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Article ; Online: Temporal relationships between blood glucose, lipids and BMI, and their impacts on atherosclerosis: a prospective cohort study.

Jin, Shanshan / Liu, Junyi / Jia, Yubing / Sun, Changhao / Na, Lixin

2024 Volume 14, Issue 6, Page(s) e079521

Abstract: Objectives: This study aimed to explore the temporal relationship between blood glucose, lipids and body mass index (BMI), and their impacts on atherosclerosis (AS).: Design: A prospective cohort study was designed.: Setting and participants: A ... ...

Abstract	Objectives: This study aimed to explore the temporal relationship between blood glucose, lipids and body mass index (BMI), and their impacts on atherosclerosis (AS). Design: A prospective cohort study was designed. Setting and participants: A total of 2659 subjects from Harbin Cohort Study on Diet, Nutrition and Chronic Non-communicable Diseases, and aged from 20 to 74 years were included. Primary and secondary outcome measures: Body weight, height, fasting blood glucose (FBG) and 2-hour postprandial glucose (2-h PG), blood lipids including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) were measured at baseline and follow-up. Brachial ankle pulse wave velocity (baPWV) was examined at follow-up as a marker of AS risk. Logistic regression analysis, cross-lagged path analysis and mediation analysis were performed to explore the temporal relationships between blood glucose, lipids and BMI, and their impacts on AS risk. Results: Logistic regression analysis indicated that increased FBG, 2-h PG, TC, TG, LDL-c and BMI were positively associated with AS risk, while increased HDL-c was negatively associated with AS risk. The path coefficients from baseline blood parameters to the follow-up BMI were significantly greater than those from baseline BMI to the follow-up blood parameters. Mediation analysis suggested that increased FBG, 2-h PG, TC, TG and LDL-c could increase AS risk via increasing BMI, the effect intensity from strong to weak was LDL-c>TC>TG>FBG>2 h PG, while increased HDL-c could decrease AS risk via decreasing BMI. Conclusions: Changes in blood glucose and lipids could cause change in BMI, which mediated the impacts of blood glucose and lipids on AS risk. These results highlight the importance and provide support for the early and comprehensive strategies of AS prevention and control.
MeSH term(s)	Humans ; Middle Aged ; Male ; Body Mass Index ; Prospective Studies ; Blood Glucose/metabolism ; Blood Glucose/analysis ; Female ; Atherosclerosis/blood ; Atherosclerosis/etiology ; Adult ; Lipids/blood ; Aged ; Risk Factors ; Pulse Wave Analysis ; Young Adult ; China/epidemiology ; Ankle Brachial Index ; Triglycerides/blood ; Logistic Models
Chemical Substances	Blood Glucose ; Lipids ; Triglycerides
Language	English
Publishing date	2024-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-079521
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of soda water on blood lipid and metabolic profiling of urine in hyperlipidemia rats using UPLC/Triple-TOF MS.

Han, Dan / Shi, Litian / Yu, Junjie / Na, Lixin

Heliyon

2023 Volume 9, Issue 11, Page(s) e21666

Abstract: The effects of a natural soda water (Shi Han Quan, SHQ) on hyperlipidemia and the changes of urine metabolic profiling by metabolomics techniques were investigate. Thirty six Wistar rats weighing 160-200 g were divided into control group, hyperlipidemia ( ...

Abstract	The effects of a natural soda water (Shi Han Quan, SHQ) on hyperlipidemia and the changes of urine metabolic profiling by metabolomics techniques were investigate. Thirty six Wistar rats weighing 160-200 g were divided into control group, hyperlipidemia (HL) group, and hyperlipidemia + SHQ water (SHQ) group. The metabolites in urine were determined using ultra high performance liquid chromatography-triple-time of flight-mass spectrometry (UPLC/Triple-TOF MS). At the end of 1 month and 3 months, the total glyceride (TG) level was significantly lower in SHQ group compared to HL group. There was no significantly difference in total cholesterol (TC) levels in HL group compared with SHQ group. The results showed that dinking SHQ water can improve the TG, but with no effects on TC. After drinking SHQ water for 3 months, the rats in different groups could be classified into different clusters according to the metabolites in urine. Total 15 important metabolites were found and correlated with disturbance of amino acid, phospholipid, fatty acid and vitamin metabolism, which suggested the changes of metabolism in the body and possible mechanism by which SHQ improved the TG. These findings provide a new insight for the prevention and control of hyperlipidemia.
Language	English
Publishing date	2023-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21666
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Article ; Online: Protective effect of manganese treatment on insulin resistance in HepG2 hepatocytes.

