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  1. Artikel ; Online: Atraumatic Bone Marrow Edema Involving the Epiphyses.

    Woertler, Klaus / Neumann, Jan

    Seminars in musculoskeletal radiology

    2023  Band 27, Heft 1, Seite(n) 45–53

    Abstract: Bone marrow edema (BME)-like signal intensity involving the epiphyses of tubular bones represents a frequent magnetic resonance imaging finding associated with a wide spectrum of bone and joint disorders. It is important to distinguish this finding from ... ...

    Abstract Bone marrow edema (BME)-like signal intensity involving the epiphyses of tubular bones represents a frequent magnetic resonance imaging finding associated with a wide spectrum of bone and joint disorders. It is important to distinguish this finding from cellular infiltration of bone marrow and to be aware of the differential diagnosis of underlying causes. With a general focus on the adult musculoskeletal system, this article reviews the pathophysiology, clinical presentation, histopathology, and imaging findings of nontraumatic conditions associated with epiphyseal BME-like signal intensity: transient bone marrow edema syndrome, subchondral insufficiency fracture, avascular necrosis, osteoarthritis, arthritis, and bone neoplasms.
    Mesh-Begriff(e) Adult ; Humans ; Bone Marrow ; Epiphyses ; Diagnosis, Differential ; Edema ; Fractures, Stress
    Sprache Englisch
    Erscheinungsdatum 2023-03-03
    Erscheinungsland United States
    Dokumenttyp Review ; Journal Article
    ZDB-ID 1360919-1
    ISSN 1098-898X ; 1089-7860
    ISSN (online) 1098-898X
    ISSN 1089-7860
    DOI 10.1055/s-0043-1761498
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch ; Dissertation / Habilitation: Quantifizierung des UL30-Gens des Cytomegalievirus mittels Realtime-PCR

    Neumann, Jan Kristian

    eine Untersuchung zur Früherkennung von Cytomegalievirus-Infektionen bei Transplantationspatienten

    2005  

    Verfasserangabe vorgelegt von Jan Kristian Neumann
    Sprache Deutsch
    Umfang IV, 62 S. : Ill., graph. Darst.
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Kiel, Univ., Diss., 2005
    HBZ-ID HT014519834
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  3. Artikel ; Online: Artificial Intelligence Resolves Kinetic Pathways of Magnesium Binding to RNA.

    Neumann, Jan / Schwierz, Nadine

    Journal of chemical theory and computation

    2022  Band 18, Heft 2, Seite(n) 1202–1212

    Abstract: Magnesium is an indispensable cofactor in countless vital processes. In order to understand its functional role, the characterization of the binding pathways to biomolecules such as RNA is crucial. Despite the importance, a molecular description is still ...

    Abstract Magnesium is an indispensable cofactor in countless vital processes. In order to understand its functional role, the characterization of the binding pathways to biomolecules such as RNA is crucial. Despite the importance, a molecular description is still lacking since the transition from the water-mediated outer-sphere to the direct inner-sphere coordination is on the millisecond time scale and therefore out of reach for conventional simulation techniques. To fill this gap, we use transition path sampling to resolve the binding pathways and to elucidate the role of the solvent in the binding process. The results reveal that the molecular void provoked by the leaving phosphate oxygen of the RNA is immediately filled by an entering water molecule. In addition, water molecules from the first and second hydration shell couple to the concerted exchange. To capture the intimate solute-solvent coupling, we perform a committor analysis as the basis for a machine learning algorithm that derives the optimal deep learning model from thousands of scanned architectures using hyperparameter tuning. The results reveal that the properly optimized deep network architecture recognizes the important solvent structures, extracts the relevant information, and predicts the commitment probability with high accuracy. Our results provide detailed insights into the solute-solvent coupling which is ubiquitous for kosmotropic ions and governs a large variety of biochemical reactions in aqueous solutions.
    Mesh-Begriff(e) Artificial Intelligence ; Magnesium/chemistry ; RNA/chemistry ; Solvents/chemistry ; Water/chemistry
    Chemische Substanzen Solvents ; Water (059QF0KO0R) ; RNA (63231-63-0) ; Magnesium (I38ZP9992A)
    Sprache Englisch
    Erscheinungsdatum 2022-01-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1549-9626
    ISSN (online) 1549-9626
    DOI 10.1021/acs.jctc.1c00752
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Atraumatic Bone Marrow Edema Involving the Epiphyses

    Woertler, Klaus / Neumann, Jan

    Seminars in Musculoskeletal Radiology

    (Nontumor Marrow Changes)

    2023  Band 27, Heft 01, Seite(n) 45–53

    Abstract: Bone marrow edema (BME)-like signal intensity involving the epiphyses of tubular bones represents a frequent magnetic resonance imaging finding associated with a wide spectrum of bone and joint disorders. It is important to distinguish this finding from ... ...

