of 4 dengue virus serotypes (DENV-1-4). To examine serotypes during the dengue epidemic in Nicaragua in 2022, we performed real-time genomic surveillance in-country and documented cocirculation of all 4 serotypes. We observed a shift toward co-dominance of DENV-1 and DENV-4 over previously dominant DENV-2. By analyzing 135 new full-length DENV sequences, we found that introductions underlay the resurgence: DENV-1 clustered with viruses from Ecuador in 2014 rather than those previously seen in Nicaragua; DENV-3, which last circulated locally in 2014, grouped instead with Southeast Asia strains expanding into Florida and Cuba in 2022; and new DENV-4 strains clustered within a South America lineage spreading to Florida in 2022. In contrast, DENV-2 persisted from the formerly dominant Nicaragua clade. We posit that the resurgence emerged from travel after the COVID-19 pandemic and that the resultant intensifying hyperendemicity could affect future dengue immunity and severity.
    Mesh-Begriff(e) Dengue Virus/genetics ; Dengue Virus/classification ; Nicaragua/epidemiology ; Humans ; Dengue/epidemiology ; Dengue/virology ; COVID-19/epidemiology ; COVID-19/virology ; Serogroup ; SARS-CoV-2/genetics ; Phylogeny ; Pandemics
    Sprache Englisch
    Erscheinungsdatum 2024-05-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid3006.231553
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Burden of SARS-CoV-2 and protection from symptomatic second infection in children.

    Kubale, John / Balmaseda, Angel / Frutos, Aaron M / Sanchez, Nery / Plazaola, Miguel / Ojeda, Sergio / Saborio, Saira / Lopez, Roger / Barilla, Carlos / Vasquez, Gerald / Moreira, Hanny / Gajewski, Anna / Campredon, Lora / Maier, Hannah / Chowdhury, Mahboob / Cerpas, Cristhiam / Harris, Eva / Kuan, Guillermina / Gordon, Aubree

    medRxiv : the preprint server for health sciences

    2022  

    Abstract: Importance: The impact of the SARS-CoV-2 pandemic on children remains unclear. Better understanding of the burden of COVID-19 among children and their protection against re-infection is crucial as they will be among the last groups vaccinated.: ... ...

    Abstract Importance: The impact of the SARS-CoV-2 pandemic on children remains unclear. Better understanding of the burden of COVID-19 among children and their protection against re-infection is crucial as they will be among the last groups vaccinated.
    Objective: To characterize the burden of COVID-19 and assess how protection from symptomatic re-infection among children may vary by age.
    Design: A prospective, community-based pediatric cohort study conducted from March 1, 2020 through October 15, 2021.
    Setting: The Nicaraguan Pediatric Influenza Cohort is a community-based cohort in District 2 of Managua, Nicaragua.
    Participants: A total of 1964 children aged 0-14 years participated in the cohort. Non-immunocompromised children were enrolled by random selection from a previous pediatric influenza cohort. Additional newborn infants aged ≤4 weeks were randomly selected and enrolled monthly, via home visits.
    Exposures: Prior COVID-19 infection as confirmed by positive anti SARS-CoV-2 antibodies (receptor binding domain [RBD] and spike protein) or real time RT-PCR confirmed COVID-19 infection ≥60 days prior to current COVID-19.
    Main outcomes and measures: Symptomatic COVID-19 cases confirmed by real time RT-PCR and hospitalization within 28 days of symptom onset of confirmed COVID-19 case.
    Results: Overall, 49.8% of children tested were seropositive over the course of the study. There were also 207 PCR-confirmed COVID-19 cases, 12 (6.4%) of which were severe enough to require hospitalization. Incidence of COVID-19 was highest among children aged <2 years-16.1 per 100 person-years (95% Confidence Interval [CI]: 12.5, 20.5)-approximately three times that of children in any other age group assessed. Additionally, 41 (19.8%) symptomatic SARS-CoV-2 episodes were re-infections, with younger children slightly more protected against symptomatic reinfection. Among children aged 6-59 months, protection was 61% (Rate Ratio [RR]:0.39, 95% CI:0.2,0.8), while protection among children aged 5-9 and 10-14 years was 64% (RR:0.36,0.2,0.7), and 49% (RR:0.51,0.3-0.9), respectively.
    Conclusions and relevance: In this prospective community-based pediatric cohort rates of symptomatic and severe COVID-19 were highest among the youngest participants, with rates stabilizing around age 5. Reinfections represent a large proportion of PCR-positive cases, with children <10 years displaying greater protection from symptomatic reinfection. A vaccine for children <5 years is urgently needed.
    Key points: Question:
    Sprache Englisch
    Erscheinungsdatum 2022-01-05
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2022.01.03.22268684
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Association of SARS-CoV-2 Seropositivity and Symptomatic Reinfection in Children in Nicaragua.

