Artikel ; Online: Salvage transoral robotic surgery in recurrent oropharyngeal carcinoma: a single-center retrospective study.
2024 Band 281, Heft 6, Seite(n) 3167–3177
Abstract: Purpose: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to ...
Abstract | Purpose: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to present oncological and functional outcomes of a monocentric experience in salvage transoral robotic surgery. Methods: We performed a single-center retrospective analysis of patients submitted to transoral robotic salvage surgery with or without neck dissection for cT1-3 rOPSCC. We investigated complication rate, survival outcomes (Overall Survival, Disease Specific Survival, Loco-Regional Recurrence Free Survival) and functional outcomes (tracheal tube and/or gastrostomy dependence). Results: Sixty-one patients were included in the analysis. No major complications or perioperative deaths were recorded. The estimated 2-year OS was 76.7%, DSS 81.8% and LRRFS 50.5%. In multivariable analysis rpT, PNI (perineural infiltration) and HPV-positivity were significantly associated with LRRFS (Hazard Ratios: T3 vs T1 6.43, PNI yes vs no 4.19, HPV+ yes vs no 2.63). At last follow up, 97% of patients were tracheal tube-free, while 93% were gastrostomy-free. Conclusion: Transoral robotic salvage surgery is a successful treatment in selected patients affected by rOPSCC because it grants good oncologic and functional outcomes. |
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Mesh-Begriff(e) | Humans ; Robotic Surgical Procedures/methods ; Retrospective Studies ; Male ; Salvage Therapy/methods ; Oropharyngeal Neoplasms/surgery ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/mortality ; Female ; Middle Aged ; Neoplasm Recurrence, Local/surgery ; Aged ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/mortality ; Neck Dissection/methods ; Adult ; Treatment Outcome ; Natural Orifice Endoscopic Surgery/methods ; Aged, 80 and over |
Sprache | Englisch |
Erscheinungsdatum | 2024-03-28 |
Erscheinungsland | Germany |
Dokumenttyp | Journal Article |
ZDB-ID | 1017359-6 |
ISSN | 1434-4726 ; 0937-4477 |
ISSN (online) | 1434-4726 |
ISSN | 0937-4477 |
DOI | 10.1007/s00405-024-08590-4 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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