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Artikel: Novel Concepts in Systemic Sclerosis Pathogenesis: Role for miRNAs.

Szabo, Iulia / Muntean, Laura / Crisan, Tania / Rednic, Voicu / Sirbe, Claudia / Rednic, Simona

2021 Band 9, Heft 10

Abstract: Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes. It is characterized by the pathogenic triad: microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms modulate gene expression without ... ...

Abstract	Systemic sclerosis (SSc) is a rare connective tissue disease with heterogeneous clinical phenotypes. It is characterized by the pathogenic triad: microangiopathy, immune dysfunction, and fibrosis. Epigenetic mechanisms modulate gene expression without interfering with the DNA sequence. Epigenetic marks may be reversible and their differential response to external stimuli could explain the protean clinical manifestations of SSc while offering the opportunity of targeted drug development. Small, non-coding RNA sequences (miRNAs) have demonstrated complex interactions between vasculature, immune activation, and extracellular matrices. Distinct miRNA profiles were identified in SSc skin specimens and blood samples containing a wide variety of dysregulated miRNAs. Their target genes are mainly involved in profibrotic pathways, but new lines of evidence also confirm their participation in impaired angiogenesis and aberrant immune responses. Research approaches focusing on earlier stages of the disease and on differential miRNA expression in various tissues could bring novel insights into SSc pathogenesis and validate the clinical utility of miRNAs as biomarkers and therapeutic targets.
Sprache	Englisch
Erscheinungsdatum	2021-10-14
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines9101471
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Nutrition in Spondyloarthritis and Related Immune-Mediated Disorders.

Popa, Stefan Lucian / Dumitrascu, Dinu Iuliu / Brata, Vlad Dumitru / Duse, Traian Adrian / Florea, Maria Delia / Ismaiel, Abdulrahman / Muntean, Laura Mirela / Grad, Simona

Nutrients

2022 Band 14, Heft 6

Abstract: Recent research on the pathogenesis of spondyloarthritis and related immune-mediated diseases associated with human leukocyte antigen class I molecule B27 (HLA-B27) has led to significant progress in terms of management and prognosis, with multiple ... ...

Abstract	Recent research on the pathogenesis of spondyloarthritis and related immune-mediated diseases associated with human leukocyte antigen class I molecule B27 (HLA-B27) has led to significant progress in terms of management and prognosis, with multiple treatments being constantly evaluated and implemented. Correlations between the genetic background of spondyloarthritis and inflammatory bowel diseases and the inflammatory processes involving gut microbiota have been established. This knowledge has allowed progress in pharmacological therapy. The role of diet in the pathogenesis and treatment of diseases pertaining to the HLA-B27 spectrum is of great significance, considering possible future applications in individualized medicine. Diet impacts the composition of gut microbiota, representing a substrate for the synthesis of metabolites affecting the mucosal immune system. Certain pro-inflammatory mediators, such as emulsifiers and microparticles, induce a more profound cytokine response, promoting inflammation. Numerous diets, including the low-starch diet, the Mediterranean diet, diets with low contents of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (low-FODMAP diets), gluten-free diets and fasting, have been analysed and correlated with patients' symptomatology and dietary adherence. The aim of this review is to provide an extensive perspective on the diets available to patients with spondyloarthritis and related immune-mediated disorders.
Mesh-Begriff(e)	Diet, Carbohydrate-Restricted ; Gastrointestinal Microbiome/physiology ; Humans ; Monosaccharides ; Nutritional Status ; Spondylarthritis
Chemische Substanzen	Monosaccharides
Sprache	Englisch
Erscheinungsdatum	2022-03-17
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14061278
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Nutrition in Spondyloarthritis and Related Immune-Mediated Disorders

Popa, Stefan Lucian / Dumitrascu, Dinu Iuliu / Brata, Vlad Dumitru / Duse, Traian Adrian / Florea, Maria Delia / Ismaiel, Abdulrahman / Muntean, Laura Mirela / Grad, Simona