    Kubale, John / Balmaseda, Angel / Frutos, Aaron M / Sanchez, Nery / Plazaola, Miguel / Ojeda, Sergio / Saborio, Saira / Lopez, Roger / Barilla, Carlos / Vasquez, Gerald / Moreira, Hanny / Gajewski, Anna / Campredon, Lora / Maier, Hannah E / Chowdhury, Mahboob / Cerpas, Cristhiam / Harris, Eva / Kuan, Guillermina / Gordon, Aubree

    JAMA network open

    2022  Band 5, Heft 6, Seite(n) e2218794

    Abstract: Importance: The impact of the SARS-CoV-2 pandemic on children remains unclear. Better understanding of the burden of COVID-19 among children and their risk of reinfection is crucial, as they will be among the last groups vaccinated.: Objective: To ... ...

    Abstract Importance: The impact of the SARS-CoV-2 pandemic on children remains unclear. Better understanding of the burden of COVID-19 among children and their risk of reinfection is crucial, as they will be among the last groups vaccinated.
    Objective: To characterize the burden of COVID-19 and assess how risk of symptomatic reinfection may vary by age among children.
    Design, setting, and participants: In this prospective, community-based pediatric cohort study conducted from March 1, 2020, to October 15, 2021, 1964 nonimmunocompromised children aged 0 to 14 years were enrolled by random selection from the Nicaraguan Pediatric Influenza Cohort, a community-based cohort in District 2 of Managua, Nicaragua. Additional newborn infants aged 4 weeks or younger were randomly selected and enrolled monthly via home visits.
    Exposures: Prior COVID-19 infection as confirmed by positive anti-SARS-CoV-2 antibodies (receptor binding domain and spike protein) or real-time reverse transcriptase-polymerase chain reaction (RT-PCR)-confirmed COVID-19 infection at least 60 days before current COVID-19 infection.
    Main outcomes and measures: Symptomatic COVID-19 cases confirmed by real-time RT-PCR and hospitalization within 28 days of symptom onset of a confirmed COVID-19 case.
    Results: This cohort study assessed 1964 children (mean [SD] age, 6.9 [4.4] years; 985 [50.2%] male). Of 1824 children who were tested, 908 (49.8%; 95% CI, 47.5%-52.1%) were seropositive during the study. There were also 207 PCR-confirmed COVID-19 cases, 12 (5.8%) of which were severe enough to require hospitalization. Incidence of COVID-19 was highest among children younger than 2 years (16.1 cases per 100 person-years; 95% CI, 12.5-20.5 cases per 100 person-years), which was approximately 3 times the incidence rate in any other child age group assessed. In addition, 41 symptomatic SARS-CoV-2 episodes (19.8%; 95% CI, 14.4%-25.2%) were reinfections.
    Conclusions and relevance: In this prospective, community-based pediatric cohort study, rates of symptomatic and severe COVID-19 were highest among the youngest participants, with rates stabilizing at approximately 5 years of age. In addition, symptomatic reinfections represented a large proportion of symptomatic COVID-19 cases.
    Mesh-Begriff(e) Adolescent ; COVID-19/epidemiology ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Nicaragua/epidemiology ; Prospective Studies ; Reinfection ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2022-06-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.18794
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: High Co-circulation of Influenza and Severe Acute Respiratory Syndrome Coronavirus 2.

