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Article: Behavioral screening of conserved RNA-binding proteins reveals CEY-1/YBX RNA-binding protein dysfunction leads to impairments in memory and cognition.

Hayden, Ashley N / Brandel, Katie L / Merlau, Paul R / Vijayakumar, Priyadharshini / Leptich, Emily J / Pietryk, Edward W / Gaytan, Elizabeth S / Ni, Connie W / Chao, Hsiao-Tuan / Rosenfeld, Jill A / Arey, Rachel N

bioRxiv : the preprint server for biology

2024  

Abstract: RNA-binding proteins (RBPs) regulate translation and plasticity which are required for memory. RBP dysfunction has been linked to a range of neurological disorders where cognitive impairments are a key symptom. However, of the 2,000 RBPs in the human ... ...

Abstract RNA-binding proteins (RBPs) regulate translation and plasticity which are required for memory. RBP dysfunction has been linked to a range of neurological disorders where cognitive impairments are a key symptom. However, of the 2,000 RBPs in the human genome, many are uncharacterized with regards to neurological phenotypes. To address this, we used the model organism
Language English
Publishing date 2024-05-02
Publishing country United States
Document type Preprint
DOI 10.1101/2024.01.05.574402
Database MEDical Literature Analysis and Retrieval System OnLINE

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