Nutrients. 2022 Mar. 17, v. 14, no. 6

2022

Abstract	Recent research on the pathogenesis of spondyloarthritis and related immune-mediated diseases associated with human leukocyte antigen class I molecule B27 (HLA-B27) has led to significant progress in terms of management and prognosis, with multiple treatments being constantly evaluated and implemented. Correlations between the genetic background of spondyloarthritis and inflammatory bowel diseases and the inflammatory processes involving gut microbiota have been established. This knowledge has allowed progress in pharmacological therapy. The role of diet in the pathogenesis and treatment of diseases pertaining to the HLA-B27 spectrum is of great significance, considering possible future applications in individualized medicine. Diet impacts the composition of gut microbiota, representing a substrate for the synthesis of metabolites affecting the mucosal immune system. Certain pro-inflammatory mediators, such as emulsifiers and microparticles, induce a more profound cytokine response, promoting inflammation. Numerous diets, including the low-starch diet, the Mediterranean diet, diets with low contents of fermentable oligosaccharides, disaccharides, monosaccharides and polyols (low-FODMAP diets), gluten-free diets and fasting, have been analysed and correlated with patients’ symptomatology and dietary adherence. The aim of this review is to provide an extensive perspective on the diets available to patients with spondyloarthritis and related immune-mediated disorders.
Schlagwörter	FODMAP diet ; HLA antigens ; Mediterranean diet ; cytokines ; fasting ; genetic background ; immune system ; inflammation ; intestinal microorganisms ; metabolites ; mucosal immunity ; pathogenesis ; polyols ; precision medicine ; prognosis
Sprache	Englisch
Erscheinungsverlauf	2022-0317
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14061278
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Contributions Regarding the Optimization of Job Descriptions Elaboration Process in the Knowledge-based Organization

Muntean Laura / Titu Aurel Mihail / Oprean Constantin

Lecture Notes in Engineering and Computer Science, Vol 2210, Iss 1, Pp 1088-

2014 Band 1093

Schlagwörter	Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
Sprache	Englisch
Erscheinungsdatum	2014-03-01T00:00:00Z
Verlag	Newswood and International Association of Engineers
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Contributions Regarding the Design of a Procedure for the Elaboration of the Job Descriptions

Muntean Laura / Oprean Constantin / Titu Aurel Mihail

Lecture Notes in Engineering and Computer Science, Vol 2210, Iss 1, Pp 969-

2014 Band 974

Schlagwörter	Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
Sprache	Englisch
Erscheinungsdatum	2014-03-01T00:00:00Z
Verlag	Newswood and International Association of Engineers
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Acroosteolysis in systemic sclerosis: An insight into hypoxia-related pathogenesis.

Siao-Pin, Simon / Damian, Laura-Otilia / Muntean, Laura Mirela / Rednic, Simona

Experimental and therapeutic medicine

2016 Band 12, Heft 5, Seite(n) 3459–3463

Abstract: Acro-osteolysis, or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. The mechanisms that disturbs local homeostatic balance of bone formation and resorption in favor of osteoclast ... ...

Abstract	Acro-osteolysis, or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. The mechanisms that disturbs local homeostatic balance of bone formation and resorption in favor of osteoclast activation and pathological bone loss remain to be established. Vascular alterations and reduced capillary density impair tissue oxygenation in systemic sclerosis, and the resulting hypoxia might contribute directly to the disease progression. In this paper we summarize the current evidence for hypoxia as the common pathophysiological denominator of digital vasculopathy and enhanced osteoclastic activity in systemic sclerosis-associated acroosteolysis. The hypoxia-inducible transcription factor HIF-1α and VEGF signaling has a critical role in regulating osteoclastic bone-resorption and angiogenesis, and increased osteoclastogenesis and higher VEGF levels may contribute to acroosteolysis in systemic sclerosis. The cells of the osteoblast lineage also have important roles in angiogenic-osteogenic coupling. The research in this field might help limiting the disability associated with the disease.
Sprache	Englisch
Erscheinungsdatum	2016-10-05
Erscheinungsland	Greece
Dokumenttyp	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2016.3782
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Bone mineral density, carotid artery intima-media thickness, and Klotho gene polymorphism in postmenopausal women

Muntean Laura / Simon Siao-pin / Popp Radu / Albu Adriana / Fodor Daniela

Open Medicine, Vol 9, Iss 2, Pp 315-

2014 Band 324

Schlagwörter	klotho ; osteoporosis ; atherosclerosis ; genetics ; carotid intima-media thickness ; Medicine ; R
Sprache	Englisch
Erscheinungsdatum	2014-04-01T00:00:00Z
Verlag	De Gruyter
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Clinical and ultrasound findings in patients with calcium pyrophosphate dihydrate deposition disease.

