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Artikel ; Online: The D

Wimer, Lauren / Goncharova, Elena / Galkina, Sofiya / Nyangau, Edna / Shankaran, Mahalakshmi / Davis, Asia / Prado, Leandro / Munoz, Maria Castro / Epstein, Sharon / Patterson, Cavan / Shaum, Nicholas / Hellerstein, Mark / Evans, William / Melov, Simon

Aging cell

2023  Band 22, Heft 8, Seite(n) e13897

Abstract: Developing accurate methods to quantify age-related muscle loss (sarcopenia) could greatly accelerate development of therapies to treat muscle loss in the elderly, as current methods are inaccurate or expensive. The current gold standard method for ... ...

Abstract Developing accurate methods to quantify age-related muscle loss (sarcopenia) could greatly accelerate development of therapies to treat muscle loss in the elderly, as current methods are inaccurate or expensive. The current gold standard method for quantifying sarcopenia is dual-energy X-ray absorptiometry (DXA) but does not measure muscle directly-it is a composite measure quantifying "lean mass" (muscle) excluding fat and bone. In humans, DXA overestimates muscle mass, which has led to erroneous conclusions about the importance of skeletal muscle in human health and disease. In animal models, DXA is a popular method for measuring lean mass. However, instrumentation is expensive and is potentially limited by anesthesia concerns. Recently, the D
Mesh-Begriff(e) Muscle, Skeletal ; Absorptiometry, Photon ; Body Composition ; Animals ; Mice ; Male ; Female ; Mice, Inbred C57BL ; Creatinine/urine ; Body Weights and Measures/methods
Chemische Substanzen Creatinine (AYI8EX34EU)
Sprache Englisch
Erscheinungsdatum 2023-06-05
Erscheinungsland England
Dokumenttyp Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID 2113083-8
ISSN 1474-9726 ; 1474-9718
ISSN (online) 1474-9726
ISSN 1474-9718
DOI 10.1111/acel.13897
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