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Artikel ; Online: Respiratory-related cortical activity in patients with COPD and aged normal individuals: towards a different vision of dyspnoea?

Morélot-Panzini, Capucine

2018 Band 596, Heft 24, Seite(n) 6137–6138

Mesh-Begriff(e)	Aging ; Dyspnea ; Humans ; Pulmonary Disease, Chronic Obstructive
Sprache	Englisch
Erscheinungsdatum	2018-11-24
Erscheinungsland	England
Dokumenttyp	Journal Article ; Comment
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP276761
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Fooling the brain to alleviate dyspnoea.

Morélot-Panzini, Capucine

The European respiratory journal

2017 Band 50, Heft 2

Mesh-Begriff(e)	Brain ; Dyspnea ; Humans
Sprache	Englisch
Erscheinungsdatum	2017-08-17
Erscheinungsland	England
Dokumenttyp	Editorial ; Comment
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.01383-2017
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Dyspnoea relief as an inherent benefit of high flow nasal cannula therapy: A laboratory randomized trial in healthy humans.

Bianquis, Clara / Rolland-Debord, Camille / Rivals, Isabelle / Similowski, Thomas / Morélot-Panzini, Capucine

Respirology (Carlton, Vic.)

2023 Band 29, Heft 1, Seite(n) 46–55

Abstract: Background and objective: Persistent dyspnoea is a public health issue for which the therapeutic arsenal is limited. This study tested high-flow nasal cannula therapy (HFNT) as a means to alleviate experimental dyspnoea.: Methods: Thirty-two healthy ... ...

Abstract	Background and objective: Persistent dyspnoea is a public health issue for which the therapeutic arsenal is limited. This study tested high-flow nasal cannula therapy (HFNT) as a means to alleviate experimental dyspnoea. Methods: Thirty-two healthy subjects underwent an experimental dyspnoea induced by thoracoabdominal elastic loading. HFNT was administered with alternately FiO Results: HFNT21 and HFNT100 significantly reduced dyspnoea, respectively of ∆A-VAS = 0.80 cm [-0.02-1.5]; p = 0.007 and ∆A-VAS = 1.00 cm [0.08-1.75]; p < 0.0001; ∆S-VAS = 0.70 cm [-0.15-1.98]), p < 0.0001 and ∆S-VAS = 0.70 cm [0.08-1.95]), p = 0.0002) with no significant difference between HFNT21 and HFNT100. HFNT did not significantly alter the respiratory rate or the heart rate, reduced PtcCO Conclusion: HFNT was associated with a statistically significant reduction in the intensity of the sensory and affective components of dyspnoea, independent of oxygen addition. This relief of laboratory dyspnoea could result from a reduction of afferent-reafferent mismatch.
Mesh-Begriff(e)	Humans ; Cannula ; Oxygen Inhalation Therapy ; Oxygen ; Dyspnea/therapy ; Oximetry
Chemische Substanzen	Oxygen (S88TT14065)
Sprache	Englisch
Erscheinungsdatum	2023-09-01
Erscheinungsland	Australia
Dokumenttyp	Randomized Controlled Trial ; Journal Article
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14580
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: 18

Bondeelle, Louise / Vercellino, Laetitia / Dres, Martin / Bachasson, Damien / Demoule, Alexandre / Morélot-Panzini, Capucine / Similowski, Thomas / Bergeron, Anne

Respiratory medicine and research

2023 Band 84, Seite(n) 101023

Mesh-Begriff(e)	Humans ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Respiratory Muscles ; Graft vs Host Disease/diagnostic imaging ; Graft vs Host Disease/etiology ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy
Chemische Substanzen	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Sprache	Englisch
Erscheinungsdatum	2023-05-19
Erscheinungsland	France
Dokumenttyp	Letter
ISSN	2590-0412
ISSN (online)	2590-0412
DOI	10.1016/j.resmer.2023.101023
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: "In their own words": delineating the contours of dyspnea invisibility in patients with advanced chronic obstructive pulmonary disease from quantitative discourse analysis.

