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Artikel ; Online: Comparative Hippocampal Proteome and Phosphoproteome in a Niemann-Pick, Type C1 Mouse Model Reveal Insights into Disease Mechanisms.

Nguyen, Thu T A / Mohanty, Varshasnata / Yan, Ying / Francis, Kevin R / Cologna, Stephanie M

2023 Band 23, Heft 1, Seite(n) 84–94

Abstract: Niemann-Pick disease, type C (NPC) is a neurodegenerative, lysosomal storage disorder in individuals carrying two mutated copies of either ... ...

Abstract	Niemann-Pick disease, type C (NPC) is a neurodegenerative, lysosomal storage disorder in individuals carrying two mutated copies of either the
Mesh-Begriff(e)	Animals ; Mice ; Proteome/genetics ; Proteome/metabolism ; Disease Models, Animal ; Intracellular Signaling Peptides and Proteins/metabolism ; Niemann-Pick Disease, Type C/genetics ; Hippocampus/metabolism
Chemische Substanzen	Proteome ; Intracellular Signaling Peptides and Proteins
Sprache	Englisch
Erscheinungsdatum	2023-11-24
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.3c00375
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Factors affecting loneliness among left-behind children.

Nguyen, Luot V / Nguyen, Thu T A / Trinh, Linh T / Nguyen, Hanh H V

Current issues in personality psychology

2023 Band 12, Heft 1, Seite(n) 41–50

Abstract: Background: In Vietnam, research on the impact of parental migration on left-behind children (LBC) has discussed various dimensions of the subject such as subjective well-being, emotional states, social skills, self-esteem and nutrition of LBC. However, ...

Abstract	Background: In Vietnam, research on the impact of parental migration on left-behind children (LBC) has discussed various dimensions of the subject such as subjective well-being, emotional states, social skills, self-esteem and nutrition of LBC. However, there are still gaps in studies on loneliness among LBC in Vietnam. The study aims to explore the status of loneliness in LBC, including associated protective and risk factors, to make suggestions on preventive measures against LBC's loneliness. Participants and procedure: The conveniently selected sample includes 439 LBC in 4 Vietnamese provinces: Thai Nguyen, Bac Ninh, Thai Binh and Nghe An. The mean age is 12.73 ( Results: The total loneliness score of LBC is 28.62 ( Conclusions: Perceived social support from friends, care-giving attachment and resilience factors of RAC, RFS, and RHS are protective factors for LBC against loneliness. Parents, teachers and guardians are encouraged to have a close connection with LBC, provide adequate care giving; and create a supportive environment for LBC in pursuing healthy peer relationships and train/improve children's skills to strengthen their resilience.
Sprache	Englisch
Erscheinungsdatum	2023-04-17
Erscheinungsland	Poland
Dokumenttyp	Journal Article
ZDB-ID	3030312-6
ISSN	2353-561X ; 2353-4192
ISSN (online)	2353-561X
ISSN	2353-4192
DOI	10.5114/cipp/162007
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Mass spectrometry-based lipid analysis and imaging.

Pathmasiri, Koralege C / Nguyen, Thu T A / Khamidova, Nigina / Cologna, Stephanie M

Current topics in membranes

2021 Band 88, Seite(n) 315–357

Abstract: Mass spectrometry imaging (MSI) is a powerful tool for in situ mapping of analytes across a sample. With growing interest in lipid biochemistry, the ability to perform such mapping without antibodies has opened many opportunities for MSI and lipid ... ...

Abstract	Mass spectrometry imaging (MSI) is a powerful tool for in situ mapping of analytes across a sample. With growing interest in lipid biochemistry, the ability to perform such mapping without antibodies has opened many opportunities for MSI and lipid analysis. Herein, we discuss the basics of MSI with particular emphasis on MALDI mass spectrometry and lipid analysis. A discussion of critical advancements as well as protocol details are provided to the reader. In addition, strategies for improving the detection of lipids, as well as applications in biomedical research, are presented.
Mesh-Begriff(e)	Lipids ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemische Substanzen	Lipids
Sprache	Englisch
Erscheinungsdatum	2021-11-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1063-5823
ISSN	1063-5823
DOI	10.1016/bs.ctm.2021.10.005
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Endogenous Protein-Protein Interaction Network of the NPC Cholesterol Transporter 1 in the Cerebral Cortex.

