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  1. AU="Nguyen, Hang Minh"
  2. AU="Ceasar, M"
  3. AU="López-Cotarelo, Pilar"
  4. AU="Lenc, E"
  5. AU="Brabcova, Zuzana"
  6. AU="Bayırlı Turan, Derya"
  7. AU=Sleigh James N
  8. AU="Thanee, Malinee"
  9. AU="Watchara Fongkum"

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  1. Artikel ; Online: Promising clinical and immunological efficacy of Bacillus clausii spore probiotics for supportive treatment of persistent diarrhea in children.

    Dang, Ha Thuy / Tran, Dien Minh / Phung, Thuy Thi Bich / Bui, Anh Thi Phuong / Vu, Yen Hai / Luong, Minh Thi / Nguyen, Hang Minh / Trinh, Huong Thi / Nguyen, Tham Thi / Nguyen, Anh Hoa / Van Nguyen, Anh Thi

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 6422

    Abstract: Persistent diarrhea is a severe gastroenteric disease with relatively high risk of pediatric mortality in developing countries. We conducted a randomized, double-blind, controlled clinical trial to evaluate the efficacy of liquid-form Bacillus clausii ... ...

    Abstract Persistent diarrhea is a severe gastroenteric disease with relatively high risk of pediatric mortality in developing countries. We conducted a randomized, double-blind, controlled clinical trial to evaluate the efficacy of liquid-form Bacillus clausii spore probiotics (LiveSpo CLAUSY; 2 billion CFU/5 mL ampoule) at high dosages of 4-6 ampoules a day in supporting treatment of children with persistent diarrhea. Our findings showed that B. clausii spores significantly improved treatment outcomes, resulting in a 2-day shorter recovery period (p < 0.05) and a 1.5-1.6 folds greater efficacy in reducing diarrhea symptoms, such as high frequency of bowel movement of ≥ 3 stools a day, presence of fecal mucus, and diapered infant stool scale types 4-5B. LiveSpo CLAUSY supportive treatment achieved 3 days (p < 0.0001) faster recovery from diarrhea disease, with 1.6-fold improved treatment efficacy. At day 5 of treatment, a significant decrease in blood levels of pro-inflammatory cytokines TNF-α, IL-17, and IL-23 by 3.24% (p = 0.0409), 29.76% (p = 0.0001), and 10.87% (p = 0.0036), respectively, was observed in the Clausy group. Simultaneously, there was a significant 37.97% decrease (p = 0.0326) in the excreted IgA in stool at day 5 in the Clausy group. Overall, the clinical study demonstrates the efficacy of B. clausii spores (LiveSpo CLAUSY) as an effective symptomatic treatment and immunomodulatory agent for persistent diarrhea in children.Trial registration: NCT05812820.
    Mesh-Begriff(e) Infant ; Humans ; Child ; Bacillus clausii ; Spores, Bacterial ; Diarrhea/therapy ; Cytokines ; Probiotics/therapeutic use
    Chemische Substanzen Cytokines
    Sprache Englisch
    Erscheinungsdatum 2024-03-18
    Erscheinungsland England
    Dokumenttyp Randomized Controlled Trial ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56627-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Acceptability of seasonal influenza vaccines among health care workers in Vietnam in 2017

    Nguyen, Thoa Thi Minh / Lafond, Kathryn E / Nguyen, Tung Xuan / Tran, Phu Dac / Nguyen, Hang Minh / Ha, Van Thi Cam / Do, Thu Thi / Ha, Nga Thu / Seward, Jane F / McFarland, Jeffrey W

    Vaccine. 2020 Feb. 18, v. 38, no. 8

    2020  

    Abstract: A demonstration project in Vietnam provided 11,000 doses of human seasonal influenza vaccine free of charge to healthcare workers (HCWs) in 4 provinces of Vietnam. Through this project, we conducted an acceptability survey to identify the main reasons ... ...

