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  1. Buch ; Online ; E-Book: Evidence-based validation of herbal medicine

    Mukherjee, Pulok K.

    translational research on botanicals

    2022  

    Verfasserangabe edited by Pulok K. Mukherjee
    Schlagwörter Electronic books
    Sprache Englisch
    Umfang 1 Online-Ressource (xx, 839 Seiten), Illustrationen
    Ausgabenhinweis Second edition
    Verlag Elsevier
    Erscheinungsort Amsterdam
    Erscheinungsland Niederlande
    Dokumenttyp Buch ; Online ; E-Book
    Anmerkung Description based on publisher supplied metadata and other sources
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021483291
    ISBN 978-0-323-98456-0 ; 9780323855426 ; 0-323-98456-8 ; 0323855423
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch: Evidence based validation of herbal medicine

    Mukherjee, Pulok K.

    farm to pharma

    2015  

    Titelvarianten Evidence-based validation of herbal medicine
    Verfasserangabe ed. by Pulok K. Mukherjee
    Sprache Englisch
    Umfang XVII, 537 S. : Ill., graph. Darst.
    Verlag Amsterdam u.a.
    Erscheinungsort Elsevier
    Erscheinungsland Niederlande
    Dokumenttyp Buch
    HBZ-ID HT018704046
    ISBN 978-0-12-800874-4 ; 0-12-800874-1
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2015 A 2505 ausleihbar (Lesesaal) Lesesaal EG

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  3. Buch: Quality control and evaluation of herbal drugs

    Mukherjee, Pulok K.

    evaluating natural products and traditional medicine

    2019  

    Verfasserangabe Pulok K. Mukherjee
    Schlagwörter Medicinal plants/Quality control
    Thema/Rubrik (Code) 615.321
    Sprache Englisch
    Umfang xxiii, 762 Seiten, Illustrationen
    Verlag Elsevier
    Erscheinungsort Amsterdam
    Erscheinungsland Niederlande
    Dokumenttyp Buch
    HBZ-ID HT020157889
    ISBN 978-0-12-813374-3 ; 9780128133989 ; 0-12-813374-0 ; 0128133988
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2019 A 1172 ausleihbar (Lesesaal) Lesesaal EG

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  4. Artikel ; Online: Antimicrobial and Probiotic Potential of Lactobacilli Associated with Traditional Fermented Beverages.

    Huidrom, Surmani / Mukherjee, Pulok K / Devi, Sarangthem Indira

    Current microbiology

    2024  Band 81, Heft 5, Seite(n) 137

    Abstract: Fermented foods have been recognized as a source of probiotic bacteria which can have a positive effect when administered to humans and animals. Discovering new probiotics in fermented food products poses a global economic and health importance. In this ... ...

    Abstract Fermented foods have been recognized as a source of probiotic bacteria which can have a positive effect when administered to humans and animals. Discovering new probiotics in fermented food products poses a global economic and health importance. In this study, we investigated the antimicrobial and probiotic potential of lactobacilli isolated from fermented beverages produced traditionally by ethnic groups in Northeast India. Out of thirty Lactobacilli, fifteen exhibited strong antimicrobial activity against Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter aerogenes with significant anti-biofilm and anti-quorum sensing activity. These isolates also showed characteristics associated with probiotic properties, such as tolerance to low pH and bile salts, survival in the gastric tract, auto-aggregation, and hydrophobicity without exhibiting hemolysis formation or resistance to certain antibiotics. The isolates were identified using gram staining, biochemical tests, and 16S rDNA sequencing. They exhibited probiotic potential, broad-spectrum of antibacterial activity, promising anti-biofilm, anti-quorum sensing activity, non-hemolytic, and tolerance to acidic pH and bile salts. Overall, four specific Lactobacillus isolates, Lactiplantibacillus plantarum BRD3A and Lacticaseibacillus paracasei RB10OW from fermented rice-based beverage, and Lactiplantibacillus plantarum RB30Y and Lacticaseibacillus paracasei MP11A from traditional local curd demonstrated potent antimicrobial and probiotic properties. These findings suggest that these lactobacilli isolates from fermented beverages have the potential to be used as probiotics with therapeutic benefits, highlighting the importance of traditional fermented foods for promoting gut health and infectious disease management.
    Mesh-Begriff(e) Animals ; Humans ; Lactobacillus ; Anti-Infective Agents ; Fermented Beverages ; Anti-Bacterial Agents/pharmacology ; Bile Acids and Salts
    Chemische Substanzen Anti-Infective Agents ; Anti-Bacterial Agents ; Bile Acids and Salts
    Sprache Englisch
    Erscheinungsdatum 2024-04-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-024-03656-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1446: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel ; Online: Chapter 16 Antiviral Evaluation of Herbal Drugs

    Mukherjee, Pulok K.