Zhang, Qingwen / Song, Shili / Jiang, Ruyue / Zhang, Jingyi / Na, Lixin

Nutricion hospitalaria

2023 Volume 40, Issue 4, Page(s) 746–754

Abstract: Introduction: Objectives: manganese (Mn) is closely related to type 2 diabetes mellitus and insulin resistance (IR), but the exact mechanism is unclear. This study aimed to explore the regulatory effects and mechanism of Mn on IR using hepatocyte IR ... ...

Title translation	Efecto protector del tratamiento con manganeso sobre la resistencia a la insulina en hepatocitos HepG2.
Abstract	Introduction: Objectives: manganese (Mn) is closely related to type 2 diabetes mellitus and insulin resistance (IR), but the exact mechanism is unclear. This study aimed to explore the regulatory effects and mechanism of Mn on IR using hepatocyte IR model induced by high palmitate (PA), high glucose (HG) or insulin. Methods: HepG2 cells were exposed to PA (200 μM), HG (25 mM) or insulin (100 nM) respectively, alone or with 5 μM Mn for 24 hours. The expression of key proteins in insulin signaling pathway, intracellular glycogen content and glucose accumulation, reactive oxygen species (ROS) level and Mn superoxide dismutase (MnSOD) activity were detected. Results: compared with control group, the expression of phosphorylated protein kinase B (Akt), glycogen synthase kinase-3β (GSK-3β) and forkhead box O1 (FOXO1) in the three IR groups was declined, and this decrease was reversed by Mn. The reduction of intracellular glycogen content and increase in glucose accumulation in IR groups were also inhibited by Mn. Additionally, the production of ROS was increased in IR models, compared with normal control group, while Mn reduced the excessive production of ROS induced by PA, HG or insulin. However, Mn did not alter the activity of MnSOD in the three IR models. Conclusion: this study demonstrated that Mn treatment can improve IR in hepatocytes. The mechanism is probably by reducing the level of intracellular oxidative stress, enhancing the activity of Akt/GSK-3β/FOXO1 signal pathway, promoting glycogen synthesis, and inhibiting gluconeogenesis.
MeSH term(s)	Humans ; Insulin Resistance ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/pharmacology ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycogen Synthase Kinase 3 beta/pharmacology ; Manganese/pharmacology ; Manganese/metabolism ; Reactive Oxygen Species/metabolism ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Hepatocytes ; Insulin/pharmacology ; Insulin/metabolism ; Glucose/pharmacology ; Glycogen/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Manganese (42Z2K6ZL8P) ; Reactive Oxygen Species ; Insulin ; Glucose (IY9XDZ35W2) ; Glycogen (9005-79-2)
Language	English
Publishing date	2023-07-06
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1481223-x
ISSN	1699-5198 ; 0212-1611
ISSN (online)	1699-5198
ISSN	0212-1611
DOI	10.20960/nh.04521
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Article: Retraction Note to: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours.

Xu, Fei / Na, Lixin / Li, Yanfei / Chen, Linjun

Cell & bioscience

2021 Volume 11, Issue 1, Page(s) 157

Language	English
Publishing date	2021-08-06
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	2593367-X
ISSN	2045-3701
ISSN	2045-3701
DOI	10.1186/s13578-021-00667-5
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Article ; Online: Vitamin D deficiency in early life regulates gut microbiome composition and leads to impaired glucose tolerance in adult and offspring rats.

Liu, Jing / Liu, Junyi / Zhang, Jingyi / Liu, Chunyan / Qu, Chunbo / Na, Lixin

Food & function

2023 Volume 14, Issue 12, Page(s) 5768–5786

Abstract: Vitamin D has been found to be involved in glucose metabolism in recent years. Its deficiency is very common, especially in children. Whether vitamin D deficiency in early life affects adult diabetes risk is unknown. In this study, a rat model of early ... ...

