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Artikel ; Online: Neighborhood archetypes and breast cancer survival in California.

Shariff-Marco, Salma / DeRouen, Mindy C / Yang, Juan / Jain, Jennifer / Nelson, David O / Weden, Margaret M / Gomez, Scarlett L

Annals of epidemiology

2021 Band 57, Seite(n) 22–29

Abstract: Purpose: Previous studies on neighborhoods and breast cancer survival examined neighborhood variables as unidimensional measures (e.g. walkability or deprivation) individually and thus cannot inform how the multitude of highly correlated neighborhood ... ...

Abstract	Purpose: Previous studies on neighborhoods and breast cancer survival examined neighborhood variables as unidimensional measures (e.g. walkability or deprivation) individually and thus cannot inform how the multitude of highly correlated neighborhood domains interact to impact breast cancer survival. Neighborhood archetypes were developed that consider interactions among a broad range of neighborhood social and built environment attributes and examine their associations with breast cancer survival. Methods: Archetypes were measured using latent class analysis (LCA) fit to California census tract-level data. Thirty-nine social and built environment attributes relevant to eight neighborhood domains (socioeconomic status (SES), urbanicity, demographics, housing, land use, commuting and traffic, residential mobility, and food environment) were included. The archetypes were linked to cancer registry data on breast cancer cases (diagnosed 1996-2005 with follow-up through Dec 31, 2017) to evaluate their associations with overall and breast cancer-specific survival using Cox proportional hazards models. Analyses were stratified by race/ethnicity. Results: California neighborhoods were best described by nine archetypal patterns that were differentially associated with overall and breast cancer-specific survival. The lowest risk of overall death was observed in the upper middle class suburb (reference) and high status neighborhoods, while the highest was observed among inner city residents with a 39% greater risk of death (95% CI = 1.35 to 1.44). Results were similar for breast cancer-specific survival. Stratified analyses indicated that differences in survival by neighborhood archetypes varied according to individuals' race/ethnicity. Conclusions: By describing neighborhood archetypes that differentiate survival following breast cancer diagnosis, the study provides direction for policy and clinical practice addressing contextually-rooted social determinants of health including SES, unhealthy food environments, and greenspace.
Mesh-Begriff(e)	Breast Neoplasms ; California/epidemiology ; Ethnicity ; Humans ; Residence Characteristics ; Social Class ; Socioeconomic Factors
Sprache	Englisch
Erscheinungsdatum	2021-02-10
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1074355-8
ISSN	1873-2585 ; 1047-2797
ISSN (online)	1873-2585
ISSN	1047-2797
DOI	10.1016/j.annepidem.2021.01.004
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The authors respond.

Hurley, Susan / Nelson, David O / Bernstein, Leslie / Reynolds, Peggy

Epidemiology (Cambridge, Mass.)

2015 Band 26, Heft 4, Seite(n) e51

Mesh-Begriff(e)	Breast Neoplasms/etiology ; Circadian Rhythm ; Female ; Humans ; Lighting/adverse effects ; Residence Characteristics
Sprache	Englisch
Erscheinungsdatum	2015-07
Erscheinungsland	United States
Dokumenttyp	Comment ; Letter
ZDB-ID	1053263-8
ISSN	1531-5487 ; 1044-3983
ISSN (online)	1531-5487
ISSN	1044-3983
DOI	10.1097/EDE.0000000000000306
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: A breast cancer case-control study of polybrominated diphenyl ether (PBDE) serum levels among California women

Hurley, Susan / Goldberg, Debbie / Park, June-Soo / Petreas, Myrto / Bernstein, Leslie / Anton-Culver, Hoda / Neuhausen, Susan L / Nelson, David O / Reynolds, Peggy

Environment international. 2019 June, v. 127

2019

Abstract: Polybrominated diphenyl ethers (PBDEs) are among the most persistent and pervasive global environmental contaminants. Their toxic and endocrine-disrupting properties have made them a focus of concern for breast cancer. Our objective was to evaluate the ... ...

