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  1. Book: Einfluss der Kontrastmittelgabe bei der quantitativen Bestimmung des zerebralen Wassergehalts

    Neumann, Katja

    (Berichte aus der Medizin)

    2019  

    Abstract: Der Schlaganfall ist die häufigste Ursache für Behinderungen im Erwachsenenalter. In der neuroradiologischen Schlaganfalldiagnostik ist die exakte Bestimmung des Schlaganfallalters ein noch ungelöstes Problem. Der genaue Zeitpunkt des Auftretens des ... ...

    Series title Berichte aus der Medizin
    Abstract Der Schlaganfall ist die häufigste Ursache für Behinderungen im Erwachsenenalter. In der neuroradiologischen Schlaganfalldiagnostik ist die exakte Bestimmung des Schlaganfallalters ein noch ungelöstes Problem. Der genaue Zeitpunkt des Auftretens des Schlaganfalls ist bei etwa 20 % der Patienten unbekannt. Mit den derzeit üblichen Methoden, CT und MRT, ist es nicht möglich zu bestimmen, ob die Patienten sich im relevanten Zeitfenster von 4,5 Stunden befinden („Lysefenster“). Aus histologischen...
    Keywords Schlaganfall ; Kontrastmittel ; Water Mapping ; Wassergehalt ; MRT ; Kontrastmittelgabe ; Schlaganfalldiagnostik ; Neuroradiologie
    Language German
    Size 60 p.
    Edition 1
    Publisher Shaker Verlag
    Document type Book
    Note Hochschulschriften Medizin
    Format 148 x 210
    ISBN 9783844064568 ; 3844064567
    Database PDA

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  2. Book ; Thesis: Einfluss der Kontrastmittelgabe bei der quantitativen Bestimmung des zerebralen Wassergehalts

    Neumann, Katja

    (Berichte aus der Medizin)

    2019  

    Author's details Katja Neumann
    Series title Berichte aus der Medizin
    Keywords Kontrastmittel ; Kontrastmittelgabe ; MRT ; Neuroradiologie ; Schlaganfall ; Schlaganfalldiagnostik ; Wassergehalt ; Water Mapping ; Diagnose ; Hirnödem
    Subject Encephalödem ; Gehirnödem ; Enzephalödem ; Röntgenkontrastmittel ; X-ray contrast media ; Radiopaques ; Ärztliche Diagnose ; Apoplektischer Insult ; Apoplexia cerebri ; Apoplexie ; Gehirnschlag ; Hirnschlag ; Zerebrovaskulärer Insult ; ZVI ; Ischämischer Insult ; Stroke
    Subject code 610
    Language German
    Size VI, 36, xv Seiten, Illustrationen, Diagramme, 21 cm x 14.8 cm, 86 g
    Publisher Shaker Verlag
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, RWTH Aachen University, 2018
    HBZ-ID HT019955586
    ISBN 978-3-8440-6456-8 ; 3-8440-6456-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 A 324 available for loan (reading room) Lesesaal EG

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  3. Book ; Online ; Thesis: Einfluss von IL-10 auf den Systemischen Lupus erythematodes am murinen FcγRIIB-K.o. Modell

    Neumann, Katja

    2015  

    Title variant Influences of IL-10 in the pathogenesis of SLE in the murine FcγRIIB-knock-out model
    Author's details Katja Neumann
    Language German
    Size Online-Ressource
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Medizinische Fakultät Charité - Universitätsmedizin Berlin, Diss.--Berlin, 2015
    Database Special collection on veterinary medicine and general parasitology

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  4. Book ; Online ; Thesis: Einfluss von IL-10 auf den Systemischen Lupus erythematodes am murinen FcγRIIB-K.o. Modell

    Neumann, Katja

    2015  

    Title variant Influences of IL-10 in the pathogenesis of SLE in the murine FcγRIIB-knock-out model
    Author's details Katja Neumann
    Language German
    Size Online-Ressource
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Medizinische Fakultät Charité - Universitätsmedizin Berlin, Diss.--Berlin, 2015
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article: Microvascular Impairment in Patients With Cerebral Small Vessel Disease Assessed With Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Study.

    Neumann, Katja / Günther, Matthias / Düzel, Emrah / Schreiber, Stefanie

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 871612

    Abstract: In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion ... ...

    Abstract In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL.
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.871612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Reliability and Reproducibility of Hadamard Encoded Pseudo-Continuous Arterial Spin Labeling in Healthy Elderly.