    Quality Control and Evaluation of Herbal Drugs

    Abstract: Abstract The viral infection and resistance to the existing antiviral drugs are alarming, which is a serious public health concern. Medicinal plants are valuable resources for treatment of viral infections and can be used for the management of infections ...

    Abstract Abstract The viral infection and resistance to the existing antiviral drugs are alarming, which is a serious public health concern. Medicinal plants are valuable resources for treatment of viral infections and can be used for the management of infections like herpes simplex virus (HSV), human immunodeficiency virus (HIV), influenza, etc. The antiviral screening of plant extracts should be highly selective, specific, and sensitive for bioactivity guided isolation of the active compounds from the plant extracts. The antiviral screening system should be validated for accuracy, reproducibility, simplicity, and cost effectiveness. This chapter highlights on various aspects for screening and evaluation of antiviral natural components including factors affecting antiviral in vivo studies, host cells, organisms, and culture media followed by different virus-specific assays for antiviral screening of natural products.
    Schlagwörter covid19
    Verlag Elsevier; PMC
    Dokumenttyp Artikel ; Online
    DOI 10.1016/b978-0-12-813374-3.00016-8
    Datenquelle COVID19

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  6. Artikel ; Online: Antiviral Evaluation of Herbal Drugs

    Mukherjee, Pulok K.

    Quality Control and Evaluation of Herbal Drugs

    Abstract: The viral infection and resistance to the existing antiviral drugs are alarming, which is a serious public health concern. Medicinal plants are valuable resources for treatment of viral infections and can be used for the management of infections like ... ...

    Abstract The viral infection and resistance to the existing antiviral drugs are alarming, which is a serious public health concern. Medicinal plants are valuable resources for treatment of viral infections and can be used for the management of infections like herpes simplex virus (HSV), human immunodeficiency virus (HIV), influenza, etc. The antiviral screening of plant extracts should be highly selective, specific, and sensitive for bioactivity guided isolation of the active compounds from the plant extracts. The antiviral screening system should be validated for accuracy, reproducibility, simplicity, and cost effectiveness. This chapter highlights on various aspects for screening and evaluation of antiviral natural components including factors affecting antiviral in vivo studies, host cells, organisms, and culture media followed by different virus-specific assays for antiviral screening of natural products.
    Schlagwörter covid19
    Verlag Elsevier; PMC
    Dokumenttyp Artikel ; Online
    DOI 10.1016/b978-0-12-813374-3.00016-8
    Datenquelle COVID19

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  7. Buch: Quality control and evaluation of herbal drugs

    Mukherjee, Pulok K.

    evaluating natural products and traditional medicine

    2019  

    Abstract: The use of herbal medicine in therapeutics is on the rise in both developed and developing countries and this book facilitates the necessary development of quality standards for these medicines. This book elucidates on various challenges and ... ...

    Verfasserangabe Pulok K. Mukherjee
    Abstract The use of herbal medicine in therapeutics is on the rise in both developed and developing countries and this book facilitates the necessary development of quality standards for these medicines. This book elucidates on various challenges and opportunities for quality evaluation of herbal drugs with several integrated approaches including metabolomics, chemoprofiling, marker analysis, stability testing, good practices for manufacturing, clinical aspects, and ethnopharmacology and ethnomedicine inspired drug development. The book highlights on various methods, techniques and approaches for evaluating the purity, quality, safety and efficacy of herbal drugs. Particular attention is paid to methods that assess these drugs' activity, the compounds responsible and their underlying mechanisms of action. The book describes the quality control parameters followed in India and other countries, including Japan, China, Bangladesh, and other Asian countries, as well as the regulatory profiles of the European Union and North America. This book will be useful in bio-prospecting of natural products and traditional medicine-inspired drug discovery and development.--Back cover
    Schlagwörter Materia medica, Vegetable/Quality control. ; Herbs/Therapeutic use/Quality control. ; Natural products/Quality control. ; Traditional medicine. ; Phytothérapie/Qualité/Contrôle. ; Herbes/Emploi en thérapeutique/Qualité/Contrôle. ; Produits naturels/Qualité/Contrôle.
    Sprache Englisch
    Umfang xxiii, 762 pages :, illustrations ;, 28 cm
    Verlag Elsevier
    Erscheinungsort Amsterdam, Netherlands ; Cambridge, MA, United States
    Dokumenttyp Buch
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel: Molecular combination networks in medicinal plants: understanding synergy by network pharmacology in Indian traditional medicine