Abstract	Polybrominated diphenyl ethers (PBDEs) are among the most persistent and pervasive global environmental contaminants. Their toxic and endocrine-disrupting properties have made them a focus of concern for breast cancer. Our objective was to evaluate the risk of breast cancer associated with serum PBDE levels in a case-control study nested within the California Teachers Study.Participants were 902 women with invasive breast cancer (cases) and 936 with no such diagnosis (controls) who provided 10 mL of blood and were interviewed between 2011 and 2015. Blood samples were collected from cases an average of 35 months after diagnosis. PBDEs were measured in serum using automated solid phase extraction and gas chromatography/high resolution mass spectrometry. Statistical analyses were restricted to the three congeners with detection frequencies ≥75%: 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47), 2,2′,4,4′,6-pentabromodiphenyl ether (BDE-100), and 2,2′,4,4′,5,5′-hexabromodiphenyl ether (BDE-153). Unconditional logistic regression was used to estimate multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CI) for each BDE congener, adjusting for serum lipids and other potential confounders.The OR for each of the three BDE congeners was close to unity with a CI that included one. Analyses stratified by menopausal status, tumor hormone responsiveness, BMI, and changes in body weight yielded similarly null results.Our findings provide no evidence that serum levels of BDE-47, BDE-100 or BDE-153 are associated with breast cancer risk. These results should be interpreted in the context of study limitations which include the reliance on PBDE measurements that may not represent pre-diagnostic, early-life or chronic exposures and a lack of information on genetic polymorphisms and other factors which may affect endogenous estrogen levels.
Schlagwörter	blood lipids ; blood sampling ; blood serum ; body mass index ; body weight ; breast neoplasms ; case-control studies ; chronic exposure ; confidence interval ; estrogens ; gas chromatography ; genetic polymorphism ; mass spectrometry ; menopause ; odds ratio ; pollution ; polybrominated diphenyl ethers ; regression analysis ; risk ; solid phase extraction ; teachers ; toxicity ; women ; California
Sprache	Englisch
Erscheinungsverlauf	2019-06
Umfang	p. 412-419.
Erscheinungsort	Elsevier Ltd
Dokumenttyp	Artikel
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2019.03.043
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Breast cancer risk and serum levels of per- and poly-fluoroalkyl substances: a case-control study nested in the California Teachers Study.

Hurley, Susan / Goldberg, Debbie / Wang, Miaomiao / Park, June-Soo / Petreas, Myrto / Bernstein, Leslie / Anton-Culver, Hoda / Nelson, David O / Reynolds, Peggy

Environmental health : a global access science source

2018 Band 17, Heft 1, Seite(n) 83

Abstract: Background: Per- and poly- fluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Their potential as breast carcinogens is unclear. Our objective was to evaluate the risk ... ...

Abstract	Background: Per- and poly- fluoroalkyl substances (PFASs) are a large family of synthetic chemicals, some of which are mammary toxicants and endocrine disruptors. Their potential as breast carcinogens is unclear. Our objective was to evaluate the risk of breast cancer associated with serum PFAS concentrations in a nested case-control study within the California Teachers Study. Methods: Participants were 902 women with invasive breast cancer (cases) and 858 with no such diagnosis (controls) who provided 10 mL of blood and were interviewed during 2011-2015, an average of 35 months after case diagnosis. PFASs were measured using automated online SPE-HPLC-MS/MS methods. Statistical analyses were restricted to six PFASs with detection frequencies ≥ 95%: PFOA (Perfluorooctanoic acid), PFNA (Perfluorononanoic acid), PFUnDA (Perfluoroundecanoic acid), PFHxS (Perfluorohexane sulfonic acid), PFOS (Perfluorooctane sulfonic acid), and MeFOSAA (2-(N-Methyl-perfluorooctane sulfonamido) acetic acid. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs), estimating the breast cancer risk associated with each PFAS. Results: For all cases of invasive breast cancer, none of the adjusted ORs were statistically significant but marginally significant ORs < 1.0 were observed for PFUnDA and PFHxS (p-trend = 0.08). Adjusted ORs < 1.0 for PFUnDA and PFHxS were statistically significant (p ≤ 0.05) among the 107 cases with hormone-negative tumors but not the 743 with hormone-positive tumors. Conclusion: Overall, these findings do not provide evidence that serum PFAS levels measured after diagnosis are related to breast cancer risk. The few inverse associations found may be due to chance or may be artifacts of study design. Future studies should incorporate information about genetic susceptibility, endogenous estrogen levels, and measurements of PFASs prior to diagnosis and treatment.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Alkanesulfonic Acids/blood ; Breast Neoplasms/blood ; Breast Neoplasms/epidemiology ; California/epidemiology ; Case-Control Studies ; Environmental Monitoring ; Environmental Pollutants/blood ; Fatty Acids/blood ; Female ; Fluorocarbons/blood ; Humans ; Middle Aged ; Odds Ratio ; Risk ; Young Adult
Chemische Substanzen	Alkanesulfonic Acids ; Environmental Pollutants ; Fatty Acids ; Fluorocarbons
Sprache	Englisch
Erscheinungsdatum	2018-11-27
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1476-069X
ISSN (online)	1476-069X
DOI	10.1186/s12940-018-0426-6
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evaluating an owner-to-worker training intervention in California nail salons using personal air monitoring.