    Neumann, Katja / Schidlowski, Martin / Günther, Matthias / Stöcker, Tony / Düzel, Emrah

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 711898

    Abstract: The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured with arterial spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable essentials to assess the integrity of cerebral tissue. Brain perfusion changes, ...

    Abstract The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured with arterial spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable essentials to assess the integrity of cerebral tissue. Brain perfusion changes, due to aging, an intervention, or neurodegenerative diseases for example, could be investigated in longitudinal ASL studies with reliable ASL sequences. Generally, pseudo-continuous ASL (pCASL) is preferred because of its larger signal-to-noise ratio (SNR) compared to pulsed ASL (PASL) techniques. Available pCASL versions differ regarding their feature details. To date only little is known about the reliability and reproducibility of CBF and ATT measures obtained with the innovative Hadamard encoded pCASL variant, especially if applied on participants in old age. Therefore, we investigated an in-house developed Hadamard encoded pCASL sequence on a group of healthy elderly at two different 3 Tesla Siemens MRI systems (Skyra and mMR Biograph) and evaluated CBF and ATT reliability and reproducibility for several regions-of-interests (ROI). Calculated within-subject coefficients of variation (wsCV) demonstrated an excellent reliability of perfusion measures, whereas ATT appeared to be even more reliable than CBF [e.g., wsCV(CBF) = 2.9% vs. wsCV(ATT) = 2.3% for a gray matter (GM) ROI on Skyra system]. Additionally, a substantial agreement of perfusion values acquired on both MRI systems with an inter-session interval of 78 ± 17.6 days was shown by high corresponding intra-class correlation (ICC) coefficients [e.g., ICC(CBF) = 0.704 and ICC(ATT) = 0.754 for a GM ROI]. The usability of this novel Hadamard encoded pCASL sequence might improve future follow-up perfusion studies of the aging and/or diseased brain.
    Language English
    Publishing date 2021-08-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.711898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; Thesis: Einfluss von IL-10 auf den Systemischen Lupus erythematodes am murinen FcγRIIB-K.o. Modell

    Neumann, Katja [Verfasser]

    2015  

    Author's details Katja Neumann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article ; Online: Engraftment Effects after Intra-Bone Marrow versus Intravenous Allogeneic Stem Cell Transplantation in a Reduced-Intensity Conditioning Dog Leukocyte Antigen-Identical Canine Model.

    Schaefer, Stephanie / Lange, Sandra / Werner, Juliane / Machka, Christoph / Neumann, Katja / Knuebel, Gudrun / Vogel, Heike / Lindner, Iris / Glass, Änne / Murua Escobar, Hugo / Nolte, Ingo / Junghanss, Christian

    Transplantation and cellular therapy

    2021  Volume 28, Issue 2, Page(s) 70.e1–70.e5

    Abstract: Following conventional i.v. hematopoietic stem cell transplantation (IV-HSCT), most of the hematopoietic stem cells get trapped in peripheral organs and do not reach the bone marrow niche. A promising approach to overcome this cell loss during the homing ...

    Abstract Following conventional i.v. hematopoietic stem cell transplantation (IV-HSCT), most of the hematopoietic stem cells get trapped in peripheral organs and do not reach the bone marrow niche. A promising approach to overcome this cell loss during the homing process seems to be the infusion of hematopoietic stem cells directly into the bone marrow cavity (intra-bone marrow [IBM]-HSCT). This study aimed to investigate the engraftment efficiency of IBM-HSCT compared with IV-HSCT following reduced-intensity conditioning in a canine HSCT model. Furthermore, the impact of 2 different graft infusion rates during IBM-HSCT on the engraftment was evaluated. Dogs received 4.5 Gy total body irradiation for conditioning at day -1 and 15 mg/kg cyclosporin A twice daily at days -1 to +35 as immunosuppression. The IV-HSCT group (n = 7) received unmodified bone marrow. The IBM-HSCT cohorts received buffy coat-enriched bone marrow that was applied into the humerus and femur simultaneously with an infusion time of either 10 minutes (IBM10; n = 8) or 60 minutes (IBM60; n = 7). Statistical analyses were performed using the Kruskal-Wallis test followed by the Mann-Whitney U test with Bonferroni correction for multiple comparisons. Statistical significance was declared at Bonferroni-adjusted P < .017. All dogs initially engrafted. One dog of the IBM10 cohort died at day +15 from infection. All 21 evaluable dogs developed a durable mixed donor chimerism over the course of 112 days. Engraftment kinetics did not differ significantly across the 3 groups. Leukocyte and platelet nadirs, as well as the durations of leukopenia and thrombocytopenia, were comparable in the 3 groups. Signs of toxicity for ingestion, body temperature, activity, and defecation did not show statistically significant differences among the 3 groups; only weight loss was greater in the IBM60 group compared with the IV group. IBM-HSCT following reduced-intensity conditioning resulted in an engraftment efficiency and hematopoietic recovery comparable to that seen with conventional IV-HSCT. In addition, modification of the graft infusion rate had no impact on engraftment and hematopoietic recovery in the canine IBM-HSCT model.
    MeSH term(s) Animals ; Bone Marrow ; Dogs ; Graft vs Host Disease ; HLA Antigens ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Transplantation Conditioning/methods
    Chemical Substances HLA Antigens
    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2021.11.010
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    Zs.A 5082: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Age-related functional changes in domain-specific medial temporal lobe pathways.