Abstract	Vitamin D has been found to be involved in glucose metabolism in recent years. Its deficiency is very common, especially in children. Whether vitamin D deficiency in early life affects adult diabetes risk is unknown. In this study, a rat model of early life vitamin D deficiency (F1 Early-VDD) was established by depriving it of vitamin D from the 0 to the 8th week. Further, some rats were switched to normal feeding conditions and sacrificed at the 18th week. Other rats were mated randomly to generate offspring rats (F2 Early-VDD), and F2 rats were fed under normal conditions and sacrificed at the 8th week. Serum 25(OH)D
MeSH term(s)	Rats ; Animals ; Gastrointestinal Microbiome ; Glucose Intolerance ; Vitamin D Deficiency/metabolism ; Vitamin D/metabolism ; Vitamins
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo00503h
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Article ; Online: Geographic location and ethnicity comprehensively influenced vitamin D status in college students: a cross-section study from China.

Luo, Yingyi / Qu, Chunbo / Zhang, Rui / Zhang, Jingyi / Han, Dan / Na, Lixin

Journal of health, population, and nutrition

2023 Volume 42, Issue 1, Page(s) 145

Abstract: Background: Vitamin D plays an important role in the health of adolescents, whereas vitamin D status of Chinese college students was seldom studied in China. To explore the vitamin D status and its relationship with ethnicity and geographic location in ... ...

Abstract	Background: Vitamin D plays an important role in the health of adolescents, whereas vitamin D status of Chinese college students was seldom studied in China. To explore the vitamin D status and its relationship with ethnicity and geographic location in Chinese college students. Methods: The freshmen were taken a physical examination by trained medical personnel after they reported to university. Demographic information including age, gender, ethnicity, region of original residence was collected using a questionnaire survey. Serum 25(OH)D Results: Totally 3220 freshmen who came from 26 provinces, autonomous districts or municipalities were recruited, with a mean age of 18.75 ± 1.18 years and 70.2% of them were female. The mean serum 25(OH)D Conclusions: Vitamin D deficiency is an important health problem in Chinese college students. Sunlight activities, dietary and life-style intervention for college students according to geographic location and ethnicities should be considered.
MeSH term(s)	Adolescent ; Humans ; Female ; Young Adult ; Adult ; Male ; Vitamin D ; Ethnicity ; Vitamin D Deficiency/epidemiology ; Diet ; China/epidemiology
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-12-20
Publishing country	Bangladesh
Document type	Journal Article
ZDB-ID	2025045-9
ISSN	2072-1315 ; 1606-0997
ISSN (online)	2072-1315
ISSN	1606-0997
DOI	10.1186/s41043-023-00488-x
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Article: Roles of Epigenetic Modifications in the Differentiation and Function of Pancreatic β-Cells.

Xu, Fei / Liu, Jing / Na, Lixin / Chen, Linjun

publication RETRACTED

Frontiers in cell and developmental biology

2020 Volume 8, Page(s) 748

Abstract: Diabetes, a metabolic disease with multiple causes characterized by high blood sugar, has become a public health problem. Hyperglycaemia is caused by deficiencies in insulin secretion, impairment of insulin function, or both. The insulin secreted by ... ...

Abstract	Diabetes, a metabolic disease with multiple causes characterized by high blood sugar, has become a public health problem. Hyperglycaemia is caused by deficiencies in insulin secretion, impairment of insulin function, or both. The insulin secreted by pancreatic β cells is the only hormone in the body that lowers blood glucose levels and plays vital roles in maintaining glucose homeostasis. Therefore, investigation of the molecular mechanisms of pancreatic β cell differentiation and function is necessary to elucidate the processes involved in the onset of diabetes. Although numerous studies have shown that transcriptional regulation is essential for the differentiation and function of pancreatic β cells, increasing evidence indicates that epigenetic mechanisms participate in controlling the fate and regulation of these cells. Epigenetics involves heritable alterations in gene expression caused by DNA methylation, histone modification and non-coding RNA activity that does not result in DNA nucleotide sequence alterations. Recent research has revealed that a variety of epigenetic modifications play an important role in the development of diabetes. Here, we review the mechanisms by which epigenetic regulation affects β cell differentiation and function.
Language	English
Publishing date	2020-08-28
Publishing country	Switzerland
Document type	Systematic Review ; Retracted Publication
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2020.00748
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Article: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours.

Xu, Fei / Na, Lixin / Li, Yanfei / Chen, Linjun

publication RETRACTED

Cell & bioscience

2020 Volume 10, Issue 1, Page(s) 54

Abstract: The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis. Compared with those of other signalling pathways, the ... ...