Quach, Thu / Von Behren, Julie / Nelson, David O / Nguyen, Tuan N / Tsoh, Janice / Le, Minhthu / Fu, Lisa / Beckman, Stella / Reynolds, Peggy

American journal of industrial medicine

2018 Band 61, Heft 10, Seite(n) 831–841

Abstract: Background: Chemicals in nail products have been linked to numerous health concerns.: Methods: We recruited Vietnamese-American nail salon owners and workers in California and randomized salons into an intervention or control group. Owners in the ... ...

Abstract	Background: Chemicals in nail products have been linked to numerous health concerns. Methods: We recruited Vietnamese-American nail salon owners and workers in California and randomized salons into an intervention or control group. Owners in the intervention group received training and then provided education to workers in their salons on best practices to reduce workplace chemical exposures. Methyl methacrylate (MMA), toluene, and total volatile organic compounds (TVOCs) were measured using personal air monitors worn by workers during the work-shift. Results: We enrolled 77 salons (37 intervention and 40 control) and 200 workers. There was no significant intervention effect between the two groups. However, MMA and TVOCs were higher for workers who used gel polish and acrylic nails as well as in busy salons. Conclusions: Although the intervention did not show reductions in chemical levels, identifying worker tasks and salon characteristics that predict chemical levels can inform future interventions to reduce exposures.
Mesh-Begriff(e)	Adult ; Air Pollutants, Occupational ; Air Pollution, Indoor ; Asian Americans ; Beauty Culture/education ; California ; Environmental Monitoring/methods ; Female ; Humans ; Male ; Methylmethacrylate ; Middle Aged ; Occupational Exposure/prevention & control ; Occupational Health ; Teaching ; Toluene ; Volatile Organic Compounds ; Workplace
Chemische Substanzen	Air Pollutants, Occupational ; Volatile Organic Compounds ; Methylmethacrylate (196OC77688) ; Toluene (3FPU23BG52)
Sprache	Englisch
Erscheinungsdatum	2018-08-12
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	604538-8
ISSN	1097-0274 ; 0271-3586
ISSN (online)	1097-0274
ISSN	0271-3586
DOI	10.1002/ajim.22897
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Residential exposure to estrogen disrupting hazardous air pollutants and breast cancer risk: the California Teachers Study.

Liu, Ruiling / Nelson, David O / Hurley, Susan / Hertz, Andrew / Reynolds, Peggy

Epidemiology (Cambridge, Mass.)

2015 Band 26, Heft 3, Seite(n) 365–373

Abstract: Background: Some studies show increased breast cancer risk from exposure to xenoestrogens, but few have explored exposures via ambient air, which could impact large populations.: Objectives: This study explored the association between breast cancer ... ...