    Serientitel Nontumor Marrow Changes
    Abstract Bone marrow edema (BME)-like signal intensity involving the epiphyses of tubular bones represents a frequent magnetic resonance imaging finding associated with a wide spectrum of bone and joint disorders. It is important to distinguish this finding from cellular infiltration of bone marrow and to be aware of the differential diagnosis of underlying causes. With a general focus on the adult musculoskeletal system, this article reviews the pathophysiology, clinical presentation, histopathology, and imaging findings of nontraumatic conditions associated with epiphyseal BME-like signal intensity: transient bone marrow edema syndrome, subchondral insufficiency fracture, avascular necrosis, osteoarthritis, arthritis, and bone neoplasms.
    Schlagwörter transient bone marrow edema syndrome ; subchondral insufficiency fracture ; avascular necrosis ; osteoarthritis ; bone neoplasms
    Sprache Englisch
    Erscheinungsdatum 2023-02-01
    Verlag Thieme Medical Publishers, Inc.
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ZDB-ID 1360919-1
    ISSN 1098-898X ; 1089-7860
    ISSN (online) 1098-898X
    ISSN 1089-7860
    DOI 10.1055/s-0043-1761498
    Datenquelle Thieme Verlag

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  5. Buch ; Dissertation / Habilitation: Die Lebervenen und ihre Drainagegebiete

    Neumann, Jan-Oliver

    computergestützte Analyse mit Hilfe des Operationsplanungssystems LENA

    2006  

    Verfasserangabe vorgelegt von Jan-Oliver Neumann
    Thema/Rubrik (Code) 617.5
    Sprache Deutsch
    Umfang VIII, 97 S., Ill., graph. Darst., 30 cm
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Heidelberg, Univ., Diss., 2006
    HBZ-ID HT014862385
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  6. Artikel: Faktoren der steigenden Inanspruchnahme von Notaufnahmen

    Neumann, Jan

    Recht und Politik im Gesundheitswesen

    2019  Band 25, Heft 4, Seite(n) 78

    Sprache Deutsch
    Dokumenttyp Artikel
    ZDB-ID 1308617-0
    ISSN 0948-3209
    Datenquelle Current Contents Medizin

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  7. Buch ; Online ; Dissertation / Habilitation: Die Koordination des WTO-Rechts mit anderen völkerrechtlichen Ordnungen.

    Neumann, Jan [Verfasser]

    Konflikte des materiellen Rechts und Konkurrenzen der Streitbeilegung.

    2020  

    Verfasserangabe Jan Neumann
    Schlagwörter Recht ; Law
    Thema/Rubrik (Code) sg340
    Sprache Deutsch
    Verlag Duncker & Humblot
    Erscheinungsort Berlin
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    ISBN 978-3-428-50802-0 ; 3-428-50802-5
    Datenquelle Digitale Dissertationen im Internet

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  8. Artikel: Feasibility of Fluid Responsiveness Assessment in Patients at Risk for Increased Intracranial Pressure.

    Zivkovic, Aleksandar R / Kjaev, Aleko / Schönenberger, Silvia / Krieg, Sandro M / Weigand, Markus A / Neumann, Jan-Oliver

    Journal of clinical medicine

    2024  Band 13, Heft 6

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2024-03-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061786
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Stereotactic frame-based biopsy of infratentorial lesions via the suboccipital-transcerebellar approach with the Zamorano-Duchovny stereotactic system-a retrospective analysis of 79 consecutive cases.

    Kaes, Manuel / Beynon, Christopher / Kiening, Karl / Neumann, Jan-Oliver / Jakobs, Martin

    Acta neurochirurgica

    2024  Band 166, Heft 1, Seite(n) 147

    Abstract: Objective: Lesions of the posterior fossa (brainstem and cerebellum) are challenging in diagnosis and treatment due to the fact that they are often located eloquently and total resection is rarely possible. Therefore, frame-based stereotactic biopsies ... ...