Dedonder, Jonathan / Gelgon, Christelle / Guerder, Antoine / Nion, Nathalie / Lavault, Sophie / Morélot-Panzini, Capucine / Gonzalez-Bermejo, Jésus / Benoit, Laelia / Similowski, Thomas / Serresse, Laure

Respiratory research

2024 Band 25, Heft 1, Seite(n) 21

Abstract: Background: Dyspnea conveys an upsetting or distressing experience of breathing awareness. It heavily weighs on chronic respiratory disease patients, particularly when it persists despite maximal treatment of causative abnormalities. The physical, ... ...

Abstract	Background: Dyspnea conveys an upsetting or distressing experience of breathing awareness. It heavily weighs on chronic respiratory disease patients, particularly when it persists despite maximal treatment of causative abnormalities. The physical, psychological and social impacts of persistent dyspnea are ill-appreciated by others. This invisibility constitutes a social barrier and impedes access to care. This study aimed to better understand dyspnea invisibility in patients with chronic obstructive pulmonary disease (COPD) through quantitative discourse analysis. Methods: We conducted a lexicometric analysis (lemmatization, descending hierarchical classification, multicomponent analysis, similarity analysis) of 11 patients' discourses (6 men, severe COPD; immediate postexacerbation rehabilitation) to identify semantic classes and communities, which we then confronted with themes previously identified using interpretative phenomenological analysis (IPA). Results: Class#1 ("experience and need for better understanding"; 38.9% of semantic forms, 50% of patients) illustrates the gap that patients perceive between their experience and what others see, confirming the importance of dyspnea invisibility in patients' concerns. Class#2 ("limitations"; 28.7% of forms) and Class#3 (management"; 13.1% of forms) point to the weight of daily limitations in performing basic activities, of the need to accept or adapt to the constraints of the disease. These three classes matched previously identified IPA-derived themes. Class#4 ("hospitalization"; 18.2% of forms) points to the importance of interactions with the hospital, especially during exacerbations, which constitutes novel information. Conclusions: Lexicometry confirms the importance of dyspnea invisibility as a burden to COPD patients.
Mesh-Begriff(e)	Male ; Humans ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Dyspnea/diagnosis ; Dyspnea/etiology ; Dyspnea/therapy ; Hospitalization ; Hospitals
Sprache	Englisch
Erscheinungsdatum	2024-01-04
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-023-02655-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Sensory interventions to relieve dyspnoea in critically ill mechanically ventilated patients.

Bureau, Côme / Niérat, Marie-Cécile / Decavèle, Maxens / Rivals, Isabelle / Dangers, Laurence / Beurton, Alexandra / Virolle, Sara / Deleris, Robin / Delemazure, Julie / Mayaux, Julien / Morélot-Panzini, Capucine / Dres, Martin / Similowski, Thomas / Demoule, Alexandre

The European respiratory journal

2024 Band 63, Heft 1

Abstract: Background: In critically ill patients receiving mechanical ventilation, dyspnoea is frequent, severe and associated with an increased risk of neuropsychological sequelae. We evaluated the efficacy of sensory interventions targeting the brain rather ... ...

Abstract	Background: In critically ill patients receiving mechanical ventilation, dyspnoea is frequent, severe and associated with an increased risk of neuropsychological sequelae. We evaluated the efficacy of sensory interventions targeting the brain rather than the respiratory system to relieve dyspnoea in mechanically ventilated patients. Methods: Patients receiving mechanical ventilation for ≥48 h and reporting dyspnoea (unidimensional dyspnoea visual analogue scale (Dyspnoea-VAS)) first underwent increased pressure support and then, in random order, auditory stimulation (relaxing music Results: We included 46 patients (tracheotomy or intubation n=37; noninvasive ventilation n=9). Increasing pressure support decreased Dyspnoea-VAS by median 40 mm (p<0.001). Exposure to music decreased Dyspnoea-VAS compared with exposure to pink noise by median 40 mm (p<0.001). Exposure to facial air flux decreased Dyspnoea-VAS compared with limb air flux by median 30 mm (p<0.001). Increasing pressure support, but not music exposure and facial air flux, reduced Conclusions: In mechanically ventilated patients, sensory interventions can modulate the processing of respiratory signals by the brain irrespective of the intensity of the neural drive to breathe. It should therefore be possible to alleviate dyspnoea without resorting to pharmacological interventions or having to infringe the constraints of mechanical ventilation lung protection strategies by increasing ventilatory support.
Mesh-Begriff(e)	Humans ; Respiration, Artificial ; Critical Illness ; Dyspnea/therapy ; Positive-Pressure Respiration ; Noninvasive Ventilation
Sprache	Englisch
Erscheinungsdatum	2024-01-18
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.02215-2022
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Increasing sweep gas flow reduces respiratory drive and dyspnea in non-intubated veno-arterial ECMO patients - a pilot study.