Javanshad, Roshan / Nguyen, Thu T A / Azaria, Ruth D / Li, Wenping / Edmison, Daisy / Gong, Liang-Wei / Gowrishankar, Swetha / Lieberman, Andrew P / Schultz, Mark L / Cologna, Stephanie M

Journal of proteome research

2024

Abstract: NPC intracellular cholesterol transporter 1 (NPC1) is a multipass, transmembrane glycoprotein mostly recognized for its key role in facilitating cholesterol efflux. Mutations in ... ...

Abstract	NPC intracellular cholesterol transporter 1 (NPC1) is a multipass, transmembrane glycoprotein mostly recognized for its key role in facilitating cholesterol efflux. Mutations in the
Sprache	Englisch
Erscheinungsdatum	2024-04-30
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.3c00788
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis.

Koster, Kevin P / Fyke, Zach / Nguyen, Thu T A / Niqula, Amanda / Noriega-González, Lorena Y / Woolfrey, Kevin M / Dell'Acqua, Mark L / Cologna, Stephanie M / Yoshii, Akira

Frontiers in synaptic neuroscience

2024 Band 16, Seite(n) 1384625

Abstract: Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), is associated ... ...

Abstract	Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation. The depalmitoylating enzyme, palmitoyl-protein thioesterase 1 (PPT1), is associated with the devastating pediatric neurodegenerative condition, infantile neuronal ceroid lipofuscinosis (CLN1). CLN1 is characterized by the accumulation of autofluorescent lysosomal storage material (AFSM) in neurons and robust neuroinflammation. Converging lines of evidence suggest that in addition to cellular waste accumulation, the symptomology of CLN1 corresponds with disruption of synaptic processes. Indeed, loss of Ppt1 function in cortical neurons dysregulates the synaptic incorporation of the GluA1 AMPA receptor (AMPAR) subunit during a type of synaptic plasticity called synaptic scaling. However, the mechanisms causing this aberration are unknown. Here, we used the
Sprache	Englisch
Erscheinungsdatum	2024-05-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2592086-8
ISSN	1663-3563
ISSN	1663-3563
DOI	10.3389/fnsyn.2024.1384625
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Discovery of a Small-Molecule Modulator of the Autophagy-Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons.

Hippman, Ryan S / Snead, Amanda M / Petros, Zoe A / Korkmaz-Vaisys, Melissa A / Patel, Sruchi / Sotelo, Daniel / Dobria, Andrew / Salkovski, Maryna / Nguyen, Thu T A / Linares, Ricardo / Cologna, Stephanie M / Gowrishankar, Swetha / Aldrich, Leslie N

ACS chemical neuroscience

2023 Band 14, Heft 24, Seite(n) 4363–4382

Abstract: Autophagy is a major catabolic degradation and recycling process that maintains homeostasis in cells and is especially important in postmitotic neurons. We implemented a high-content phenotypic assay to discover small molecules that promote autophagic ... ...

Abstract	Autophagy is a major catabolic degradation and recycling process that maintains homeostasis in cells and is especially important in postmitotic neurons. We implemented a high-content phenotypic assay to discover small molecules that promote autophagic flux and completed target identification and validation studies to identify protein targets that modulate the autophagy pathway and promote neuronal health and survival. Efficient syntheses of the prioritized compounds were developed to readily access analogues of the initial hits, enabling initial structure-activity relationship studies to improve potency and preparation of a biotin-tagged pulldown probe that retains activity. This probe facilitated target identification and validation studies through pulldown and competition experiments using both an unbiased proteomics approach and western blotting to reveal Lamin A/C and LAMP1 as the protein targets of compound
Mesh-Begriff(e)	Humans ; Lamin Type A/metabolism ; Autophagy/physiology ; Neurons/metabolism ; Lysosomes/metabolism ; Alzheimer Disease/metabolism ; Lysosomal-Associated Membrane Protein 1/metabolism
Chemische Substanzen	Lamin Type A ; LAMP1 protein, human ; Lysosomal-Associated Membrane Protein 1
Sprache	Englisch
Erscheinungsdatum	2023-12-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.3c00573
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: PPARα and PPARγ Signaling Is Enhanced in the Brain of the Naked Mole-Rat, a Mammal that Shows Intrinsic Neuroprotection from Oxygen Deprivation.