    Abstract A demonstration project in Vietnam provided 11,000 doses of human seasonal influenza vaccine free of charge to healthcare workers (HCWs) in 4 provinces of Vietnam. Through this project, we conducted an acceptability survey to identify the main reasons that individuals chose to be vaccinated or not to inform and improve future immunization activities.We conducted a descriptive cross-sectional survey from May to August 2017 among HCWs at 13 selected health facilities. We employed logistic regression to determine the association between demographic and professional factors, and the decision to receive seasonal influenza vaccine. We performed post-hoc pairwise comparisons among reasons for and against vaccination using Chi square and Fisher’s exact tests (for cell sizes <5).A total of 1,450 HCWs participated in the survey, with a higher proportion of females than males (74% versus 26%). The median age of the participating HCWs was 35 years (median range 25.8–44.2). Among those surveyed, 700 (48%) HCWs were vaccinated against seasonal influenza during the first half of 2017. Younger HCWs under 30 and 30–39 years old were less likely to get vaccinated against seasonal influenza than HCWs ≥50 years old (OR = 0.5; 95%CI 0.4–0.8 and OR = 0.6; 95%CI 0.4–0.8 respectively). Nurses and other employees were more likely to get seasonal influenza vaccination than physicians (OR = 1.5; 95%CI 1.0–2.4 and OR = 2.0; 95%CI 1.2–3.2 respectively). The most common reason for accepting vaccination was fear of getting influenza (66%) and the most common reason for not getting vaccinated was concern about vaccine side effects (23%).Acceptability of seasonal influenza vaccines in this setting varied among HCWs by age group and job category. Interventions to increase acceptance of vaccine among HCWs in this setting where influenza vaccine is being introduced free for the first time should include targeted risk communication on vaccine safety and efficacy.
    Schlagwörter adverse effects ; cross-sectional studies ; fearfulness ; females ; human resources ; humans ; influenza ; influenza vaccination ; influenza vaccines ; males ; nurses ; physicians ; regression analysis ; risk communication ; surveys ; Vietnam
    Sprache Englisch
    Erscheinungsverlauf 2020-0218
    Umfang p. 2045-2050.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2019.12.047
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel: COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.

    Phung, Thuy Thi Bich / Chu, Son Van / Vu, Son Thien / Pham, Hanh Thi / Nguyen, Hang Minh / Nguyen, Hoan Dang / Le, Ngan Thi / Nguyen, Dung Van / Truong, Phuong Thai / Vu, Van Thi Tuong / Nguyen, Anh Thi Van

    Diagnostics (Basel, Switzerland)

    2020  Band 10, Heft 7

    Abstract: We investigated Nucleos(t)ide-analogue (NA)-resistance mutations (mt) in 142 treatment-naive children with Chronic Hepatitis B (CHB), using a sensitive co-amplification at lower denaturation temperature (COLD)-PCR with Sanger DNA sequencing. An NA ... ...

    Abstract We investigated Nucleos(t)ide-analogue (NA)-resistance mutations (mt) in 142 treatment-naive children with Chronic Hepatitis B (CHB), using a sensitive co-amplification at lower denaturation temperature (COLD)-PCR with Sanger DNA sequencing. An NA resistance-associated mt in the hepatitis B virus (HBV) reverse transcriptase (RT) was found in 66.2% of the patients, with nonclassical mt contributing the most (64.8%). Significantly higher frequencies of Lamivudine (LMV) and Adefovir dipivoxil (ADF) resistance-associated mt were found in genotypes B and C, respectively (OR
    Sprache Englisch
    Erscheinungsdatum 2020-07-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics10070491
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Acceptability of seasonal influenza vaccines among health care workers in Vietnam in 2017.

    Nguyen, Thoa Thi Minh / Lafond, Kathryn E / Nguyen, Tung Xuan / Tran, Phu Dac / Nguyen, Hang Minh / Ha, Van Thi Cam / Do, Thu Thi / Ha, Nga Thu / Seward, Jane F / McFarland, Jeffrey W

    Vaccine

    2020  Band 38, Heft 8, Seite(n) 2045–2050

    Abstract: Introduction: A demonstration project in Vietnam provided 11,000 doses of human seasonal influenza vaccine free of charge to healthcare workers (HCWs) in 4 provinces of Vietnam. Through this project, we conducted an acceptability survey to identify the ... ...