    Mukherjee, Pulok K. / Banerjee, Subhadip / Kar, Amit

    Phytochemistry reviews. 2021 Aug., v. 20, no. 4

    2021  

    Abstract: Translation of traditional medicine is moving away from the reductionist approach towards harnessing the synergy of poly-pharmacological phyto-combinations that modulate the activity of target networks of underlying disease phenotypes. Metabolomics ... ...

    Abstract Translation of traditional medicine is moving away from the reductionist approach towards harnessing the synergy of poly-pharmacological phyto-combinations that modulate the activity of target networks of underlying disease phenotypes. Metabolomics enabled the profiling of herbal extracts and formulations in high resolution through LC-MS/MS, GC-MS and NMR providing the possibility of multi-component drug discovery. Phytopharmaceuticals are multi-molecular combinations which follow a combinatory treatment module which minimizes off-target toxicity by synergistic potency and improve outcomes by synergistic efficacy. Combination synergy is a multi-dimensional concept where synergy can be observed from a network pharmacology perspective. Network pharmacology uses systems-level drug–response phenotypes originating from various ‘omics’ platforms. This network pharmacology with metabolomics has been proven to be effective in elucidating the mechanisms of action of medicinal plants and complex traditional formulations. LC-MS/MS of medicinal plants along with network pharmacology unveil synergistic molecular combinations which interact with neighbouring targets in a combination synergy network. Case studies on some traditional herbs mentioned in Ayurveda, has been reported based on the combination of network-based methods and metabolomics for establishing the mechanism for their therapeutic potentials. The synergistic combination of molecules interacts with target-disease networks which provide novel, mechanistic insights towards understanding their therapeutic potentials. This review along with case-studies illustrates various strategies to explore the mechanism of action for different synergistic natural products combinations through neighbourhood-based network pharmacology approach.
    Schlagwörter Ayurvedic medicine ; case studies ; drugs ; mechanism of action ; metabolomics ; pharmacology ; phytopharmaceuticals ; therapeutics ; toxicity
    Sprache Englisch
    Erscheinungsverlauf 2021-08
    Umfang p. 693-703.
    Erscheinungsort Springer Netherlands
    Dokumenttyp Artikel
    Anmerkung Review
    ZDB-ID 2065661-0
    ISSN 1572-980X ; 1568-7767
    ISSN (online) 1572-980X
    ISSN 1568-7767
    DOI 10.1007/s11101-020-09730-4
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel: Tolypothrix Dichloromethane Ethylacetate fraction (TDEF) inhibits cisplatin resistance H357 cell through PI3K/AKT/beta-catenin pathway.

    Heisnam, Rameshwari / Thoithoisana Devi, Soibam / Mohanty, Sibasish / Mukherjee, Pulok K / Rayala, Vvs Prasanna Kumari / Radhakrishnanand, Pullapanthula / Dash, Rupesh / Sharma, Nanaocha

    American journal of cancer research

    2024  Band 14, Heft 3, Seite(n) 1071–1086

    Abstract: Chemoresistance is one of the major factors for treatment failure in OSCC. Reprogramming chemoresistance cells to undergo drug induced apoptotic cell death is a feasible approach to overcome drug resistance. Cyanobacteria is considered important sources ... ...

    Abstract Chemoresistance is one of the major factors for treatment failure in OSCC. Reprogramming chemoresistance cells to undergo drug induced apoptotic cell death is a feasible approach to overcome drug resistance. Cyanobacteria is considered important sources of lead compounds for the development of drugs for treating cancer chemoresistance. This study deals with the role of Tolypothrix Dichloromethane Ethyl acetate fraction (TDEF) inducing apoptosis in cisplatin resistance H357 cell (H357cisR) and the underlying mechanisms sensitizing the chemoresistance. TDEF showing effective activity against H357cisR with IC
    Sprache Englisch
    Erscheinungsdatum 2024-03-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    DOI 10.62347/JTNQ4812
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Paris polyphylla Sm. characterized extract infused ointment accelerates diabetic wound healing in In-vivo model.