Pergande, Melissa R / Amoroso, Vince G / Nguyen, Thu T A / Li, Wenping / Vice, Emily / Park, Thomas J / Cologna, Stephanie M

Journal of proteome research

2021 Band 20, Heft 9, Seite(n) 4258–4271

Abstract: Naked mole-rats (NMRs) are a long-lived animal that do not develop age-related diseases including neurodegeneration and cancer. Additionally, NMRs have a profound ability to consume reactive oxygen species (ROS) and survive long periods of oxygen ... ...

Abstract	Naked mole-rats (NMRs) are a long-lived animal that do not develop age-related diseases including neurodegeneration and cancer. Additionally, NMRs have a profound ability to consume reactive oxygen species (ROS) and survive long periods of oxygen deprivation. Here, we evaluated the unique proteome across selected brain regions of NMRs at different ages. Compared to mice, we observed numerous differentially expressed proteins related to altered mitochondrial function in all brain regions, suggesting that the mitochondria in NMRs may have adapted to compensate for energy demands associated with living in a harsh, underground environment. Keeping in mind that ROS can induce polyunsaturated fatty acid peroxidation under periods of neuronal stress, we investigated docosahexaenoic acid (DHA) and arachidonic acid (AA) peroxidation under oxygen-deprived conditions and observed that NMRs undergo DHA and AA peroxidation to a far less extent compared to mice. Further, our proteomic analysis also suggested enhanced peroxisome proliferator-activated receptor (PPAR)-retinoid X receptor (RXR) activation in NMRs via the PPARα-RXR and PPARγ-RXR complexes. Correspondingly, we present several lines of evidence supporting PPAR activation, including increased eicosapetenoic and omega-3 docosapentaenoic acid, as well as an upregulation of fatty acid-binding protein 3 and 4, known transporters of omega-3 fatty acids and PPAR activators. These results suggest enhanced PPARα and PPARγ signaling as a potential, innate neuroprotective mechanism in NMRs.
Mesh-Begriff(e)	Animals ; Brain ; Mice ; Mole Rats ; Neuroprotection ; Oxygen ; PPAR alpha/genetics ; PPAR gamma/genetics ; Proteomics
Chemische Substanzen	PPAR alpha ; PPAR gamma ; Oxygen (S88TT14065)
Sprache	Englisch
Erscheinungsdatum	2021-08-05
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.1c00131
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Characterization of the Cerebrospinal Fluid Proteome in Patients with Fragile X-Associated Tremor/Ataxia Syndrome.

Abbasi, Diana A / Nguyen, Thu T A / Hall, Deborah A / Robertson-Dick, Erin / Berry-Kravis, Elizabeth / Cologna, Stephanie M

Cerebellum (London, England)

2021 Band 21, Heft 1, Seite(n) 86–98

Abstract: Fragile X-associated tremor/ataxia syndrome (FXTAS), first described in 2001, is a neurodegenerative and movement disorder, caused by a premutation in the fragile X mental retardation 1 (FMR1) gene. To date, the biological mechanisms causing this ... ...

Abstract	Fragile X-associated tremor/ataxia syndrome (FXTAS), first described in 2001, is a neurodegenerative and movement disorder, caused by a premutation in the fragile X mental retardation 1 (FMR1) gene. To date, the biological mechanisms causing this condition are still not well understood, as not all premutation carriers develop FXTAS. To further understand this syndrome, we quantitatively compared the cerebrospinal fluid (CSF) proteome of FXTAS patients with age-matched controls using mass spectrometry. We identified 415 proteins of which 97 were altered in FXTAS patients. These proteins suggest changes in acute phase response signaling, liver X receptor/ retinoid X receptor (LXR/RXR) activation, and farnesoid X receptor (FXR)/RXR activation, which are the main pathways found to be affected. Additionally, we detected changes in many other proteins including amyloid-like protein 2, contactin-1, afamin, cell adhesion molecule 4, NPC intracellular cholesterol transporter 2, and cathepsin B, that had been previously noted to hold important roles in other movement disorders. Specific to RXR pathways, several apolipoproteins (APOA1, APOA2, APOA4, APOC2, and APOD) showed significant changes in the CSF of FXTAS patients. Lastly, CSF parameters were analyzed to investigate abnormalities in blood brain barrier function. Correlations were observed between patient albumin quotient values, a measure of permeability, and CGG repeat length as well as FXTAS rating scale scores.
Mesh-Begriff(e)	Ataxia/genetics ; Fragile X Mental Retardation Protein/genetics ; Fragile X Syndrome ; Humans ; Proteome/genetics ; Proteome/metabolism ; Tremor ; Trinucleotide Repeat Expansion
Chemische Substanzen	FMR1 protein, human ; Proteome ; Fragile X Mental Retardation Protein (139135-51-6)
Sprache	Englisch
Erscheinungsdatum	2021-05-27
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2112586-7
ISSN	1473-4230 ; 1473-4222
ISSN (online)	1473-4230
ISSN	1473-4222
DOI	10.1007/s12311-021-01262-7
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Correction to: Characterization of the Cerebrospinal Fluid Proteome in Patients with Fragile X-Associated Tremor/Ataxia Syndrome.