    Abstract Objective: Lesions of the posterior fossa (brainstem and cerebellum) are challenging in diagnosis and treatment due to the fact that they are often located eloquently and total resection is rarely possible. Therefore, frame-based stereotactic biopsies are commonly used to asservate tissue for neuropathological diagnosis and further treatment determination. The aim of our study was to assess the safety and diagnostic success rate of frame-based stereotactic biopsies for lesions in the posterior fossa via the suboccipital-transcerebellar approach.
    Methods: We performed a retrospective database analysis of all frame-based stereotactic biopsy cases at our institution since 2007. The aim was to identify all surgical cases for infratentorial lesion biopsies via the suboccipital-transcerebellar approach. We collected clinical data regarding outcomes, complications, diagnostic success, radiological appearances, and stereotactic trajectories.
    Results: A total of n = 79 cases of stereotactic biopsies for posterior fossa lesions via the suboccipital-transcerebellar approach (41 female and 38 male) utilizing the Zamorano-Duchovny stereotactic system were identified. The mean age at the time of surgery was 42.5 years (± 23.3; range, 1-87 years). All patients were operated with intraoperative stereotactic imaging (n = 62 MRI, n = 17 CT). The absolute diagnostic success rate was 87.3%. The most common diagnoses were glioma, lymphoma, and inflammatory disease. The overall complication rate was 8.7% (seven cases). All patients with complications showed new neurological deficits; of those, three were permanent. Hemorrhage was detected in five of the cases having complications. The 30-day mortality rate was 7.6%, and 1-year survival rate was 70%.
    Conclusions: Our data suggests that frame-based stereotactic biopsies with the Zamorano-Duchovny stereotactic system via the suboccipital-transcerebellar approach are safe and reliable for infratentorial lesions bearing a high diagnostic yield and an acceptable complication rate. Further research should focus on the planning of safe trajectories and a careful case selection with the goal of minimizing complications and maximizing diagnostic success.
    Mesh-Begriff(e) Humans ; Male ; Female ; Adult ; Retrospective Studies ; Stereotaxic Techniques ; Brain Stem/surgery ; Cerebellum/surgery ; Biopsy/methods ; Brain Neoplasms/surgery
    Sprache Englisch
    Erscheinungsdatum 2024-03-23
    Erscheinungsland Austria
    Dokumenttyp Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-024-06036-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: The role of sarcopenia in fragility fractures of the pelvis - is sarcopenia an underestimated risk factor?

    Mair, Olivia / Neumann, Jan / Rittstieg, Philipp / Müller, Michael / Biberthaler, Peter / Hanschen, Marc

    BMC geriatrics

    2024  Band 24, Heft 1, Seite(n) 461

    Abstract: Background: Fragility fractures of the pelvis (FFPs) represent a significant health burden, particularly for the elderly. The role of sarcopenia, an age-related loss of muscle mass and function, in the development and impact of these fractures is not ... ...

    Abstract Background: Fragility fractures of the pelvis (FFPs) represent a significant health burden, particularly for the elderly. The role of sarcopenia, an age-related loss of muscle mass and function, in the development and impact of these fractures is not well understood. This study aims to investigate the prevalence and impact of osteoporosis and sarcopenia in patients presenting with FFPs.
    Methods: This retrospective study evaluated 140 elderly patients with FFPs. The diagnosis of sarcopenia was assessed by psoas muscle area (PMA) and the height-adjusted psoas muscle index (PMI) measured on computed tomography (CT) scans. Clinical data, radiological findings and functional outcomes were recorded and compared with the presence or absence of sarcopenia and osteoporosis.
    Results: Our study cohort comprised 119 female (85.0%) and 21 (15.0%) male patients. The mean age at the time of injury or onset of symptoms was 82.26 ± 8.50 years. Sarcopenia was diagnosed in 68.6% (n = 96) patients using PMA and 68.8% (n = 88) using PMI. 73.6% (n = 103) of our study population had osteoporosis and 20.0% (n = 28) presented with osteopenia. Patients with sarcopenia and osteoporosis had longer hospital stays (p < 0.04), a higher rate of complications (p < 0.048) and functional recovery was significantly impaired, as evidenced by a greater need for assistance in daily living (p < 0.03). However, they were less likely to undergo surgery (p < 0.03) and the type of FFP differed significantly (p < 0.04). There was no significant difference in mortality rate, pre-hospital health status, age or gender.
    Conclusion: Our study highlights the important role of sarcopenia in FFPs in terms of the serious impact on health and quality of life in elderly patients especially when osteoporosis and sarcopenia occur together. Identifying and targeting sarcopenia in older patients may be an important strategy to reduce pelvic fractures and improve recovery. Further research is needed to develop effective prevention and treatment approaches that target muscle health in the elderly.
    Mesh-Begriff(e) Humans ; Sarcopenia/epidemiology ; Male ; Female ; Retrospective Studies ; Aged, 80 and over ; Aged ; Risk Factors ; Pelvic Bones/injuries ; Pelvic Bones/diagnostic imaging ; Osteoporosis/epidemiology ; Osteoporosis/complications ; Psoas Muscles/diagnostic imaging ; Osteoporotic Fractures/epidemiology ; Tomography, X-Ray Computed/methods ; Prevalence ; Fractures, Bone/epidemiology ; Fractures, Bone/complications
    Sprache Englisch
    Erscheinungsdatum 2024-05-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-024-05082-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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