Abstract	Background: Some studies show increased breast cancer risk from exposure to xenoestrogens, but few have explored exposures via ambient air, which could impact large populations. Objectives: This study explored the association between breast cancer risk and residential exposures to ambient estrogen disruptors among participants in a large cohort study, the California Teachers Study. Methods: Participants consisted of 112,379 women free of breast cancer and living at a California address in 1995/1996. Eleven hazardous air pollutants from the US Environmental Protection Agency 2002 list were identified as estrogen disruptors based on published endocrine disrupting chemical lists and literature review. Census-tract estrogen disruptor air concentrations modeled by the US Environmental Protection Agency in 2002 were assigned to participants' baseline addresses. Cox proportional hazards models were used to estimate hazard ratios associated with exposure to each estrogen disruptor and a summary measure of nine estrogenic hazardous air pollutants among all participants and selected subgroups, adjusting for age, race/birthplace, socioeconomic status, and known breast cancer risk factors. Results: Five thousand three hundred sixty-one invasive breast cancer cases were identified between 1995 and 2010. No associations were found between residential exposure to ambient estrogen disruptors and overall breast cancer risk or hormone receptor-positive breast cancer risk, nor among targeted subgroups of participants (pre-/peri-menopausal women, post-menopausal women, never-smokers, non-movers, and never-smoking non-movers). However, elevated risks for hormone receptor-negative tumors were observed for higher exposure to cadmium compounds and possibly inorganic arsenic among never-smoking non-movers. Conclusion: Long-term, low-dose exposure to ambient cadmium compounds or possibly inorganic arsenic may be a risk factor for breast cancer.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Air Pollutants/adverse effects ; Breast Neoplasms/chemically induced ; Breast Neoplasms/epidemiology ; California/epidemiology ; Cohort Studies ; Endocrine Disruptors/adverse effects ; Estrogen Antagonists/adverse effects ; Faculty/statistics & numerical data ; Female ; Humans ; Inhalation Exposure/adverse effects ; Inhalation Exposure/statistics & numerical data ; Middle Aged ; Proportional Hazards Models ; Risk Factors ; Young Adult
Chemische Substanzen	Air Pollutants ; Endocrine Disruptors ; Estrogen Antagonists
Sprache	Englisch
Erscheinungsdatum	2015-03-04
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1053263-8
ISSN	1531-5487 ; 1044-3983
ISSN (online)	1531-5487
ISSN	1044-3983
DOI	10.1097/EDE.0000000000000277
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Hazardous air pollutants and breast cancer risk in California teachers: a cohort study.

Garcia, Erika / Hurley, Susan / Nelson, David O / Hertz, Andrew / Reynolds, Peggy

Environmental health : a global access science source

2015 Band 14, Seite(n) 14

Abstract: Background: Studies suggest that higher breast cancer rates in urban areas persist after accounting for the prevalence of known risk factors, leading to speculation that urban environmental exposures, such as air pollution, may play a role in the ... ...

