Artikel ; Online: Survival after long-term ART exposure: findings from an Asian patient population retained in care beyond 5 years on ART.
2020 Band 25, Heft 3, Seite(n) 131–142
Abstract: Background: This study investigated survival in people living with HIV being followed-up from 5 and 10 years after antiretroviral therapy (ART) initiation in a multi-country Asian cohort.: Methods: We included patients in follow-up >5 years after ART ...
Abstract | Background: This study investigated survival in people living with HIV being followed-up from 5 and 10 years after antiretroviral therapy (ART) initiation in a multi-country Asian cohort. Methods: We included patients in follow-up >5 years after ART initiation. Factors associated with mortality beyond 5 and 10 years on ART were analysed using competing risk regression with time-updated variables. Results: Of 13,495 patients retained after 5 years on ART, 279 subsequently died (0.56/100 person-years). Increased mortality was associated with age >50 years (sub-hazard ratio [sHR] 2.24, 95% CI 1.58, 3.15, compared with ≤40 years), HIV exposure through injecting drug use (sHR 2.17, 95% CI 1.32, 3.56), HIV viral load ≥1,000 copies/ml: sHR 1.52, 95% CI 1.05, 2.21, compared with <400), regimen (second-line regimen: sHR 2.11, 95% CI 1.52, 2.94, and third-line regimen: sHR 2.82, 95% CI 2.00, 3.98, compared with first-line regimen), HBV coinfection (sHR 2.23, 95% CI 1.49, 3.33), fasting plasma glucose ≥126 mg/dl (sHR 1.98, 95% CI 1.22, 3.21, compared with <100 mg/dl) and estimated glomerular filtration rate <60 ml/min/1.73 m Conclusions: Next to preventing ART failure, HIV programmes should carefully monitor and treat comorbidities, including hepatitis, kidney disease and diabetes, to optimize survival after long-term ART exposure. |
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Mesh-Begriff(e) | Adult ; Age Factors ; Anti-HIV Agents/therapeutic use ; Female ; HIV Infections/drug therapy ; HIV Infections/mortality ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Thailand/epidemiology ; Time Factors ; Viral Load |
Chemische Substanzen | Anti-HIV Agents |
Sprache | Englisch |
Erscheinungsdatum | 2020-05-04 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1339842-8 |
ISSN | 2040-2058 ; 1359-6535 |
ISSN (online) | 2040-2058 |
ISSN | 1359-6535 |
DOI | 10.3851/IMP3358 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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