Vele, Paulina / Simon, Siao-Pin / Damian, Laura / Felea, Ioana / Muntean, Laura / Filipescu, Ileana / Rednic, Simona

Medical ultrasonography

2018 Band 20, Heft 2, Seite(n) 159–163

Abstract: Aim: To evaluate the presence and distribution of calcium pyrophosphate (CPP) deposits in joints commonly affected by CPP deposition (CPPD) disease (acromio-clavicular, gleno-humeral, wrists, hips, knees, ankles, and symphysis pubis joints) using ... ...

Abstract	Aim: To evaluate the presence and distribution of calcium pyrophosphate (CPP) deposits in joints commonly affected by CPP deposition (CPPD) disease (acromio-clavicular, gleno-humeral, wrists, hips, knees, ankles, and symphysis pubis joints) using ultrasound (US). Material and methods: Thirty consecutive patients fulfilling McCarty diagnostic criteria for CPPD were consecutively enrolled in the study. The data registered using the US included the affected joints, the calcification site, and the pattern of calcification (thin hyperechoic bands, parallel to the surface of the hyaline cartilage, hyperechoic spots, and hyperechoic nodular or oval deposits). The presence of CPP crystals in knees was confirmed by polarized light microscopy examination of the synovial fluid and radiographs of the knees were performed in all patients. Results: In 30 patients, 390 joints were scanned, (13 joints in every patient). The mean±standard deviation number of joints with US CPPD evidence per patient was 2.93±1.8 (range 1-9). The knee was the most common joint involved both clinically and using US examination. The second US pattern (with hyperechoic spots) was the most frequent. Fibrocartilage calcifications were more common than hyaline calcification. Using radiography as reference method, the sensitivity and specificity of US for diagnosis CPPD in knees was 79.31%, 95CI(66.65%-88.83%), and 14.29%, 95CI(1.78%-42.81%), respectively. Conclusions: The knee is the most frequent joint affected by CPPD. The second ultrasound pattern is the most common. CPPD affects the fibrocartilage to a greater extent than the hyaline cartilage.
Mesh-Begriff(e)	Chondrocalcinosis/diagnostic imaging ; Chondrocalcinosis/pathology ; Female ; Humans ; Joints/diagnostic imaging ; Joints/pathology ; Knee Joint/diagnostic imaging ; Knee Joint/pathology ; Male ; Middle Aged ; Prospective Studies ; Sensitivity and Specificity ; Synovial Fluid/diagnostic imaging ; Ultrasonography/methods
Sprache	Englisch
Erscheinungsdatum	2018-05-04
Erscheinungsland	Romania
Dokumenttyp	Journal Article
ZDB-ID	2529623-1
ISSN	2066-8643 ; 1844-4172
ISSN (online)	2066-8643
ISSN	1844-4172
DOI	10.11152/mu-1193
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Bone mineral density, vertebral fractures and body mass index in postmenopausal women with abdominal aortic calcification.

Simon, Siao-pin / Fodor, Daniela / Muntean, Laura / Poanta, Laura / Cristea, Paulina / Rednic, Simona

Endocrine research

2014 Band 39, Heft 1, Seite(n) 1–6

Abstract: Background: Evidence suggest that there are connections between osteoporosis and cardiovascular diseases.: Objectives: The aim of the study was to analyze the relationship between radiological measurements of abdominal aorta calcifications (AAC) and ... ...

Abstract	Background: Evidence suggest that there are connections between osteoporosis and cardiovascular diseases. Objectives: The aim of the study was to analyze the relationship between radiological measurements of abdominal aorta calcifications (AAC) and bone mineral density (BMD) in postmenopausal women. Methods: In this cross-sectional study were included 125 postmenopausal women 50-84 years of age. BMD of the spine and hip was measured by dual energy X-ray absorptiometry (DXA). AAC were assessed by lateral radiographs of lumbar spine (L1-L4), using the antero-posterior severity score (0-24). Vertebral fractures were evaluated from T4 to L4 using Genant's semiquantitative method. Results: Forty-one (32.8%) patients had osteoporosis and 61 (48.8%) had AAC with a mean score of 3.1. Postmenopausal women with AAC were older and had significantly lower femoral neck and trochanteric BMD than subjects without AAC (all p < 0.01). There were no significant differences in the frequency of fractures between subjects with AAC and those without AAC (p > 0.05). In univariate analysis, age, height, weight, femoral and trochanter BMD were significantly associated with the severity of AAC score. In multiple regression analysis, femoral neck BMD, but not lumbar spine, trochanter BMD or age, was an independent predictor of AAC. Conclusions: Reduced femoral neck BMD is negatively associated with the presence of AAC in postmenopausal women. The association between BMD and AAC seems to be age-independent, which suggests a common pathogenesis for bone loss and vascular calcifications.
Mesh-Begriff(e)	Aged ; Aged, 80 and over ; Aortic Diseases/complications ; Aortic Diseases/physiopathology ; Body Mass Index ; Bone Density/physiology ; Calcinosis/complications ; Calcinosis/physiopathology ; Cross-Sectional Studies ; Female ; Humans ; Middle Aged ; Postmenopause/physiology ; Spinal Fractures/complications ; Spinal Fractures/physiopathology
Sprache	Englisch
Erscheinungsdatum	2014
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605823-1
ISSN	1532-4206 ; 0743-5800
ISSN (online)	1532-4206
ISSN	0743-5800
DOI	10.3109/07435800.2013.794425
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Power Doppler signal at the enthesis and bone erosions are the most discriminative OMERACT ultrasound lesions for SpA: results from the DEUS (Defining Enthesitis on Ultrasound in Spondyloarthritis) multicentre study.