    Berron, David / Neumann, Katja / Maass, Anne / Schütze, Hartmut / Fliessbach, Klaus / Kiven, Verena / Jessen, Frank / Sauvage, Magdalena / Kumaran, Dharshan / Düzel, Emrah

    Neurobiology of aging

    2018  Volume 65, Page(s) 86–97

    Abstract: There is now converging evidence from studies in animals and humans that the medial temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and scene information. Recent functional magnetic resonance imaging studies in humans ... ...

    Abstract There is now converging evidence from studies in animals and humans that the medial temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and scene information. Recent functional magnetic resonance imaging studies in humans suggest that this domain-specific organization may be associated with a functional preference of the anterior-lateral part of the entorhinal cortex (alErC) for objects and the posterior-medial entorhinal cortex (pmErC) for scenes. As MTL subregions are differentially affected by aging and neurodegenerative diseases, the question was raised whether aging may affect the 2 pathways differentially. To address this possibility, we developed a paradigm that allows the investigation of object memory and scene memory in a mnemonic discrimination task. A group of young (n = 43) and healthy older subjects (n = 44) underwent functional magnetic resonance imaging recordings during this novel task, while they were asked to discriminate exact repetitions of object and scene stimuli from novel stimuli that were similar but modified versions of the original stimuli ("lures"). We used structural magnetic resonance images to manually segment anatomical components of the MTL including alErC and pmErC and used these segmented regions to analyze domain specificity of functional activity. Across the entire sample, object processing was associated with activation of the perirhinal cortex (PrC) and alErC, whereas for scene processing, activation was more predominant in the parahippocampal cortex and pmErC. Functional activity related to mnemonic discrimination of object and scene lures from exact repetitions was found to overlap between processing pathways and suggests that while the PrC-alErC pathway was more involved in object discrimination, both pathways were involved in the discrimination of similar scenes. Older adults were behaviorally less accurate than young adults in discriminating similar lures from exact repetitions, but this reduction was equivalent in both domains. However, this was accompanied by significantly reduced domain-specific activity in PrC in older adults compared to what was observed in the young. Furthermore, this reduced domain-specific activity was associated to worse performance in object mnemonic discrimination in older adults. Taken together, we show the fine-grained functional organization of the MTL into domain-specific pathways for objects and scenes and their mnemonic discrimination and further provide evidence that aging might affect these pathways in a differential fashion. Future experiments will elucidate whether the 2 pathways are differentially affected in early stages of Alzheimer's disease in relation to amyloid or tau pathology.
    MeSH term(s) Adult ; Aged ; Entorhinal Cortex/diagnostic imaging ; Entorhinal Cortex/pathology ; Entorhinal Cortex/physiology ; Female ; Healthy Aging/pathology ; Healthy Aging/physiology ; Hippocampus/diagnostic imaging ; Hippocampus/pathology ; Hippocampus/physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/diagnostic imaging ; Neural Pathways/pathology ; Neural Pathways/physiology ; Perirhinal Cortex/diagnostic imaging ; Perirhinal Cortex/pathology ; Perirhinal Cortex/physiology ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/pathology ; Temporal Lobe/physiology ; Young Adult
    Language English
    Publishing date 2018-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/j.neurobiolaging.2017.12.030
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1685: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 10: Show issues

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  10. Book ; Thesis: Ziele und Zwecke der Deutschen Konzernrechnungslegung

    Neumann, Katja

    1999  

    Author's details von Katja Neumann
    Keywords Rechnungslegung ; Konzern ; Deutschland
    Language German
    Size V, 171 S.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Heidelberg, 1999
    Database Former special subject collection: coastal and deep sea fishing

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