Bureau, Côme / Schmidt, Matthieu / Chommeloux, Juliette / Rivals, Isabelle / Similowski, Thomas / Hékimian, Guillaume / Luyt, Charles-Edouard / Niérat, Marie-Cécile / Dangers, Laurence / Dres, Martin / Combes, Alain / Morélot-Panzini, Capucine / Demoule, Alexandre

Anesthesiology

2024

Abstract: Background.: Data on assessment and management of dyspnea in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock are lacking. We hypothesized that increasing sweep gas flow through the VA-ECMO oxygenator may ... ...

Abstract	Background.: Data on assessment and management of dyspnea in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock are lacking. We hypothesized that increasing sweep gas flow through the VA-ECMO oxygenator may decrease dyspnea in non-intubated VA-ECMO patients exhibiting clinically significant dyspnea, with a parallel reduction in respiratory drive. Methods.: Non-intubated, spontaneously breathing, supine patients on VA-ECMO for cardiogenic shock who presented with a visual analog dyspnea scale (dyspnea-VAS) ≥ 40/100 mm were included. Sweep gas flow was increased up to +6 L/min by three steps of +2 L/min each. Dyspnea was assessed with dyspnea-VAS and Multidimensional Dyspnea Profile. The respiratory drive was assessed by the electromyographic activity of the alae nasi and parasternal muscles. Results.: We included 21 patients. On inclusion, median dyspnea-VAS was 50 ([interquartile range] 45-60) mm and sweep gas flow was 1.0 L/min (0.5-2.0). An increase in sweep gas flow significantly decreased dyspnea-VAS (50[45-60] at baseline vs 20[10-30] at 6L/min; p<0.001). The decrease in dyspnea was greater for the sensory component of dyspnea (-50%[43-75]) than for the affective and emotional components (-17%[0-25] and -12%[0-17], p<0.001). An increase in sweep gas flow significantly decreased electromyographic activity of the alae nasi and parasternal muscles (-23%[36-10] and -20[41-0], p<0.001). There was a significant correlation between the sweep gas flow and the dyspnea-VAS (r=-0.91 95%CI[-0.94, -0.87]), between the respiratory drive and the sensory component of dyspnea (r=0.29 95%CI[0.13, 0.44]), between the respiratory drive and the affective component of dyspnea (r=0.29 95%CI[0.02, 0.54]) and between the sweep gas flow and the alae nasi and parasternal (r=-0.31 95%CI[-0.44, -0.22] and r=-0.25 95%CI[-0.44, -0.16]). Conclusion.: In critically ill patients with VA-ECMO, an increase in sweep gas flow through the oxygenation membrane decreases dyspnea, possibly mediated by a decrease in respiratory drive.
Sprache	Englisch
Erscheinungsdatum	2024-03-04
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000004962
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Clinical correlates of respiratory disorders in patients with severe multiple sclerosis: A cross-sectional cohort.

Maillart, Elisabeth / Redolfi, Stefania / Louapre, Céline / Houot, Marion / Chaugne, Emeline / Laveneziana, Pierantonio / Ungureanu, Aurelian / Stankoff, Bruno / Arnulf, Isabelle / Papeix, Caroline / Bodini, Benedetta / Similowski, Thomas / Lubetzki, Catherine / Morélot-Panzini, Capucine

Multiple sclerosis (Houndmills, Basingstoke, England)

2024 Band 30, Heft 6, Seite(n) 726–737

Abstract: Background: Respiratory disorders remain incompletely described in multiple sclerosis (MS), even though they are a frequent cause of death.: Methods: The objective was to describe respiratory disorders in MS patients with Expanded Disability Status ... ...