Di Matteo, Andrea / Smerilli, Gianluca / Di Donato, Stefano / Liu, An Ran / Becciolini, Andrea / Camarda, Federica / Cazenave, Tomas / Cipolletta, Edoardo / Corradini, Davide / de Agustín, Juan José / Destro Castaniti, Giulia Maria / Di Donato, Eleonora / Di Geso, Luca / Duran, Emine / Farisogullari, Bayram / Fornaro, Marco / Francioso, Francesca / Giorgis, Pamela / Granel, Amelia /

Hernández-Díaz, Cristina / Horvath, Rudolf / Hurnakova, Jana / Jesus, Diogo / Karadag, Omer / Li, Ling / Marin, Josefina / Martire, María Victoria / Michelena, Xabier / Moscioni, Erica / Muntean, Laura / Piga, Matteo / Rosemffet, Marcos / Rovisco, João / Sahin, Didem / Salaffi, Fausto / Saraiva, Liliana / Scioscia, Crescenzio / Tamas, Maria-Magdalena / Tanimura, Shun / Venetsanopoulou, Aliki / Ventura-Rios, Lucio / Villota, Orlando / Villota-Eraso, Catalina / Voulgari, Paraskevi V / Vukatana, Gentiana / Zacariaz Hereter, Johana / Marzo-Ortega, Helena / Grassi, Walter / Filippucci, Emilio

Annals of the rheumatic diseases

2024

Abstract: Objectives: To assess, in spondyloarthritis (SpA), the discriminative value of the Outcome Measures in Rheumatology (OMERACT) ultrasound lesions of enthesitis and their associations with clinical features in this population.: Methods: In this ... ...

Abstract	Objectives: To assess, in spondyloarthritis (SpA), the discriminative value of the Outcome Measures in Rheumatology (OMERACT) ultrasound lesions of enthesitis and their associations with clinical features in this population. Methods: In this multicentre study involving 20 rheumatology centres, clinical and ultrasound examinations of the lower limb large entheses were performed in 413 patients with SpA (axial SpA and psoriatic arthritis) and 282 disease controls (osteoarthritis and fibromyalgia). 'Active enthesitis' was defined as (1) power Doppler (PD) at the enthesis grade ≥1 plus entheseal thickening and/or hypoechoic areas, or (2) PD grade >1 (independent of the presence of entheseal thickening and/or hypoechoic areas). Results: In the univariate analysis, all OMERACT lesions except enthesophytes/calcifications showed a significant association with SpA. PD (OR=8.77, 95% CI 4.40 to 19.20, p<0.001) and bone erosions (OR=4.75, 95% CI 2.43 to 10.10, p<0.001) retained this association in the multivariate analysis. Among the lower limb entheses, only the Achilles tendon was significantly associated with SpA (OR=1.93, 95% CI 1.30 to 2.88, p<0.001) in the multivariate analyses. Active enthesitis showed a significant association with SpA (OR=9.20, 95% CI 4.21 to 23.20, p<0.001), and unlike the individual OMERACT ultrasound lesions it was consistently associated with most clinical measures of SpA disease activity and severity in the regression analyses. Conclusions: This large multicentre study assessed the value of different ultrasound findings of enthesitis in SpA, identifying the most discriminative ultrasound lesions and entheseal sites for SpA. Ultrasound could differentiate between SpA-related enthesitis and other forms of entheseal pathology (ie, mechanical enthesitis), thus improving the assessment of entheseal involvement in SpA.
Sprache	Englisch
Erscheinungsdatum	2024-03-05
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard-2023-225443
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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