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  1. Artikel: Cellular Uptake of Gold Nanorods in Breast Cancer Cell Lines.

    White, Bryan E / White, Molly K / Nima Alsudani, Zeid A / Watanabe, Fumiya / Biris, Alexandru S / Ali, Nawab

    Nanomaterials (Basel, Switzerland)

    2022  Band 12, Heft 6

    Abstract: Nanosized materials have been proposed for a wide range of biomedical applications, given their unique characteristics. However, how these nanomaterials interact with cells and tissues, as well as how they bio-distribute in organisms, is still under ... ...

    Abstract Nanosized materials have been proposed for a wide range of biomedical applications, given their unique characteristics. However, how these nanomaterials interact with cells and tissues, as well as how they bio-distribute in organisms, is still under investigation. Differences such as the nanoparticle size, shape, and surface chemistry affect the basic mechanisms of cellular uptake and responses, which, in turn, affects the nanoparticles' applicability for biomedical applications. Thus, it is vital to determine how a specific nanoparticle interacts with cells of interest before extensive
    Sprache Englisch
    Erscheinungsdatum 2022-03-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12060937
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Gold Nanorod Substrate for Rat Fetal Neural Stem Cell Differentiation into Oligodendrocytes.

    Sharma, Krishna Deo / Alghazali, Karrer M / Hamzah, Rabab N / Pandanaboina, Sahitya Chetan / Nima Alsudani, Zeid A / Muhi, Malek / Watanabe, Fumiya / Zhou, Guo-Lei / Biris, Alexandru S / Xie, Jennifer Yanhua

    Nanomaterials (Basel, Switzerland)

    2022  Band 12, Heft 6

    Abstract: Gold nanorods (AuNRs) have been proposed to promote stem cell differentiation in vitro and in vivo. In this study, we examined a particular type of AuNR in supporting the differentiation of rat fetal neural stem cells (NSCs) into oligodendrocytes (ODCs). ...

    Abstract Gold nanorods (AuNRs) have been proposed to promote stem cell differentiation in vitro and in vivo. In this study, we examined a particular type of AuNR in supporting the differentiation of rat fetal neural stem cells (NSCs) into oligodendrocytes (ODCs). AuNRs were synthesized according to the seed-mediated method resulting in nanorods with an aspect ratio of around 3 (~12 nm diameter, 36 nm length) and plasmon resonance at 520 and 780 nm, as confirmed by transmission electron microscopy (TEM) and UV-vis spectroscopy, respectively. A layer-by-layer approach was used to fabricate the AuNR substrate on the functionalized glass coverslips. NSCs were propagated for 10 days using fibroblast growth factor, platelet-derived growth-factor-supplemented culture media, and differentiated on an AuNR or poly-D-lysine (PDL)-coated surface using differentiation media containing triiodothyronine for three weeks. Results showed that NSCs survived better and differentiated faster on the AuNRs compared to the PDL surface. By week 1, almost all cells had differentiated on the AuNR substrate, whereas only ~60% differentiated on the PDL surface, with similar percentages of ODCs and astrocytes. This study indicates that functionalized AuNR substrate does promote NSC differentiation and could be a viable tool for tissue engineering to support the differentiation of stem cells.
    Sprache Englisch
    Erscheinungsdatum 2022-03-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12060929
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Development of a polymeric biomedical device platform with controlled disassembly and in vivo testing in a swine intestinal model.

    Alghazali, Karrer M / Pedersen, Alisha P / Hamzah, Rabab N / Mulon, Pierre-Yves / Rifkin, Rebecca E / Mhannawee, Anwer / Nima Alsudani, Zeid A / Griffin, Christopher / Muhi, Malek A H / Mullen, Nikki / Donnell, Robert L / Anderson, David E / Biris, Alexandru S

    Scientific reports

    2022  Band 12, Heft 1, Seite(n) 3208

    Abstract: The aim of this study was to create a surgical guide platform that maintains its integrity while the surgeon performs an intestinal anastomosis or another similar procedure, which then breaks apart and is eliminated from the body in a controlled manner. ... ...

    Abstract The aim of this study was to create a surgical guide platform that maintains its integrity while the surgeon performs an intestinal anastomosis or another similar procedure, which then breaks apart and is eliminated from the body in a controlled manner. The device contains mixed polymeric structures that give it a controlled rate of disassembly that could meet the requirements of a specific surgical purpose. The intraluminal anastomotic guide was manufactured as a hollow cylinder composed of layers of porous polyurethane/PCL with polyvinylpyrrolidone as the binding agent similar to a "brick-mortar" architecture. This combination of polymeric structures is a promising manufacturing method from which a variety of tunable devices can be fabricated for specific medical procedures and site-specific indications. The guide was designed to rapidly disassemble within the intestinal lumen after use, reliably degrading while maintaining sufficient mechanical rigidity and stability to support manipulation during complex surgical procedures. The nature of the device's disassembly makes it suitable for use in hollow structures that discharge their contents, resulting in their elimination from the body. A swine model of intestinal anastomosis was utilized to validate the use and function of the device.
    Mesh-Begriff(e) Anastomosis, Surgical/methods ; Animals ; Digestive System Surgical Procedures/methods ; Intestines/surgery ; Polymers ; Porosity ; Swine
    Chemische Substanzen Polymers
    Sprache Englisch
    Erscheinungsdatum 2022-02-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-06339-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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