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  1. Artikel ; Online: Corrigendum to "Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of Parkinson's disease" [Cell. Immunol. 327 (2018) 77-82].

    Karpenko, M N / Vasilishina, A A / Gromova, E A / Muruzheva, Z M / Bernadotte, A

    Cellular immunology

    2018  Band 334, Seite(n) 99

    Sprache Englisch
    Erscheinungsdatum 2018-09-10
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Published Erratum
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2018.08.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Role of Copper Dyshomeostasis in the Pathogenesis of Parkinson's Disease.

    Karpenko, M N / Ilyicheva, E Yu / Muruzheva, Z M / Milyukhina, I V / Orlov, Yu A / Puchkova, L V

    Bulletin of experimental biology and medicine

    2018  Band 164, Heft 5, Seite(n) 596–600

    Abstract: Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding ... ...

    Abstract Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apoceruloplasmin to holoceruloplasmin in patients with Parkinson's disease was similar in both groups. Treatment of blood serum with Helex 100, a high-affinity copper chelator, revealed reduced content of labile copper atoms per ceruloplasmin molecule in patients with Parkinson's disease in comparison with that in healthy controls. The mechanism underlying impaired metabolic incorporation of labile copper atoms into CP molecule is discussed as a possible cause of copper dyshomeostasis associated with Parkinson's disease.
    Mesh-Begriff(e) Animals ; Autonomic Nervous System/metabolism ; Autonomic Nervous System/physiology ; Blood Pressure/physiology ; Copper/metabolism ; Heart Rate/physiology ; Humans ; Hypoxia/metabolism ; Hypoxia/physiopathology ; Male ; Parkinson Disease/metabolism ; Parkinson Disease/physiopathology ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism
    Chemische Substanzen Copper (789U1901C5) ; Superoxide Dismutase (EC 1.15.1.1)
    Sprache Englisch
    Erscheinungsdatum 2018-03-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 390407-6
    ISSN 1573-8221 ; 0007-4888 ; 0365-9615
    ISSN (online) 1573-8221
    ISSN 0007-4888 ; 0365-9615
    DOI 10.1007/s10517-018-4039-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of Parkinson's disease.

    Karpenko, M N / Vasilishina, A A / Gromova, E A / Muruzheva, Z M / Miliukhina, I V / Bernadotte, A

    Cellular immunology

    2018  Band 327, Seite(n) 77–82

    Abstract: Several parameters representing the clinical diversity of Parkinson's disease (PD), including severity, phenotypes, cognitive decline, anxiety and depression were analyzed to examine the link with interleukin-1β (IL-1β), the interleukin-1 receptor ... ...

    Abstract Several parameters representing the clinical diversity of Parkinson's disease (PD), including severity, phenotypes, cognitive decline, anxiety and depression were analyzed to examine the link with interleukin-1β (IL-1β), the interleukin-1 receptor antagonist (IL-1RA), IL-6, IL-10, and tumor necrosis factor-α (TNFα) and also to determine the relationship between levels of these factors in serum and cerebrospinal fluid (CSF). Significantly elevated serum IL-1β and IL-6 and reduced IL-1RA levels were found in the PD group. In CSF and serum, inflammatory factors behaved differently, with increased CSF TNFα indicating rapid PD progression, and increased IL-1β in serum. A low level of IL-6 was associated with a longer duration of PD. Anxiety, depression, non-tremor phenotype and late-onset PD correlated with a high serum level of IL-10. The serum TNFα level was lower in PD patients with mild cognitive impairment compared to controls. Serum IL-1β, IL-6 and IL-10 levels correlated with CSF markers.
    Mesh-Begriff(e) Aged ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Female ; Humans ; Interleukin 1 Receptor Antagonist Protein/analysis ; Interleukin 1 Receptor Antagonist Protein/blood ; Interleukin 1 Receptor Antagonist Protein/cerebrospinal fluid ; Interleukin-10/analysis ; Interleukin-10/blood ; Interleukin-10/cerebrospinal fluid ; Interleukin-1beta/analysis ; Interleukin-1beta/blood ; Interleukin-1beta/cerebrospinal fluid ; Interleukin-6/analysis ; Interleukin-6/blood ; Interleukin-6/cerebrospinal fluid ; Male ; Middle Aged ; Parkinson Disease/blood ; Parkinson Disease/cerebrospinal fluid ; Parkinson Disease/metabolism ; Tumor Necrosis Factor-alpha/analysis ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/cerebrospinal fluid
    Chemische Substanzen Biomarkers ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1beta ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Interleukin-10 (130068-27-8)
    Sprache Englisch
    Erscheinungsdatum 2018-02-19
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2018.02.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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