    Kshetrimayum, Vimi / Chanu, Khaidem Devika / Biona, Thokchom / Kar, Amit / Haldar, Pallab Kanti / Mukherjee, Pulok K / Sharma, Nanaocha

    Journal of ethnopharmacology

    2024  Band 331, Seite(n) 118296

    Abstract: Ethnopharmacological relevance: The dried rhizome of Paris polyphylla Sm. is extensively used by traditional healers in India, China, and Vietnam to treat skin inflammation, cut wounds, uterine and traumatic bleeding, and cancer.: Aim of the study: ... ...

    Abstract Ethnopharmacological relevance: The dried rhizome of Paris polyphylla Sm. is extensively used by traditional healers in India, China, and Vietnam to treat skin inflammation, cut wounds, uterine and traumatic bleeding, and cancer.
    Aim of the study: The traditional use of P. polyphylla rhizomes for treating wounds and bleeding has been reported previously. However, the potential of P. polyphylla in the treatment of diabetic wounds has not yet been explored. Our present study focused on the investigation of the wound-healing activity of P. polyphylla infused ointment in streptozotocin (STZ)-induced diabetic rats to validate the traditional claim.
    Materials and methods: Hydroalcoholic extract of the dried rhizomes of P. polyphylla were quantified by validated and optimized HPTLC (High-performance thin layer chromatography) method for Paris saponin VII, Dioscin and Polyphyllin V. The extract was used to prepare P. polyphylla ointments (5 and 10%). P. polyphylla ointment was subjected to physiochemical analysis and skin irritation test. Thirty STZ-induced diabetic adult male Wistar albino rats were divided into five groups (n = 6) and a circular excision wound was created. P. polyphylla ointment, ointment base (OB), and standard (STD) (Povidone Iodine 10%) were administered topically. The wound area of all groups were recorded every six days and compared with that of control. The epithelization period of each group was recorded. On day 18, the histopathological study of skin tissues of all groups was performed using hematoxylin and eosin (H&E) and Mallory's trichrome (MT).
    Results: Marker analysis and quantification of phytomolecules in hydroalcoholic extract ofP. Polyphylla were found to be of paris saponin VII (3.28 ± 0.08% w/w), dioscin (1.94 ± 0.12% w/w), and polyphyllin V (1.87 ± 0.84% w/w). A physiochemical study of P. polyphylla ointment showed that the prepared ointment was within an acceptable range and was not irritable to the skin. Daily topical administration of 10% P. polyphylla ointment (PP10) for 18 days completely healed the STZ-induced diabetic wounds. On day 18, the 5% P. polyphylla ointment (PP5) showed 99.1 ± 2.9% wound closure, while that of the standard and control was 78.4 ± 7.3% and 18.5 ± 5.9%, respectively. The epithelialization period of PP10 was 18 days, whereas that of the control was 28 days. Histopathological analysis of the progression of PP10 and PP5 wounds showed a decrease in inflammatory cells, regenerated epithelial layer, keratosis layer, hair follicles, fibroblasts, and collagen. Upon collagen intensity quantification of MT stained sections, an increase in collagen density of PP10 and PP5 treated groups was observed, showing accelerated wound healing potential of P. polyphylla extract in diabetic wounds compared to the standard ointment.
    Conclusion: This study suggested the potential of P. polyphylla rhizomes derived formulation to treat diabetic wounds, although the plant is traditionally used to treat normal wounds. The results indicate the validation of traditional claim, which has been explored commercially in industrial aspect.
    Mesh-Begriff(e) Animals ; Wound Healing/drug effects ; Ointments ; Diabetes Mellitus, Experimental/drug therapy ; Rats, Wistar ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology ; Male ; Rats ; Rhizome ; Skin/drug effects ; Skin/pathology ; Skin/injuries ; Streptozocin
    Chemische Substanzen Ointments ; Plant Extracts ; Streptozocin (5W494URQ81)
    Sprache Englisch
    Erscheinungsdatum 2024-05-04
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118296
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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