    Kubale, John T / Frutos, Aaron M / Balmaseda, Angel / Cerpas, Cristhiam / Saborio, Saira / Ojeda, Sergio / Barilla, Carlos / Sanchez, Nery / Vasquez, Gerald / Moreira, Hanny / Shotwell, Abigail / Meyers, Alyssa / Lopez, Roger / Plazaola, Miguel / Kuan, Guillermina / Gordon, Aubree

    Open forum infectious diseases

    2022  Band 9, Heft 12, Seite(n) ofac642

    Abstract: In the first 2 years of the coronavirus disease 2019 pandemic, influenza transmission decreased substantially worldwide, meaning that health systems were not faced with simultaneous respiratory epidemics. In 2022, however, substantial influenza ... ...

    Abstract In the first 2 years of the coronavirus disease 2019 pandemic, influenza transmission decreased substantially worldwide, meaning that health systems were not faced with simultaneous respiratory epidemics. In 2022, however, substantial influenza transmission returned to Nicaragua where it co-circulated with severe acute respiratory syndrome coronavirus 2, causing substantial disease burden.
    Sprache Englisch
    Erscheinungsdatum 2022-11-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac642
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Burden of SARS-CoV-2 and protection from symptomatic second infection in children

    Kubale, John T / Balmaseda, Angel / Frutos, Aaron M / Sanchez, Nery / Plazaola, Miguel / Ojeda, Sergio / Saborio, Saira / Lopez, Roger / Barilla, Carlos / Vasquez, Gerald / Moreira, Hanny / Gajewski, Anna / Campredon, Lora / Maier, Hannah / Chowdhury, Mahboob / Cerpas, Cristhiam / Harris, Eva / Kuan, Guillermina / Gordon, Aubree

    medRxiv

    Abstract: Importance The impact of the SARS-CoV-2 pandemic on children remains unclear. Better understanding of the burden of COVID-19 among children and their protection against re-infection is crucial as they will be among the last groups vaccinated. Objective ... ...

    Abstract Importance The impact of the SARS-CoV-2 pandemic on children remains unclear. Better understanding of the burden of COVID-19 among children and their protection against re-infection is crucial as they will be among the last groups vaccinated. Objective To characterize the burden of COVID-19 and assess how protection from symptomatic re-infection among children may vary by age. Design A prospective, community-based pediatric cohort study conducted from March 1, 2020 through October 15, 2021. Setting The Nicaraguan Pediatric Influenza Cohort is a community-based cohort in District 2 of Managua, Nicaragua. Participants A total of 1964 children aged 0-14 years participated in the cohort. Non-immunocompromised children were enrolled by random selection from a previous pediatric influenza cohort. Additional newborn infants aged ≤ 4 weeks were randomly selected and enrolled monthly, via home visits. Exposures Prior COVID-19 infection as confirmed by positive anti SARS-CoV-2 antibodies (receptor binding domain [RBD] and spike protein) or real time RT-PCR confirmed COVID-19 infection ≥ 60 days prior to current COVID-19. Main Outcomes and Measures Symptomatic COVID-19 cases confirmed by real time RT-PCR and hospitalization within 28 days of symptom onset of confirmed COVID-19 case. Results Overall, 49.8% of children tested were seropositive over the course of the study. There were also 207 PCR-confirmed COVID-19 cases, 12 (6.4%) of which were severe enough to require hospitalization. Incidence of COVID-19 was highest among children aged <2 years — 16.1 per 100 person-years (95% Confidence Interval [CI]: 12.5, 20.5) — approximately three times that of children in any other age group assessed. Additionally, 41 (19.8%) symptomatic SARS-CoV-2 episodes were re-infections, with younger children slightly more protected against symptomatic reinfection. Among children aged 6-59 months, protection was 61% (Rate Ratio [RR]:0.39, 95% CI:0.2,0.8), while protection among children aged 5-9 and 10-14 years was 64% (RR:0.36,0.2,0.7), and 49% (RR:0.51,0.3-0.9), respectively.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2022-01-05
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2022.01.03.22268684
    Datenquelle COVID19

    Volltext online

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