Abstract	Background: Studies suggest that higher breast cancer rates in urban areas persist after accounting for the prevalence of known risk factors, leading to speculation that urban environmental exposures, such as air pollution, may play a role in the etiology of breast cancer. Combining modeled ambient air concentrations with data from a large prospective cohort of California women with over 15 years of follow-up, we examined the relationship between breast cancer incidence and modeled concentrations of air pollutants shown to be mammary gland carcinogens (MGCs). Methods: The study population of 112,378 California Teachers Study participants included 5,676 women diagnosed with invasive breast cancer. Modeled annual average ambient air concentrations of 24 MGCs from the U.S. Environmental Protection Agency were linked to participants' addresses. Cox proportional hazards models were used to estimate hazard rate ratios and 95% confidence intervals associated with residential MGC levels. MGCs were examined individually and as a combined summary variable for all participants, in selected subsets, and by tumor hormone responsiveness. Results: Initial models yielded some evidence for increased risk for several compounds, including acrylamide, carbon tetrachloride, chloroprene, 4,4'-methylene bis(2-chloroaniline), propylene oxide, and vinyl chloride, but after adjustment for multiple comparisons, only results for propylene oxide and vinyl chloride remained statistically significant. In subset analyses, estrogen-receptor positive or progesterone-receptor positive (ER+/PR+) tumors were associated with higher ambient levels of acrylamide, benzidine, carbon tetrachloride, ethylidene dichloride, and vinyl chloride, while ER-/PR- tumors were associated with higher ambient levels of benzene. Interesting results for different compounds were observed within certain subsets of the population. Conclusion: While our initial models yielded several elevated risk estimates, after adjusting for multiple comparisons and breast cancer risk factors, most hazard ratios were no longer statistically significant. Our subset analyses, however, suggest that elevated risk may be associated with some compounds for certain subgroups of interest. A summary variable for all 24 MGCs did not offer any advantage over the models for individual compounds. Results must be interpreted cautiously, as estimated exposure was limited to modeled annual average ambient air concentrations, and could not account for other sources or routes other than inhalation.
Mesh-Begriff(e)	Adult ; Aged ; Aged, 80 and over ; Air Pollutants/toxicity ; Breast Neoplasms/chemically induced ; Breast Neoplasms/epidemiology ; California/epidemiology ; Carcinogens/toxicity ; Cohort Studies ; Environmental Exposure ; Environmental Monitoring ; Female ; Humans ; Incidence ; Mammary Glands, Human/drug effects ; Middle Aged ; Models, Theoretical ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Young Adult
Chemische Substanzen	Air Pollutants ; Carcinogens
Sprache	Englisch
Erscheinungsdatum	2015-01-30
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2092232-2
ISSN	1476-069X ; 1476-069X
ISSN (online)	1476-069X
ISSN	1476-069X
DOI	10.1186/1476-069X-14-14
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Time Trends in Per- and Polyfluoroalkyl Substances (PFASs) in California Women: Declining Serum Levels, 2011-2015.

Hurley, Susan / Goldberg, Debbie / Wang, Miaomiao / Park, June-Soo / Petreas, Myrto / Bernstein, Leslie / Anton-Culver, Hoda / Nelson, David O / Reynolds, Peggy

Environmental science & technology

2017 Band 52, Heft 1, Seite(n) 277–287

Abstract: After several decades of widespread use, some per- and polyfluoroalkyl substances (PFASs) were phased-out of use due to concerns raised by their persistent, bioaccumulative, and toxic properties. Our objective was to evaluate temporal trends in serum ... ...

Abstract	After several decades of widespread use, some per- and polyfluoroalkyl substances (PFASs) were phased-out of use due to concerns raised by their persistent, bioaccumulative, and toxic properties. Our objective was to evaluate temporal trends in serum PFAS levels among 1257 middle-aged and older California women (ages 40-94) during a four year period, beginning approximately 5-10 years after these phase-outs began. An online SPE-HPLC-MS/MS was used to measure 10 long-chain PFASs in serum from blood collected cross-sectionally during 2011-2015 from a subset of participants in the California Teachers Study. Results from multivariable linear regression analyses indicated that serum concentrations of nearly all PFASs declined on average 10% to 20% per year. Serum levels of perfluorohexanesulfonic acid (PFHxS) did not significantly decline. With the exception of PFHxS, the downward trend in serum concentrations was evident for all PFASs across all ages, although declines were comparatively steeper among the oldest women. These findings suggest that the phase-out of some common PFASs has resulted in reduced human exposures to them. The lack of a decline for PFHxS suggests that these exposures may be ongoing and underscores the importance of continued biomonitoring and research efforts to elucidate current pathways of exposure.
Mesh-Begriff(e)	California ; Environmental Monitoring ; Environmental Pollutants ; Female ; Fluorocarbons ; Humans ; Middle Aged ; Tandem Mass Spectrometry
Chemische Substanzen	Environmental Pollutants ; Fluorocarbons
Sprache	Englisch
Erscheinungsdatum	2017-12-19
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.7b04650
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Tracing a Path to the Past: Exploring the Use of Commercial Credit Reporting Data to Construct Residential Histories for Epidemiologic Studies of Environmental Exposures.

Hurley, Susan / Hertz, Andrew / Nelson, David O / Layefsky, Michael / Von Behren, Julie / Bernstein, Leslie / Deapen, Dennis / Reynolds, Peggy

American journal of epidemiology

2017 Band 185, Heft 3, Seite(n) 238–246

Abstract: Large-scale environmental epidemiologic studies often rely on exposure estimates based on linkage to residential addresses. This approach, however, is limited by the lack of residential histories typically available for study participants. Our objective ... ...