Abstract	The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis. Compared with those of other signalling pathways, the components of the PI3K/AKT/mTOR signalling pathway are complicated. The regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway are important in many human diseases, including ischaemic brain injury, neurodegenerative diseases, and tumours. PI3K/AKT/mTOR signalling pathway inhibitors include single-component and dual inhibitors. Numerous PI3K inhibitors have exhibited good results in preclinical studies, and some have been clinically tested in haematologic malignancies and solid tumours. In this review, we briefly summarize the results of research on the PI3K/AKT/mTOR pathway and discuss the structural composition, activation, communication processes, regulatory mechanisms and biological functions of the PI3K/AKT/mTOR signalling pathway in the pathogenesis of neurodegenerative diseases and tumours.
Language	English
Publishing date	2020-04-01
Publishing country	England
Document type	Journal Article ; Review ; Retracted Publication
ZDB-ID	2593367-X
ISSN	2045-3701
ISSN	2045-3701
DOI	10.1186/s13578-020-00416-0
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Article ; Online: Vitamin D status in children and its association with glucose metabolism in northern China: a combination of a cross-sectional and retrospective study.

Liu, Junyi / Fu, Liqun / Jin, Shanshan / Jia, Yubing / Zhang, Jingyi / Sun, Changhao / Na, Lixin

BMJ open

2022 Volume 12, Issue 11, Page(s) e061146

Abstract: Objectives: This study aimed to explore the vitamin D status of children in northern China and the association between vitamin D and glucose metabolism.: Design: Cross-sectional study was conducted among child participants and retrospective study ... ...

Abstract	Objectives: This study aimed to explore the vitamin D status of children in northern China and the association between vitamin D and glucose metabolism. Design: Cross-sectional study was conducted among child participants and retrospective study designs were conducted among adult participants. Setting and participants: Both studies were recruited from Harbin, 326 children were included in children's study, 8469 adults were included in adult study. Primary and secondary outcome measures: Physical examination, lifestyle and dietary habit data were recorded in all the participants. Serum insulin, glucose, 25(OH)D Result: In the children's study, only 10.7% of participants were vitamin D sufficient (≥30 ng/mL). Inverse correlations between serum 25(OH)D Conclusion: Our findings suggest that vitamin D deficiency is widespread in northern China. Vitamin D deficiency in childhood was associated with IR and increased the risk of type 2 diabetes in male adults.
MeSH term(s)	Adult ; Child ; Female ; Male ; Humans ; Vitamin D ; Cross-Sectional Studies ; Retrospective Studies ; Insulin Resistance ; Diabetes Mellitus, Type 2/epidemiology ; Vitamins ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Rickets ; Insulin ; Glucose ; China/epidemiology
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins ; Insulin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-061146
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Article ; Online: Diet, physical activity, and UV protection comprehensively influenced vitamin D status in college students: a cross-section study from China.

Luo, Yingyi / Qu, Chunbo / Zhang, Rui / Zhang, Jingyi / Han, Dan / Zhang, Qingwen / Li, Jiaxing / Na, Lixin

Journal of health, population, and nutrition

2023 Volume 42, Issue 1, Page(s) 73

Abstract: Background: Vitamin D deficiency is one of the most prevalent health problems worldwide in all age groups, whereas vitamin D status of Chinese college students was seldom studied in China. The purpose of this study was to explore the vitamin D status in ...

Abstract	Background: Vitamin D deficiency is one of the most prevalent health problems worldwide in all age groups, whereas vitamin D status of Chinese college students was seldom studied in China. The purpose of this study was to explore the vitamin D status in Chinese college freshmen and its influencing factors, providing evidence for nutrition strategy application. Methods: Information including demographic status, diet habit, physical activity, and ultraviolet ray (UV) protection was collected by online questionnaire. Serum 25(OH)D Results: Totally 1667 freshmen from 26 provinces, autonomous districts or municipalities, were recruited, with a mean age of 18.6 ± 0.9 years. The mean serum 25(OH)D Conclusions: Vitamin D deficiency is very common in Chinese college students. Milk and yogurt intake and outdoor activity should be encouraged while candy intake should be limited for preventing vitamin D deficiency. Public health policies should focus on these changeable lifestyles and consider well-balanced guidelines on UV protection and vitamin D supplementation.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Adult ; Vitamin D ; Diet ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/prevention & control ; Exercise ; Students ; Dietary Supplements
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-07-26
Publishing country	Bangladesh
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2025045-9
ISSN	2072-1315 ; 1606-0997
ISSN (online)	2072-1315
ISSN	1606-0997
DOI	10.1186/s41043-023-00421-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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