    Abstract Introduction: A demonstration project in Vietnam provided 11,000 doses of human seasonal influenza vaccine free of charge to healthcare workers (HCWs) in 4 provinces of Vietnam. Through this project, we conducted an acceptability survey to identify the main reasons that individuals chose to be vaccinated or not to inform and improve future immunization activities.
    Methods: We conducted a descriptive cross-sectional survey from May to August 2017 among HCWs at 13 selected health facilities. We employed logistic regression to determine the association between demographic and professional factors, and the decision to receive seasonal influenza vaccine. We performed post-hoc pairwise comparisons among reasons for and against vaccination using Chi square and Fisher's exact tests (for cell sizes <5).
    Results: A total of 1,450 HCWs participated in the survey, with a higher proportion of females than males (74% versus 26%). The median age of the participating HCWs was 35 years (median range 25.8-44.2). Among those surveyed, 700 (48%) HCWs were vaccinated against seasonal influenza during the first half of 2017. Younger HCWs under 30 and 30-39 years old were less likely to get vaccinated against seasonal influenza than HCWs ≥50 years old (OR = 0.5; 95%CI 0.4-0.8 and OR = 0.6; 95%CI 0.4-0.8 respectively). Nurses and other employees were more likely to get seasonal influenza vaccination than physicians (OR = 1.5; 95%CI 1.0-2.4 and OR = 2.0; 95%CI 1.2-3.2 respectively). The most common reason for accepting vaccination was fear of getting influenza (66%) and the most common reason for not getting vaccinated was concern about vaccine side effects (23%).
    Conclusion: Acceptability of seasonal influenza vaccines in this setting varied among HCWs by age group and job category. Interventions to increase acceptance of vaccine among HCWs in this setting where influenza vaccine is being introduced free for the first time should include targeted risk communication on vaccine safety and efficacy.
    Mesh-Begriff(e) Adult ; Attitude of Health Personnel ; Cross-Sectional Studies ; Female ; Health Personnel/statistics & numerical data ; Humans ; Influenza Vaccines/administration & dosage ; Influenza, Human/prevention & control ; Male ; Middle Aged ; Patient Acceptance of Health Care ; Surveys and Questionnaires ; Vaccination/statistics & numerical data ; Vietnam/epidemiology
    Chemische Substanzen Influenza Vaccines
    Sprache Englisch
    Erscheinungsdatum 2020-01-27
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2019.12.047
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Genome-wide analysis of SARS-CoV-2 strains circulating in Vietnam: Understanding the nature of the epidemic and role of the D614G mutation.

    Dao, Manh H / Phan, Lan T / Cao, Thang M / Luong, Quang C / Pham, Hang T T / Vu, Nhung H P / Khuu, Nghia V / Nguyen, Thinh V / Nguyen, Long T / Nguyen, Hieu T / Nguyen, Anh H / Huynh, Loan Kim Thi / Huynh, Thao P / Nguyen, Quan H / Truong, Hieu C / Nguyen, Hang Minh / Trinh, Tung Xuan / Nguyen, Dung T / Nguyen, Trieu B /
    Do, Hung T / Pham, Quang D / Nguyen, Thuong V

    Journal of medical virology

    2021  Band 93, Heft 9, Seite(n) 5660–5665

    Abstract: Genome-wide analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is essential to better understand infectivity and virulence and to track coronavirus disease 2019 (COVID-19) cases and outbreaks. We performed whole-genome ... ...

    Abstract Genome-wide analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is essential to better understand infectivity and virulence and to track coronavirus disease 2019 (COVID-19) cases and outbreaks. We performed whole-genome sequencing of 27 SARS-CoV-2 strains isolated between January 2020 and April 2020. A total of 54 mutations in different genomic regions was found. The D614G mutation, first detected in March 2020, was identified in 18 strains and was more likely associated with a lower cycle threshold (<25) in real-time reverse-transcription polymerase chain reaction diagnostic tests than the original D614 (prevalence ratio = 2.75; 95% confidence interval, 1.19-6.38). The integration of sequencing and epidemiological data suggests that SARS-CoV-2 transmission in both quarantine areas and in the community in Vietnam occur at the beginning of the epidemic although the country implemented strict quarantine quite early, with strict contact tracing, and testing. These findings provide insights into the nature of the epidemic, as well as shape strategies for COVID-19 prevention and control in Vietnam.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; Contact Tracing ; Female ; Genetic Variation ; Humans ; Male ; Middle Aged ; Mutation ; Phylogeny ; Quarantine ; Regression Analysis ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/genetics ; Vietnam/epidemiology ; Whole Genome Sequencing ; Young Adult
    Chemische Substanzen Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-06-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27103
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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