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  1. Article ; Online: Advancing antibody-drug conjugates in gynecological malignancies: myth or reality?

    Nerone, Marta / Grande, Maria Del / Sessa, Cristiana / Colombo, Ilaria

    Exploration of targeted anti-tumor therapy

    2022  Volume 3, Issue 2, Page(s) 149–171

    Abstract: Antibody-drug conjugates (ADCs) represent a new class of therapeutic agents designed to target specific antigens on tumor cells, combining the specificity of monoclonal antibodies to the cytotoxicity of classic chemotherapy agents. These drugs have been ... ...

    Abstract Antibody-drug conjugates (ADCs) represent a new class of therapeutic agents designed to target specific antigens on tumor cells, combining the specificity of monoclonal antibodies to the cytotoxicity of classic chemotherapy agents. These drugs have been extensively studied both in solid and hematologic malignancies, leading to substantial improvement in the therapeutic landscape for several tumors. Despite no ADC have been yet approved for the treatment of gynecological malignancies, some agents have shown promising results and might have the potential to become part of the standard of care. Among them, mirvetuximab soravtansine has shown activity in platinum-resistant ovarian cancer with high folate-α receptor expression, as a single agent and in combination. Tisotumab vedotin is active in patients with pre-treated cervical cancer, and further investigation is ongoing. The purpose of this review is to summarize the structural and functional characteristics of ADCs and analyze the most recent and promising data regarding the clinical development of ADCs in gynecological malignancies. The available data on the efficacy of the more studied ADCs in ovarian, endometrial, and cervical cancers will be discussed along with toxicities of special interest, the mechanisms of resistance, and future possible drugs combination.
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2692-3114
    ISSN (online) 2692-3114
    DOI 10.37349/etat.2022.00077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Beyond PARP Inhibitors in Advanced Breast Cancer Patients with Germline

    Nerone, Marta / Rossi, Lorenzo / Condorelli, Rosaria / Ratti, Vilma / Conforti, Fabio / Palazzo, Antonella / Graffeo, Rossella

    Cancers

    2023  Volume 15, Issue 13

    Abstract: We explored the outcomes of ... ...

    Abstract We explored the outcomes of germline
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Predictive variables of palbociclib dose reduction and its impact on survival outcomes: A retrospective bicentric study.

    Ogliari, Francesca Rita / Caspani, Francesca / Rossi, Lorenzo / Nerone, Marta / Vallini, Ilaria / Gueli, Rossana

    The breast journal

    2021  Volume 27, Issue 4, Page(s) 415–416

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols ; Breast Neoplasms ; Drug Tapering ; Female ; Humans ; Piperazines ; Pyridines ; Receptor, ErbB-2 ; Retrospective Studies
    Chemical Substances Piperazines ; Pyridines ; Receptor, ErbB-2 (EC 2.7.10.1) ; palbociclib (G9ZF61LE7G)
    Language English
    Publishing date 2021-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1111/tbj.14195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Whole-Body Composition Features by Computed Tomography in Ovarian Cancer: Pilot Data on Survival Correlations.

    Raia, Giorgio / Del Grande, Maria / Colombo, Ilaria / Nerone, Marta / Manganaro, Lucia / Gasparri, Maria Luisa / Papadia, Andrea / Del Grande, Filippo / Rizzo, Stefania

    Cancers

    2023  Volume 15, Issue 9

    Abstract: Background: The primary objective of this study was to assess the associations of computed tomography (CT)-based whole-body composition values with overall survival (OS) and progression-free survival (PFS) in epithelial ovarian cancer (EOC) patients. ... ...

    Abstract Background: The primary objective of this study was to assess the associations of computed tomography (CT)-based whole-body composition values with overall survival (OS) and progression-free survival (PFS) in epithelial ovarian cancer (EOC) patients. The secondary objective was the association of body composition with chemotherapy-related toxicity.
    Methods: Thirty-four patients (median age 64.9 years; interquartile range 55.4-75.4) with EOC and thorax and abdomen CT scans were included. Clinical data recorded: age; weight; height; stage; chemotherapy-related toxicity; and date of last contact, progression and death. Automatic extraction of body composition values was performed by dedicated software. Sarcopenia was defined according to predefined cutoffs. Statistical analysis included univariate tests to investigate associations of sarcopenia and body composition with chemotoxicity. Association of body composition parameters and OS/PFS was evaluated by log-rank test and Cox proportional hazard model. Multivariate models were adjusted for FIGO stage and/or age at diagnosis.
    Results: We found significant associations of skeletal muscle volume with OS (
    Conclusions: In this exploratory study, we found significant associations of whole-body composition parameters with OS and PFS. These results open a window to the possibility to perform body composition profiling without approximate estimations.
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15092602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: PCSK9 inhibitors for treating dyslipidemia in patients at different cardiovascular risk: a systematic review and a meta-analysis.

    Squizzato, Alessandro / Suter, Matteo Basilio / Nerone, Marta / Giugliano, Robert Patrick / Dentali, Francesco / Maresca, Andrea Maria / Campiotti, Leonardo / Grandi, Anna Maria / Guasti, Luigina

    Internal and emergency medicine

    2017  Volume 12, Issue 7, Page(s) 1043–1053

    Abstract: Statin-induced lowering of low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular morbidity and mortality, but many patients do not adequately reduce their LDL-C levels. Monoclonal antibodies targeting PCKS9 are currently in the advanced ... ...

    Abstract Statin-induced lowering of low-density lipoprotein cholesterol (LDL-C) reduces cardiovascular morbidity and mortality, but many patients do not adequately reduce their LDL-C levels. Monoclonal antibodies targeting PCKS9 are currently in the advanced phase of development. We aimed to investigate the efficacy and safety of PCSK9 inhibitors in patients at different cardiovascular risk in a systematic review. Studies were searched on MEDLINE and EMBASE until January 2016. Differences in the outcomes among groups were expressed as mean differences, or pooled odds ratio (OR) and corresponding 95% confidence interval (CI), which were calculated using a fixed-effects and a random-effects model. Statistical heterogeneity was evaluated using the I
    MeSH term(s) Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Dyslipidemias/drug therapy ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Proprotein Convertase 9/antagonists & inhibitors ; Risk Factors
    Chemical Substances Antibodies, Monoclonal ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2017-07-10
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-017-1708-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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