Abstract	Background: Respiratory disorders remain incompletely described in multiple sclerosis (MS), even though they are a frequent cause of death. Methods: The objective was to describe respiratory disorders in MS patients with Expanded Disability Status Score (EDSS) ⩾ 6.5. Diaphragm dysfunction was defined by at least two of the seven criteria: clinical signs, inspiratory recruitment of neck muscles during wakefulness, reduced upright vital capacity (VC) < 80%, upright-to-supine VC ⩾ 15% of upright VC, decrease in Maximal Inspiratory Pressure < 60%, phasic activation of inspiratory neck muscles during sleep, and opposition of thoracic and abdominal movements during sleep. Cough weakness was defined by a peak cough flow < 270 L/min and/or need for cough assist. Sleep apnea syndrome was defined by an apnea-hypopnea index ⩾ 15. Results: Notably, 71 MS patients were included: median age 54 [48, 61] years; median disease duration 21.4 [16.0, 31.4] years. Of these, 52 patients had one or more respiratory disorders; diaphragm dysfunction was the most frequent ( Conclusion: Respiratory disorders are frequent in severe MS, mostly diaphragm dysfunction. Of interest, instrumental interventions are available to address these disorders.
Mesh-Begriff(e)	Humans ; Male ; Female ; Middle Aged ; Cross-Sectional Studies ; Multiple Sclerosis/complications ; Multiple Sclerosis/physiopathology ; Respiration Disorders/etiology ; Respiration Disorders/physiopathology ; Diaphragm/physiopathology ; Cough/physiopathology ; Cough/etiology ; Severity of Illness Index ; Sleep Apnea Syndromes/physiopathology ; Adult
Sprache	Englisch
Erscheinungsdatum	2024-03-22
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	1290669-4
ISSN	1477-0970 ; 1352-4585
ISSN (online)	1477-0970
ISSN	1352-4585
DOI	10.1177/13524585241238840
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: NIV in amyotrophic lateral sclerosis: The 'when' and 'how' of the matter.

Morelot-Panzini, Capucine / Bruneteau, Gaëlle / Gonzalez-Bermejo, Jesus

Respirology (Carlton, Vic.)

2019 Band 24, Heft 6, Seite(n) 521–530

Abstract: Non-invasive ventilation (NIV) has become an essential part of the treatment of amyotrophic lateral sclerosis (ALS) since 2006. NIV very significantly improves survival, quality of life and cognitive performances. The initial NIV settings are simple, but ...

Abstract	Non-invasive ventilation (NIV) has become an essential part of the treatment of amyotrophic lateral sclerosis (ALS) since 2006. NIV very significantly improves survival, quality of life and cognitive performances. The initial NIV settings are simple, but progression of the disease, ventilator dependence and upper airway involvement sometimes make long-term adjustment of NIV more difficult, with a major impact on survival. Unique data concerning the long-term adjustment of NIV in ALS show that correction of leaks, management of obstructive apnoea and adaptation to the patient's degree of ventilator dependence improve the prognosis. Non-ventilatory factors also impact the efficacy of NIV and various solutions have been described and must be applied, including cough assist techniques, control of excess salivation and renutrition. NIV in ALS has been considerably improved as a result of application of all of these measures, avoiding the need for tracheostomy in the very great majority of cases. More advanced use of NIV also requires pulmonologists to master the associated end-of-life palliative care, as well as the modalities of discontinuing ventilation when it becomes unreasonable.
Mesh-Begriff(e)	Amyotrophic Lateral Sclerosis/physiopathology ; Amyotrophic Lateral Sclerosis/psychology ; Amyotrophic Lateral Sclerosis/therapy ; Cognition ; Humans ; Noninvasive Ventilation/methods ; Prognosis ; Quality of Life
Sprache	Englisch
Erscheinungsdatum	2019-03-25
Erscheinungsland	Australia
Dokumenttyp	Journal Article ; Review
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.13525
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Dyspnoea modifies the recognition of fearful expressions by healthy humans.

Vinckier, Fabien / Morélot-Panzini, Capucine / Similowski, Thomas

The European respiratory journal

2018 Band 51, Heft 2

Mesh-Begriff(e)	Adult ; Carbon Dioxide ; Dyspnea/physiopathology ; Dyspnea/psychology ; Facial Expression ; Facial Recognition ; Fear ; Female ; Healthy Volunteers ; Humans ; Hypercapnia ; Male ; Respiration ; Risk Factors ; Stroop Test ; Young Adult
Chemische Substanzen	Carbon Dioxide (142M471B3J)
Sprache	Englisch
Erscheinungsdatum	2018-02-14
Erscheinungsland	England
Dokumenttyp	Letter
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.02253-2017
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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