Abbasi, Diana A / Nguyen, Thu T A / Hall, Deborah A / Robertson-Dick, Erin / Berry-Kravis, Elizabeth / Cologna, Stephanie M

Cerebellum (London, England)

2021 Band 21, Heft 1, Seite(n) 99–100

Sprache	Englisch
Erscheinungsdatum	2021-09-10
Erscheinungsland	United States
Dokumenttyp	Published Erratum
ZDB-ID	2112586-7
ISSN	1473-4230 ; 1473-4222
ISSN (online)	1473-4230
ISSN	1473-4222
DOI	10.1007/s12311-021-01321-z
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: PPARα and PPARγ Signaling Is Enhanced in the Brain of the Naked Mole-Rat, a Mammal that Shows Intrinsic Neuroprotection from Oxygen Deprivation

Pergande, Melissa R. / Amoroso, Vince G. / Nguyen, Thu T. A. / Li, Wenping / Vice, Emily / Park, Thomas J. / Cologna, Stephanie M.

Journal of proteome research. 2021 Aug. 05, v. 20, no. 9

2021

Abstract	Naked mole-rats (NMRs) are a long-lived animal that do not develop age-related diseases including neurodegeneration and cancer. Additionally, NMRs have a profound ability to consume reactive oxygen species (ROS) and survive long periods of oxygen deprivation. Here, we evaluated the unique proteome across selected brain regions of NMRs at different ages. Compared to mice, we observed numerous differentially expressed proteins related to altered mitochondrial function in all brain regions, suggesting that the mitochondria in NMRs may have adapted to compensate for energy demands associated with living in a harsh, underground environment. Keeping in mind that ROS can induce polyunsaturated fatty acid peroxidation under periods of neuronal stress, we investigated docosahexaenoic acid (DHA) and arachidonic acid (AA) peroxidation under oxygen-deprived conditions and observed that NMRs undergo DHA and AA peroxidation to a far less extent compared to mice. Further, our proteomic analysis also suggested enhanced peroxisome proliferator-activated receptor (PPAR)-retinoid X receptor (RXR) activation in NMRs via the PPARα-RXR and PPARγ-RXR complexes. Correspondingly, we present several lines of evidence supporting PPAR activation, including increased eicosapetenoic and omega-3 docosapentaenoic acid, as well as an upregulation of fatty acid-binding protein 3 and 4, known transporters of omega-3 fatty acids and PPAR activators. These results suggest enhanced PPARα and PPARγ signaling as a potential, innate neuroprotective mechanism in NMRs.
Schlagwörter	Heterocephalus glaber ; arachidonic acid ; brain ; docosahexaenoic acid ; docosapentaenoic acid ; energy ; fatty acid-binding proteins ; gene expression regulation ; hypoxia ; mitochondria ; mole rats ; neurodegenerative diseases ; neurons ; neuroprotective effect ; peroxidation ; proteome ; proteomics ; reactive oxygen species ; research
Sprache	Englisch
Erscheinungsverlauf	2021-0805
Umfang	p. 4258-4271.
Erscheinungsort	American Chemical Society
Dokumenttyp	Artikel
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.1c00131
Datenquelle	NAL Katalog (AGRICOLA)

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