Artikel ; Online: Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial.
2022 Band 28, Heft 11, Seite(n) 2424–2435
Abstract: Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this phase 1b/2a, open-label, randomized controlled trial using a four-group ... ...
Abstract | Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this phase 1b/2a, open-label, randomized controlled trial using a four-group factorial design, we investigated whether early intervention in newly diagnosed people with HIV-1 with a monoclonal anti-HIV-1 antibody with a CD4-binding site, 3BNC117, followed by a histone deacetylase inhibitor, romidepsin, shortly after ART initiation altered the course of HIV-1 infection ( NCT03041012 ). The trial was undertaken in five hospitals in Denmark and two hospitals in the United Kingdom. The coprimary endpoints were analysis of initial virus decay kinetics and changes in the frequency of CD4 |
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Mesh-Begriff(e) | Female ; Humans ; Male ; Anti-Retroviral Agents/therapeutic use ; Anti-Retroviral Agents/pharmacology ; CD4-Positive T-Lymphocytes ; Depsipeptides/therapeutic use ; Depsipeptides/pharmacology ; HIV Infections ; HIV-1 ; Proviruses ; Viral Load |
Chemische Substanzen | Anti-Retroviral Agents ; Depsipeptides ; romidepsin (CX3T89XQBK) |
Sprache | Englisch |
Erscheinungsdatum | 2022-10-17 |
Erscheinungsland | United States |
Dokumenttyp | Clinical Trial, Phase I ; Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1220066-9 |
ISSN | 1546-170X ; 1078-8956 |
ISSN (online) | 1546-170X |
ISSN | 1078-8956 |
DOI | 10.1038/s41591-022-02023-7 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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