Abstract	Large-scale environmental epidemiologic studies often rely on exposure estimates based on linkage to residential addresses. This approach, however, is limited by the lack of residential histories typically available for study participants. Our objective was to evaluate the feasibility of using address data from LexisNexis (a division of RELX, Inc., Dayton, Ohio), a commercially available credit reporting company, to construct residential histories for participants in the California Teachers Study (CTS), a prospective cohort study initiated in 1995-1996 to study breast cancer (n = 133,479). We evaluated the degree to which LexisNexis could provide retrospective addresses prior to study enrollment, as well as the concordance with existing prospective CTS addresses ascertained at the time of the completion of 4 self-administered questionnaires. For approximately 80% of CTS participants, LexisNexis provided at least 1 retrospective address, including nearly 25,000 addresses completely encompassed by time periods prior to enrollment. This approach more than doubled the proportion of the study population for whom we had an address of residence during the childbearing years-an important window of susceptibility for breast cancer risk. While overall concordance between the prospective addresses contained in these 2 data sources was good (85%), it was diminished among black women and women under the age of 40 years.
Mesh-Begriff(e)	Accounting ; Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/epidemiology ; California ; Cohort Studies ; Databases, Factual ; Demography ; Environmental Exposure/statistics & numerical data ; Epidemiologic Methods ; Female ; Humans ; Middle Aged ; Young Adult
Sprache	Englisch
Erscheinungsdatum	2017--01
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kww108
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Temporal Evaluation of Polybrominated Diphenyl Ether (PBDE) Serum Levels in Middle-Aged and Older California Women, 2011–2015

Hurley, Susan / Goldberg, Debbie / Nelson, David O / Guo, Weihong / Wang, Yunzhu / Baek, Hyoung-Gee / Park, June-Soo / Petreas, Myrto / Bernstein, Leslie / Anton-Culver, Hoda / Reynolds, Peggy

Environmental Science & Technology. 2017 Apr. 18, v. 51, no. 8

2017

Abstract: In response to health concerns and widespread human exposures, two widely used commercial formulations of polybrominated diphenyl ethers (PBDEs) were banned in the United States in 2005. Initial biomonitoring data have provided early indications of ... ...

Abstract	In response to health concerns and widespread human exposures, two widely used commercial formulations of polybrominated diphenyl ethers (PBDEs) were banned in the United States in 2005. Initial biomonitoring data have provided early indications of reduced human exposures since these bans took effect. Our objective was to evaluate temporal trends in PBDE serum levels among a population of older California women during a four-year period, beginning approximately five years after these formulations were banned. Automated solid phase extraction and gas chromatography/high resolution mass spectrometry were used to measure PBDE levels in blood collected during 2011–2015 among 1253 women (ages 40–94) participating in the California Teachers Study. Only congeners with detection frequencies (DF) ≥ 75% were included in the present analysis: BDE-47 (DF = 88%); BDE-100 (DF = 78%); and BDE-153 (DF = 80%). Results from age- and race/ethnicity-adjusted linear regression analyses indicated modest, but statistically significant, average annual percent increases in the serum concentrations of all three PBDEs over the four-year study period. While not without limitations, these results, in the context of other biomonitoring data, suggest that earlier reported declines in PBDE levels may have plateaued and may now be starting to increase. Further biomonitoring to ascertain current trends and determinants of population exposures is warranted.
Schlagwörter	blood serum ; environmental monitoring ; gas chromatography ; humans ; mass spectrometry ; polybrominated diphenyl ethers ; regression analysis ; solid phase extraction ; women ; California
Sprache	Englisch
Erscheinungsverlauf	2017-0418
Umfang	p. 4697-4704.
Erscheinungsort	American Chemical Society
Dokumenttyp	Artikel
ISSN	1520-5851
DOI	10.1021%2Facs.est.7b00565
Datenquelle	NAL Katalog (AGRICOLA)

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Über subito bestellen

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Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED